Tag: 100-200

Iron-catalysed 1,2-aryl migration of tertiary azides was written by Wei, Kaijie;Yang, Tonghao;Chen, Qing;Liang, Siyu;Yu, Wei. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Formula: C6H12O2 This article mentions the following:

The 1,2-Aryl migration of α,α-diaryl tertiary azides RC(R¹)(C₆H₅)N₃ (R = Ph, 4-fluorophenyl, iso-Pr, iso-Bu, etc.; R¹ = 4-methylphenyl, Et, phenyl) was achieved by using the catalytic system of FeCl₂/N-heterocyclic carbene (NHC) SIPr.HCl. The reaction generated aniline products RCHR¹NHC₆H₅ in good yields after one-pot reduction of the migration-resultant imines. In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5Formula: C6H12O2).

Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C6H12O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Structure-activity relationships of benzoic acid derivatives as antifeedants for the pine weevil, Hylobius abietis was written by Unelius, C. Rikard;Nordlander, Goeran;Nordenhem, Henrik;Hellqvist, Claes;Legrand, Sacha;Borg-Karlson, Anna-Karin. And the article was included in Journal of Chemical Ecology in 2006.Electric Literature of C9H10O4 This article mentions the following:

Aromatic organic compounds found in the feces of the pine weevil, Hylobius abietis (L.) (Coleoptera: Curculionidae), have been shown to deter feeding behavior in this species, which is a serious pest of planted conifer seedlings in Europe. We evaluated 55 benzoic acid derivatives and a few homologs as antifeedants for H. abietis. Structure-activity relationships were identified by bioassaying related compounds obtained by rational syntheses of functional group analogs and structural isomers. We identified 5 main criteria of efficiency as antifeedants among the benzoic acid derivatives By predicting optimal structures for H. abietis antifeedants, we attempted to find a com. antifeedant to protect conifer seedlings against damage by H. abietis in regenerating forests. New, highly effective antifeedants are Me 2,4-dimethoxybenzoate, iso-Pr 2,4-dimethoxybenzoate, Me 2-hydroxy-3-methoxybenzoate, Me (3,5-dimethoxyphenyl)acetate, and Me (2,5-dimethoxyphenyl)acetate. Of these, Me 2,4-dimethoxybenzoate and iso-Pr 2,4-dimethoxybenzoate have the highest antifeedant indexes of all substances tested and are the best candidates for practical applications in order to protect planted seedlings in the field. In the experiment, the researchers used many compounds, for example, Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8Electric Literature of C9H10O4).

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Electric Literature of C9H10O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Visible-light-induced α-oxyamination of 1,3-dicarbonyls with TEMPO via a photoelectrocatalytic process applying a DSSC anode or in a DSSC system was written by Gong, Ming;Kim, Jung Keun;Zhao, Xiuli;Li, Yabo;Zhang, Jianye;Huang, Mengmeng;Wu, Yangjie. And the article was included in Green Chemistry in 2019.Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate This article mentions the following:

A green and environmentally friendly photoelectrocatalytic one-pot method was developed for the α-oxyamination between 1,3-dicarbonyls and TEMPO via a photoelectrocatalytic process using visible light as the energy source. The recovered DSSC anode (photocatalyst) could be used > 8 times, at the same time, the α-oxyamination reaction proceeding in the DSSC device might be involved in the photoelectrocatalysis process. Mechanistic studies establish that the reaction might undergo both the visible-light-induced radical and the ionic reaction processes. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: Ethyl 3-oxo-3-(thiophen-2-yl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Production of Hydroxy Fatty Acids, Precursors of γ-Hexalactone, Contributes to the Characteristic Sweet Aroma of Beef was written by Ueda, Shuji;Hosoda, Mana;Kasamatsu, Kumi;Horiuchi, Masahiro;Nakabayashi, Rio;Kang, Bubwoong;Shinohara, Masakazu;Nakanishi, Hiroki;Ohto-Nakanishi, Takayo;Yamanoue, Minoru;Shirai, Yasuhito. And the article was included in Metabolites in 2022.Safety of 5-Ethyldihydrofuran-2(3H)-one This article mentions the following:

Aroma is an essential factor for meat quality. The meat of Japanese Black cattle exhibits fine marbling and a rich and sweet aroma with a characteristic lactone composition The mechanism of lactone formation associated with beef aroma has not been elucidated. In this study, we examined the precursors of γ-hexalactone, an indicator of the sweet aroma of beef and identified the mechanism underlying γ-hexalactone production A low-temperature vacuum system was used to prepare beef tallow from Japanese Black cattle and Holstein cattle. The odor components were identified using headspace-gas chromatog. The anal. revealed that γ-hexalactone, γ-dodecalactone, δ-tetradecalactone, and δ-hexadecalactone were present as sweet aroma components of beef tallow prepared from marbling and muscle. Since we previously reported that γ-hexalactone formation correlates with linoleic acid content in beef, we analyzed ten oxidized fatty acids derived from linoleic acid by liquid chromatog.-triple quadrupole mass spectrometry and detected two hydroxy-octadecadienoic acids (9S-HODE and 13S-HODE) in beef tallow. Significant differences in arachidonic acid 15-lipoxygenase and cyclooxygenase protein expression levels among s.c. fat, i.m. fat, and muscle tissue were observed Our results suggest that the combination of linoleic acid and the expression of lipid oxidase derived from beef muscle and i.m. fat produce hydroxy fatty acids that result in a sweet aroma. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Safety of 5-Ethyldihydrofuran-2(3H)-one).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of 5-Ethyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of 1-[3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine_2A Inverse Agonists for the Treatment of Insomnia was written by Teegarden, Bradley R.;Li, Hongmei;Jayakumar, Honnappa;Strah-Pleynet, Sonja;Dosa, Peter I.;Selaya, Susan D.;Kato, Naomi;Elwell, Katie H.;Davidson, Jarrod;Cheng, Karen;Saldana, Hazel;Frazer, John M.;Whelan, Kevin;Foster, Jonathan;Espitia, Stephan;Webb, Robert R.;Beeley, Nigel R. A.;Thomsen, William;Morairty, Stephen R.;Kilduff, Thomas S.;Al-Shamma, Hussien A.. And the article was included in Journal of Medicinal Chemistry in 2010.Recommanded Product: 16413-26-6 This article mentions the following:

Insomnia affects a growing portion of the adult population in the U. S. Most current therapeutic approaches to insomnia primarily address sleep onset latency. Through the 5-hydroxytryptamine_2A (5-HT_2A) receptor, serotonin (5-HT) plays a role in the regulation of sleep architecture, and antagonists/inverse-agonists of 5-HT_2A have been shown to enhance slow wave sleep (SWS). We describe here a series of 5-HT_2A inverse-agonists that when dosed in rats, both consolidate the stages of NREM sleep, resulting in fewer awakenings, and increase a physiol. measure of sleep intensity. These studies resulted in the discovery of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin)(I), a potent inverse-agonist of 5-HT_2A that was advanced into clin. trials for the treatment of insomnia. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Recommanded Product: 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Scent chemistry and pollinators in the holoparasitic plant Cynomorium songaricum (Cynomoriaceae) was written by Wang, D.;Yu, H.;Chen, G.. And the article was included in Plant Biology (Berlin, Germany) in 2021.COA of Formula: C10H20O2 This article mentions the following:

Holoparasitic plants are interesting heterotrophic angiosperms. However, carrion- or faeces-mimicking is rarely described for such plants. There is no information on the pollination biol. of Cynomoriaceae, despite the fact that these plants are rare and vulnerable. This is the first study to reveal pollination in a member of this family, Cynomorium songaricum, a root holoparasite with a distinctive and putrid floral odor. From 2016 to 2018, we studied the floral volatiles, floral visitors and pollinators, behavioral responses of visitors to floral volatiles, breeding system, flowering phenol. and floral biol. of two wild populations of C. songaricum in Alxa, Inner Mongolia, China. A total of 42 volatiles were identified in inflorescences of C. songaricum. Among these volatiles are compounds known as typical carrion scents, such as p-cresol, indole, di-Me disulfide and 1-octen-3-ol. C. songaricum is pollinated by various Diptera, such as Musca domestica, M. stabulans (Muscidae), Delia setigera, D. platura (Anthomyiidae), Lucilia sericata, L. caesar (Calliphoridae), Wohlfahrtia indigens, Sarcophaga noverca, S. crassipalpis and Sarcophila meridionalis (Sarcophagidae). The inflorescence scent of C. songaricum attracted these pollinators. The plants significantly benefit from insect pollination, although wind can be a pollen vector in the absence of pollinators. C. songaricum is a cross-pollinated, self-incompatible plant. In the experiment, the researchers used many compounds, for example, Isopentyl 3-methylbutanoate (cas: 659-70-1COA of Formula: C10H20O2).

Isopentyl 3-methylbutanoate (cas: 659-70-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.COA of Formula: C10H20O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tandem Solid-Phase Extraction Columns for Simultaneous Aroma Extraction and Fractionation of Wuliangye and Other Baijiu was written by He, Zhanglan;Yang, Kangzhuo;Liu, Zhipeng;An, Mingzhe;Qiao, Zongwei;Zhao, Dong;Zheng, Jia;Qian, Michael C.. And the article was included in Molecules in 2021.Recommanded Product: 706-14-9 This article mentions the following:

Wuliangye baijiu is one of the most famous baijiu in China, with a rich, harmonic aroma profile highly appreciated by consumers. Thousands of volatiles have been identified for the unique aroma profile. Among them, fatty acid esters have been identified as the main contributors to the aroma profile. In addition, many non-ester minor compounds, many of which are more polar than the esters, have been identified to contribute to the characteristic aroma unique to Wuliangye baijiu. The anal. of these minor compounds has been challenging due to the dominance of esters in the sample. Thus, it is desirable to fractionate the aroma extract into subgroups based on functional group or polarity to simplify the anal. This study attempts a new approach to achieve simultaneous volatile extraction and fractionation using tandem LiChrolut EN and silica gel solid-phase extraction (SPE) columns. A baijiu sample (10 mL, diluted in 40 mL of water) was first passed through the LiChrolut EN (1.0 g) column. The loaded LiChrolut EN column was then dried with air and coupled with a silica gel (5.0 g) SPE column with anhydrous Na2SO4 (10.0 g) in between. The volatile compounds were eluted from the LiChrolut EN column and simultaneously fractionated on the silica gel column based on polarity. The simultaneous extraction and fractionation technique enabled the fractionations of all fatty acid esters into less polar fractions. Fatty acids, alcs., pyrazines, furans, phenols, hydroxy esters, and other polar compounds were collected in more polar fractions. This technique was used to study the volatile compounds in Wuliangye, Moutai, and Fengjiu baijiu. In addition to fatty acid esters, many minor polar compounds, including 2,6-dimethylpyrazine, 2-ethyl-6-methylpyrazine, 2-ethyl-3,5-dimethylpyrazine, p-cresol, and 2-acetylpyrrole, were unequivocally identified in the samples. The procedure is fast and straightforward, with low solvent consumption. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9Recommanded Product: 706-14-9).

5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 706-14-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic studies towards bis-heterodimeric netropsin analogs was written by Al-Said, Naim H.;Shawakfeh, Khaled Q.. And the article was included in Jordan Journal of Chemistry in 2007.SDS of cas: 5930-92-7 This article mentions the following:

An expedient synthetic method has been developed for the preparation of a properly functionalized pyrrole-imidazole template suitable for the construction of heterodimeric bislexitropsins. The pyrrole-imidazole carboxamide derivatives are connected through the nitrogen atoms of central heterocyclic rings by a tether of bis-ethoxyethane chain. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7SDS of cas: 5930-92-7).

Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.SDS of cas: 5930-92-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

C-N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis was written by Chen, Ying-Chu;Faver, John C.;Ku, Angela F.;Miklossy, Gabriella;Riehle, Kevin;Bohren, Kurt M.;Ucisik, Melek N.;Matzuk, Martin M.;Yu, Zhifeng;Simmons, Nicholas. And the article was included in Bioconjugate Chemistry in 2020.HPLC of Formula: 41191-92-8 This article mentions the following:

DNA-encoded chem. library (DECL) screens are a rapid and economical tool to identify chem. starting points for drug discovery. As a robust transformation for drug discovery, palladium-catalyzed C-N coupling is a valuable synthetic method for the construction of DECL chem. matter; however, currently disclosed methods have only been demonstrated on DNA-attached (hetero)aromatic iodide and bromide electrophiles. We developed conditions utilizing an N-heterocyclic carbene-palladium catalyst that extends this reaction to the coupling of DNA-conjugated (hetero)aromatic chlorides with (hetero)aromatic and select aliphatic amine nucleophiles. In addition, we evaluated steric and electronic effects within this catalyst series, carried out a large substrate scope study on two representative (hetero)aryl bromides, and applied this newly developed method within the construction of a 63 million-membered DECL. In the experiment, the researchers used many compounds, for example, Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8HPLC of Formula: 41191-92-8).

Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 41191-92-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481 was written by Boy, Kenneth M.;Guernon, Jason M.;Zuev, Dmitry S.;Xu, Li;Zhang, Yunhui;Shi, Jianliang;Marcin, Lawrence R.;Higgins, Mendi A.;Wu, Yong-Jin;Krishnananthan, Subramaniam;Li, Jianqing;Trehan, Ashok;Smith, Daniel;Toyn, Jeremy H.;Meredith, Jere E.;Burton, Catherine R.;Kimura, S. Roy;Zvyaga, Tatyana;Zhuo, Xiaoliang;Lentz, Kimberley A.;Grace, James E.;Denton, Rex;Morrison, John S.;Mathur, Arvind;Albright, Charles F.;Ahlijanian, Michael K.;Olson, Richard E.;Thompson, Lorin A.;Macor, John E.. And the article was included in ACS Medicinal Chemistry Letters in 2019.Application In Synthesis of Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:

A triazine hit identified from a screen of the BMS compound collection was optimized for potency, in vivo activity, and off-target profile to produce the bicyclic pyrimidine γ-secretase modulator BMS-932481. The compound showed robust reductions of Aβ_1-42 and Aβ_1-40 in the plasma, brain, and cerebrospinal fluid of mice and rats. Consistent with the γ-secretase modulator mechanism, increases in Aβ_1-37 and Aβ_1-38 were observed, with no change in the total amount of Aβ_1-x produced. No Notch-based toxicity was observed, and the overall preclin. profile of BMS-932481 supported its further evaluation in human clin. trials. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Application In Synthesis of Ethyl 2-(4-fluorophenyl)acetate).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of Ethyl 2-(4-fluorophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics