Tag: 100-200

Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors was written by Vats, Lalit;Sharma, Vikas;Angeli, Andrea;Kumar, Rajiv;Supuran, Claudiu T.;Sharma, Pawan K.. And the article was included in European Journal of Medicinal Chemistry in 2018.Recommanded Product: 13669-10-8 This article mentions the following:

The design, synthesis and biol. evaluation of a library of 1,2,3-triazole carboxylates incorporating carboxylic acid, hydroxymethyl, carboxylic acid hydrazide, carboxamide and benzenesulfonamide moieties was disclosed. All the compounds were investigated for their inhibition potential against carbonic anhydrase (CA, EC 4.2.1.1) human (h) isoforms hCA 1, 2, 4 and 9, well established drug targets. The cytosolic isoform hCA 1 was inhibited with Ki’s ranging between 53.2 nM and 7.616 μM whereas the glaucoma associated cytosolic isoform hCA 2 was inhibited with Ki’s in the range 21.8 nM-0.807 μM. The membrane bound isoform hCA 4, involved in glaucoma and retinitis pigmentosa among others, was effectively inhibited by some of these compounds with Ki < 60 nM, better than the reference drug acetazolamide (AAZ). The tumor associated isoform hCA 9, a recently validated antitumor/antimetastatic drug target, was also effectively inhibited by some of the new sulfonamides, which possessed the potential to be used as tools for exploring in more details the selective inhibition of hCAs involved in various pathologies. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and evaluation of novel imidazo[4,5-c]pyridine derivatives as antimycobacterial agents against Mycobacterium tuberculosis was written by Madaiah, Malavalli;Prashanth, Maralekere K.;Revanasiddappa, Hosakere D.;Veeresh, Bantal. And the article was included in New Journal of Chemistry in 2016.Related Products of 16413-26-6 This article mentions the following:

The current study involves the synthesis of novel imidazo[4,5-c]pyridine derivatives (IPD) containing amide/urea/sulfonamide. The synthesized compounds were evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis. The pharmacol. activities were determined by the objective to better understand their structure-activity relationship (SAR) for their in vitro antimycobacterial activity against M. tuberculosis. Some synthesized compounds showed significant activity against M. tuberculosis based on the agar dilution method. Among the forty-one compounds screened, compounds 21, 22 and 23 were found to be the most active compounds against M. tuberculosis. In the in vivo animal model, 21, 22 and 23 decreased the bacterial load in lung and spleen tissues at the dose of 50 mg kg^-1 body weight In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Related Products of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Encapsulation of Zanthoxylum bungeanum essential oil to enhance flavor stability and inhibit lipid oxidation of C hinese-style sausage was written by Meng, Fan-Bing;Lei, Yu-Ting;Zhang, Qian;Li, Yun-Cheng;Chen, Wei-Jun;Liu, Da-Yu. And the article was included in Journal of the Science of Food and Agriculture in 2022.COA of Formula: C12H20O2 This article mentions the following:

Zanthoxylum bungeanum essential oil (ZBEO) is a popular seasoning, commonly used in the food industry. It contains many easily degraded and highly volatile bioactive substances. Control of the stability of the bioactive substances in ZBEO is therefore very important in the food industry. In this study, microencapsulation was applied to improve ZBEO stability. The key parameters for microcapsule preparation were optimized by the Box-Behnken design method, and the optimum conditions were as follows: ratio of core to wall, 1:8; ratio of hydroxypropyl-α-cyclodextrin (HPCD) to soy protein isolate (SPI), 4; total solids content, 12%; and homogenization speed, 12 000 rpm. Antioxidant experiments have indicated that tea polyphenols (TPPs) effectively inhibited hydroxy-α-sanshool degradation in ZBEO microcapsules. Application of ZBEO microcapsules in Chinese-style sausage effectively inhibited lipid oxidation in sausages and protected hydroxy-α-sanshool and typical volatiles from volatilization and degradation during sausage storage. The results suggested that ZBEO microencapsulation is an effective strategy for improving the stability of its bioactive components and flavor ingredients during food processing. 2022 Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3COA of Formula: C12H20O2).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C12H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

11,12-Secoprostaglandins. 3. 8-Alkylthio(sulfinyl and sulfonyl)-12-hydroxyalkanoic acids and related compounds was written by Smith, Robert L.;Bicking, John B.;Gould, Norman P.;Lee, Ta-Jyh;Robb, Charles M.;Kuehl, Frederick A. Jr.;Mandel, Lewis R.;Cragoe, Edward J. Jr.. And the article was included in Journal of Medicinal Chemistry in 1977.Related Products of 62020-09-1 This article mentions the following:

Seven title compounds with structural features of 11,12-secoprostaglandins were prepared and tested for prostaglandin E mimicry in stimulating cyclic AMP [60-92-4] in the mouse ovary and in binding to the rat lipocyte prostaglandin receptor. The most active compound, 8-(methylsulfonyl)-12-hydroxyheptadecanoic acid (I) [59768-16-0], markedly stimulated cyclic AMP formation in the mouse ovary and human psoriatic skin slices, showed significant affinity for a prostaglandin receptor, and effectively inhibited antigen-induced lymphocyte transformation. I is not a substrate for 15-hydroxyprostaglandin dehydrogenase and is not a phosphodiesterase inhibitor. Structure-activity relations are discussed. In the experiment, the researchers used many compounds, for example, Methyl 2-(methylsulfonyl)acetate (cas: 62020-09-1Related Products of 62020-09-1).

Methyl 2-(methylsulfonyl)acetate (cas: 62020-09-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 62020-09-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A systematic investigation of comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry with dynamic pressure gradient modulation for high peak capacity separations was written by Schoneich, Sonia;Trinklein, Timothy J.;Warren, Cable G.;Synovec, Robert E.. And the article was included in Analytica Chimica Acta in 2020.SDS of cas: 118-61-6 This article mentions the following:

Dynamic pressure gradient modulation (DPGM) in full modulation mode is optimized for comprehensive two-dimensional (2D) gas chromatog. (GC x GC) with time-of-fight mass spectrometry (TOFMS) detection to obtain high peak capacity separations and demonstrate broad applicability for complex samples. A pulse valve introduces an auxiliary carrier gas flow at a T-union connecting the first dimension (¹D) column to the second dimension (²D) column. At a sufficiently high auxiliary pressure (P_aux) the ¹D flow is temporarily stopped. Then, during each modulation period (P_M) the valve is turned off briefly, a period termed the pulse width (p_w), allowing the ¹D effluent to essentially be reinjected onto the ²D column for the modulated separations Modifications to the modulator assembly are provided to improve performance. Method optimization is demonstrated for a 116-component test mixture by tuning the P_aux and the p_w. For a P_M = 2 s and ¹F of 0.10 mL/min, the optimal p_w and initial P_aux selected were 200 ms and 330.9 kPa (33 psig), resp. The 30 min separation of the test mixture provided a ¹D peak capacity of ¹n_c = 330 and a ²D peak capacity of ²n_c = 15, hence an ideal 2D peak capacity n_c,2D = ¹n_c x ²n_c = 4950. Likewise, the 2D peak capacity corrected for undersampling of the ¹D separation was 4500 and corrected for both undersampling and sampling variation via statistical overlap theory was 4090. These results provide a 2-fold improvement in peak capacity relative to the previous DPGM study in full modulation mode for GC x GC-TOFMS. The optimized conditions were applied for a variety of applications: diesel fuel, derivatized cow serum, solid phase microextraction (SPME) of coffee headspace, and SPME of river water headspace. Addnl., the fraction of 2D separation space utilized (f_coverage), as defined by the min. convex hull method, ranged from 0.60 to 0.85. We observed that any f_coverage correction to 2D peak capacity is highly sample dependent, since all samples, except for the diesel sample, were run with the same separation conditions, and yet the f_coverage ranged from 0.60 to 0.80. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6SDS of cas: 118-61-6).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 118-61-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Facile Construction of Troponoid Derivatives Incorporating Imidazolin-2-one Moieties was written by Yu, Jing;Chen, Xiaobei;Liu, Ye;Wu, Bing;Li, Haiyan;Hu, Yanwei;Wang, Liang;Zhang, Shilei. And the article was included in Synthesis in 2020.Quality Control of 3-Cyanophenylisocyanate This article mentions the following:

Troponoid derivatives incorporating imidazolin-2-one moieties I [R = 4-Me, 3-F, 3-CF₃-4-Cl, etc.] were efficiently constructed via a cascade process, under simple thermal conditions, which features a novel nitrogen source, is catalyst- and oxidant-free and was high atom- and step-economy. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Quality Control of 3-Cyanophenylisocyanate).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Quality Control of 3-Cyanophenylisocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Primary Alcohols via Nickel Pentacarboxycyclopentadienyl Diamide Catalyzed Hydrosilylation of Terminal Epoxides was written by Steiniger, Keri A.;Lambert, Tristan H.. And the article was included in Organic Letters in 2021.Quality Control of Ethyl 2-hydroxy-3-phenylpropanoate This article mentions the following:

The efficient and regioselective hydrosilylation of epoxides co-catalyzed by a pentacarboxycyclopentadienyl (PCCP) diamide Ni complex and Lewis acid is reported. This method allows for the reductive opening of terminal, monosubstituted epoxides to form unbranched, primary alcs. A range of substrates including both terminal and nonterminal epoxides work, and a mechanistic rationale is provided. This work represents the 1st use of a PCCP derivative as a ligand for transition-metal catalysis. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Quality Control of Ethyl 2-hydroxy-3-phenylpropanoate).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of Ethyl 2-hydroxy-3-phenylpropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Towards Gram-positive antivirulence drugs: New inhibitors of Streptococcus agalactiae Stk1 was written by Oxoby, Mayalen;Moreau, Francois;Durant, Lionel;Denis, Alexis;Genevard, Jean-Marie;Vongsouthi, Vanida;Escaich, Sonia;Gerusz, Vincent. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Related Products of 16413-26-6 This article mentions the following:

A structure-activity relationship study from a screening hit and structure-based design strategy has led to the identification of bisarylureas as potent inhibitors of Streptococcus agalactiae Stk1. As this target has been directly linked to bacterial virulence, these inhibitors can be considered as a promising step towards antivirulence drugs. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Related Products of 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sequential Hydrozirconation/Cyclization of Dienes, a New Route toward Trans 2-Substituted Vinylcyclopentanes was written by Clergue, Sebastien;Vasse, Jean-Luc. And the article was included in Organic Letters in 2014.Product Details of 19432-68-9 This article mentions the following:

Trans-2-substituted vinylcyclopentanes such as I (R = Ph, 2-BrC₆H₄, 4-MeOC₆H₄, 2-thienyl, PhCH₂, PhCH₂OCH₂CH₂CH₂) were prepared in 25-72% yields and in 2.8:1->19:1 diastereoselectivities by diastereoselective reductive cyclizations of 7-methoxy-1,5-heptadienes such as (E)-H₂C:CHCH₂CHRCH:CHCH₂OMe (R = Ph, 2-BrC₆H₄, 4-MeOC₆H₄, 2-thienyl, PhCH₂, PhCH₂OCH₂CH₂CH₂) mediated by (chloro)(hydrido)zirconocene (Schwartz’s reagent) and Me₃SiOTf. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Product Details of 19432-68-9).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Product Details of 19432-68-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Unusual Tethering Effects in the Schmidt Reaction of Hydroxyalkyl Azides with Ketones: Cation-π and Steric Stabilization of a Pseudoaxial Phenyl Group was written by Katz, Christopher E.;Aube, Jeffrey. And the article was included in Journal of the American Chemical Society in 2003.Name: Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:

The Lewis acid-promoted reactions of chiral 2-aryl-3-azido-1-propanols with 4-substituted cyclohexanones lead to iminium ethers and ultimately caprolactams (following a hydrolysis step). In this study, it is shown that these reactions afford variable ratios of products, depending on the electronic nature of the Ph group. These results are interpreted in the context of a cation-π stabilizing effect in the product-determining reaction intermediate. Remarkably, the best selectivity was obtained when an azidopropanol reagent containing a quaternary center was used; a control experiment showed that the high selectivity observed in this result depended upon the free rotation of the pseudoaxial aromatic group in the intermediate that affords the major product. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Name: Ethyl 2-(4-fluorophenyl)acetate).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Name: Ethyl 2-(4-fluorophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics