Tag: 100-200

On March 31, 2017, Osawa, Tsutomu; Tanabe, Yuya; Fujiwara, Manabu published an article.Related Products of 3976-69-0 The title of the article was Sodium Ion as the Most Essential and Effective Element for the Enantio-Differentiating Hydrogenation of Prochiral Ketones over Tartaric Acid Modified Ni Catalyst. And the article contained the following:

In order to investigate the role of metal ions on a tartaric acid modified nickel catalyst, the enantiodifferentiating hydrogenations of Me acetoacetate and Me levulinate were carried out. The effects of the addition of 17 metal salts of acetic acid on the enantioselectivity and the hydrogenation rate were investigated during the hydrogenation of Me acetoacetate. Among the examined metal salts, the addition of NaBr caused the great increase in the enantioselectivity and the hydrogenation rate during the hydrogenations of both Me acetoacetate and Me levulinate. Based on the strength of the interaction between the metal salts of tartaric acid and the substrate, the sodium salts would have the strongest interaction with the substrate, hence, this would be attributed to the highest enantioselectivity and hydrogenation rate for the sodium salts of tartaric acid. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Related Products of 3976-69-0

The Article related to ketoester enantioselective hydrogenation catalyst nickel tartaric acid sodium ion, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Related Products of 3976-69-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Choliq, Azka Azkiya; Nakae, Rio; Watanabe, Mariko; Misaki, Tomonori; Fujita, Morifumi; Okamoto, Yasuaki; Sugimura, Takashi published an article in 2019, the title of the article was Enhanced Enantioselectivity Achieved at Low Hydrogen Pressure for the Asymmetric Hydrogenation of Methyl Acetoacetate over a Tartaric Acid NaBr-Modified Raney Nickel Catalyst: A Kinetic Study.Safety of (R)-Methyl 3-hydroxybutanoate And the article contains the following content:

To ensure high enantiopurity of the product, enantio-differentiating hydrogenation of Me acetoacetate over a (R,R)-tartaric acid-modified Raney nickel catalyst is normally performed under elevated H2-pressure (∼10 MPa). In this study, higher enantioselectivity than previously reported for Me acetoacetate was achieved (92% ee) under low H2-pressure of 0.42 MPa. Effects of reaction conditions on the enantioselectivity and hydrogenation rate were investigated using a low-pressure reaction system (<0.5 MPa of H2). It was found that impurities in the solvent greatly reduce the enantioselectivity of MAA. The low-pressure reaction system enabled a satisfactory kinetic approach. The reaction rate was well described by Langmuir-Hinshelwood formalism, verifying the previous assumption that the addition of adsorbed hydrogen to the substrate interacting with surface tartrate is a rate-determining step. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Safety of (R)-Methyl 3-hydroxybutanoate

The Article related to methyl acetoacetate modified ni catalyst enantioselective hydrogenation kinetics, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Safety of (R)-Methyl 3-hydroxybutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 4, 2022, Hu, Shuanghua; Lin, Zhaiwei; Cui, Baicheng published a patent.Name: Ethyl 3-fluoro-2-methylbenzoate The title of the patent was Preparation of pyridazinone derivatives and its application as anti-influenza drugs with CEN inhibitory effect. And the patent contained the following:

The present invention relates to the preparation of pyridazinone derivatives and its application as anti-influenza drugs with CEN inhibitory effect. In particular, the pyridazinone derivative I (wherein, R1 = H or, -C(=O)Y1, -C(=O)-O-Y1, etc.; Y1 = optionally substituted C1-10 alkyl, optionally substituted C3-8 cycloalkyl, optionally substituted aryl, etc.; where R* and R** = H or optionally substituted C1-6 alkyl; R2 and R3 = H, C1-6 alkyl, -C(O)-C1-6 alkyl, etc.; where R* and R** = H and optionally substituted C1-6 alkyl; q is 0-6; R4 = compound II; R9 and R10 = optionally substituted aryl, and optionally substituted heteroaryl; wherein the substituents are independent C1-6 alkyl, -C(O)- C1-6 alkyl, etc.; where R* and R** = H and optionally substituted C1-6 alkyl, and q is 0-6; R9 and R10 = linked to form the compound III; wherein n and m = 0-3, Q = CR*R**, NR*, O, S, SO, SO2; R* and R** = H and optionally substituted C1-6 alkyl;). Further, (R5 and R6 = H, or is selected from optionally substituted C1-8 alkyl, optionally substituted C2-8 alkenyl, etc.; wherein R* and R** = H and optionally substituted C1-6 alkyl, and q is 0-6; R7 and R8 = H, C1-6 alkyl, -C(O)- C1-6 alkyl, etc.; R* and R** = H and optionally substituted C1-6 alkyl; q is 0-6; R5, R7 or R6, R8 can be connected into a 5-8 membered saturated or unsaturated ring, such as a 6-membered ring, the ring may be a carbocyclic ring, or a heterocyclic ring containing O or N) or its pharmaceutically acceptable salts, solvates, hydrates, polycrystals, prodrugs, co-crystals, tautomers, stereoisomers, were prepared The inventive pyridazinone derivatives can be used as anti-influenza drugs with CEN inhibitory effect. The experimental process involved the reaction of Ethyl 3-fluoro-2-methylbenzoate(cas: 114312-57-1).Name: Ethyl 3-fluoro-2-methylbenzoate

The Article related to pyridazinone derivative preparation antiinfluenza drug cen inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Name: Ethyl 3-fluoro-2-methylbenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Xiao-Feng; Wang, Yao-Feng; Guo, Tao; Luan, Li-Kun; Liu, Shan-Shan; Xu, Bao-Hua published an article in 2022, the title of the article was Synthesis of adiponitrile from dimethyl adipate and ammonia in the vapor-phase over niobium oxide.Formula: C7H10O3 And the article contains the following content:

An environmentally benign route leading to adiponitrile (ADN), a nylon-6,6 intermediate, was achieved by direct vapor-phase nitrilation of di-Me adipate (DMA) with ammonia (NH3) in a fixed-bed reactor. The challenges of this reaction include not only inhibiting both intramol. cyclization and the intermol. polycondensation of the electron-withdrawing group functionalized carbon chain but also suppressing the thermolysis of aliphatic DMA and ADN. Both amphoteric oxides and acidic oxides enable the transformation but exhibit different reactivities. Under evaluation conditions, the acidic oxides exhibit moderate to good nitrile selectivity, while the amphoteric oxides exhibit high DMA conversions with relatively low nitrile selectivity. Under the optimized conditions, the desired ADN was obtained with a selectivity of 84.3% with 97.7% DMA conversion over Nb2O5-1000 consisting of a monoclinic structure/phase (H-Nb2O5). The structure-performance relationship of this catalyst was preliminarily discussed. Furthermore, a tentative reaction pathway consisting of ammonolysis and dehydration processes in a tandem mode was proposed. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Formula: C7H10O3

The Article related to adiponitrile dimethyl adipate ammonia vapor niobium oxide, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Formula: C7H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 20, 2013, Zhao, Baoli; Cheng, Kai; Hu, Liujiang published a patent.COA of Formula: C11H11NO2 The title of the patent was Preparation of arylenealkyne substituted indolizine derivatives as antitumor agents. And the patent contained the following:

This patent supplies chem. structural formula I of title arylenealkyne indolizine derivatives, in which R1 is H or halogen atom, R2 is cyano, COOEt or COOBu, and R3 is C1-C4 alkyl. 3-[2-(4-Chlorophenyl)ethynyl]-1-indolizinecarbonitrile (II) was prepared by reacting 4-chloro-2,2-dibromovinylbenzene and 1-indolizinecarbonitrile in the presence of inorganic alkali and Pd catalyst in N,N-DMF under nitrogen protection at 80-100°C, and separating and purifying. Compound II was prepared and showed IC50 value of 3.2 μm/mL against colon cancer cells. The arylenealkyne substituted indolizine derivatives are applied for producing antineoplastic drug. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).COA of Formula: C11H11NO2

The Article related to indolizine arylenealkyne preparation antitumor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C11H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 24, 2014, Madanahalli Ranganath Rao, Jagannath; Gurram Ranga, Madhavan; Pachiyappan, Shanmugam published a patent.Category: esters-buliding-blocks The title of the patent was Preparation of spirooxindole derivatives for use as AMPK activators. And the patent contained the following:

Title compounds I [A = bond, (un)substituted aryl, or heteroaryl; B = (un)substituted cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; C = (un)substituted aryl or heteroaryl; X = N or CR3; Y = H, OH, (un)substituted heteroaryl, etc.; Z = bond or a linking moiety; R1 and R2 independently = H or (un)substituted alkyl; R3 and R5 independently = H, halo, CN, NO2, etc.; R4 = H, F, Cl, Br, or I; R6 and R7 independently = H or (un)substituted alkyl; n = 0 to 2], and their pharmaceutically acceptable salts, are prepared and disclosed as AMPK activators. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in AMPK biol. activity assays, e.g., II demonstrated 166% activation of beta 1 at 10 μM. The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Category: esters-buliding-blocks

The Article related to spirooxindole preparation ampk activator, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 2, 2009, Xia, Ji-Bao; Wang, Xue-Qiang; You, Shu-Li published an article.Computed Properties of 93476-46-1 The title of the article was Synthesis of Biindolizines through Highly Regioselective Palladium-Catalyzed C-H Functionalization. And the article contained the following:

Biindolizines were synthesized under mild conditions with excellent regioselectivity in high yields through palladium- catalyzed C-H functionalization of indolizines. Synthesis of a macrocyclic compound was also achieved via intramol. double C-H functionalization. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Computed Properties of 93476-46-1

The Article related to biindolizine regioselective preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Basavaraj, M.; Giles, D.; Das, A. K.; Sakharam, A. G. published an article in 2018, the title of the article was Synthesis and characterization of some novel indolizine derivatives.Quality Control of Ethyl indolizine-1-carboxylate And the article contains the following content:

A novel approach was adopted for the synthesis of Indolizine nucleus. Pyridinium-N-methylides were synthesized by reacting pyridine with different haloacetic acids. Further, the indolizine nucleus were synthesized through 1,3-cycloaddition of pyridinium-N-methylides with electron deficient alkynes or alkenes in presence of MnO2 to give indolizine carboxylates. Later on, derivatives of indolizine were prepared by treating indolizine carboxylates with hydralazine and metformin. Synthesis of indolizine 2-carboxylic acid was achieved, by reacting 2-Me pyridine with Et bromopyruvate. The resulting acid was treated with hydralazine and metformin to form corresponding indolizine derivatives Synthesized compounds were characterized by IR and NMR spectroscopic techniques. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Quality Control of Ethyl indolizine-1-carboxylate

The Article related to indolizinyl carbohydrazide preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of Ethyl indolizine-1-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 19, 2021, Qian, Peng; Liu, Jiaojiao; Zhang, Yan; Wang, Zhiyong published an article.Electric Literature of 85-91-6 The title of the article was Tunable Electrosynthesis of Anthranilic Acid Derivatives via a C-C Bond Cleavage of Isatins. And the article contained the following:

A facile and direct electrocatalytic C-C bond cleavage/functionalization reaction of isatins with alcs./ammonia to form 2-aminobenzoates/2-aminobenzamides I [R1 = OMe, OEt; R2 = H, 5-F, 3-Me, etc.; R3 = NH2, HNC(O)OMe, etc.] was developed. With isatins as the amino-attached C1 sources, a variety of aminobenzoates and aminobenzamides were synthesized in moderate to good yields under mild conditions. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Electric Literature of 85-91-6

The Article related to aminobenzoate or aminobenzamide green preparation, isatin alc or ammonia carbon bond cleavage, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.Electric Literature of 85-91-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2015, Yang, Jianxin; Yin, Yunxing; He, Zhenmin; Ma, Li; Li, Xin; Zhang, Zhiliu; Lin, Xiaojuan; Ma, Rujia published an article.Quality Control of Methyl 2-hydroxy-3,3-dimethylbutanoate The title of the article was 2-Hydroxymalonitrile – A useful reagent for one-step synthesis of α-Hydroxy esters. And the article contained the following:

An efficient one-pot synthesis of α-hydroxy esters via the reaction of 2-hydroxymalonitrile with an aldehyde or a ketone was described. The experimental process involved the reaction of Methyl 2-hydroxy-3,3-dimethylbutanoate(cas: 121129-31-5).Quality Control of Methyl 2-hydroxy-3,3-dimethylbutanoate

The Article related to aldehyde ketone hydroxymalonitrile alc esterification, alpha hydroxy ester preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.Quality Control of Methyl 2-hydroxy-3,3-dimethylbutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics