Tag: 100-200

Synthesis of substituted benzenoids and biphenyls via Diels-Alder cycloaddition of 6-methoxy-2-pyrones was written by Ahmed, Salman A.;Bardshiri, Esfandiar;Simpson, Thomas J.. And the article was included in Tetrahedron Letters in 1988.HPLC of Formula: 81245-24-1 This article mentions the following:

Pyranones I (R¹ = alkyl, Ph; R² = H, Me) were heated with R³C椤氬挵CO₂Me (R³ = CO₂Me, H) in PhMe to give benzoate esters II. Esters R¹CO₂Et underwent a Grignard reaction with CH₂:CHCHR²Br and the products were converted, in a series of reactions, to I. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1HPLC of Formula: 81245-24-1).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.HPLC of Formula: 81245-24-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of Solvent on the Mechanical and Structural Properties of N-Alkyldiamide Organogels was written by Khacef, Leila;Legros, Philippe;Herve, Pascal;Ovarlez, Guillaume;Medina-Gonzalez, Yaocihuatl. And the article was included in Langmuir in 2021.Quality Control of Ethyl 2-hydroxybenzoate This article mentions the following:

Here, we study organogels prepared thanks to a new organogelator, the N-oleyldiamide mol., which shows a remarkable propensity to gelify a large scope of solvents, from aprotic to high protic solvents. The solvent plays a key role in the formation and stability of supramol. self-assemblies. However, the understanding and the control of its effects can be complex as many parameters are a priori involved. This study aims to understand the effect of solvent on the structures of organogels and on their final mech. properties. Five solvent classes have been selected ranking from low protic to high protic, according to the Hansen H-bond parameter 鏈猦. The solvent proticity appears to be one of the main parameters that affect the organogel internal structure and therefore the final rheol. properties. For a given organogelator fraction, the terminal elastic modulus measured by oscillatory rheol. is observed to increase significantly with the Hansen H-bond solvent parameter 鏈猦. Materials of different mech. properties are then shown to display various structures, which are investigated thanks to cryo-SEM. Besides, wide-angle X-ray scattering (WAXS) has been used to probe the gelator organization at the mol. scale with regard to the solvent nature, to understand the supramol. self-assembly of this promising mol. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Quality Control of Ethyl 2-hydroxybenzoate).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of Ethyl 2-hydroxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of fermentation temperature on volatile compounds of Petit Verdot red wines from the Spanish region of La Mancha (central-southeastern Spain) was written by Izquierdo-Canas, P. M.;Gonzalez Vinas, M. A.;Mena-Morales, A.;Perez Navarro, J.;Garcia-Romero, E.;Marchante-Cuevas, L.;Gomez-Alonso, S.;Sanchez-Palomo, E.. And the article was included in European Food Research and Technology in 2020.Application of 695-06-7 This article mentions the following:

The aim of this work was to research the relationship between volatile composition of Petit Verdot red wines and the fermentation temperature Winemaking process was carried out at 17鎺矯, 21鎺矯, and 25鎺矯 temperatures Solid-phase extraction (SPE) and gas chromatog.-mass spectrometry (GC-MS) were used to analyze volatile compounds The odor activity values (OAVs) from the different compounds were classified into seven odorant series that describe the aroma profile (fruity, floral, green/fresh, sweet, spicy, fatty, and other odours). The value of each aromatic series was obtained by adding the OAVs of the volatile compounds to each series. The volatile composition was significantly affected by the temperature of the fermentation In general, the increase in the fermentation temperature of La Mancha Petit Verdot red wines from 17 to 25鎺矯 produced an increase in the concentration of volatile aroma compounds The highest aroma contributions to Petit Verdot wine were fruity, sweet and floral series, followed by fatty and spicy series, regardless of fermentation temperature The highest values of aromatic series were found in wines fermented at 21鎺矯. The results of this work show that changes in the fermentation temperature of wines can have a significant impact on their volatile compound profile. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Application of 695-06-7).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application of 695-06-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Essential Oils from Different Myrtaceae Species from Brazilian Atlantic Forest Biome – Chemical Dereplication and Evaluation of Antitrypanosomal Activity was written by Silva Maiolini, Tatiane Cristina;Rosa, Welton;de Oliveira Miranda, Daniel;Costa-Silva, Thais A.;Tempone, Andre G.;Pires Bueno, Paula Carolina;Ferreira Dias, Danielle;Aparecida Chagas de Paula, Daniela;Sartorelli, Patricia;Lago, Joao Henrique G.;Gomes Soares, Marisi. And the article was included in Chemistry & Biodiversity in 2022.Recommanded Product: (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate This article mentions the following:

Chagas Disease (CD), caused by flagellate protozoan Trypanosoma cruzi, is a Neglected Tropical Diseases (NTD) that affect approx. seven million people worldwide with a restrict therapeutical arsenal. In the present study, the essential oils from 18 Myrtaceae species were extracted, chem. dereplicated, and evaluated in vitro against T. cruzi. From these, eight essential oils were considered promising (IC50<10 娓璯/mL and SI>10) against the protozoan: Eugenia florida, E. acutata, E. widgrenii, Calyptranthes brasilienses, C. widgreniana, Plinia cauliflora, Campomanesia xanthocarpa, and Psidium guajava. Multivariate data anal. pointed out (E)-caryophyllene, 浼?humulene, limonene, caryophyllene oxide, and 浼?copaene playing an important role in the anti-T. cruzi activity. The obtained results demonstrated the potential of essential oils of Myrtaceae species as valuable sources of bioactive compounds against T. cruzi. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Recommanded Product: (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Probiotic ice cream with Malus floribunda fruit sauce: Quality properties, mineral, and volatile composition was written by Arslaner, Ayla;Salik, Mehmet Ali. And the article was included in Journal of Food Processing and Preservation in 2022.COA of Formula: C12H20O2 This article mentions the following:

This study investigated the effect of Malus floribunda fruit sauce (MFS) on the quality properties, minerals, volatiles, and viability of Lactobacillus acidophilus La-5 in probiotic ice creams. The MFS increased the dry matter, acidity, total sugar, invert sugar, and calories while decreasing fat, protein, ash, sucrose contents, viscosity, overrun, first dripping, complete melting time, and the pH of samples. The heavy metal contents were within safe limits. The MFS increased the perception of a fruity taste/aroma due to the increase in the terpenes and terpenoids, which reflected pos. on the sensory scores. The highest taste and odor score (4.72) was seen in the MFIC sample. L. acidophilus La-5 counts (7.49 log cfu/g) and the survival rate (100.69%) of MFIC were significantly higher at the end of storage. Consequently, MFS may be used as a source of flavoring agents in ice cream and MFIC is a satisfactory vehicle for L. acidophilus La-5. Novelty impact statement : There is no study in the scientific literature on the use of Malus floribunda fruit sauce (MFS) as a potential functional ingredient in probiotic ice cream production MFS supplementation caused a significant change of volatile compounds in ice cream samples, which reflected pos. on the sensory scores. MFS enhanced survival rates of Lactobacillus acidophilus La-5 in ice creams during the 60 days of storage. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3COA of Formula: C12H20O2).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.COA of Formula: C12H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of temperature on the chemical shift of the ¹³C NMR of 灏?dicarbonyl compounds and their fluoroborate (BF₂) chelates was written by Khatipov, S. A.;Shapet’ko, N. N.;Andreichikov, Yu. S.;Muldakhmetov, Z. M.. And the article was included in Zhurnal Fizicheskoi Khimii in 1985.SDS of cas: 39163-39-8 This article mentions the following:

The chem. shifts were studied of the 灏?C nucleus in I, II, and III. The effect was determined of BF₂ replacement of the enolic H on the shifts. The degrees of asymmetry of the hydrocarbon residues are given. There is no activational process for the migration of enolic H atoms in I, II, III, and their BF₂ chelates. In the experiment, the researchers used many compounds, for example, Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate (cas: 39163-39-8SDS of cas: 39163-39-8).

Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate (cas: 39163-39-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 39163-39-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Influence of the Production System (Intensive vs. Extensive) at Farm Level on Proximate Composition and Volatile Compounds of Portuguese Lamb Meat was written by Echegaray, Noemi;Dominguez, Ruben;Cadavez, Vasco A. P.;Bermudez, Roberto;Purrinos, Laura;Gonzales-Barron, Ursula;Hoffman, Ettiene;Lorenzo, Jose M.. And the article was included in Foods in 2021.Electric Literature of C6H10O2 This article mentions the following:

Todays society demands healthy meat with a special emphasis on integrated animal husbandry combined with the concern for animal welfare. In this sense, the raising of lambs in an extensive system has been one of the most common practices, which results in meats with high nutritional value. However, both the production system and the diet play a fundamental role in the chem. composition of the meat, which has a direct impact on the content of volatile compounds Thus, the aim of this study was to determine the effect of two production systems (intensive and extensive) on the chem. composition and volatile profile of lamb meat. Twenty-eight lambs of the Bordaleira-de-Entre-Douro-e-Minho (BEDM) sheep breed were raised for meat production under the intensive or extensive system and were fed with concentrate and pasture, resp. All animals were carried out in the muscle longissimus thoracis et lumborum. Results evidenced that all the composition parameters were affected by the production system. Extensively-reared lambs produced meat with the highest fat and protein contents, while these animals had the lowest percentages of moisture and ash. Similarly, the total content of volatile compounds was affected (p < 0.05) by the production system and were higher in the meat of lambs reared extensively. Furthermore, the content of total acids, alcs., aldehydes, esters, ethers, furans and sulfur compounds as well as most of the individual compounds were also affected (p < 0.05) by the production system, whereas total hydrocarbons and ketones were not affected (p > 0.05). As a general conclusion, the production system had very high influence not only in proximate composition but also in the volatile compounds In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Electric Literature of C6H10O2).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Electric Literature of C6H10O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

An efficient one-pot construction of substituted pyrimidinones was written by Lu, Yuelie;Xiang, Tingjian;Bartberger, Michael D.;Bernard, Charles;Bostick, Tracy;Huang, Liang;Liu, Longbin;Siegmund, Aaron;Sukay, Gregory;Guo, Gary;Elipe, Maria Silva;Tormos, Wanda;Dominguez, Celia;Koch, Kevin;Burgess, Laurence E.;Basil, Thomas C.;Ibrahim, Prabha;Hummel, Conrad. And the article was included in Tetrahedron in 2006.SDS of cas: 587-88-2 This article mentions the following:

A concise, scalable synthesis of 5-aryl-3-methyl-2-methylthio-6-pyridin-4-yl-3H-pyrimidin-4-ones (aryl = 3-MeC₆H₄, 4-FC₆H₄, 3,4-Cl₂C₆H₃, 2-naphthyl, etc.), as building block for p38 kinase inhibitor B, from Et arylacetates, 4-cyanopyridine and Me isothiocyanate is described. Subsequent hydrolysis of the methylthio group to the hydroxy group and chlorination provided the key intermediates, 2-chloro-3-methyl-6-pyridin-4-yl-5-aryl-3H-pyrimidin-4-ones. This class of reactive building blocks enabled the rapid evaluation of a variety of side chains at the 2-position of the pyrimidinone in SAR studies of inhibitors of p38 MAP kinase. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2SDS of cas: 587-88-2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 587-88-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists was written by Horne, Daniel B.;Tamayo, Nuria A.;Bartberger, Michael D.;Bo, Yunxin;Clarine, Jeffrey;Davis, Carl D.;Gore, Vijay K.;Kaller, Matthew R.;Lehto, Sonya G.;Ma, Vu V.;Nishimura, Nobuko;Nguyen, Thomas T.;Tang, Phi;Wang, Weiya;Youngblood, Beth D.;Zhang, Maosheng;Gavva, Narender R.;Monenschein, Holger;Norman, Mark H.. And the article was included in Journal of Medicinal Chemistry in 2014.Recommanded Product: 16413-26-6 This article mentions the following:

Trifluoromethylaryl-substituted tetrahydroisoquinolinecarboxamides, tetrahydronaphthyridinecarboxamides, a tetrahydropyridopyrimidinecarboxamide, and a tetrahydropyridopyrazinecarboxamide such as tetrahydronaphthyridinecarboxamide I were prepared as inhibitors of the transient receptor potential melastatin 8 (TRPM8) cation channel, the predominant mammalian thermosensor for both temperature- and cooling agent-induced sensations in a subpopulation of peripheral sensory neurons, for potential use in the treatment of pain and bladder disorders. The inhibition of human and rat TRPM8 cation channels by the compounds and their degradation by liver microsomes were determined; for I and three other compounds, the oral and i.v. pharmacokinetics were determined in rats. I demonstrated robust efficacy at inhibiting the response of TRPM8 to cooling agents (icilin) and cold temperatures in rats with ED₉₀ values <3 mg/kg. Trifluoromethylaryl Grignard reagents used for the preparation of some of the title compounds have been found to decompose very exothermically and should be prepared and used with caution. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Recommanded Product: 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Novel complex N-heterocycles via intramolecular 1,5-electrocyclizations: octahydropyrido[4”,3”:2′,3′]cyclobuta[1′,2′:4,5]pyrrolo[2,3-b]pyridines was written by Walter, Harald;Sundermann, Carsten. And the article was included in Heterocycles in 1998.SDS of cas: 14667-47-1 This article mentions the following:

2-Amino-3-isoprenylpyridine (I) and 2-amino-5-chloro-3-isoprenylpyridine (II) are prepared The toluenesulfonic acid catalyzed reaction of I and II with 1-benzyl-, 1-benzoyl-, and 1-methylpiperidin-4-one lead to novel pyrrolo[2,3-b]pyridines (III; R¹ = H, Cl; R² = Me, benzyl, benzoyl) in good to excellent yields in diastereoisomerically pure form. An intramol. 1,5-electrocyclization of a dipolar reactive intermediate as a key step is proposed for the formation of III. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1SDS of cas: 14667-47-1).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 14667-47-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics