Tag: 100-200

On February 12, 1993, Shi, Guo-qiang; Schlosser, Manfred published an article.COA of Formula: C10H11FO2 The title of the article was A novel and versatile access to fluorinated carbo- and heterocyclic compounds employing electron-rich fluorodienes as cycloaddition components. And the article contained the following:

The readily accessible 2-fluoro-1-trimethylsiloxy-1,3-dienes undergo Diels-Alder type cycloaddition with a variety of dienophiles under mild conditions. In this way, fluoro-2-cyclohexenols, fluoro-2,5-dihydropyranols, fluoro-2,5-dihydro-2-pyridinols, fluoropyridines, fluoro-3,6-dihydro-1,2-oxazines and fluoropyrroles can be efficiently prepared The experimental process involved the reaction of Ethyl 3-fluoro-4-methylbenzoate(cas: 86239-00-1).COA of Formula: C10H11FO2

The Article related to diels alder fluorotrimethylsiloxybutadiene, butadiene fluorotrimethylsiloxy diels alder, cyclohexenol fluoro, pyranol fluorodihydro, pyridinol fluorodihydro, pyridine fluoro, oxazine fluorodihydro, pyrrole fluoro and other aspects.COA of Formula: C10H11FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 26, 2022, Paulisch, Tiffany O.; Mai, Lukas A.; Strieth-Kalthoff, Felix; James, Michael J.; Henkel, Christian; Guldi, Dirk M.; Glorius, Frank published an article.Application In Synthesis of Methyl 2-cyclopentanonecarboxylate The title of the article was Dynamic Kinetic Sensitization of β-Dicarbonyl Compounds-Access to Medium-Sized Rings by De Mayo-Type Ring Expansion. And the article contained the following:

Herein, we present a photocatalyzed two-carbon ring expansion of β-dicarbonyl compounds with unactivated olefins that provides facile access to medium-sized rings. Selective sensitization of the substoichiometric enol tautomer enables reactivity of substrates incompatible with the classical De Mayo reaction conditions. Key to success was the identification of the metal-based sensitizer fac-[Ir(CF3-pmb)3], which was excited using common near-visible LEDs, and possesses a high triplet excited state energy of 73.3 kcal mol-1. This exactly falls in the range between the triplet energies of the enol and keto tautomer, thereby enabling a dynamic kinetic sensitization. Demonstrating the applicability of fac-[Ir(CF3-pmb)3] as a photocatalyst in organic synthesis for the first time, a two-step photocycloaddition-ring-opening cascade with β-ketoesters, -diketones, and -ketoamides was described. The mechanism was corroborated by time-resolved spectroscopy, as well as further exptl. and computational studies. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Application In Synthesis of Methyl 2-cyclopentanonecarboxylate

The Article related to alkene cyclic dicarbonyl compound photocatalyst diastereoselective regioselective ring enlargement, dicarbonyl compound preparation, de mayo reaction, energy transfer, photochemistry, ring expansion, spectroscopy and other aspects.Application In Synthesis of Methyl 2-cyclopentanonecarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Awadelkareem, Amir Mahgoub; Al-Shammari, Eyad; Elkhalifa, Abd Elmoneim O.; Adnan, Mohd; Siddiqui, Arif Jamal; Snoussi, Mejdi; Khan, Mohammad Idreesh; Azad, Z. R. Azaz Ahmad; Patel, Mitesh; Ashraf, Syed Amir published an article in 2022, the title of the article was Phytochemical and In Silico ADME/Tox Analysis of Eruca sativa Extract with Antioxidant, Antibacterial and Anticancer Potential against Caco-2 and HCT-116 Colorectal Carcinoma Cell Lines.HPLC of Formula: 85-91-6 And the article contains the following content:

Eruca sativa Mill. (E. sativa) leaves recently grabbed the attention of scientific communities around the world due to its potent bioactivity. Therefore, the present study investigates the metabolite profiling of the ethanolic crude extract of E. sativa leaves using high resolution-liquid chromatog.-mass spectrometry (HR-LC/MS), including antibacterial, antioxidant and anticancer potential against human colorectal carcinoma cell lines. In addition, computer-aided anal. was performed for determining the pharmacokinetic properties and toxicity prediction of the identified compounds Our results show that E. sativa contains several bioactive compounds, such as vitamins, fatty acids, alkaloids, flavonoids, terpenoids and phenols. Furthermore, the antibacterial assay of E. sativa extract showed inhibitory effects of the tested pathogenic bacterial strains. Moreover, the antioxidant activity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) were found to be IC50 = 66.16 μg/mL and 76.05 μg/mL, resp. E. sativa also showed promising anticancer activity against both the colorectal cancer cells HCT-116 (IC50 = 64.91 μg/mL) and Caco-2 (IC50 = 83.98 μg/mL) in a dose/time dependent manner. The phytoconstituents identified showed promising pharmacokinetics properties, representing a valuable source for drug or nutraceutical development. These investigations will lead to the further exploration as well as development of E. sativa-based nutraceutical products. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).HPLC of Formula: 85-91-6

The Article related to gene expression eruca antioxidant antibacterial anticancer agent colorectal carcinoma, eruca sativa, bioactive compounds, colorectal cancer, erucin, isothiocyanates, jarjeer, nutraceutical, phytochemical analysis and other aspects.HPLC of Formula: 85-91-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 31, 2017, Abronina, Polina I.; Zinin, Alexander I.; Malysheva, Nelly N.; Stepanova, Elena V.; Chizhov, Alexander O.; Torgov, Vladimir I.; Kononov, Leonid O. published an article.SDS of cas: 707-07-3 The title of the article was A Novel Glycosyl Donor with a Triisopropylsilyl Nonparticipating Group in Benzyl-Free Stereoselective 1,2-cis-Galactosylation. And the article contained the following:

A novel glycosyl donor with a triisopropylsilyl (TIPS) nonparticipating group at O-2 is introduced for use in 1,2-cis-galactosylation. Coupling the 2-O-TIPS-substituted thiogalactoside donor with a series of mono- and disaccharide glycosyl acceptors was found to lead exclusively to α-linked oligosaccharides. The observed exceptionally high α-selectivity was interpreted in terms of conformational changes in the glycosyl cation induced by the bulky 2-O-TIPS group. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).SDS of cas: 707-07-3

The Article related to coupling disaccharide oligosaccharide protecting group preparation stereoselective glycosylation, stereoselective glycosylation galactosylation conformation glycoside preparation thioglycoside disaccharide trisaccharide and other aspects.SDS of cas: 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 1, 2017, Luo, Shipeng; Zhang, Xiao; Zheng, Yu; Harms, Klaus; Zhang, Lilu; Meggers, Eric published an article.Recommanded Product: (Trimethoxymethyl)benzene The title of the article was Enantioselective Alkynylation of Aromatic Aldehydes Catalyzed by a Sterically Highly Demanding Chiral-at-Rhodium Lewis Acid. And the article contained the following:

The enantioselective catalytic alkynylation of aromatic aldehydes is reported using a sterically highly hindered bis-cyclometalated rhodium-based Lewis acid catalyst featuring the octahedral metal as the only stereogenic center. Yields of 58-98% with 79-98% enantiomeric excess were achieved using 1-2 mol % of catalyst. This work complements previous work from the authors’ laboratory on the enantioselective alkynylation of 2-trifluoroacetyl imidazoles and trifluoromethyl ketones using catalysts with octahedral metal-centered chirality. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Recommanded Product: (Trimethoxymethyl)benzene

The Article related to biscyclometalated rhodium lewis acid catalyst preparation mol crystal structure, arylaldehyde terminal alkyne enantioselective alkynylation biscyclometalated rhodium lewis acid, chiral diaryl propargylic alc preparation and other aspects.Recommanded Product: (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 21, 2020, Paul, Melanie; Teubner, Melissa; Grimm-Lebsanft, Benjamin; Golchert, Christiane; Meiners, Yannick; Senft, Laura; Keisers, Kristina; Liebhaeuser, Patricia; Roesener, Thomas; Biebl, Florian; Buchenau, Soeren; Naumova, Maria; Murzin, Vadim; Krug, Roxanne; Hoffmann, Alexander; Pietruszka, Joerg; Ivanovic-Burmazovic, Ivana; Ruebhausen, Michael; Herres-Pawlis, Sonja published an article.COA of Formula: C7H10O3 The title of the article was Exceptional Substrate Diversity in Oxygenation Reactions Catalyzed by a Bis(μ-oxo) Copper Complex. And the article contained the following:

The enzyme tyrosinase contains a reactive side-on peroxo dicopper(II) center as catalytically active species in C-H oxygenation reactions. The tyrosinase activity of the isomeric bis(μ-oxo) dicopper(III) form has been discussed controversially. The synthesis of bis(μ-oxo) dicopper(III) species [Cu2(μ-O)2(L1)2](X)2 ([O1](X)2, X = PF6-, BF4-, OTf-, ClO4-), stabilized by the new hybrid guanidine ligand 2-(2-((dimethylamino)methyl)phenyl)-1,1,3,3-tetramethylguanidine (L1), and its characterization by UV/Vis, Raman, and XAS spectroscopy, as well as cryo-UHR-ESI mass spectrometry, are described. The highlight selective oxygenation of a plethora of phenolic substrates such as 1H-indol-7-ol, naphthalen-1-ol, pyridin-4-ol, etc. mediated by [O1](PF6)2, results in mono- and bicyclic quinones such as 3,4-pyridinedione, 1,2-naphthalenedione, 1H-indole-6,7-dione and provides an attractive strategy for designing new phenazines e.g., benzo[a]phenazine. The selectivity is predicted by using the Fukui function, which is hereby introduced into tyrosinase model chem. The bioinspired catalysis harnesses mol. dioxygen for organic transformations and achieves a substrate diversity reaching far beyond the scope of the enzyme. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).COA of Formula: C7H10O3

The Article related to phenazine preparation, quinone preparation phenylenediamine condensation copper complex catalyst, aryl alc oxygenation copper complex catalyst, copper catalysis, dioxygen activation, guanidines, phenazines, tyrosinase and other aspects.COA of Formula: C7H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Yakun; Li, Yueyun; Lian, Mingming; Zhang, Jixia; Liu, Zhaomin; Tang, Xiaofei; Yin, Hang; Meng, Qingwei published an article in 2019, the title of the article was Asymmetric α-alkylation of cyclic β-keto esters and β-keto amides by phase-transfer catalysis.Computed Properties of 10472-24-9 And the article contains the following content:

Without employing any transition metal, a highly enantioselective α-alkylation of cyclic β-keto esters and β-keto amides has been realized by phase-transfer catalysis. This improved procedure is applicable to different kinds of bromides with cinchona derivatives and gives the corresponding products e.g., I and e.g., II, in excellent enantiopurities (up to 98% ee) and good yields (up to 98%). Moreover, the reaction was scalable and the phase-transfer catalyst was recyclable. This provided an alternative and competitive method to the asym. α-alkylation of β-dicarbonyl compounds The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Computed Properties of 10472-24-9

The Article related to indanone preparation enantioselective, keto ester alkyl bromide alkylation cinchona phase transfer catalyst, amide keto alkyl bromide alkylation cinchona phase transfer catalyst, tetralone preparation enantioselective and other aspects.Computed Properties of 10472-24-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 2020, Yakovenko, Georgiy G.; Lukianov, Oleh A.; Yagodkina-Yakovenko, Marta S.; Bol’but, Andriy V.; Vovk, Mikhailo V. published an article.Category: esters-buliding-blocks The title of the article was Synthesis of 5-amino-1H-pyrazolo[4,3-b]pyridine derivatives and annulation of imidazole and pyrimidine rings thereto. And the article contained the following:

A series of 5-amino-1H-pyrazolo[4,3-b]pyridine derivatives I [R1 = Me, Et, Ph, etc.; R2 = H, OMe; R3 = CN, C(O)NH2, CO2tBu] was synthesized via Friedlander reaction of N-Boc-protected 1-alkyl(aryl)-5-formyl-1Hpyrazol-4-amines with alkyl nitriles. Cyclocondensation of some of the compounds I with orthoesters, Et oxalyl chloride or carbonyldiimidazole to afford pyrazolo[3′,4′,5,6]pyrido[2,3-d]pyrimidine derivatives II [R4 = Me, tBu, Ph; R5 = H, iPr, Ph] and III [R1 = Me, Et, Ph, etc.] was reported. Cyclocondensation of some of the compounds I with chloroacetaldehyde, bromotrifluoroacetone or Et bromopyruvate to form imidazo[1,2-a]pyrazolo[3,4-e]pyridines IV [R6 = Me, Et, tBu, Ph; R2 = H, OMe; R7 = CN, C(O)NH2; R8 = H, CO2Et, CF3] was reported. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Category: esters-buliding-blocks

The Article related to amino pyrazolopyridine preparation, formyl pyrazole amine alkyl nitrile friedlander, imidazopyrazolopyridine preparation, carbonyl halide amino pyrazolopyridine cyclocondensation, pyrazolopyridopyrimidine preparation and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2020, Xiang, Xiao-Feng; Lan, Yi-Bin; Gao, Xiao-Tong; Xie, Han; An, Zhao-Yan; Lv, Zhi-Hao; Yin-Shi; Duan, Chang-Qing; Wu, Guang-Feng published an article.Recommanded Product: 123-25-1 The title of the article was Characterization of odor-active compounds in the head, heart, and tail fractions of freshly distilled spirit from Spine grape (Vitis davidii Foex) wine by gas chromatography-olfactometry and gas chromatography-mass spectrometry. And the article contained the following:

Differences in key odor-active volatile compounds among the head, heart, and tail fractions of freshly distilled spirits from Spine grape (Vitis davidii Foex) wine were identified for the first time by gas chromatog.-olfactometry and gas chromatog.-mass spectrometry. Results from aroma extract dilution anal. (AEDA) showed that there were 34, 45, and 37 odor-active compounds in the head, heart and tail fractions, resp. Besides, 20, 22, and 17 quantified compounds, resp., showed odor activity values (OAVs) > 1. The head fraction was characterized by fruity, fusel/solvent notes owing to higher concentrations of higher alcs. and esters, while the tail fraction had more intense smoky/animal, sweaty/fatty attributes due to higher concentrations of volatile phenols and fatty acids. Finally, the heart fraction was characterized by Et octanoate, Et hexanoate, Et 3-phenylpropanoate, Et cinnamate, isoamyl alc., guaiacol, 4-ethylguaiacol, 4-vinylguaiacol, 2,3-butanedione, and (E)-β-damascenone. Furthermore, observation of the distillation progress indicated that different volatiles with various b.ps. and solubilities followed diverse distillation patterns: concentrations of most esters, higher alcs., terpenes and C13-norisoprenoids decreased, while concentrations of volatile phenols, fatty acids and some aromatic compounds increased during distillation As a result, their final concentrations in the three distillate fractions varied significantly. The experimental process involved the reaction of Diethyl succinate(cas: 123-25-1).Recommanded Product: 123-25-1

The Article related to vitis head heart tail fraction gas chromatog olfactometry ms, aroma, aroma extract dilution analysis, distillation cut, gas chromatography-olfactometry-mass spectrometry, spine grape (vitis davidii foex), wine spirit and other aspects.Recommanded Product: 123-25-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 12, 2008, Dragovich, Peter S.; Murphy, Douglas E.; Dao, Kimkim; Kim, Sun Hee; Li, Lian-Sheng; Ruebsam, Frank; Sun, Zhongxiang; Tran, Chinh V.; Xiang, Alan X.; Zhou, Yuefen published an article.Application of 119993-56-5 The title of the article was Efficient synthesis of (1R,2S) and (1S,2R)-2-aminocyclopentanecarboxylic acid ethyl ester derivatives in enantiomerically pure form. And the article contained the following:

A 4-step synthesis of an optically active synthetic intermediate [(1R,2S)-2-(4′-fluorobenzylamino)cyclopentanecarboxylic acid Et ester complex with (S)-(+)-mandelic acid (I), >99% de] required for the preparation of a promising HCV NS5B polymerase inhibitor is reported. This process utilizes mandelic acid as a resolving agent, which can be recovered in good yield by a simple extraction An optimized version of the chem. described avoids the use of chromatog. purifications making it suitable for large-scale applications. In addition, the straightforward conversion of compound I to enantiomerically pure (1R,2S)-2-aminocyclopentanecarboxylic acid Et ester and the corresponding Boc and Cbz derivatives (Boc = tert-butoxycarbonyl, Cbz = benzyloxycarbonyl) is reported. The preparation of the enantiomer of I, compound (II), in enantiomerically pure form and the conversion of this entity to (1S,2R)-2-aminocyclopentanecarboxylic acid Et ester and the corresponding Boc and Cbz derivatives is also described. The experimental process involved the reaction of Ethyl 2-aminocyclopentanecarboxylate hydrochloride(cas: 119993-56-5).Application of 119993-56-5

The Article related to enantiopure amino cyclopentanecarboxylic acid ethyl complex mandelic acid synthesis, aminocyclopentanecarboxylic acid ethyl ester hcv ns5b polymerase inhibitor preparation, mandelic acid resolving agent extraction hydrogenation and other aspects.Application of 119993-56-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics