Tag: 100-200

On April 22, 1999, Cameron, Kimberly O’Keefe; Lefker, Bruce Allen; Rosati, Robert Louis published a patent.Electric Literature of 142327-44-4 The title of the patent was Preparation of prostaglandin agonists and their use to treat bone disorders. And the patent contained the following:

Title prostaglandin agonists GAB(KM)QZ [A is SO2, CO; G is Ar, alkylene, ArCONHalkylene, amino, oxyalkylene, etc.; B is N, CH; Q is alkylene, alkyl, alkylene-W-alkylene, alkylene-W-X-alkylene; W is oxy, thio, sulfino, sulfonyl, aminosulfonyl, etc.; X is aryl; K is a bond, alkylene, thioalkylene, alkylenethioalkylene, etc.; M is Ar, ArSar, ArSOAr, ArSO2Ar, ArOAr], prodrugs thereof and the pharmaceutically acceptable salts of said compounds and said prodrugs are prepared as well as methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists are discussed. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Electric Literature of 142327-44-4

The Article related to arylsulfonylaminoaliphaticcaboxylic acid preparation prostaglandin agonist, arylsulfonylaminoaromaticcaboxylic acid preparation prostaglandin agonist, Aliphatic Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Electric Literature of 142327-44-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 25, 2018, Blumel, Marcus; Nagasawa, Shota; Blackford, Katherine; Hare, Stephanie R.; Tantillo, Dean J.; Sarpong, Richmond published an article.Formula: C10H14O3 The title of the article was Rearrangement of Hydroxylated Pinene Derivatives to Fenchone-Type Frameworks: Computational Evidence for Dynamically-Controlled Selectivity. And the article contained the following:

An acid-catalyzed Prins/semipinacol rearrangement cascade reaction of hydroxylated pinene derivatives that leads to tricyclic fenchone-type scaffolds in very high yields and diastereoselectivity has been developed. Quantum chem. anal. of the selectivity-determining step provides support for the existence of an extremely flat potential energy surface around the transition state structure. This transition state structure appears to be ambimodal, i.e., the fenchone-type tricyclic scaffolds are formed in preference to the competing formation of a bornyl (camphor-type) skeleton under dynamic control via a post-transition state bifurcation (PTSB). The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Formula: C10H14O3

The Article related to diastereoselective prins semipinacol rearrangement cascade hydroxylated pinene derivative fenchone, Terpenes and Terpenoids: Monoterpenes (C10), Including Cannabinoids, Chrysanthemic Acids, and Iridoid Aglycons and other aspects.Formula: C10H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 9, 2016, Chen, Austin; Bravo, Yalda; Stock, Nicholas; Pedram, Bijan; Jacintho, Jason; Clark, Ryan C.; Truong, Yen published a patent.Application of 37480-41-4 The title of the patent was Thio-substituted benzamides as antiviral agents for the treatment of treatment HBV infection and their preparation. And the patent contained the following:

The invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of formula I. Compounds of formula I wherein each R1, R2, and R3 are halo; R4 is (un)substituted C3-7 cycloalkyl (un)substituted C1-6 alkyl-C3-7 cycloalkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by thioetherification of N-(3,4,5-trifluoromethylphenyl)-4-fluoro-3-iodobenzamide with 1-(mercaptomethyl)cyclopropylacetic acid. The invention compounds were evaluated for their antiviral activity (some data given). The experimental process involved the reaction of Methyl 1-methyl-4-oxocyclohexanecarboxylate(cas: 37480-41-4).Application of 37480-41-4

The Article related to thiobenzamide preparation antiviral treatment hbv infection, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Application of 37480-41-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 15, 2020, Ye, Zhaolian; Zhuang, Yu; Chen, Yantong; Zhao, Zhuzi; Ma, Shuaishuai; Huang, Hongying; Chen, Yanfang; Ge, Xinlei published an article.Name: Methyl 2-cyclopentanonecarboxylate The title of the article was Aqueous-phase oxidation of three phenolic compounds by hydroxyl radical: Insight into secondary organic aerosol formation yields, mechanisms, products and optical properties. And the article contained the following:

This work performed a systematic investigation on the aqueous hydroxyl radical (OH) – induced photochem. oxidation of three modestly-soluble precursors from biomass combustion including 4-methylsyringol (DMP), eugenol (Eug), and 2,4,6-trimethylphenol (TRMP) under both simulated sunlight and UV light irradiations. An Aerodyne soot particle aerosol mass spectrometer (SP-AMS) was used to monitor the bulk chem. and elemental compositions of aqueous secondary organic aerosol (aqSOA) formed. AqSOA mass yields varied in ranges of 80-190% and 0-200% under sunlight and UV light conditions, resp. AqSOA oxygen-to-carbon (O/C) ratio and carbon oxidation state increased steadily under sunlight + OH condition, but increased then decreased under UV + OH condition. Organic acids including malic acid, glycolic acid, formic acid and oxalic acid were formed, and their total accounted for ∼12% of SOA mass. The UV-vis spectral change suggested formation of light-absorbing organics Reaction pathways were proposed by combining gas chromatog.-mass spectrometry (GC-MS) and SP-AMS results. Under sunlight + OH condition, oligomerization, functionalization, and fragmentation processes all involved in aqSOA evolution, with more contribution from functionalization via hydroxylation and oxygenation reactions. Reaction mechanism of UV + OH oxidation was initially dominated by functionalization then by fragmentation, indicating by the decrease of total organic carbon (TOC) contents, formation of small organic acids and low-mol.-weight products. Our work highlights that combination of SP-AMS with GC-MS is a powerful method for laboratory investigation of aqueous-phase reactions. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Name: Methyl 2-cyclopentanonecarboxylate

The Article related to phenolic compound oxidation hydroxyl radical secondary organic aerosol, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Radiation Chemistry and Photochemistry and other aspects.Name: Methyl 2-cyclopentanonecarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qiao, Chang; Yao, Xiang-Yang; Liu, Xiao-Fang; Li, Hong-Ru; He, Liang-Nian published an article in 2018, the title of the article was Efficient Iron-Catalyzed Reductive N-Alkylation of Aromatic Amines with Carboxylic Acids and Phenylsilane.Application of 85-91-6 And the article contains the following content:

Herein, an earth-abundant iron-catalyzed protocol for the N-alkylation of anilines using carboxylic acid as alkyl source and phenylsilane as reducing agent was reported. With Fe2(CO)9 as a catalyst, a broad range of primary and secondary anilines are successfully converted to the corresponding tertiary anilines. Furthermore, this N-alkylation mainly goes through the amide pathway; while the aldehyde pathway can not be ruled out. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Application of 85-91-6

The Article related to tertiary aniline preparation green chem, aniline carboxylic acid reductive alkylation iron catalyst phenylsilane, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Application of 85-91-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Wenzhao; Zhu, Yunbo; Zhang, Long; Luo, Sanzhong published an article in 2018, the title of the article was Asymmetric α-Alkylation of β-Ketocarbonyls via Direct Phenacyl Bromide Photolysis by Chiral Primary Amine.Recommanded Product: 517-23-7 And the article contains the following content:

Enantioselective α-photoalkylation of β-ketocarbonyls without any external photosensitizer was described in this work. The photoalkylation reactions, enabled solely by a chiral primary amine catalyst, provided convenient constructions of all-carbon quaternary stereocenters with good activity and high enantioselectivity. Mechanism studies revealed a direct photolytic radical chain process under visible light irradiation The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Recommanded Product: 517-23-7

The Article related to diketone phenacyl bromide amine photochem enantioselective regioselective alkylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Recommanded Product: 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 15, 2016, Choliq, Azka Azkiya; Watanabe, Junya; Misaki, Tomonori; Okamoto, Yasuaki; Sugimura, Takashi published an article.HPLC of Formula: 3976-69-0 The title of the article was Enantioselective hydrogenation of β-aryl-β-ketoester over α-hydroxy acid-modified Raney nickel catalysts: competitive hydrogenation with methyl acetoacetate. And the article contained the following:

The enantioselective hydrogenation of the aromatic β-ketoesters, Me 3-phenyl-3-oxopropanoate (1) and its p-methoxy analog (2), was studied over tartaric acid-modified Raney nickel catalysts. A competitive hydrogenation approach was used to clarify the catalytic behaviors of the enantio-differentiating hydrogenation of aromatic β-ketoesters over tartaric acid-modified Raney nickel, malic acid-modified Raney nickel, and unmodified Raney nickel in comparison with aliphatic one, represented by Me acetoacetate. The authors found that the enantioselectivity could be elucidated by the interaction modes between the surface modifier, Ni metal surface, and the substrate as well as the keto/enol ratio of the substrate. The authors suggest that the moderate enantioselectivity of 1 over tartaric acid-modified Raney nickel is the result of distorted, weak two-point hydrogen bond interactions with surface tartrate due to unfavorable phenyl-Ni metal surface interactions. The p-methoxy group of 2 suppresses the phenyl-Ni metal surface interactions, resulting in an increase in the enantioselectivity of 2 over tartaric acid-modified Raney nickel. Ligand acceleration effects were observed with Me acetoacetate and 2 but not with 1. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).HPLC of Formula: 3976-69-0

The Article related to aryl keto ester enantioselective hydrogenation tartaric acid nickel catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.HPLC of Formula: 3976-69-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 20, 2021, He, Tianyu; Chen, Dengfeng; Qian, Shencheng; Zheng, Yu; Huang, Shenlin published an article.Application of 10472-24-9 The title of the article was Selective C-C Bond Cleavage of Cycloalkanones by NaNO2/HCl. And the article contained the following:

A novel selective fragmentation of cycloalkanones by NaNO2/HCl has been established. The C-C bond cleavage reaction proceeds smoothly under mild conditions, selectively affording versatile keto acids or oxime acids. The methodol. can streamline the synthesis of valuable chiral mols. and isocoumarins from readily available feedstocks. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Application of 10472-24-9

The Article related to keto oxime acid preparation, cycloalkanone selective bond cleavage, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Application of 10472-24-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 9, 2018, Patel, Harshkumar H.; Prater, Matthew B.; Squire, Scott O.; Sigman, Matthew S. published an article.Synthetic Route of 517-23-7 The title of the article was Formation of Chiral Allylic Ethers via an Enantioselective Palladium-Catalyzed Alkenylation of Acyclic Enol Ethers. And the article contained the following:

This report details a palladium-catalyzed process to access highly functionalized, optically active allylic aryl ethers. A number of electron-deficient alkenyl triflates underwent enantioselective and site-selective coupling with acyclic aryl enol ethers in the presence of a chiral palladium catalyst. This transform provides chiral allylic ether products in high yields and excellent enantiomeric ratios, furnishing a unique disconnection to incorporate heteroatoms at a stereocenter. Finally, the applicability of the products to target synthesis was demonstrated through the formation of a chiral allylic alc. and the generation of a flavone-inspired product. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Synthetic Route of 517-23-7

The Article related to chiral allylic aryl ether preparation palladium catalyzed alkenylation, enantioselective palladium catalyzed alkenylation acyclic enol ether, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Synthetic Route of 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 2, 2017, Hemeon, Ivan William; Safina, Brian; Sutherlin, Daniel published a patent.Category: esters-buliding-blocks The title of the patent was Preparation of fluorinated aromatic ethers as sodium channel blockers useful in treatment of diseases. And the patent contained the following:

The invention relates to preparation of fluorinated aromatic ethers of formula I wherein the variables RAA, n, ring A, X1, L, m, X2, R2, R3, R4, R5, X, and R6 are as defined in the disclosure, and pharmaceutically acceptable salts thereof, , and compositions containing such compounds that are sodium channel blockers, and methods for using such compounds and compositions for the treatment of various diseases. The experimental process involved the reaction of Ethyl 2-aminocyclopentanecarboxylate hydrochloride(cas: 119993-56-5).Category: esters-buliding-blocks

The Article related to adamantylmethyl fluoroaryl ether preparation sodium channel blocker therapeutic agent, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics