Tag: 100-200

Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists was written by Fracchiolla, Giuseppe;Laghezza, Antonio;Piemontese, Luca;Parente, Mariagiovanna;Lavecchia, Antonio;Pochetti, Giorgio;Montanari, Roberta;Di Giovanni, Carmen;Carbonara, Giuseppe;Tortorella, Paolo;Novellino, Ettore;Loiodice, Fulvio. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Category: esters-buliding-blocks This article mentions the following:

PPARs are transcription factors that govern lipid and glucose homeostasis and play a central role in cardiovascular disease, obesity, and diabetes. Thus, there is significant interest in developing new agonists for these receptors. Given that the introduction of fluorine generally has a profound effect on the phys. and/or biol. properties of the target mol., we synthesized a series of fluorinated analogs of the previously reported compound 2 (I), some of which turned out to be remarkable PPARα and PPARγ dual agonists. Docking experiments were also carried out to gain insight into the interactions of the most active derivatives with both receptors. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Category: esters-buliding-blocks).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Combined effects of tangerine oil vapour mixed with banana flavor to enhance the quality and flavor of ‘Hom Thong’ bananas and evaluating consumer acceptance and responses using electroencephalography (EEG) was written by Saengwong-Ngam, Ravinun;Koomhin, Phanit;Songsamoe, Sumethee;Matan, Nirundorn;Matan, Narumol. And the article was included in Journal of Food Science and Technology (New Delhi, India) in 2022.SDS of cas: 659-70-1 This article mentions the following:

The objectives of this study were to investigate the effect of tangerine oil (TO) at 25, 50 and 75μL mixed with banana flavor (BF) at 25, 50 and 75μL to protect the quality and enhance the flavor of bananas. Then, 25μL TO + BF 50μL were selected for studying the quality of bananas stored at 13°C ± 2°C for 7 days, and was used to test consumer brain responses using an electroencephalog. (EEG). Results showed that mold grew and decomposition occurred in 10 and 50% of the 25μL TO + 50μL BF mixture and control, resp., after 7 days. Furthermore, this ratio increased ripening by having higher L*, b*, firmness and total soluble solid than the control (p < 0.05), whereas titratable acidity and pH were maintained (p > 0.05). The EEG demonstrated that consumption of TO-treated banana could increase brain alertness using stimulating the beta wave activity on banana stimulations for human brain. Limonene, one of the main components of TO, was found in the flesh of treated banana after storage for 4 wk and possibly interacted with other components to improve antifungal activity and brain response. In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1SDS of cas: 659-70-1).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.SDS of cas: 659-70-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Genetic and physical mapping of the Rhodobacter sphaeroides photosynthetic gene cluster from R-prime pWS2 was written by Wu, Yongqiang;MacGregor, Barbara J.;Donohue, Timothy J.;Kaplan, Samuel;Yen, Bill. And the article was included in Plasmid in 1991.Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate This article mentions the following:

Plasmid pWS2 is an R68.45 chimera originally isolated as an R-prime which complemented the R. sphaeroides bch-420 allele. PWS2 is also able to complement a wide range of R. sphaeroides pigment and photosynthetic mutants employing nitrosoguanidine, transposon or insertion-generated mutations effecting puhA, puc, puf, cycA, bch, and crt genes. A combination of orthogonal-field-alternation gel electrophoresis, transverse alternating field gel electrophoresis, and conventional electrophoresis have been used to estimate the size of pWS2 at ≃168.3 ± 3.5 kb. A restriction map of the ≃109 kb of R. sphaeroides insert DNA was generated by partial and complete restriction endonuclease digestion coupled with Southern hybridization anal. using either gene-specific or junction fragment probes. Genes encoding bacteriochlorophyll (Bchl)-binding proteins (pufBALMX, PucBA, and puhA), cytochrome c₂ (cycA), and enzymes involved in Bchl (bch) and carotenoid (crt) biosynthesis have been shown to reside within a contiguous 53-kb region of the R. sphaeroides DNA present on pWS2. The puf operon lies at one end of the 53-kb segment, while the genes puhA, cycA, and pucBA, the latter 2 of which are located within ≃12.0 kb of each other, define the other end of this 53-kb region. The genetic and phys. mapping data provided in this paper are discussed in terms of the similarities and differences in the organization of the photosynthetic gene cluster between R. sphaeroides and other photosynthetic bacteria as well as highlighting the use of pWS2 in studies of photosynthetic gene structure and function. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Expedient Synthesis of Substituted Benzoheterocycles using 2-Butoxy-2,3-dihydrofurans as [4+2] Benzannulation Reagents was written by Liu, Changhui;Huang, Wenbo;Wang, Man;Pan, Bin;Gu, Yanlong. And the article was included in Advanced Synthesis & Catalysis in 2016.Category: esters-buliding-blocks This article mentions the following:

2-Alkoxy-2,3-dihydrofurans were found to be versatile benzannulation reagents. Indoles can be synthesized in good to excellent yields via the [4+2] annulation of 2-butoxy-2,3-dihydrofuran with pyrroles catalyzed by copper bromide. With the same protocol, carbazoles can also be obtained when indoles are used as starting material with the aid of p-toluenesulfonic acid. This type of benzannulation reagent can also be used to synthesize benzofuran, benzothiophene and naphthalene derivatives in the presence of a catalytic amount of triflic acid in moderate yields. This benzannulation protocol features wide substrate scope and mild reaction condition. Moreover, most of examples have a good regioselectivity. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Category: esters-buliding-blocks).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Infant supplement quality evaluation by inductively coupled plasma – mass spectrometry, gas chromatography, and isotope ratio mass spectrometry was written by Dehelean, A.;Kovacs, E. D.;Magdas, D. A.;Cristea, G.;Voica, C.;Feher, I.;Kovacs, M. H.;Marincas, O.;Zhang, Z.;Li, P.;Zang, Q.. And the article was included in Analytical Letters in 2019.Computed Properties of C10H20O2 This article mentions the following:

There is a growing interest by both consumers and industry in the development of food products with functional properties or health benefits. These food supplements are especially important for infants; thus their safety must be guaranteed. However, the use of different raw materials, process technologies, and storage technologies may impact food quality and safety in undesirable ways. The purpose of this work was to investigate com. available infant food supplements targeting: (1) content of macro/micro nutrients and toxic metals; (2) volatile organic compounds that contribute to flavor and aroma composition of food; (3) content of fatty acids; and (4) δ¹³C to determine the origin of the raw material for these products. These were performed in order to evaluate their quality with respect to nutraceutical value and safety. Different chemometric methods were used for the statistical interpretation of the data including anal. of variance (ANOVA), Pearson correlation, principal component anal. (PCA), and linear discriminant anal. (LDA). In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1Computed Properties of C10H20O2).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C10H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tetrasubstituted 1,3-Enynes by Gold-Catalyzed Direct C(sp²)-H Alkynylation of Acceptor-Substituted Enamines was written by Han, Chunyu;Tian, Xianhai;Zhang, Huili;Rominger, Frank;Hashmi, A. Stephen K.. And the article was included in Organic Letters in 2021.SDS of cas: 13669-10-8 This article mentions the following:

A gold-catalyzed synthesis of tetrasubstituted 1,3-enynes from hypervalent iodine(III) reagents and activated alkenes is reported. This reaction involves an in situ formed alkynyl Au(III) species and a subsequent direct C(sp²)-H functionalization of alkenes, offering 26 enynes in 62-92% yield with excellent functional group tolerance. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8SDS of cas: 13669-10-8).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 13669-10-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRα) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs) was written by Lu, Yanli;Mao, Fei;Li, Xiaokang;Zheng, Xinyu;Wang, Manjiong;Xu, Qing;Zhu, Jin;Li, Jian. And the article was included in Journal of Medicinal Chemistry in 2017.Recommanded Product: 16413-26-6 This article mentions the following:

Stem cell factor receptor (c-KIT) and platelet derived growth factor receptor alpha (PDGFRα) kinases play an important role in gastrointestinal stromal tumors (GISTs). Here, the authors have discovered an c-KIT/PDGFRα dual inhibitor, compound I, with single-digit nanomolar potency against c-KIT and PDGFRα. Compared to Imatinib (1), I showed better antiproliferative efficacy against various TEL-c-KIT/PDGFRα-BaF3 isogenic cells, including three 1-resistant BaF3 cell lines, as well as against GIST-T1 and GIST-882 cell lines. Furthermore, compound I showed a good KinomeScan selectivity (468 kinases) (S score (1) = 0.01 at 1 μM concentration), good metabolic stability in liver microsomes, and no hERG inhibitory activity. It was worth noting that I inhibited GIST-T1 tumor growth (TGI = 81.5%) and even the BaF3-TEL-cKIT-T670I tumor progression (TGI = 41.9%, 1-resistant GISTs) at a dosage of 100 mg/kg/day without exhibiting apparent toxicity. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Recommanded Product: 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of 2,2-dimethyl-5-hydroxymethyl-1,3-dioxane was written by Li, Peijie;Xu, Zheng;Wu, Xiaochun;Wu, Yong. And the article was included in Huaxi Yaoxue Zazhi in 2001.Name: Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate This article mentions the following:

2,2-Dimethyl-5-hydromethyl-1,3-dioxane was synthesized from di-Et malonate by condensation with formaldehyde in the presence of KHCO₃, further condensation with 2,2-dimethoxypropane, decarboxylation in DMSO-NaCl, and reduction with LiAlH₄, provide product with over all yield 41%. In the experiment, the researchers used many compounds, for example, Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7Name: Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate).

Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate (cas: 82962-54-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Name: Ethyl 2,2-dimethyl-1,3-dioxane-5-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sulfone-stabilized carbanions for the reversible covalent capture of a posttranslationally-generated cysteine oxoform found in protein tyrosine phosphatase 1B (PTP1B) was written by Parsons, Zachary D.;Ruddraraju, Kasi Viswanatharaju;Santo, Nicholas;Gates, Kent S.. And the article was included in Bioorganic & Medicinal Chemistry in 2016.Synthetic Route of C4H8O4S This article mentions the following:

Redox regulation of protein tyrosine phosphatase 1B (PTP1B) involves oxidative conversion of the active site cysteine thiolate into an electrophilic sulfenyl amide residue. Reduction of the sulfenyl amide by biol. thiols regenerates the native cysteine residue. Here the authors explored fundamental chem. reactions that may enable covalent capture of the sulfenyl amide residue in oxidized PTP1B. Various sulfone-containing carbon acids were found to react readily with a model peptide sulfenyl amide via attack of the sulfonyl carbanion on the electrophilic sulfur center in the sulfenyl amide. Both the products and the rates of these reactions were characterized. The results suggest that capture of a peptide sulfenyl amide residue by sulfone-stabilized carbanions can slow, but not completely prevent, thiol-mediated generation of the corresponding cysteine-containing peptide. Sulfone-containing carbon acids may be useful components in the construction of agents that knock down PTP1B activity in cells via transient covalent capture of the sulfenyl amide oxoform generated during insulin signaling processes. In the experiment, the researchers used many compounds, for example, Methyl 2-(methylsulfonyl)acetate (cas: 62020-09-1Synthetic Route of C4H8O4S).

Methyl 2-(methylsulfonyl)acetate (cas: 62020-09-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C4H8O4S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

N-Substituted pyrrolopyrimidines and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors was written by Casalvieri, Kimberly A.;Matheson, Christopher J.;Warfield, Becka M.;Backos, Donald S.;Reigan, Philip. And the article was included in Bioorganic & Medicinal Chemistry in 2021.Reference of 20637-09-6 This article mentions the following:

In the current study, a series of pyrrolopyrimidines and purines were developed to replace the pteridinone ring of BI-D1870, with a range of N-substituents that extended to the substrate binding site to probe complementary interactions, while retaining the 2,6-difluorophenol-4-amino group to maintain interactions with the hinge domain and the DFG motif. Several compounds inhibited cellular RSK2 activity and compounds that uncoupled cellular RSK2 inhibition from potent cytotoxicity in the MOLM-13 AML cell line were identified . These N-substituted probes revealed an opportunity to further examine substituents that extend from the ATP- to the substrate-binding site may confer improved RSK potency and selectivity. In the experiment, the researchers used many compounds, for example, Methyl 4-(4-aminophenyl)butanoate (cas: 20637-09-6Reference of 20637-09-6).

Methyl 4-(4-aminophenyl)butanoate (cas: 20637-09-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 20637-09-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics