Tag: 100-200

Screening and characteristic aroma analysis of aroma-producing yeasts in high-temperature Daqu was written by Lu, Yan-xiang;Liang, Hui-zhen;Chen, Peng;Liu, Zheng;Zhong, Cheng. And the article was included in Shipin Yanjiu Yu Kaifa in 2021.Computed Properties of C10H18O2 This article mentions the following:

Two yeast strains characterized by high aroma production, namely Y3 and Y5, were obtained from the high-temperature Daqu. After separation and purification, primary screening for aroma production using liquid fermentation, and secondary screening using solid fermentation were performed. Headspace solid-phase microextraction-gas chromatog.-mass spectrometry (HS-SPME-GC-MS) was employed to detect and analyze the products obtained after solid-state fermentation of Y3 and Y5. As a result, 43 and 37 volatile aroma compounds were recovered from Y3 and Y5, resp. The main aroma producing compounds among the products obtained after Y3 solid-state fermentation were 灏?phenethyl alc., isoamyl alc., isovaleric acid, and Et butyrate, and those obtained after Y5 solid-state fermentation were 灏?phenylethanol, 4-vinylguaiacol, and isoamyl alc. acid. Based on the morphol., physiol., and biochem. examinations, and mol. identification, Y3 was identified as Saccharomycopsis fibuligera, and Y5 was identified as Wickerhamomyces anomalus. Thereafter, Y3 and Y5 were mixed in equal proportions, and added to the Maotai-flavored liquor fermented grains to simulate the production and fermentation, and then the distilled liquor samples were examined using gas chromatog. (GC) for skeleton composition The results revealed that both Y3 and Y5 significantly increased the levels of Et acetate, Et lactate, and 灏?phenylethanol in liquor. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9Computed Properties of C10H18O2).

5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C10H18O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT_2C Receptor Agonists was written by Carpenter, Joseph;Wang, Ying;Wu, Gang;Feng, Jianxin;Ye, Xiang-Yang;Morales, Christian L.;Broekema, Matthias;Rossi, Karen A.;Miller, Keith J.;Murphy, Brian J.;Wu, Ginger;Malmstrom, Sarah E.;Azzara, Anthony V.;Sher, Philip M.;Fevig, John M.;Alt, Andrew;Bertekap, Robert L.;Cullen, Mary Jane;Harper, Timothy M.;Foster, Kimberly;Luk, Emily;Xiang, Qian;Grubb, Mary F.;Robl, Jeffrey A.;Wacker, Dean A.. And the article was included in Journal of Medicinal Chemistry in 2017.Synthetic Route of C8H11NO2 This article mentions the following:

Agonism of the 5-HT_2C receptor represents one of the most well-studied and clin. proven mechanisms for pharmacol. weight reduction Selectivity over the closely related 5-HT_2A and 5-HT_2B receptors is critical as their activation has been shown to lead to undesirable side effects and major safety concerns. In this communication, we report the development of a new screening paradigm that utilizes an active site mutant D134A (D3.32) 5-HT_2C receptor to identify atypical agonist structures. We addnl. report the discovery and optimization of a novel class of nonbasic heterocyclic amide agonists of 5-HT_2C. SAR investigations around the screening hits provided a diverse set of potent agonists at 5-HT_2C with high selectivity over the related 5-HT_2A and 5-HT_2B receptor subtypes. Further optimization through replacement of the amide with a variety of five- and six-membered heterocycles led to the identification of 6-(1-ethyl-3-(quinolin-8-yl)-1H-pyrazol-5-yl)pyridazin-3-amine (69). Oral administration of 69 to rats reduced food intake in an ad libitum feeding model, which could be completely reversed by a selective 5-HT_2C antagonist. In the experiment, the researchers used many compounds, for example, Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7Synthetic Route of C8H11NO2).

Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Synthetic Route of C8H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Physico-chemical parameters and antioxidant activity of Romanian sea buckthorn berries was written by Ion, Violeta Alexandra;Parvulescu, Oana Cristina;Velcea, Diana;Popa, Oana;Ahmadi, Mirela. And the article was included in Revista de Chimie (Bucharest, Romania) in 2019.Reference of 659-70-1 This article mentions the following:

Physico-chem. parameters of Romanian sea buckthorn fresh or dried berries, including titratable acidity (2.28 鍗?0.06 g malic acid/100 g FM), pH (2.60 鍗?0.08), contents of moisture (75.94 鍗?2.14 g/100 g FM), ash (2.83 鍗?0.11 g/100 g DM), ascorbic acid (1337.6 鍗?37.2 mg/100 g FM), oil (3.82 鍗?0.16 g/100 g FM), and macro elements, mainly K (11654 mg/kg DM), Mg (668 mg/kg DM), Ca (645 mg/kg DM), Na (401 mg/kg DM), and P (271 mg/kg DM), were evaluated in this paper. The most abundant volatile compounds found in the volatile fraction of berries were isopentyl isovalerate (30.8%), heptanal (11.7%), Et hexanoate (10.5%), Et isovalerate (8.1%), hexanal (7.5%), and Et 2-methylbutyrate (6.3%). Total phenolic content, total flavonoids content, and antioxidant activity (expressed as DPPH free radical scavenging activity by inhibition of DPPH) of extract solutions obtained from dried berries by MAE using ethanol/water mixture as a solvent were estimated at different ratios of solvent volume/vegetal material mass (15-30 mL/g) and ethanol/water (50/50, 60/40, 70/30, and 80/20 volume/volume). Inhibition of DPPH (22.61-48.60%) was well correlated with total phenolic content (4.42-10.04 mg caffeic acid equivalent/g DM) and total flavonoids content (5.37-11.14 mg quercetin equivalent/g DM). In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1Reference of 659-70-1).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Reference of 659-70-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

2-Aminonicotinic Acid 1-Oxides Are Chemically Stable Inhibitors of Quinolinic Acid Synthesis in the Mammalian Brain: A Step toward New Antiexcitotoxic Agents was written by Vallerini, Gian Paolo;Amori, Laura;Beato, Claudia;Tararina, Margarita;Wang, Xiao-Dan;Schwarcz, Robert;Costantino, Gabriele. And the article was included in Journal of Medicinal Chemistry in 2013.Reference of 14667-47-1 This article mentions the following:

3-Hydroxyanthranilic acid 3,4-dioxygenase (3-HAO) is the enzyme responsible for the production of the neurotoxic tryptophan metabolite quinolinic acid (QUIN). Elevated brain levels of QUIN are observed in several neurodegenerative diseases, but pharmacol. investigation on its role in the pathogenesis of these conditions is difficult because only one class of substrate-analog 3-HAO inhibitors, with poor chem. stability, has been reported so far. Here we describe the design, synthesis, and biol. evaluation of a novel class of chem. stable inhibitors based on the 2-aminonicotinic acid 1-oxide nucleus. After the preliminary in vitro evaluation of newly synthesized compounds using brain tissue homogenate, we selected the most active inhibitor and showed its ability to acutely reduce the production of QUIN in the rat brain in vivo. These findings provide a novel pharmacol. tool for the study of the mechanisms underlying the onset and propagation of neurodegenerative diseases. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Reference of 14667-47-1).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Reference of 14667-47-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and conversions of some 浼?hydroxyisobutyric acid esters was written by Kuz’michev, O. V.;Ustavshchikov, B. F.;Farberov, M. I.. And the article was included in Zhurnal Organicheskoi Khimii in 1968.Computed Properties of C11H14O3 This article mentions the following:

Reaction of Me2C(OH)CO2Na (I) with organic halides gave esters Me2C(OH)CO2R (II), which on dehydration gave H2C:CMeCO2R (III), of possible interest as polymerization monomers. Preparation of II was carried out either by heating the reagents in HCONMe2 or by fusing them together. Dehydration was done by heating II, containing 1-5% Cu-hydroquinone complex (a polymerization inhibitor) at 60-80鎺?in C6H6, PhMe, or xylene with PCl5. The following II and III were prepared (R, % yield, b.p./mm., n20D, and d20 of II and % yield, b.p./mm., n20D, and d20 of III given): H2C:CHCH2, 99.0, 166鎺?760, 1.4311, 1.0040, 40.0, 141鎺?760, 1.4330, 0.9300; H2C:CMeCH2, 88.0, 179鎺?760, 1.4338, 0.9870, 21.0, 70鎺?25, 1.4386, 0.9250; PhCH2, 84.5, 125鎺?10, 1.5010, 1.0860, 16.5, 236鎺?760, 1.5145, 1.0480; 2,4-Me2C6H3CH2, 97.0, 146鎺?5, 1.5051, 1.0650, 23.0, 115鎺?2, 1.5130, 1.0230; p-PhOC6H4CH2, 97.0, 173-5鎺?2, 1.5540, 1.1700, 16.5, 138鎺?1, 1.5760, 1.1589. Reaction of 1,5-bis(chloromethyl)-2,4-dimethylbenzene or (p-ClCH2C6H4)2O with I gave 99.0% 1,5-bis(浼?hydroxyisobutyryloxymethyl)-2,4-dimethylbenzene, m. 73.5, and 99.0% p-Me2C(OH)CO2CH2C6H4)2O, b1.5 220鎺? n20D 1.5470, d20 1.2190, which were dehydrated to give 31.5% 1,5-bis(methacryloxymethyl)-2,4-dimethylbenzene, b1 140-5鎺? n20D 1.5336, d20 1.1609, and 40.0% (p-H2C:CHCO2CH2C6H4)2O, b1 180鎺? n20D 1.5695, d20 1.1900. Passage of II vapors over a Ca phosphate catalyst at high temperature gave simultaneous dehydration and hydrolysis to H2C:CMeCO2H and the corresponding alcs. or dialcs. In the experiment, the researchers used many compounds, for example, Benzyl 2-hydroxy-2-methylpropanoate (cas: 19444-23-6Computed Properties of C11H14O3).

Benzyl 2-hydroxy-2-methylpropanoate (cas: 19444-23-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Computed Properties of C11H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Development of a Practical and Scalable Synthesis of (R)- and (S)-3-Amino-2-[(benzyloxy)methyl]propan-1-ol Monohydrochloride: A Useful C-4 Chiral Building Block was written by Yoshida, Shinya;Obitsu, Kazuyoshi;Hayashi, Yasumasa;Shibazaki, Mitsuyoshi;Kimura, Takenori;Takahashi, Takumi;Asano, Toru;Kubota, Hirokazu;Mukuta, Takashi. And the article was included in Organic Process Research & Development in 2012.Related Products of 82962-54-7 This article mentions the following:

The development of a practical and scalable synthesis of a C-4 chiral amine building block (R)-1璺疕Cl and (S)-1璺疕Cl is described. This important chiral intermediate (R)-1璺疕Cl is efficiently synthesized from the com. available, inexpensive, and simple 2-(hydroxymethyl)-1,3-propanediol using lipase-catalyzed enantioselective hydrolysis as a key reaction. Development resulted in a telescoped process that was operated successfully and reproducibly in a pilot-plant-scale synthesis, and 22 kg of chiral amine (R)-1璺疕Cl was prepared in the first scale-up synthesis. This synthetic method is also useful for preparation of the important chiral building block (S)-1璺疕Cl, which is the enantiomer of (R)-1璺疕Cl. In the experiment, the researchers used many compounds, for example, Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7Related Products of 82962-54-7).

Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 82962-54-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics was written by Karaj, Endri;Dlamini, Samkeliso;Koranne, Radhika;Sindi, Shaimaa H.;Perera, Lalith;Taylor, William R.;Viranga Tillekeratne, L. M.. And the article was included in Bioorganic Chemistry in 2022.HPLC of Formula: 155380-11-3 This article mentions the following:

We recently reported a new class of imidazole-based chalcones as potential antimitotic agents. In view of their promising cytotoxic activity, a comprehensive structure-activity relationship (SAR) of these compounds was undertaken focusing on four major structural variations: the length of the mol., the Michael acceptor character, the nature and substitution pattern of ring B, and the nature of the amide functionality tethering ring B. These second-generation analogs (IBCs) demonstrated a superior bioactivity profile than the previously reported imidazole chalcones (referred to as IPEs). The analog IBC-2 with one less methylene group (nor series) and para-fluoro substituted ring B demonstrated the best cytotoxicity profile among the library of compounds A computational anal. of the NCI-60 data associated both IBCs and the previously reported IPEs with the privileged pharmacol. pharmacophore of chalcones. Interestingly, biol. studies suggest that the imidazole ring is essential for cytotoxic activity of the elongated chalcone analogs. Immunofluorescence studies revealed that IBC-2, unlike IPEs, has the ability to induce microtubule catastrophe independently of Aurora-B inhibition. The effects of IBC-2 on microtubule dynamics are similar to those of Nocodazole, but the cell cycle effects appear to be different. In-silico studies demonstrate that the members of the new series have the ability to bind to the colchicine binding site of 灏?tubulin with binding scores similar to those of IPEs, corresponding chalcones and Nocodazole. Although tubulin binding can partially explain the biol. effects of IBC-2, on-going target identification studies are aimed at further investigation of its biol. targets. In the experiment, the researchers used many compounds, for example, Methyl 2-(4-(hydroxymethyl)phenyl)acetate (cas: 155380-11-3HPLC of Formula: 155380-11-3).

Methyl 2-(4-(hydroxymethyl)phenyl)acetate (cas: 155380-11-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 155380-11-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chemical composition and oxidative stability of eleven pecan cultivars produced in southern Brazil was written by Reis Ribeiro, Stephanie;Klein, Bruna;Machado Ribeiro, Quellen;Duarte dos Santos, Ingrid;Gomes Genro, Ana Luisa;de Freitas Ferreira, Daniele;Janner Hamann, Jonas;Smanioto Barin, Juliano;Cichoski, Alexandre Jose;Fronza, Diniz;Both, Vanderlei;Wagner, Roger. And the article was included in Food Research International in 2020.Category: esters-buliding-blocks This article mentions the following:

Nuts are considered highly nutritious foods and a source of health-promoting compounds Therefore, the aim of this study was to evaluate the chem. composition (proximate composition, fatty acids, volatile compounds, total phenolics, squalene, and 灏?sitosterol) of eleven pecan cultivars harvested in Rio Grande do Sul State (Brazil) and investigate their oxidative stability by the Rancimat method. ‘Barton’ is the main cultivar produced in Brazil and presented the highest protein, linoleic acid, and linolenic acid values and the lowest saturated fatty acid values, which provide health benefits. ‘Mahan’ showed the highest oxidation induction time, both in extracted oil and ground samples, low abundance of lipid oxidation compounds, low polyunsaturated fatty acids, high levels of oleic acid and 灏?sitosterol, which suggests potential for storage. ‘Stuart’ and ‘Success’ had the highest total dietary fiber values. Moreover, anal. showed that ‘Chickasaw’ and ‘Success’ had large quantities of compounds correlated to lipid oxidation, suggesting low stability for long-term storage. These results imply that the physicochem. characteristics and proximate composition of pecan nut cultivars from southern Brazil have variable parameters that may depend on their genetic variability. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Category: esters-buliding-blocks).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Changes in free and glycosidically bound volatile compounds of nectarine fruit during low-temperature storage was written by Zhang, Q.;Zhou, D. D.;Jiang, M. W.;Tu, K.. And the article was included in International Food Research Journal in 2022.Recommanded Product: 5-Ethyldihydrofuran-2(3H)-one This article mentions the following:

Free and glycosidically bound volatiles are two essential aroma compounds contributing to the flavor of nectarine fruits. To explore the relationship between free and bound volatiles in nectarine fruits during postharvest storage, they were first harvested and then subjected to the temperatures of 1, 5, and 8鎺矯 for 35 d, and the changes in volatile compounds, 灏?glucosidase (灏?Glu) activity, and the expression of UGT (UDP-glucosyltransferase) involved in the accumulation of bound linalool were determined Results showed that nectarine fruits stored at 5鎺矯 had the lowest contents of free volatile compounds due to damage from chilling injury, and the contents of esters and lactones decreased at 1 and 5鎺矯. The contents of bound volatiles increased during the early storage period, and decreased afterwards due to an increase in 灏?Glu activity. Corresponding to the higher contents of bound volatiles at 1鎺矯, the 灏?Glu activity in nectarine fruits stored at 1鎺矯 was significantly lower than that in nectarine fruits stored at the other two temperatures In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Recommanded Product: 5-Ethyldihydrofuran-2(3H)-one).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 5-Ethyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Enantiomer separation of mandelates and their analogs on cyclodextrin derivative chiral stationary phases by capillary GC was written by Nie, Meng-Yan;Zhou, Liang-Mo;Wang, Qing-Hai;Zhu, Dao-Qian. And the article was included in Analytical Sciences in 2001.Related Products of 15399-05-0 This article mentions the following:

Enantiomer separation of mandelates and their analogs, which are important intermediates in asym. synthetic and pharmaceutical chem., was studied by capillary gas chromatog. using different cyclodextrin derivative chiral stationary phases (CD CSPs). The used cyclodextrin derivatives included permethylated 灏?CD (PMBCD), permethylated 绾?CD, heptakis(2,6-di-O-butyl-3-O-butyryl)-灏?CD, heptakis(2,6-di-O-pentyl-3-O-acetyl)-灏?CD and heptakis(2,6-di-O-nonyl-3-O-trifluoroacetyl)-灏?CD (DNTBCD), resp. Among all the CSPs used, PMBCD and DNTBCD exhibited the broadest and best enantioselectivity for all the racemates studied. Some thermodn. parameters were evaluated and an enthalpy-entropy compensation effect was observed in enantiomer separation processes of mandelates and their analogs. Based on thermodn. data and mol. mechanics calculations, the chiral recognition mechanism of mandelate derivatives on CD CSPs is discussed. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Related Products of 15399-05-0).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 15399-05-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics