Tag: 100-200

Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers was written by Chu, Yeonjeong;Raja Sekhara Reddy, B.;Pratap Reddy Gajulapalli, V.;Sudhakar Babu, K.;Kim, Eunha;Lee, Sanghee. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.SDS of cas: 2253-73-8 The following contents are mentioned in the article:

Type I Interferon (IFN) signaling plays an important role in the immune defense system against virus infection and in the innate immune response, thus IFNs are widely used as anti-viral agents and treatment for immune disorder or cancer. However, there is a growing demand for novel small-mol. IFN inducer due to tolerance, toxicity, or short duration of action following direct administration of IFNs. The authors assessed arylpiperazine (ARP) as a new core skeleton of IFN inducer. To study structure-activity relation, the authors designed and synthesized a series of ARP analogs and evaluated the ability to stimulate IFN response in THP-1 human monocyte cells. Compound 1-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-(3,4,5-trimethoxyphenyl)ethenone was identified as a potent type I IFN inducer as it significantly increased cytokine secretion and increased expression of various IFN-stimulating genes which are representative biomarkers of type I IFN pathway. The authors’ results suggested a beneficial therapeutic potential of 1-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-(3,4,5-trimethoxyphenyl)ethenone as an anti-viral agent. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8SDS of cas: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X was written by Fonovic, Ursa Pecar;Knez, Damijan;Hrast, Martina;Zidar, Nace;Proj, Matic;Gobec, Stanislav;Kos, Janko. And the article was included in European Journal of Medicinal Chemistry in 2020.Product Details of 2253-73-8 The following contents are mentioned in the article:

Cathepsin X is a cysteine carboxypeptidase that is involved in various physiol. and pathol. processes. In particular, highly elevated expression and activity of cathepsin X has been observed in cancers and neurodegenerative diseases. Previously, we identified compound Z9 (1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-((4-isopropyl-4H-1,2,4-triazol-3-yl)thio)ethan-1-one) as a potent and specific reversible cathepsin X inhibitor. Here, we have explored the effects of chem. variations to Z9 of either benzodioxine or triazol moieties, and the importance of the central ketomethylenethio linker. The ketomethylenethio linker was crucial for cathepsin X inhibition, whereas changes of the triazole heterocycle did not alter the inhibitory potencies to a greater extent. Replacement of benzodioxine moiety with substituted benzenes reduced cathepsin X inhibition. Overall, several synthesized compounds showed similar or improved inhibitory potencies against cathepsin X compared to Z9, with IC₅₀ values of 7.1μM-13.6μM. Addnl., 25 inhibited prostate cancer cell migration by 21%, which is under the control of cathepsin X. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X was written by Fonovic, Ursa Pecar;Knez, Damijan;Hrast, Martina;Zidar, Nace;Proj, Matic;Gobec, Stanislav;Kos, Janko. And the article was included in European Journal of Medicinal Chemistry in 2020.Product Details of 2253-73-8 The following contents are mentioned in the article:

Cathepsin X is a cysteine carboxypeptidase that is involved in various physiol. and pathol. processes. In particular, highly elevated expression and activity of cathepsin X has been observed in cancers and neurodegenerative diseases. Previously, we identified compound Z9 (1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-((4-isopropyl-4H-1,2,4-triazol-3-yl)thio)ethan-1-one) as a potent and specific reversible cathepsin X inhibitor. Here, we have explored the effects of chem. variations to Z9 of either benzodioxine or triazol moieties, and the importance of the central ketomethylenethio linker. The ketomethylenethio linker was crucial for cathepsin X inhibition, whereas changes of the triazole heterocycle did not alter the inhibitory potencies to a greater extent. Replacement of benzodioxine moiety with substituted benzenes reduced cathepsin X inhibition. Overall, several synthesized compounds showed similar or improved inhibitory potencies against cathepsin X compared to Z9, with IC₅₀ values of 7.1μM-13.6μM. Addnl., 25 inhibited prostate cancer cell migration by 21%, which is under the control of cathepsin X. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The influence of polyphenol supplementation on ester formation during red wine alcoholic fermentation was written by Ling, Mengqi;Qi, Mengyao;Li, Siyu;Shi, Ying;Pan, Qiuhong;Cheng, Chifang;Yang, Weiming;Duan, Changqing. And the article was included in Food Chemistry in 2022.Computed Properties of C11H22O2 The following contents are mentioned in the article:

Pre-fermentative polyphenol supplementation in industrial scales (100-hL) and simulated fermentation (350 mL clarified juice) were conducted. The results showed that in practical winemaking, adding QCE (quercetin, caffeic acid and ellagic acid) increased acetate concentrations in wines and extra grape seed tannins (T) enhanced the effect of QCE supplementation. In simulated fermentation with clarified juice, the synergy effect of QCE and T was evidenced that ester formation was only promoted through mixed QCET supplementation. Besides, QCE supplementation benefited the formation of 4-vinylcatechol adducted malvidin-3-O-(acetyl/coumaroyl)-glucoside and decreased other anthocyanin derivatives derived from pyruvic acid and acetaldehyde, leading more pyruvic acid and acetaldehyde left in yeast to enhance the metabolic fluxes of esters. Findings manifested the connection between the formation of esters and anthocyanin derivatives during red wine alc. fermentation, which would be influenced by the phenolic matrix. This work could provide a perspective in winemaking industry for modulating aroma profile via polyphenol supplementation. This study involved multiple reactions and reactants, such as Isopentyl hexanoate (cas: 2198-61-0Computed Properties of C11H22O2).

Isopentyl hexanoate (cas: 2198-61-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C11H22O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sequential Fermentation with Torulaspora delbrueckii and selected Saccharomyces cerevisiae for aroma enhancement of Longyan dry white Wine was written by Wang, Suwen;Lu, Yao;Fu, Xiaofang;Wang, Meiqi;Wang, Wenxiu;Wang, Jie;Wang, Huanxiang;Liu, Yaqiong. And the article was included in International Journal of Food Science and Technology in 2022.Application In Synthesis of Isopentyl hexanoate The following contents are mentioned in the article:

In order to evaluate the effects of yeast starter on the quality and flavor profile of Longyan dry white wine, pure fermentation and sequential fermentation of selected Torulaspora delbrueckii and selected Saccharomyces cerevisiae (VL2, DELTA, X5) were performed in industrial-scale fermentation of this work. Compared with pure fermentation, sequential fermentation improved the fermentative aroma concentrations, especially the treatment of T. delbrueckii/DELTA increased the content of Et butyrate, Et caprylate and Et decanoate, which may be related to a strong citrus fruity aroma. Principal component anal. revealed a significant difference in aromatic feature of co-fermentation of T. delbrueckii/DELTA and T. delbrueckii/VL2 from their resp. pure fermentation These may be related to amino acid metabolism and further affected the formation of volatile compounds according to correlation anal. Overall, sequential fermentation using DELTA and T. delbrueckii strengthened the aroma characteristics and improved the complex of wines. It will provide a new strategy to regulate the flavor and improve the quality of Longyan dry white wine. This study involved multiple reactions and reactants, such as Isopentyl hexanoate (cas: 2198-61-0Application In Synthesis of Isopentyl hexanoate).

Isopentyl hexanoate (cas: 2198-61-0) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application In Synthesis of Isopentyl hexanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sequential Fermentation with Torulaspora delbrueckii and selected Saccharomyces cerevisiae for aroma enhancement of Longyan dry white Wine was written by Wang, Suwen;Lu, Yao;Fu, Xiaofang;Wang, Meiqi;Wang, Wenxiu;Wang, Jie;Wang, Huanxiang;Liu, Yaqiong. And the article was included in International Journal of Food Science and Technology in 2022.Reference of 112-14-1 The following contents are mentioned in the article:

In order to evaluate the effects of yeast starter on the quality and flavor profile of Longyan dry white wine, pure fermentation and sequential fermentation of selected Torulaspora delbrueckii and selected Saccharomyces cerevisiae (VL2, DELTA, X5) were performed in industrial-scale fermentation of this work. Compared with pure fermentation, sequential fermentation improved the fermentative aroma concentrations, especially the treatment of T. delbrueckii/DELTA increased the content of Et butyrate, Et caprylate and Et decanoate, which may be related to a strong citrus fruity aroma. Principal component anal. revealed a significant difference in aromatic feature of co-fermentation of T. delbrueckii/DELTA and T. delbrueckii/VL2 from their resp. pure fermentation These may be related to amino acid metabolism and further affected the formation of volatile compounds according to correlation anal. Overall, sequential fermentation using DELTA and T. delbrueckii strengthened the aroma characteristics and improved the complex of wines. It will provide a new strategy to regulate the flavor and improve the quality of Longyan dry white wine. This study involved multiple reactions and reactants, such as Octyl acetate (cas: 112-14-1Reference of 112-14-1).

Octyl acetate (cas: 112-14-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Reference of 112-14-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Removal of bisphenol A by laccases from Pleurotus ostreatus and Pleurotus pulmonarius and evaluation of ecotoxicity of degradation products was written by Neiverth de Freitas, Emanuelle;Bubna, Gisele Adriana;Brugnari, Tatiane;Kato, Camila Gabriel;Nolli, Mariene;Rauen, Thalita G.;Moreira, Regina de Fatima Peralta Muniz;Peralta, Rosely Aparecida;Bracht, Adelar;de Souza, Cristina G. M.;Peralta, Rosane Marina. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2017.Product Details of 763-69-9 The following contents are mentioned in the article:

Bisphenol A (BPA) is an endocrine disruptor compound, that is continuously released into the environment and is barely degraded in wastewater treatment plants. In this work, crude laccases from Pleurotus ostreatus and Pleurotus pulmonarius were used for the first time to degrade BPA in aqueous solution The residual BPA was quantified by HPLC and the BPA metabolites produced by action of the laccases were identified by GC-MS. BPA at 100 mg/L and 200 mg/L (0.88 mmol/L) were 100% and 85% removed, resp., in a 1 h reaction by both fungal laccases at a concentration of 8 U/L. Thirteen aromatic and aliphatic BPA metabolites were identified, including p-isopropenylphenol, methylpent-3-oic acid, ethyl-3-ethoxy propanoate, and 4-ethyl-2-methoxyphenol. The acute BPA toxicity decreased from 85% to less than 5% using the P. ostreatus laccase. P. pulmonarius laccase, did not caused reduction in toxicity, possibly because at least one BPA metabolite was as toxic as the parent compound itself. The results of this study suggest a feasible method for the complete removal of BPA from polluted environments using crude laccase from P. ostreatus. This study involved multiple reactions and reactants, such as Ethyl 3-ethoxypropanoate (cas: 763-69-9Product Details of 763-69-9).

Ethyl 3-ethoxypropanoate (cas: 763-69-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 763-69-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Inter-Tree Variation in the Chemical Composition of Boswellia papyrifera Oleo-Gum-Resin was written by DeCarlo, Anjanette;Agieb, Salah;Johnson, Stephen;Satyal, Prabodh;Setzer, William N.. And the article was included in Natural Product Communications in 2022.Related Products of 112-14-1 The following contents are mentioned in the article:

Frankincense is a fragrant resin produced by Boswellia species, and has been used for centuries as a perfume, medicine, and incense, and is an important cosmetic and therapeutic product today. A number of studies have been conducted on the resin essential oils, but many have used com. sources outside of the country of origin, leading to potential taxonomic confusion or misidentification. Individual Boswellia papyrifera resin samples were each obtained directly from 11 individual trees in Sudan, hydrodistd., the volatile phytochems. determined by gas chromatog. methods, and the chem. compositions subjected to cluster anal. All samples were very similar, with high levels of octyl acetate (49.5%-81.0%) and octanol (6.5%-13.7%), and varying levels of diterpenoids (6.6%-32.7%). The cluster anal. indicated 3 highly similar groups, defined by (1) relatively higher levels of octyl acetate (58.9%-81.0%), but with low levels of diterpenoids (6.6%-18.6%); (2) relatively lower levels of octyl acetate (49.5%-61.3%), but with a higher proportion of diterpenoids (19.0%-22.8%); and (3) with octyl acetate (51.6%) and diterpenoids (32.7%). This study involved multiple reactions and reactants, such as Octyl acetate (cas: 112-14-1Related Products of 112-14-1).

Octyl acetate (cas: 112-14-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 112-14-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

GC/MS/AMDIS in identification VOCs in industrial chemicals was written by Liu, Fen;Li, Tiandi;Xie, Yuxuan;He, Juntao;Li, Shuangfeng;Yun, Jianpei;Lin, Yiran. And the article was included in Zhonghua Laodong Weisheng Zhiyebing Zazhi in 2015.Safety of Ethyl 3-ethoxypropanoate The following contents are mentioned in the article:

GC/MS/AMDIS was used in VOCs detection in industrial chems. AMDIS and retention time locking (RTL) technol. were used, chem. raw materials volatile organic components were identified by GC/MS. Volatile organic components AMDIS database contained retention time index was made. Combined retention time with mass spectra made industrial chems. volatile components qual. identification more quickly and reliably. This study involved multiple reactions and reactants, such as Ethyl 3-ethoxypropanoate (cas: 763-69-9Safety of Ethyl 3-ethoxypropanoate).

Ethyl 3-ethoxypropanoate (cas: 763-69-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of Ethyl 3-ethoxypropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alternative accelerators: New water-soluble catalysts for isocyanate-crosslinking coatings was written by Parks, Brandon;Venham, Lanny. And the article was included in European Coatings Journal in 2014.Formula: C7H14O3 The following contents are mentioned in the article:

Novel water-soluble, hydrolytically stable, catalysts for isocyanate reactions have been developed based on tin, bismuth and zinc. All were effective in both waterborne and solventborne coatings, with some having performance similar to the industry standard DBTL. Stricter environmental regulations may affect the use of organotins, making the bismuth- and zinc-based products of great interest. This study involved multiple reactions and reactants, such as Ethyl 3-ethoxypropanoate (cas: 763-69-9Formula: C7H14O3).

Ethyl 3-ethoxypropanoate (cas: 763-69-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C7H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics