Tag: 100-200

On December 15, 2017, Zheng, Ruixiang Blake; Jegouzo, Sabine A. F.; Joe, Maju; Bai, Yu; Tran, Huu-Anh; Shen, Ke; Saupe, Jorn; Xia, Li; Ahmed, Faiaz Md.; Liu, Yu-Hsuan; Patil, Pratap Subhashrao; Tripathi, Ashish; Hung, Shang-Cheng; Taylor, Maureen E.; Lowary, Todd L.; Drickamer, Kurt published an article.Electric Literature of 707-07-3 The title of the article was Insights into Interactions of Mycobacteria with the Host Innate Immune System from a Novel Array of Synthetic Mycobacterial Glycans. And the article contained the following:

An array of homogeneous glycans representing all the major carbohydrate structures present in the cell wall of the human pathogen Mycobacterium tuberculosis and other mycobacteria has been probed with a panel of glycan-binding receptors expressed on cells of the mammalian innate immune system. The results provide an overview of interactions between mycobacterial glycans and receptors that mediate uptake and survival in macrophages, dendritic cells, and sinusoidal endothelial cells. A subset of the wide variety of glycan structures present on mycobacterial surfaces interact with cells of the innate immune system through the receptors tested. Endocytic receptors, including the mannose receptor, DC-SIGN, langerin, and DC-SIGNR (L-SIGN), interact predominantly with mannose-containing caps found on the mycobacterial polysaccharide lipoarabinomannan. Some of these receptors also interact with phosphatidyl-myo-inositol mannosides and mannose-containing phenolic glycolipids. Many glycans are ligands for overlapping sets of receptors, suggesting multiple, redundant routes by which mycobacteria can enter cells. Receptors with signaling capability interact with two distinct sets of mycobacterial glycans: targets for dectin-2 overlap with ligands for the mannose-binding endocytic receptors, while mincle binds exclusively to trehalose-containing structures such as trehalose dimycolate. None of the receptors surveyed bind furanose residues, which often form part of the epitopes recognized by antibodies to mycobacteria. Thus, the innate and adaptive immune systems can target different sets of mycobacterial glycans. This array, the first of its kind, represents an important new tool for probing, at a mol. level, biol. roles of a broad range of mycobacterial glycans, a task that has not previously been possible. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Electric Literature of 707-07-3

The Article related to mycobacterium surface glycan array host innate immuninty interaction, Immunochemistry: Adjuvants, Antigens, Haptens, and Vaccines and other aspects.Electric Literature of 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yuxiao; Liu, Yu; Shanahan, Charles S.; Xu, Xichen; Doyle, Michael P. published an article in 2014, the title of the article was A survey of enol-diazo nucleophilicity in selective C-C bond forming reactions for the synthesis of natural product-like frameworks.Computed Properties of 707-07-3 And the article contains the following content:

A survey of in situ, catalytically generated carbocations for coupling with enol (diazo)acetate nucleophiles was performed. This coupling reaction facilitate a rapid assembly of complex organic diazo compounds that provide a template for the synthesis of a variety of carbocyclic and heterocyclic ring systems. Under optimized conditions the synthesis of the target compounds was achieved using scandium triflate (Lewis acid) as a catalyst for a reaction of 2-diazo-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-butenoic acid Me ester with α-(phenyl)benzenemethanol 1-acetate derivatives and orthoformate derivatives, such as 2,2′,2”-[methylidynetris(oxy)]tris[propane], tri-Me orthovalerate. The title compounds thus formed included α-(diazo)-β-(oxo)alkanoic acid esters, such as α-diazo-β-oxo-δ-(phenyl)benzenepentanoic acid Me ester. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Computed Properties of 707-07-3

The Article related to enol diazo nucleophile coupling reaction natural product like framework, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Computed Properties of 707-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2017, Resetco, Cristina; Dikic, Tamara; Verbrugge, Tom; Du Prez, Filip E. published an article.Formula: C4H8ClNOS The title of the article was UV-cured multifunctional coating resins prepared from renewable thiolactone derivatives. And the article contained the following:

A set of multifunctional UV-cured thiol-ene polymer resins were systematically prepared from thiolactone containing monomers and different amine compounds Aminolysis of the thiolactone moiety enabled the introduction of different side chains and crosslinkers into the polymers. The glass transition temperature of the polymers varied between 22 and 90°C, depending on the type and molar ratio of amine-containing compounds relative to the monomer. The properties of the UV-cured thin films were screened using standard tests for coatings, including pencil hardness, impact resistance, and cross-hatch adhesion. Thiolactone-derived polymer films exhibited high transparency of 90%, pencil hardness in the range of 3B-HB, high impact resistance >2 kg m, and good adhesion to steel in dry conditions. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Formula: C4H8ClNOS

The Article related to uv cured coating thiolactone pencil hardness impact resistance property, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Formula: C4H8ClNOS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 29, 2011, Deng, Yongqi; Zhu, Liang; Shipps, Gerald W., Jr.; Lo, Sie-Mun; Sun, Binyuan; Huang, Xiaohua; Beinstock, Corey; Cooper, Alan B.; Gao, Xiaolei; Yao, Xin; Zhu, Hugh Y.; Kelly, Joseph M.; Boga, Sobhana Babu; Alhassan, Abdul-Basit; Tagat, Jayaram R.; Mansoor, Umar Faruk; Wilson, Kevin; O’Boyle, Brendan M.; Daniels, Matthew; Schell, Adam; Siliphaivanh, Phieng; Fischer, Christian published a patent.Application of 872046-08-7 The title of the patent was Indazolecarboxamide derivatives as ERK inhibitors and their preparation and use for the treatment of cancer. And the patent contained the following:

The invention relates to indazolecarboxamide derivatives of formula I, which are ERK inhibitors and which are useful in the treatment of cancer. Compounds of formula I wherein R is H, alkyl and hydroxyalkyl; R1 is (un)substituted heterocyclyl, (un)substituted heterocycloalkenyl, (un)substituted aryl and (un)substituted heteroaryl; R2 is H and alkyl; R3′ is (un)substituted piperidinyl, (un)substituted azepanyl, (un)substituted oxazepanyl, etc.; and pharmaceutically acceptable salts, solvates and esters thereof, are claimed. Example compound II was prepared by a general procedure (procedure given). All the invention compounds were evaluated for their ERK inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values of 14.4 nM and 28.1 nM towards cERK and aERK, resp. The experimental process involved the reaction of Methyl 2-(2,6-difluorophenyl)acetate(cas: 872046-08-7).Application of 872046-08-7

The Article related to indazolecarboxamide preparation erk inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 872046-08-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 19, 1997, Barth, Francis; Casellas, Pierre; Millan, Joseph; Oustric, Didier; Rinaldi, Murielle; Sarran, Martine published a patent.Formula: C10H11FO2 The title of the patent was 3-pyrazolecarboxamide derivatives having cannabinoid receptor affinity. And the patent contained the following:

Pyrazolecarboxamides I [R = amino, cycloalkoxy; R1 = H, (un)substituted alkyl; R2, R3 = (un)substituted Ph; R4, R5 = H, alkyl, CF3] were prepared as CB2 receptor antagonists (no data). Thus, 4-MeC6H4Ac was treated with di-Et oxalate and cyclized with N2H4, followed by alkylation with 3,4-Cl2C6H3CH2Br to give I [R = OH, R1, R4, R5 = H, R2 = 4-MeC6H4, R3 = 3,4-Cl2C6H3] which was amidated with (1S)-2-endo-amino-1,3,3-trimethylbicyclo[2.2.1]heptane (R6NH2), prepared from (1S)-(+)-fenchone, to give I [R = NHR6, R1, R4, R5 = H, R2 = 4-MeC6H4, R3 = 3,4-Cl2C6H3]. The experimental process involved the reaction of Ethyl 3-fluoro-4-methylbenzoate(cas: 86239-00-1).Formula: C10H11FO2

The Article related to pyrazolecarboxamide preparation cannabinoid antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C10H11FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 10, 2015, Kumaravel, Gnanasambandam; Peng, Hairuo; Xin, Zhili published a patent.Application In Synthesis of Methyl 1-methyl-4-oxocyclohexanecarboxylate The title of the patent was Preparation of dihydropyrazolopyridine derivatives for use as ATX modulators. And the patent contained the following:

Title compounds I [A = (un)substituted Ph, cyclohexyl, or heteroaryl; X = C(O), C(O)2, C(O)NH, or C(O)N(alkyl); Z = bond or alkylenyl; R2 = H, halo, CN, (un)substituted alkyl; R3 = CH3, CH3OCH3, (un)substituted carbocyclyl, etc.], and their pharmaceutically acceptable salts, are prepared and disclosed as ATX modulators. Thus, e.g., II was prepared by a multistep procedure (preparation given). I were evaluated in ATX activity assays, e.g., II demonstrated an IC50 value of no greater than 100 nM. The experimental process involved the reaction of Methyl 1-methyl-4-oxocyclohexanecarboxylate(cas: 37480-41-4).Application In Synthesis of Methyl 1-methyl-4-oxocyclohexanecarboxylate

The Article related to dihydropyrazolopyridine preparation atx modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application In Synthesis of Methyl 1-methyl-4-oxocyclohexanecarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 27, 1989, Kaku, Koichiro; Wada, Nobuhide; Sugiyama, Kazuhiko; Takeuchi, Akira; Toyokawa, Yasufumi; Miyazawa, Takeshige; Yoshida, Ryo published a patent.COA of Formula: C7H14O3 The title of the patent was Azinylalkanoates as herbicides. And the patent contained the following:

The title compounds [I; R = Q1, Q2, alkenyl, dihydronaphthyl, tetrahydronaphthyl, 1-oxo-1,2,3,4-tetrahydronaphthyl, epoxycycloalkyl, (substituted) indanyl; R1 = H, (substituted) alkyl, alkenyl, alkynyl, Ph, amino, cycloalkyl, nitrophenylthioalkyl, halo, (substituted) benzyl; RR1 = atoms to complete a ring; R2, R4 = H, alkyl; R2R4C = (O-containing) ring; R3 = H, halo, (substituted) alkyl, OH, cyano, thienyl, naphthyl, dihydronaphthyl, Q3; R5, R6 = H, alkyl; R7 = Ph, alkyl; R8 = H, halo, NO2, alkyl, alkoxy, alkylsulfonyl, etc.; A = alkyl, alkoxy, alkylthio, halo, haloalkoxy, amino; B = H, alkyl, alkoxy, haloalkoxy; X = O, S; Z = CH, N; m = 0-2], were prepared Thus, a mixture of Me2PhCCH(OH)CO2Et, 4,6-dimethoxy-2-methylsulfonylpyrimidine, and K2CO3 in DMF was stirred 3 h at 100° to give pyrimidinyloxybutyrate II. II at 40 g/are postemergent gave complete control of barnyard grass. The experimental process involved the reaction of Methyl 2-hydroxy-3,3-dimethylbutanoate(cas: 121129-31-5).COA of Formula: C7H14O3

The Article related to azinyloxyalkanoate preparation herbicide, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.COA of Formula: C7H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2017, Furusho, Yoshio; Endo, Takeshi published an article.Name: (Trimethoxymethyl)benzene The title of the article was Reversible capture and release of carbon dioxide by binary system of polyamidine and polyethylene glycol. And the article contained the following:

CO2 absorbents were prepared from polyethylene glycol and polyamidines with N,N’-disubstituted amidine structure in the main chain synthesized by acid-catalyzed melt polycondensation of ortho-esters and α,ω-diamines. Homogeneous binary mixtures with polyamidines captured CO2 much more efficiently under CO2 flow than the one with polyethyleneimine. CO2 capture and release by the binary mixtures was assessed in terms of effect of volatility and polyamidine structure, temperature, and polyethylene glycol. Considering the obtained results, CO2 capture/release cycles with a CO2 capture step at 40° and a CO2 releasing step at 80° were conducted in an alternating manner, demonstrating the repeatability of CO2 capture/release by the polyamidine and polyethylene glycol binary system. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Name: (Trimethoxymethyl)benzene

The Article related to flue gas carbon dioxide absorption desorption system, preparation use polyamidine polyethylene glycol binary absorbent, Air Pollution and Industrial Hygiene: Industrial Waste Gases and other aspects.Name: (Trimethoxymethyl)benzene

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 2021, Ma, Xiyang; Zhou, Debo; Liu, Lei; Wang, Linlin; Yu, Huidong; Li, Lei; Feng, Shengyu published an article.Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one The title of the article was Reprocessable Supramolecular Elastomers of Poly(Siloxane-Urethane) via Self-Complementary Quadruple Hydrogen Bonding. And the article contained the following:

Supramol. silicone materials are promising candidates toward sustainable and recyclable applications. Herein, quadruple hydrogen bond motifs are introduced into the main chain of polysiloxane for the first time, providing a new type of supramol. silicone elastomers. This structural design enables the well-defined spacing length between ureidopyrimidinone (UPY) units, exercising better control over polymer network structure. The obtained materials exhibit elastomeric properties and robust reprocessability, and can be further developed into europium (Eu)-coordinated elastomers with interesting water-responsive luminescence. It is highly anticipated that this work will broaden the scope and application of silicone-based sustainable materials. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one

The Article related to supramol recyclable polysiloxane polyurethane rubber synthesis hydrogen bonding photoluminescence, Synthetic Elastomers and Natural Rubber: Elastomer Synthesis and other aspects.Application In Synthesis of 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2019, Wei, Ping; Guo, Ze-Wang; Wu, Xiao-Ling; Liang, Shan; Ou, Xiao-Yang; Xu, Pei; Zong, Min-Hua; Yang, Ji-Guo; Lou, Wen-Yong published an article.Safety of (R)-Methyl 3-hydroxybutanoate The title of the article was Significantly enhancing the biocatalytic synthesis of chiral alcohols by semi-rationally engineering an anti-Prelog carbonyl reductase from Acetobacter sp. CCTCC M209061. And the article contained the following:

Chiral alcs. and their derivatives are vital building blocks to synthesize pharmaceutical drugs and high-valued chems. Wild-type carbonyl reductase AcCR from Acetobacter sp. has ideal enantioselectivity toward 11 prochiral substrates (e.e.>99%) but poor activity. In this work, a semi-rational engineering was performed to enhance the activity of AcCR. Fortunately, three pos. double-mutants (mut-E144A/G152L, mut-G152L/Y189 N, and mut-I147 V/G152L) with specific activity 17-61 folds higher than that of enzyme without modified were achieved. Kinetic studies suggested that the catalytic efficiencies (kcat/Km) of these mutants were also well enhanced. Finally, these modified mut-AcCRs were successfully applied in asym. reductions of 11 structurally diverse prochiral substrates (200 mM) with excellent product yields (76.8%-99.1%) and enantiomeric excess (e.e.>99%), which provides an alternative strategy for efficient synthesis of chiral alcs. for pharmaceuticals industry with ideal yield and enantioselectivity. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Safety of (R)-Methyl 3-hydroxybutanoate

The Article related to carbonyl reductase chiral alc synthesis, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.Safety of (R)-Methyl 3-hydroxybutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics