Tag: 100-200

Influence of grape composition and origin, yeast strain and spontaneous fermentation on aroma profile of Corvina and Corvinone wines was written by Luzzini, Giovanni;Slaghenaufi, Davide;Pasetto, Francesca;Ugliano, Maurizio. And the article was included in LWT–Food Science and Technology in 2021.Formula: C10H18O2 This article mentions the following:

Volatile composition and sensory properties of Corvina and Corvinone red wines in relationship to grape origin, yeast strain and inoculated vs. spontaneous fermentation were investigated. Exptl. wines were produced using freshly harvested grapes of the two varieties coming from two different areas. The results indicated that, by affecting grape composition, grape origin had a primary impact on wine aroma chem. and sensory properties. From a chem. point of view, this effect was associated not only with grape-derived compounds but also to some extent with fermentation-derived esters. Yeast strains influence was mostly associated with higher alcs. and certain esters, whereas the main characteristic of spontaneous fermentation was increased concentration of Et acetate. Sensory anal. confirmed the greater impact of grape origin compared to yeast strain, indicating clusters of odor similarities which were mostly associated with variations in the content of Et esters, C6 alcs., and norisoprenoids in Corvina and of norisoprenoids, cyclic terpenes, acetate esters, and Et acetate in Corvinone, resp. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9Formula: C10H18O2).

5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Formula: C10H18O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

FimH antagonists – solubility vs. permeability was written by Pang, Lijuan;Bezencon, Jacqueline;Kleeb, Simon;Rabbani, Said;Sigl, Anja;Smiesko, Martin;Sager, Christoph P.;Eris, Deniz;Schwardt, Oliver;Ernst, Beat. And the article was included in Carbohydrate Chemistry in 2017.Category: esters-buliding-blocks This article mentions the following:

Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are among the most prevalent infections worldwide. Since frequent antibiotic treatment favors the emergence of antibiotic resistance, efficient non-antibiotic strategies are urgently needed. The first step of the pathogenesis of UTI is the bacterial adherence to urothelial host cells, a process mediated by the mannose-binding adhesin FimH located at the tip of bacterial pili. In a preliminary study, biphenyl 浼?D-mannopyranosides with an electron-withdrawing carboxylate on the aglycon were identified as potent FimH antagonists. Although passive permeability could be established by masking the carboxylate as an ester, insufficient solubility and fast hydrolysis did not allow to maintain the therapeutic concentration in the bladder for the requested period of time. By modifying the substitution pattern, mol. planarity and symmetry of the biphenyl aglycon could be disrupted leading to improved solubility In addition, when heteroatoms were introduced to the aglycon, antagonists with further improved solubility, metabolic stability as well as passive permeability were obtained. The best representative, the pyrrolylphenyl mannoside 42f exhibited therapeutic urine concentration for up to 6 h and is therefore a promising oral candidate for UTI prevention and/or treatment. In the experiment, the researchers used many compounds, for example, Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7Category: esters-buliding-blocks).

Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Privileged structure based ligands for melanocortin receptors – Substituted benzylic piperazine derivatives was written by Fisher, Matthew J.;Backer, Ryan T.;Collado, Ivan;De Frutos, Oscar;Husain, Saba;Hsiung, Hansen M.;Kuklish, Steve L.;Mateo, Ana I.;Mullaney, Jeffrey T.;Ornstein, Paul L.;Paredes, Cristina Garcia;O’Brian, Thomas P.;Richardson, Timothy I.;Shah, Jikesh;Zgombick, John M.;Briner, Karin. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Recommanded Product: Ethyl 2-fluorophenylacetate This article mentions the following:

Replacement of the arylpiperazine moiety in I with a variety of substituted benzylic piperazines yields compounds that afford melanocortin receptor 4 (MCR4) activity. Analogs with ortho substitution on the aromatic ring afforded the highest affinity. Resolution of the stereocenter of the benzylic piperazine based privileged structure revealed that the R-enantiomer was more active. In the experiment, the researchers used many compounds, for example, Ethyl 2-fluorophenylacetate (cas: 584-74-7Recommanded Product: Ethyl 2-fluorophenylacetate).

Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: Ethyl 2-fluorophenylacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Orthogonally positioned diamino pyrrole- and imidazole-containing polyamides: synthesis of 1-(3-substituted-propyl)-4-nitropyrrole-2-carboxylic acid and 1-(3-chloropropyl)-4-nitroimidazole-2-carboxylic acid was written by Satam, Vijay;Patil, Pravin;Babu, Balaji;Rice, Toni;Porte, Alexander;Alger, Shannon;Zeller, Matthias;Lee, Moses. And the article was included in Synthetic Communications in 2014.HPLC of Formula: 5930-92-7 This article mentions the following:

Pyrrole- and imidazole-containing oligoamides can be tailored to recognize the DNA 6-8 base pair sequence. Adding a second amino group via the N(1)-position of pyrrole or imidazole in oligoamides could enhance their DNA-binding affinity and water-solubility while retaining sequence specificity. Synthesis of the key 1-substituted 4-nitropyrrole (and imidazole)-2-carboxylic acid building blocks are described. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7HPLC of Formula: 5930-92-7).

Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 5930-92-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of 4,5-Diaryl-1H-pyrazole-3-ol Derivatives as Potential COX-2 Inhibitors was written by Patel, Meena V.;Bell, Randy;Majest, Sandra;Henry, Rodger;Kolasa, Teodozyj. And the article was included in Journal of Organic Chemistry in 2004.Computed Properties of C10H11FO2 This article mentions the following:

4,5-Diaryl-1H-pyrazole-3-ol was utilized as a versatile template to synthesize several classes of compounds such as pyrazolooxazines, pyrazolobenzooxazines, pyrazolooxazoles, and annulated pyrazolooxazoles as potential COX-2 inhibitors. The pyrano- and thiopyranopyrazolooxazoles were successfully synthesized with use of pyridinium p-toluenesulfonate mediated cyclization of ketal intermediates. Diarylpyrazolobenzooxazepine analogs were synthesized by using Cu-mediated cyclization of O-alkylated aryl bromide intermediate. Arylsulfonamides were synthesized efficiently on a large scale with the 4-[4-(4-fluorophenyl)-5-hydroxy-2H-pyrazol-3-yl]benzenesulfonamide template readily synthesized from com. available 4-sulfamoylbenzoic acid. The structure of a representative compound from each class was confirmed by X-ray crystallog. Selected compounds tested for inhibitory activity against COX-1 and COX-2 enzymes showed good selectivity for COX-2 vs. COX-1 enzyme. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Computed Properties of C10H11FO2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C10H11FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

GC characterization and erectogenic enzyme inhibitory effect of essential oils from tangerine and lemon peels: A comparative study was written by Idowu Oyeleye, Sunday;Ajayi, Oluwasegun E.;Ademosun, Ayokunle O.;Oboh, Ganiyu. And the article was included in Flavour and Fragrance Journal in 2022.Safety of (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate This article mentions the following:

This study comparatively evaluated inhibitory effect of essential oils (EOs) from tangerine and lemon peels on some enzymes [angiotensin-converting enzyme (ACE), acetylcholinesterase (AChE), arginase, monoamine oxidase (MAO), phosphodiesterase-5 (PDE-5), adenosine deaminase (ADA) and 5-nucleotidase] related to erectile dysfunction (ED), as well as thiobarbituric acid reactive species (TBARs) level in isolated Wistar albino rats penile homogenate. In addition, the chem. compositions of these EOs were characterized via gas chromatog. coupled with flame ionization detector (GC-FID). The result revealed that the studied EOs were able to inhibit these erectogenic enzymes and TBARs level in a dose-dependent manner. The EOs were found to be rich in monoterpenes hydrocarbon. However, the major constituent in both oils was D-limonene, 45.48% and 34.99% abundance in lemon and tangerine EOs, resp. Other phytoconstituents detected in substantial amounts include the following: 4-Vinyl-2-methoxyphenol (5.42% and 2.97%), N-methyl-D3-Aziridine (6.58% and 10.01%) and Xanthotoxin (12.055 and 18.7%) for lemon and tangerine EOs, resp. It is suggestive that these EOs owe their exceptional inhibitory capacities to the availability of these phytochems. Hence, their ability to inhibit ACE, AChE, arginase, MAO, PDE-5, ADA and 5-nucleotidase activities, and TBARs level could be the possible mechanism by which the studied EOs exert their therapeutic potentials in the management of ED. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3Safety of (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

^tBuOLi-Promoted Hydroboration of Esters and Epoxides was written by Shi, Yinyin;Wang, Yue;Huang, Zhefan;Zhang, Fangjun;Shao, Yinlin. And the article was included in ACS Omega in 2022.Reference of 19432-68-9 This article mentions the following:

Com. available and inexpensive lithium tert-butoxide (tBuOLi) acts as a good precatalyst for the hydroboration of esters, lactones, and epoxides using pinacolborane as a borylation agent. Functional groups such as cyano-, nitro-, amino-, vinyl, and alkynyl are unaffected under the presented hydroboration process, representing high chemoselectivity. This transformation has also been effectively applied to the synthesis of key intermediates of Erlotinib and Cinacalcet. Preliminary investigations of the mechanism show that the hydroboration proceeds through the in situ formed BH₃ species. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Reference of 19432-68-9).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 19432-68-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors was written by Mosley, Cara A.;Myers, Scott J.;Murray, Ernest E.;Santangelo, Rose;Tahirovic, Yesim A.;Kurtkaya, Natalie;Mullasseril, Praseeda;Yuan, Hongjie;Lyuboslavsky, Polina;Le, Phuong;Wilson, Lawrence J.;Yepes, Manuel;Dingledine, Ray;Traynelis, Stephen F.;Liotta, Dennis C.. And the article was included in Bioorganic & Medicinal Chemistry in 2009.Recommanded Product: Methyl 4-(4-aminophenyl)butanoate This article mentions the following:

The synthesis and structure-activity relationship anal. of a novel class of amide-based biaryl NR2B-selective NMDA receptor antagonists are presented. Some of the studied compounds are potent, selective, non-competitive, and voltage-independent antagonists of NR2B-containing NMDA receptors. Like the founding member of this class of antagonists (ifenprodil), several interesting compounds of the series bind to the amino terminal domain of the NR2B subunit to inhibit function. Analog potency is modulated by linker length, flexibility, and hydrogen bonding opportunities. However, unlike previously described classes of NR2B-selective NMDA antagonists that exhibit off-target activity at a variety of monoamine receptors, the compounds described herein show much diminished effects against the hERG channel and 浼?sub>1-adrenergic receptors. Selections of the compounds discussed have acceptable half-lives in vivo and are predicted to permeate the blood-brain barrier. These data together suggest that masking charged atoms on the linker region of NR2B-selective antagonists can decrease undesirable side effects while still maintaining on-target potency. In the experiment, the researchers used many compounds, for example, Methyl 4-(4-aminophenyl)butanoate (cas: 20637-09-6Recommanded Product: Methyl 4-(4-aminophenyl)butanoate).

Methyl 4-(4-aminophenyl)butanoate (cas: 20637-09-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: Methyl 4-(4-aminophenyl)butanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Comparative study of three Achillea essential oils from eastern part of Turkey and their biological activities was written by Demirci, Betul;Baser, K. Husnu Can;Aytac, Zeki;Khan, Shabana I.;Jacob, Melissa R.;Tabanca, Nurhayat. And the article was included in Records of Natural Products in 2018.Product Details of 659-70-1 This article mentions the following:

Essential oils obtained by hydrodistillation were analyzed both by gas chromatog. (GC) and gas chromatog.-mass spectrometry (GC-MS). The main constituents found in Achillea oil were as follows: A. filipendulina Lam.: 43.8% santolina alc., 14.5% 1,8-cineole and 12.5% cis-chrysanthenyl acetate; A. magnifica Hiemerl ex Hub.-Mor.: 27.5% linalool, 5.8% spathulenol, 5.5% terpinen-4-ol, 4.7% 浼?terpineol and 4.7% 灏?eudesmol; A. tenuifolia Lam.: 12.4% artemisia ketone, 9.9% p-cymene, 7.1% camphor, 5.9% terpinen-4-ol, 4.7% caryophyllene oxide and 4.5% 浼?pinene. Furthermore, the Achillea essential oils were evaluated for antimalarial and antimicrobial activities. A. magnifica and A. filipendulina oils showed strong antimalarial activity against both chloroquine sensitive D6 (IC₅₀= 1.2 and 0.68 娓璯/mL) and chloroquine resistant W2 (IC₅₀= 1.1 and 0.9 娓璯/mL) strains of Plasmodium falciparum without any cytotoxicity to mammalian cells up to IC₅₀=47.6 娓璯/mL against Vero cells whereas A. tenuifolia oil showed no antimalarial activity up to a concentration of 20 mg/mL. All three Achillea oils showed no antibacterial activity against human pathogenic bacteria up to a concentration of 200 娓璯/mL. A. tenuifolia and A. magnifica oils demonstrated mild antifungal activity against Cryptococcus neoformans (IC₅₀= 45, 20 and 15 娓璯/mL, resp.). In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1Product Details of 659-70-1).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 659-70-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

FeCl₃-Promoted [3 + 2] Annulations of 绾?Butyrolactone Fused Cyclopropanes with Heterocumulenes was written by Feng, Manli;Yang, Pengfei;Yang, Gaosheng;Chen, Wenlong;Chai, Zhuo. And the article was included in Journal of Organic Chemistry in 2018.Product Details of 2740-88-7 This article mentions the following:

In the presence of FeCl₃ in 1,2-dichloroethane, cyclopropane-fused 绾?lactones such as I (R = Me, Et; R¹ = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 3-MeOC₆H₄, 2-MeOC₆H₄, 4-BrC₆H₄, 4-ClC₆H₄, 3-ClC₆H₄, 2-ClC₆H₄, 4-O₂NC₆H₄; R² = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 3-MeOC₆H₄, 2-MeOC₆H₄, 4-BrC₆H₄, 4-O₂NC₆H₄) underwent regio- and diastereoselective cycloadditions with isothiocyanates R³NCS (R³ = Ph, 4-MeC₆H₄, 2-MeC₆H₄, 4-MeOC₆H₄, 3-MeOC₆H₄, 2-MeOC₆H₄, 4-ClC₆H₄, 2-ClC₆H₄, 4-FC₆H₄, 4-F₃CC₆H₄, 4-O₂NC₆H₄, 3-O₂NC₆H₄, 2-O₂NC₆H₄, PhCH₂, 4-FC₆H₄CH₂, H₂C:CHCH₂, PhCH₂CH₂, Bu, cyclohexyl) and carbodiimides R⁴N:C:NR⁴ (R⁴ = cyclohexyl, i-Pr) to yield thioimidate- and amidine-containing 绾?lactones such as II (R = Me, Et; R¹ = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 3-MeOC₆H₄, 2-MeOC₆H₄, 4-BrC₆H₄, 4-ClC₆H₄, 3-ClC₆H₄, 2-ClC₆H₄, 4-O₂NC₆H₄; R² = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 3-MeOC₆H₄, 2-MeOC₆H₄, 4-BrC₆H₄, 4-O₂NC₆H₄; R³ = Ph, 4-MeC₆H₄, 2-MeC₆H₄, 4-MeOC₆H₄, 3-MeOC₆H₄, 2-MeOC₆H₄, 4-ClC₆H₄, 2-ClC₆H₄, 4-FC₆H₄, 4-F₃CC₆H₄, 4-O₂NC₆H₄, 3-O₂NC₆H₄, 2-O₂NC₆H₄, PhCH₂, 4-FC₆H₄CH₂, H₂C:CHCH₂, PhCH₂CH₂, Bu, cyclohexyl) and III (R = Et; R¹ = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 3-MeOC₆H₄, 4-BrC₆H₄, 4-ClC₆H₄, 4-O₂NC₆H₄; R² = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 3-MeOC₆H₄, 2-MeOC₆H₄, 4-BrC₆H₄, 4-O₂NC₆H₄; R⁴ = cyclohexyl, i-Pr) in 93-99% and 94-99% yields, resp., as single diastereomers. In the experiment, the researchers used many compounds, for example, 4-Fluorobenzylisothiocyanate (cas: 2740-88-7Product Details of 2740-88-7).

4-Fluorobenzylisothiocyanate (cas: 2740-88-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 2740-88-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics