Tag: 100-200

Silver-catalyzed three-component reaction of phenyldiazoacetate with arylamine and imine was written by Chen, Bai-Ling;Wang, Zhen;Zhang, You-Can;Zhao, Zhi-Gang;Chen, Zili. And the article was included in Chinese Journal of Catalysis in 2018.Related Products of 19432-68-9 This article mentions the following:

A new method was developed to diastereoselectively synthesize polysubstituted 1,2-diamine compounds from the reaction of diazoesters with arylamines and diaryl imines by using the dioxazoline ligand L₂-ligated silver catalyst. The Lewis acidity of the silver catalyst affected the different types of substrate diastereoselectivities; It also led to the formation of amine-exchange side products. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Related Products of 19432-68-9).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Related Products of 19432-68-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amide isosteres in structure-activity studies of antibacterial minor groove binders was written by Khalaf, Abedawn I.;Anthony, Nahoum;Breen, David;Donoghue, Gavin;MacKay, Simon P.;Scott, Fraser J.;Suckling, Colin J.. And the article was included in European Journal of Medicinal Chemistry in 2011.Formula: C7H8N2O4 This article mentions the following:

Antibacterial minor groove binders related to the natural product, distamycin, are development candidates for novel antibiotics. Alkenes have been found to be effective substitutes for the isosteric amide links in some positions and alkyl groups larger than Me have been found to increase binding to DNA in both selectivity and affinity. However the impact of other isosteres such as diazenes and the position of an alkyl group with respect to DNA binding and antibacterial activity are not known. The effects of some systematic variations in the structure of polyamide minor groove binders are investigated. Isosteres of the amide link (alkenes and diazenes) are compared: it is shown that all three are competent for binding to DNA but that alkene links give the tightest binding and highest antibacterial activity; no significant antibacterial activity was found for compounds with a diazene link. Within a series of alkene linked compounds, the effect of branched N-alkyl substituents on binding to DNA and antibacterial activity is investigated: it was found that C3 and C4 branched chains are acceptable at the central pyrrole residue but that at the pyrrole ring adjacent to the basic tail group, a C4 branched chain was too large both for DNA binding and for antibacterial activity. The active branched alkyl chain compounds were found to be especially active against Mycobacterium aurum, a bacterium related to the causative agent of tuberculosis. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7Formula: C7H8N2O4).

Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C7H8N2O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The rates of saponification of some o-substituted ethyl m- and p-aminobenzoates was written by Price, Charles C.;Lincoln, Dwight C.. And the article was included in Journal of the American Chemical Society in 1951.Application In Synthesis of Ethyl 3-amino-4-methylbenzoate This article mentions the following:

Steric inhibition of resonance between a MeN₂ group and a C₆H₆ ring was measured by determining the rates of saponification of 3,4-(Me₂N)MeC₆H₃CO₂Et (I) and 3,4-Me(Me₂N)C₆H₃CO₂Et (II). The inhibition of resonance by 1 o-Me group markedly affects the elec. influence of the Me₂N group in the para or meta position to the reactive ester group, although quantitatively the influence is greater in the para position. A 2nd-order inductive or field effect is necessary to account for such a resonance influence on the meta position. m-H₂NC₆H₄CO₂H on methylation yielded the HI salt of trimethyl-m-benzobetaine, which on pyrolysis gave m-Me₂NC₆H₄CO₂Me; acid (III), m. 150.5-1.3鎺? Methylation of the amino acid yielded p-Me₂NC₆H₄CO₂Me (IV), heavy, white needles, m. 237-8鎺? p-MeC₆H₄CO₂H on nitration and reduction gave 3,4-H₂N(Me)C₆H₃CO₂H (V). A slurry of 41.0 g. V in 150 cc. water treated dropwise with 137 g. Me₂SO₄ in 4 portions, each added in 30 min. (the solution was neutralized with 1 equivalent of concentrated K₂CO₃ after the addition of each portion), the solution stirred 30 min., treated with NH₄OH, extracted with Et₂O, the aqueous layer boiled with C, filtered, cooled, barely acidified with AcOH, the acid solution extracted with Et₂O, and the extracts evaporated to dryness yielded 14.0 g. I, fine, white needles from Skellysolve L, m. 124.0-6.0鎺? The Et₂O layer evaporated, the oil refluxed 1 hr. with 150 cc. 6 N HCl, the solution neutralized with K₂CO₃, the alk. solution extracted with Et₂O (extract discarded), and the aqueous layer treated as above yielded 16 g. I; the combined portions on recrystallization m. 125.6-6.6鎺? o-MeC₆H₄NHAc on bromination, hydrolysis, and methylation (Me₂SO₄) yielded 2,4-Me₂N-(Br)C₆H₃Me (VI), b₇ 105-7鎺? n_D²⁰ 1.5645. Li (3.1 g.) and 70 cc. Et₂O treated dropwise with 42.8 g. VI, the mixture stirred 4 hrs., poured over excess powd. Dry Ice, the Dry Ice evaporated, the mixture treated with water, just acidified with dilute HCl, and extracted with Et₂O, the extracts extracted with saturated Na₂CO₃, the aqueous layer boiled with C, and the filtrate cooled and barely acidified with dilute HCl yielded 8.3 g. II, white scales from hot water containing a little EtOH (monoclinic crystals from Skellysolve L), m. 131.0-1.6鎺? The Et ester of IV m. 63.5-64鎺?(from aqueous EtOH). For the Et esters the b.p./mm and n_D²⁰ are: of III, 124.5 鍗?0.3鎺?3.0, 1.5475; of V, 154.6-55鎺?6.0, m. 48.6-50.1鎺? I, 98.0 鍗?0.5鎺?0.8, 1.5270; II, 156.0 鍗?0.3鎺?12, 1.5438. In the experiment, the researchers used many compounds, for example, Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8Application In Synthesis of Ethyl 3-amino-4-methylbenzoate).

Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application In Synthesis of Ethyl 3-amino-4-methylbenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of novel Akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells was written by Yu, Meng;Zeng, Minghui;Pan, Zhaoping;Wu, Fengbo;Guo, Li;He, Gu. And the article was included in European Journal of Medicinal Chemistry in 2020.Application of 587-88-2 This article mentions the following:

A series of thieno[2,3-d]pyrimidine derivatives I (X = O, CH₂, NR¹, Z = CH₂; X = CH₂, Z = nothing; R¹ = Me, cyclopropyl, PhCH₂, Me₂NCO, etc.; R² = 4-BrC₆H₄, 4-MeC₆H₄, 2-ClC₆H₄, etc.; R³ = Et, i-Pr, cyclohexyl, etc.) were designed, synthesized and evaluated as novel AKT1 inhibitors. In vitro antitumor assay results showed that compounds I (X = CH₂; Z = nothing; R² = 4-ClC₆H₄; R³ = Et, n-Bu, cyclopentyl, cyclohexyl) and I (X = CH₂; Z = nothing; R² = 4-BrC₆H₄; R³ = i-Pr) potently suppressed the enzymic activities of AKT1 and inhibited the proliferation of HepG2, Hep3B, Huh-7 and SMMC-7721 cancer cell lines. Among these derivatives, the compound I [X = CH₂; Z = nothing; R² = 4-ClC₆H₄; R³ = cyclopentyl; (II)] demonstrated the best inhibitory activities on AKT1 (IC₅₀ = 0.034娓璏) and Huh-7 cell (IC₅₀ = 0.076娓璏). A panel of biol. assays showed that compound II suppressed the cellular proliferation of Huh-7 through Akt/mTOR signaling pathway mediated autophagy mechanism. Furthermore, the antitumor capacity of II was validated in the s.c. Huh-7 xenograft models. Together, these results demonstrated that a novel small-mol. Akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma, which may afforded a potential drug candidate for targeted cancer therapy. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Application of 587-88-2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 587-88-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design, synthesis and biological evaluation of nuclear receptor-degradation inducers was written by Itoh, Yukihiro;Kitaguchi, Risa;Ishikawa, Minoru;Naito, Mikihiko;Hashimoto, Yuichi. And the article was included in Bioorganic & Medicinal Chemistry in 2011.Quality Control of Methyl 2-methoxy-4-methylbenzoate This article mentions the following:

Compounds that regulate the function(s) of nuclear receptors (NRs) are useful for biol. studies and as candidate therapeutic agents. Most such compounds are agonists or antagonists. We have developed specific protein degradation inducers, which we designated as SNIPERs (Specific and Nongenetic IAPs-dependent Protein ERasers), for selective degradation of target proteins. SNIPERs are hybrid mols. consisting of an appropriate ligand for the protein of interest, coupled to a ligand for inhibitor of apoptosis proteins (IAPs), which target the bound protein for polyubiquitination and proteasomal degradation We considered that protein knockdown with SNIPERs would be a promising alternative approach for modulating NR function. In this study, we designed and synthesized degradation inducers targeting retinoic acid receptor (RAR), estrogen receptor (ER), and androgen receptor (AR). These newly synthesized RAR, ER, and AR SNIPERs, 9, 11, and 13, resp., were confirmed to significantly reduce the levels of the corresponding NRs in live cells. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Quality Control of Methyl 2-methoxy-4-methylbenzoate).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of Methyl 2-methoxy-4-methylbenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Three-Component Minisci Reaction with 1,3-Dicarbonyl Compounds Induced by Visible Light was written by Li, Tao;Liang, Kangjiang;Zhang, Yang;Hu, Dongyan;Ma, Zhixian;Xia, Chengfeng. And the article was included in Organic Letters in 2020.Electric Literature of C9H10O3S This article mentions the following:

A three-component Minisci reaction coupling of 1,3-dicarbonyl compounds with vinyl ethers and quinolines or isoquinolines under visible light is developed. The 1,3-dicarbonyl compound undergoes single-electron oxidation to afford an electrophilic 1,3-dicarbonyl radical under visible light irradiation Due to the polarity of the free radical, the electrophilic radical adds to the electron-rich olefin to afford the nucleophilic radical. It coupled with the heteroarene to afford the three-component coupling products. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Electric Literature of C9H10O3S).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C9H10O3S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P₁ and S1P₅ Selective Agonist for the Treatment of Autoimmune Diseases was written by Kurata, Haruto;Kusumi, Kensuke;Otsuki, Kazuhiro;Suzuki, Ryo;Kurono, Masakuni;Komiya, Takaki;Hagiya, Hiroshi;Mizuno, Hirotaka;Shioya, Hiroki;Ono, Takeji;Takada, Yuka;Maeda, Tatsuo;Matsunaga, Norikazu;Kondo, Tetsu;Tominaga, Sachiko;Nunoya, Ken-ici;Kiyoshi, Hidekazu;Komeno, Masaharu;Nakade, Shinji;Habashita, Hiromu. And the article was included in Journal of Medicinal Chemistry in 2017.Name: Methyl 4-Hydroxy-2-methoxybenzoate This article mentions the following:

The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine3-carboxylic acid (I) (13n, ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor agonist selective for S1P₁ and S1P₅, is described. While it has been revealed that the modulation of the S1P₁ receptor is an effective way to treat autoimmune diseases such as relapsing-remitting multiple sclerosis (RRMS), it was also reported that activation of the S1P₃ receptor is implicated in some undesirable effects. The authors carried out a structure-activity relationship (SAR) study of hit compound 6 with an amino acid moiety in the hydrophilic head region. Following identification of a lead compound with a dihydronaphthalene central core by inducing conformational constraint, optimization of the lipophilic tail region led to the discovery of I as a clin. candidate that exhibited >30 000-fold selectivity for S1P₁ over S1P₃ and was potent in a peripheral lymphocyte lowering (PLL) test in mice (ED₅₀ = 0.029 mg/kg, 24 h after oral dosing). In the experiment, the researchers used many compounds, for example, Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8Name: Methyl 4-Hydroxy-2-methoxybenzoate).

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Name: Methyl 4-Hydroxy-2-methoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

灏?Keto esters from ketones and ethyl chloroformate: a rapid, general, efficient synthesis of pyrazolones and their antimicrobial, in鑱?em>silico and in鑱?em>vitro cytotoxicity studies was written by Ragavan, Ramasamy Venkat;Kumar, Kalavathi Murugan;Vijayakumar, Vijayaparthasarathi;Sarveswari, Sundaramoorthy;Ramaiah, Sudha;Anbarasu, Anand;Karthikeyan, Sivashanmugam;Giridharan, Periyasamy;Kumari, Nalilu Suchetha. And the article was included in Organic and Medicinal Chemistry Letters in 2013.Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:

A series of pyrazolones I [R¹ = Ph, 4-MeOC₆H₄, cyclohexyl, 3-Cl(CH₂)₃, etc.; R² = H, Me, Et; R³ = H, 4-FC₆H₄; R¹R² = (CH₂)₆, (CH₂)₈, etc.] were synthesized via cross-Claisen condensation of ketones and Et chloroformate to give 灏?keto esters which further reacted with hydrazine derivatives, and their cytotoxicity and antimicrobial activity were studied. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Ethyl 3-oxo-3-(thiophen-2-yl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cross-Linked Enzyme-Adhered Nanoparticles (CLEANs) for Continuous-Flow Bioproduction was written by Nagy, Flora;Santa-Bell, Evelin;Jipa, Monica;Hornyanszky, Gabor;Szilagyi, Andras;Laszlo, Krisztina;Katona, Gabriel;Paizs, Csaba;Poppe, Laszlo;Balogh-Weiser, Diana. And the article was included in ChemSusChem in 2022.Synthetic Route of C12H20O2 This article mentions the following:

Nanostructured but micro-sized biocatalysts were created by bottom-up technol. using multi-functionalized silica nanoparticles (NPs) as nano-sized building blocks to form cross-linked enzyme-adhered nanoparticles (CLEANs) as robust micro-sized particles with beneficial internal structure and good mech. properties. Systematic surface modification of NPs with a grafting mixture consisting of organosilanes with reactive (aminopropyl) and inert (e. g., vinyl, Pr, Ph, or octyl) functions resulted in functional NPs enabling crosslinking agents, such as glutardialdehyde or bisepoxides (glycerol diglycidyl ether, neopentylglycol diglycidyl ether, and poly(propylene glycol) diglycidyl ether), to bind and cross-link enzymes covalently and to form macroporous microparticles. These CLEANs were able to diminish several weaknesses of traditional cross-linked enzyme aggregates as biocatalysts, such as poor mech. resistance, difficult recovery, and storage, strengthening their use for packed-bed enzyme reactors. Lipase B from Candida antarctica (CaLB) was selected as model enzyme for development of robust CLEANs, which were successfully tested for various industrially relevant applications including a kinetic resolution of a racemic alc. and the production of various natural fragrance compounds under continuous-flow conditions. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Synthetic Route of C12H20O2).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C12H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Experiments on the Walden Inversion. VII. Action of Phosphorus Pentachloride and of Thionyl Chloride on Optically Active Hydroxy Acids and Esters was written by McKenzie, Alex;Barrow, Fred. And the article was included in Journal of the Chemical Society, Transactions in 1911.Recommanded Product: 15399-05-0 This article mentions the following:

Phenylchloroacetic acid and benzylidene chloride are formed from SOCl₂ and dl-mandelic acid. l-Mandelic acid gives l-phenylchloroacetic acid, which, with Ag₂CO₃ and H₂O, forms d-mandelic acid. Me l-mandelate gives methyl l-phenylchloroacetate, PhCHClCO₂Me; b₁₁ 123-6鎺? d₄¹⁵ 1.213; [浼猐_D¹⁵ -86.7鎺? It gave l-phenylchloroacetic acid. From the ester and MeONa was obtained dl-phenylmethoxyacetic acid. Et l-mandelate gave ethyl l-phenylchloroacetate; b₁₃ 132-3鎺? d₄^16.4 1.162; [浼猐_D^16.4 -64.00. It gave l-phenylchloroacetic acid. The ester and EtONa gave dl-phenylethoxyacetic acid. l-Malie acid and SOCl₂ form d-chlorosuccinic acid. Et l-malate produced ethyl d-chlorosuccinate, EtO₂CCH₂CHClCO₂Et; b₁₆ 124鎺? d₄^19.5 1.152; [浼猐_D^19.8 32.7鎺? Et d-tartrate and SOCl₂ give from which d-tartaric acid was produced. Ethyl d,浼?hydroxy-灏?phenzylpropionate. PhCH₂OH(OH)CO₂Et, b₂ 152-4鎺? d₄¹⁷ 1.105; [浼猐_D¹⁷ 7.6鎺?m. 46-7鎺? in alc.[浼猐_D^18.6 -4.8鎺? in C₆H₆, [浼猐_D^17.5 22.5鎺? in acetone, [浼猐_D^17.5 13.6鎺? Ethyl l,浼?hydroxy-灏?phenvlpropionate b₂₀ 159-60鎺? m. 46-7鎺? in C₆H₆ [浼猐_D¹³ -22.6鎺? With PCl₃ the product is l-rotatory and the resulting Ca salt d-rotatory, in H₂O. The d-ester gave a similar result. The l-acid and PCl, gave a product l-rotatory in alc. Et l,浼?hydroxy-灏?phenylpropionate and SOCl₂ gave a d-rotatory product which formed a Ca salt that was l-rotatory in H₂O. d,灏?Hydroxy-灏?phenylpropionic acid and concentrate HCl gave a chloro acid having [浼猐_D -4.6鎺? in alc. With H₂O a hydroxy acid had 浼?sub>D 0.29鎺? in alc. With the l,灏?hydroxy-灏?phenylpropionic acid and HCl the products had [浼猐_D 6.5-21.8鎺? d,灏?Hydroxy-灏?phenylproplonic acid and PCl₃ gave a l-rotatory chloro acid, which, with moist Et₂O gave a l-rotatory compound With SOCl₂, instead of PCl₃, the products are cinnamic and dl- and d,灏?chloro-灏?phenylpropionic acids. B. H₂O converts these latter into dl- and l,灏?hydroxy-灏?phenylpropionic acids. l,灏?Hydroxy-灏?phenylpropionic acid and SOCl₂ formed cinnamic and dl- and l,灏?chloro-灏?phenylpropionic acids, from which, with H₂O, some d-hydroxy acid was produced. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Recommanded Product: 15399-05-0).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 15399-05-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics