Tag: 100-200

Organotin-catalyzed synthesis of hydroxyalkylamides from lactones via a ring-opening process was written by Liang, Xiayu;Yu, Peng;Fu, Chen;Shen, Yongcun. And the article was included in Tetrahedron Letters in 2021.Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one This article mentions the following:

A new strategy for the facile synthesis of hydroxyalkylamides through the ring-opening reaction of lactones with amine promoted by dibutyltin acetate was developed. A series of hydroxyalkylamide compounds were obtained and the method was successfully applied to the synthesis of pharmaceutically active mols. tyrosinase inhibitor V and HDAC inhibitor VI via a three-step synthetic pathway. The broad substrate scope, mild reaction conditions and practical application proved the effectiveness, compatibility and practicality of this method. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Application In Synthesis of 5-Ethyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design was written by Yeh, Teng-Kuang;Song, Jen-Shin;Chang, Po-Wei;Yu, Jin-Chen;Chang, Chia-Hwa;Liao, Fang-Yu;Tien, Ya-Wen;Kuppusamy, Ramajayam;Li, An-Siou;Chen, Chi-Han;Chen, Chieh-Wen;Lin, Li-Mei;Chang, Hsin-Huei;Huang, Chih-Hsiang;Yao, Jau-Ying;Wu, Mine-Hsine;Peng, Yi-Hui;Hsueh, Ching-Cheng;Hsiao, Wen-Chi;Chen, Pei-Husan;Lin, Chin-Yu;Hsieh, Su-Huei;Shih, Chuan;Hung, Ming-Shiu;Wu, Su-Ying;Kuo, Ching-Chuan;Ueng, Shau-Hua. And the article was included in European Journal of Medicinal Chemistry in 2022.Product Details of 16413-26-6 This article mentions the following:

Indoleamine 2,3-dioxygenase-1 (IDO1) is a potential target for the next generation of cancer immunotherapies. We describe the development of two series of IDO1 inhibitors incorporating a N-hydroxy-thiophene-carboximidamide core generated by knowledge-based drug design. Structural modifications to improve the cellular activity and pharmacokinetic (PK) properties of the compounds synthesized, including extension of the side chain of the N-hydroxythiophene-2-carboximidamide core, resulted in compound 27a, a potent IDO1 inhibitor which demonstrated significant (51%) in vivo target inhibition on IDO1 in a human SK-OV-3 ovarian xenograft tumor mouse model. This strategy is expected to be applicable to the discovery of addnl. IDO1 inhibitors for the treatment of other diseases susceptible to modulation of IDO1. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Product Details of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aminopyrazine Pathway to the Moco Metabolite Dephospho Form A was written by Klewe, Anne;Kruse, Tobias;Lindel, Thomas. And the article was included in Chemistry – A European Journal in 2017.Category: esters-buliding-blocks This article mentions the following:

An efficient synthesis of the molybdopterin/molybdenum cofactor (Moco) oxidation product dephospho Form A I is described that assembles the pteridinone system starting from an iodinated aminopyrazine. The sodium salt of dephospho Form A could be purified by precipitation from methanol, which paved the way to the title compound in the 100 mg range. By HPLC, the synthetic material was compared with a sample isolated from a recombinant Moco containing protein. Anal. of dephospho Form A is the only method that allows the quantification of the Moco content of crude cell extracts and recombinant protein preparations In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Category: esters-buliding-blocks).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Phenyl bioisosteres in medicinal chemistry: discovery of novel 绾?secretase modulators as a potential treatment for Alzheimer閳ョ灚 disease was written by Ratni, H.;Baumann, K.;Bellotti, P.;Cook, X. A.;Green, L. G.;Luebbers, T.;Reutlinger, M.;Stepan, A. F.;Vifian, W.. And the article was included in RSC Medicinal Chemistry in 2021.Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate This article mentions the following:

Ph rings are one of the most prevalent structural moieties in active pharmaceutical ingredients, even if they often contribute to poor physico-chem. properties. Herein, we propose the use of a bridged piperidine (BP) moiety as a Ph bioisostere, which could also be seen as a superior Ph alternative as it led to strongly improved drug like properties, in terms of solubility and lipophilicity. Addnl., this BP moiety compares favorably to the recently reported saturated Ph bioisosteres. We applied this concept to our 绾?secretase modulator (GSM) project for the potential treatment of Alzheimer閳ョ灚 disease delivering clin. candidates. In the experiment, the researchers used many compounds, for example, Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (cas: 135908-33-7Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate).

Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (cas: 135908-33-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of Methyl 4-aminobicyclo[2.2.2]octane-1-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Studies directed toward the preparation of key intermediates for the synthesis of trisporic acids and cassiol was written by Colombo, Maria I.;Zinczuk, Juan;Mischne, Mirta P.;Ruveda, Edmundo A.. And the article was included in Pure and Applied Chemistry in 2001.COA of Formula: C9H16O4 This article mentions the following:

An enantioselective synthesis and resolution of the key White intermediate I for the synthesis of trisporic acids are described. Attempts to develop a synthetic route toward the antiulcerogenic compound cassiol (II) by an olefination reaction of I and an alternative sequence involving a Michael addition followed by an aldol condensation of an open substrate, are also reported. In the experiment, the researchers used many compounds, for example, Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7COA of Formula: C9H16O4).

Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C9H16O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Metabolome-Based Analysis of Herbal Cough Preparations Via Headspace Solid-Phase Microextraction GC/MS and Multivariate Data Analyses: A Prospect for Its Essential Oil Equivalency was written by Baky, Mostafa H.;Farag, Mohamed A.;Rasheed, Dalia M.. And the article was included in ACS Omega in 2020.Name: Ethyl 2-hydroxybenzoate This article mentions the following:

Liquid cough preparations containing essential oils pose a challenge for isolating and quantifying their volatile components from such a complex matrix enriched with nonvolatile constituents and excipients. This study aims to develop a strategy integrating QC anal. of seven natural cough preparations in the Egyptian market and to assess volatile variation among the preparations using multivariate data analyses. Cough preparations were subjected to headspace solid-phase microextraction (HS-SPME) for determination of their essential oil composition mediating for their actions and to assess volatile differences among them. HS-SPME is a suitable technique for sample preparation that allows for extraction and enrichment of volatiles from complex nonvolatile matrixes and their direct desorption into the gas chromatog. anal. system. A total of 88 volatile components were identified belonging to seven classes, viz. aromatics, aliphatic hydrocarbons, mono/sesquiterpene hydrocarbons, and oxygenated mono/sesquiterpenes. Oxygenated monoterpenes, viz., menthol, cineole, thymol, and (E)-anethole, were the major volatiles identified in five cough preparations (79.5-98.6%), whereas aromatics, chiefly cinnamate derivatives, constituted the second class amounting for 50.5 and 27.4% in the other two cough preparations Meaningful results regarding the products’ efficacy and safety were extrapolated from this anal. procedure, where artificial preservatives (parabens) were detected in five cough preparations This study established an efficient strategy for exploring volatile profiling and defining different markers among the different cough preparations Addnl., authenticity of listed herbal ingredients in the cough preparations was also confirmed in certain preparations, while other formulations failed to show representative volatile components. Volatile variation among preparations was assessed using multivariate data analyses in an attempt to prioritize cough preparations for usage, suggesting the preference of Bronchicum and Babetone among examined cough products. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Name: Ethyl 2-hydroxybenzoate).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: Ethyl 2-hydroxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Palladium-Catalyzed Oxidative Carbonylation for the Synthesis of Polycyclic Aromatic Hydrocarbons (PAHs) was written by Ji, Fanghua;Li, Xianwei;Wu, Wanqing;Jiang, Huanfeng. And the article was included in Journal of Organic Chemistry in 2014.Reference of 587-88-2 This article mentions the following:

A direct and facile palladium-catalyzed C-H bond oxidative carbonylation reaction and oxidative cyclization for the synthesis of polycyclic aromatic hydrocarbons (PAHs) is reported herein. The intramol. cyclocarbonylation, through C-H activation and C-C, C-O bond formations under mild conditions, proceeds smoothly with good functional group tolerance in high to excellent yields. The intramol. palladium-catalyzed direct oxidative C-H bond functionalization for the C-O bond formation is also demonstrated, which provides an efficient approach for the construction of various PAHs. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Reference of 587-88-2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Reference of 587-88-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Using an electronic nose and volatilome analysis to differentiate sparkling wines obtained under different conditions of temperature, ageing time and yeast formats was written by Martinez-Garcia, Rafael;Moreno, Juan;Bellincontro, Andrea;Centioni, Luna;Puig-Pujol, Anna;Peinado, Rafael A.;Mauricio, Juan Carlos;Garcia-Martinez, Teresa. And the article was included in Food Chemistry in 2021.Electric Literature of C10H18O2 This article mentions the following:

Effect of yeast inoculation format (F), temperature (T), and “on lees” ageing time (t) factors were evaluated on the composition of sparkling wines by a quant. fingerprint obtained from volatile metabolites and the response of an electronic nose (E-nose). Wines elaborated according the traditional method at 10 and 14鎺矯, free cells and yeast biocapsules formats were monitored at 15 and 24 mo of ageing time. Sixty-six volatiles identified and quantified in the eight sampling lots were subjected to a pattern recognition technique. A dual criterion based on univariate (ANOVA) and multivariate anal. (PLS-DA) through the variable importance projection (VIP) values, allowed to identify ten volatiles as potential markers for T factor, eleven for t and twelve for F factors. The discriminant models based on E-nose dataset enable a 100% correct classification of samples, in relation with t and F factors and the 83% for T factor. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9Electric Literature of C10H18O2).

5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Electric Literature of C10H18O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fluorinated dithienyl-diketopyrrolopyrrole: a new building block for organic optoelectronic materials was written by Wang, Xiaohua;Jiang, Bin;Du, Chenchen;Ren, Xiaolei;Duan, Zhiming;Wang, Hongyu. And the article was included in New Journal of Chemistry in 2019.HPLC of Formula: 13669-10-8 This article mentions the following:

Diketopyrrolopyrrole (DPP) derivatives have been widely used as the electron-withdrawing unit to construct donor-acceptor (D-A) conjugated systems in organic electronics. The 3,6-position flanking aromatic rings of DPP could strongly influence the optoelectronic properties of DPP-based materials. In this study, a stepwise synthesis strategy was used to prepare monofluorinated and difluorinated dithienyl-DPP. The single crystal of the difluorinated model compound was also obtained. Three polymers based on bithiophene donor and dithienyl-DPP acceptor with different fluorinated positions were synthesized. And preliminary investigations of the influence of fluorination on the optoelectronic properties were performed. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8HPLC of Formula: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fe₃O₄@SiO₂@CuZnAl-O Catalysts for Conversion of Lignin in Supercritical Methanol was written by Chen, J.;Hui, S.;Bao, G.;Luo, J.;Meng, Y.;Li, J.;Wang, A.;Liang, S.. And the article was included in Fuel Cells (Weinheim, Germany) in 2021.Name: Methyl2-methylbutyrate This article mentions the following:

The catalytic degradation of lignin was exploited by magnetic core-shell Fe3O4@SiO2@CuZnAl-O catalysts in supercritical methanol (s.c.-MeOH) over temperature from 260鎺矯 to 360鎺矯 and the reaction time ranging from 0.5 h to 5 h. The magnetic core-shell-structured Fe3O4@SiO2@CuZnAl-O catalysts with different mole ratio of Cu to Zn were prepared by parallel flow co-precipitating method. Catalyst Fe3O4@[email protected] with the maximum sp. surface area (142.8 m2 g-1) exhibited the highest lignin conversion of 66% and high selectivity for phenols, ketones and benzenes. The recyclable Fe3O4@SiO2@CuZnAl-O catalyst allows high catalytic activity and selectivity for phenols, ketones and benzenes in the catalytic conversion of lignin in supercritical methanol. It is believed that this study can provide a promising strategy to prepare core-shell structured base metal nanocatalysts with metal-oxide shells. In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5Name: Methyl2-methylbutyrate).

Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: Methyl2-methylbutyrate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics