Tag: 100-200

A Cu₂O/TBAB-promoted approach to synthesize heteroaromatic 2-amines via one-pot cyclization of aryl isothiocyanates with ortho-substituted amines in water was written by Zhang, Jinli;Chen, Ling;Dong, Yibo;Yang, Jinchen;Wu, Yangjie. And the article was included in Organic & Biomolecular Chemistry in 2020.Related Products of 2253-73-8 The following contents are mentioned in the article:

An efficient approach to synthesize heteroaromatic 2-amines from one-pot desulfurization/dehydrogenative cyclization of aryl isothiocyanates with ortho-substituted amines in water was developed. This approach tolerated a wide range of functional groups on the aromatic ring, providing a practical and environment-friendly process to synthesize heteroaromatic 2-amines in moderate to excellent yields. A plausible mechanism was proposed and the role of TBAB and Cu₂O in the present strategy was suggested with the help of ESI mass spectrometry. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Related Products of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A Cu₂O/TBAB-promoted approach to synthesize heteroaromatic 2-amines via one-pot cyclization of aryl isothiocyanates with ortho-substituted amines in water was written by Zhang, Jinli;Chen, Ling;Dong, Yibo;Yang, Jinchen;Wu, Yangjie. And the article was included in Organic & Biomolecular Chemistry in 2020.Reference of 2253-73-8 The following contents are mentioned in the article:

An efficient approach to synthesize heteroaromatic 2-amines from one-pot desulfurization/dehydrogenative cyclization of aryl isothiocyanates with ortho-substituted amines in water was developed. This approach tolerated a wide range of functional groups on the aromatic ring, providing a practical and environment-friendly process to synthesize heteroaromatic 2-amines in moderate to excellent yields. A plausible mechanism was proposed and the role of TBAB and Cu₂O in the present strategy was suggested with the help of ESI mass spectrometry. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Reference of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Reference of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Highly efficient KF/Al₂O₃-catalyzed versatile hetero-Michael addition of nitrogen, oxygen, and sulfur nucleophiles to α,β-ethylenic compounds was written by Yang, Lei;Xu, Li-Wen;Xia, Chun-Gu. And the article was included in Tetrahedron Letters in 2005.Category: esters-buliding-blocks The following contents are mentioned in the article:

The first example of KF/Al₂O₃-catalyzed versatile hetero-Michael addition reaction of nitrogen, oxygen, and sulfur nucleophiles was developed for facile preparation of organic compounds of widely different structures. E.g., KF/Al₂O₃ catalyzed the reaction of EtSH with CH₂:CHCO₂Et to give 99% EtSCH₂CH₂CO₂Et. In contrast with the existing methods using many acidic catalysts, this method is very general, simple, high-yielding, environmentally friendly, and oxygen and moisture tolerant. This study involved multiple reactions and reactants, such as Ethyl 3-ethoxypropanoate (cas: 763-69-9Category: esters-buliding-blocks).

Ethyl 3-ethoxypropanoate (cas: 763-69-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents was written by Cevik, Ulviye Acar;Osmaniye, Derya;Levent, Serkan;Saglik, Beguem Nurpelin;Cavusoglu, Betuel Kaya;Oezkay, Yusuf;Kaplancikl, Zafer Asim. And the article was included in Heterocyclic Communications in 2020.COA of Formula: C4H7NS The following contents are mentioned in the article:

The aim of this study was to determine the capacity of newly synthesized 1,3,4-thiadiazole compounds I [R = Me, allyl, Ph, etc.] as chemotherapeutic agents. The structures of the obtained compounds were elucidated using ¹H-NMR, ¹³C-NMR and mass spectrometry. Although the thiadiazole derivatives I did not prove to be significantly cytotoxic to the tumor tissue cultures, compound I [R = phenyl] showed activity against the C6 rat brain cancer cell line (IC₅₀ 0.097 mM) at the tested concentrations This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8COA of Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents was written by Cevik, Ulviye Acar;Osmaniye, Derya;Levent, Serkan;Saglik, Beguem Nurpelin;Cavusoglu, Betuel Kaya;Oezkay, Yusuf;Kaplancikl, Zafer Asim. And the article was included in Heterocyclic Communications in 2020.HPLC of Formula: 2253-73-8 The following contents are mentioned in the article:

The aim of this study was to determine the capacity of newly synthesized 1,3,4-thiadiazole compounds I [R = Me, allyl, Ph, etc.] as chemotherapeutic agents. The structures of the obtained compounds were elucidated using ¹H-NMR, ¹³C-NMR and mass spectrometry. Although the thiadiazole derivatives I did not prove to be significantly cytotoxic to the tumor tissue cultures, compound I [R = phenyl] showed activity against the C6 rat brain cancer cell line (IC₅₀ 0.097 mM) at the tested concentrations This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8HPLC of Formula: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles was written by Savych, Olena;Kuchkovska, Yuliya O.;Bogolyubsky, Andrey V.;Konovets, Anzhelika I.;Gubina, Kateryna E.;Pipko, Sergey E.;Zhemera, Anton V.;Grishchenko, Alexander V.;Khomenko, Dmytro N.;Brovarets, Volodymyr S.;Doroschuk, Roman;Moroz, Yurii S.;Grygorenko, Oleksandr O.. And the article was included in ACS Combinatorial Science in 2019.Application In Synthesis of Isopropylisothiocyanate The following contents are mentioned in the article:

Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as the starting reagents. The key steps included the formation of unsym. thiourea, subsequent alkylation with 1,3-propane sultone and cyclization with azide anion. A 559-member aminotetrazole library was synthesized by this approach; the overall readily accessible (REAL) chem. space covered by the method exceeded 7 million feasible compounds This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application In Synthesis of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles was written by Savych, Olena;Kuchkovska, Yuliya O.;Bogolyubsky, Andrey V.;Konovets, Anzhelika I.;Gubina, Kateryna E.;Pipko, Sergey E.;Zhemera, Anton V.;Grishchenko, Alexander V.;Khomenko, Dmytro N.;Brovarets, Volodymyr S.;Doroschuk, Roman;Moroz, Yurii S.;Grygorenko, Oleksandr O.. And the article was included in ACS Combinatorial Science in 2019.Category: esters-buliding-blocks The following contents are mentioned in the article:

Two protocols for the combinatorial synthesis of 5-(dialkylamino)tetrazoles were developed. The best success rate (67%) was shown by the method that used primary and secondary amines, 2,2,2-trifluoroethylthiocarbamate, and sodium azide as the starting reagents. The key steps included the formation of unsym. thiourea, subsequent alkylation with 1,3-propane sultone and cyclization with azide anion. A 559-member aminotetrazole library was synthesized by this approach; the overall readily accessible (REAL) chem. space covered by the method exceeded 7 million feasible compounds This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Category: esters-buliding-blocks).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abraham model correlations for enthalpies of solvation of organic solutes dissolved in methyl acetate and octane was written by Lu, Jonathan Z.;Acree, William E. Jr.;Abraham, Michael H.. And the article was included in Physics and Chemistry of Liquids in 2020.Application of 106-73-0 The following contents are mentioned in the article:

Data have been assembled from the published literature on the enthalpies of solvation for 63 compounds dissolved in Me acetate and for 67 compounds dissolved in octane. It is shown that an Abraham solvation equation can successfully correlate the exptl. enthalpies of solvation in both Me acetate and octane to within standard deviations of 2.89 and 2.15 kJ mol^-1, resp. The correlations determined in the present study provide very accurate math. descriptions of the measured enthalpy of solvation data at 298 K, which in the case of Me acetate span a range of about 110 kJ mol^-1. This study involved multiple reactions and reactants, such as Methyl heptanoate (cas: 106-73-0Application of 106-73-0).

Methyl heptanoate (cas: 106-73-0) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 106-73-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and biological evaluation of Isosteviol derivatives as FXa inhibitors was written by Shi, Yang;Pan, Bo-Wen;Li, Wen-Chao;Wang, Qing;Wu, Qiong;Pan, Meng;Fu, Hong-Zheng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.HPLC of Formula: 2253-73-8 The following contents are mentioned in the article:

Firstly, a series of Isosteviol derivatives were synthesized and evaluated for FXa inhibitory activity. Among these compounds, the inhibitory activity of three compounds on FXa was better than that of Isosteviol. Secondly, surface plasmon resonance (SPR) assays were performed for selected compounds The three compounds have similar kinetic signatures, and affinity values were at μM level. Thirdly, two compounds displayed moderate-to-high anticoagulation activity and showed similar sensitivity to PT and aPTT. These findings will provide new insight into the exploration of FXa inhibition. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8HPLC of Formula: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and biological evaluation of Isosteviol derivatives as FXa inhibitors was written by Shi, Yang;Pan, Bo-Wen;Li, Wen-Chao;Wang, Qing;Wu, Qiong;Pan, Meng;Fu, Hong-Zheng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Synthetic Route of C4H7NS The following contents are mentioned in the article:

Firstly, a series of Isosteviol derivatives were synthesized and evaluated for FXa inhibitory activity. Among these compounds, the inhibitory activity of three compounds on FXa was better than that of Isosteviol. Secondly, surface plasmon resonance (SPR) assays were performed for selected compounds The three compounds have similar kinetic signatures, and affinity values were at μM level. Thirdly, two compounds displayed moderate-to-high anticoagulation activity and showed similar sensitivity to PT and aPTT. These findings will provide new insight into the exploration of FXa inhibition. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Synthetic Route of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics