Tag: 100-200

Organic sulfur compounds. IV. Hydrazones from 2-thienylacetic acid hydrazide and aromatic aldehydes was written by Roman, Gh.;Manciuela, Ileana;Ardeleanu, R.. And the article was included in Bulletin of the Transilvania University of Brasov, Series B: Mathematics, Physics, Chemistry, Medicine, Philology in 2003.Computed Properties of C7H8O2S This article mentions the following:

The condensation reaction between 2-thienylacetic acid hydrazide and several aromatic aldehydes was studied. The resulting ten N-arylidene hydrazides were characterized by elemental anal., IR and NMR spectroscopy. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Computed Properties of C7H8O2S).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C7H8O2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hypervalent Iodine(III) Catalyzed Balz-Schiemann Fluorination under Mild Conditions was written by Xing, Bo;Ni, Chuanfa;Hu, Jinbo. And the article was included in Angewandte Chemie, International Edition in 2018.SDS of cas: 587-88-2 This article mentions the following:

An unprecedented hypervalent iodine(III)-catalyzed Balz-Schiemann reaction was described. In the presence of a hypervalent iodine compound, the fluorination reaction proceeded under mild conditions (25-60 °C), and featured a wide substrate scope and good functional-group compatibility. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2SDS of cas: 587-88-2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 587-88-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The correlation between gut microbiota and serum metabolomic in elderly patients with chronic heart failure was written by Wang, Zhenhua;Cai, Zhaoling;Ferrari, Markus W.;Liu, Yilong;Li, Chengyi;Zhang, Tianzhang;Lyu, Guorong. And the article was included in Mediators of Inflammation in 2021.SDS of cas: 118-61-6 This article mentions the following:

Objective. Chronic heart failure (CHF) refers to a state of persistent heart failure that can be stable, deteriorated, or decompensated. The mechanism and pathogenesis of myocardial remodeling remain unknown. Based on 16S rDNA sequencing and metabolomics technol., this study analyzed the gut microbiota and serum metabolome in elderly patients with CHF to provide new insights into the microbiota and metabolic phenotypes of CHF. Methods. Blood and fecal samples were collected from 25 elderly patients with CHF and 25 healthy subjects. The expression of inflammatory factors in blood was detected by ELISA. 16S rDNA sequencing was used to analyze the changes in microorganisms in the samples. The changes of small mol. metabolites in serum samples were analyzed by LC-MS/MS. Spearman correlation coefficients were used to analyze the correlation between gut microbiota and serum metabolites. Results. Our results showed that the IL-6, IL-8, and TNF-α levels were significantly increased, and the IL-10 level was significantly decreased in the elderly patients with CHF compared with the healthy subjects. The diversity of the gut microbiota was decreased in the elderly patients with CHF. Moreover, Escherichia Shigella was neg. correlated with biocytin and RIBOFLAVIN. Haemophilus was neg. correlated with alpha-lactose, cellobiose, isomaltose, lactose, melibiose, sucrose, trehalose, and turanose. Klebsiella was pos. correlated with bilirubin and ethylsalicylate. Klebsiella was neg. correlated with citramalate, hexanoylcarnitine, inosine, isovalerylcarnitine, methylmalonate, and riboflavin. Conclusion. The gut microbiota is simplified by the disease, and serum small-mol. metabolites evidently change in elderly patients with CHF. Serum and fecal biomarkers could be used for elderly patients with CHF screening. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6SDS of cas: 118-61-6).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 118-61-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine was written by Robertson, David W.;Beedle, E. E.;Krushinski, Joseph H.;Pollock, G. Don;Wilson, Harve;Wyss, Virginia L.;Hayes, J. Scott. And the article was included in Journal of Medicinal Chemistry in 1985.Application In Synthesis of Methyl 4-Hydroxy-2-methoxybenzoate This article mentions the following:

The structural requirements for optimal inotropic activity in a series of phenylimidazopyridines were investigated. 2-Phenylimidazo[4,5-c]pyridines were generally 5-10-fold more potent than analogous 2-phenylimidazo[4,5-b]pyridines, or 8-phenylpurines. Furthermore, all the imidazo[4,5-c]pyridines were orally active; in contrast, only 1 of the imidazo[4,5-b]pyridine derivatives was significantly active orally. The structure-activity relationship of this series is presented and compared to that of the imidazo[4,5-b]pyridine and purine series. The phenylimidazopyridines (80 compounds) were prepared from o-pyridinediamines and substituted benzoic acids. In the experiment, the researchers used many compounds, for example, Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8Application In Synthesis of Methyl 4-Hydroxy-2-methoxybenzoate).

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of Methyl 4-Hydroxy-2-methoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of Biocompatible Esters and Alcohols as Cosurfactants on Structure and Solubilization Behavior of the Zwitterionic Surfactant Tetradecyldimethylamine Oxide was written by Gradzielski, Michael;Horbaschek, Klaus;Deme, Bruno. And the article was included in Industrial & Engineering Chemistry Research in 2019.Safety of Ethyl 2-hydroxybenzoate This article mentions the following:

In this work, we compare the effect of different monoterpenoid alcs. that differ with respect to their number of double bonds and simple aromatic esters of variable mol. architecture as cosurfactants on the phase behavior of the zwitterionic surfactant tetradecyldimethylamine oxide (TDMAO) and its solubilization behavior, with respect to decane as a model paraffin oil. The esters are shown to be potent cosurfactants but require higher concentrations to achieve similar effects, with respect to structural changes and solubilization enhancement. Compared to the alcs., they solubilize somewhat smaller amounts of decane, do reduce the interfacial tension substantially less, and also do not form an isotropic phase of unilamellar vesicles (L₄) but directly multilamellar vesicles (L_αl). A very interesting effect is the significance of the detailed mol. architecture of the esters, as Et benzoate and benzyl acetate, both having the same sum formula, differ significantly, with respect to their cosurfactant properties. However, all systems allow one to incorporate relatively large amounts of the oil. For the case of the esters, this always leads to the formation of oil-in-water (O/W) microemulsion droplets while the alcs. can build in relatively large amounts of oil within their vesicular structures. These findings show that these biofriendly cosurfactants allow to formulate structurally rather versatile systems and efficiently enhance oil solubility for the given surfactant system. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxybenzoate (cas: 118-61-6Safety of Ethyl 2-hydroxybenzoate).

Ethyl 2-hydroxybenzoate (cas: 118-61-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of Ethyl 2-hydroxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and structure-activity relationships of 2-substituted-8-hydroxyadenine derivatives as orally available interferon inducers without emetic side effects was written by Isobe, Yoshiaki;Tobe, Masanori;Ogita, Haruhisa;Kurimoto, Ayumu;Ogino, Tetsuhiro;Kawakami, Hajime;Takaku, Haruo;Sajiki, Hironao;Hirota, Kosaku;Hayashi, Hideya. And the article was included in Bioorganic & Medicinal Chemistry in 2003.SDS of cas: 587-88-2 This article mentions the following:

Recently we reported the adenine derivatives (2-4) as new interferon (IFN) inducers. In the present study, we conducted a detailed structure and activity relationship study of 4 and its related derivatives on IFN inducing activity. From this study, we found that compound 4 exhibited the most potent IFN inducing activity in vitro with a min. effective concentration of 0.01 μM, and 4 also showed strong IFN-inducing activity at doses of more than 0.3 mg/kg by oral administration in mice. This potency was 10-fold stronger than that of Imiquimod. Moreover, 4 did not cause emesis in ferrets even at doses as high as 10 mg/kg, whereas, 80% of animals were emetic when orally administered with the same dose of Imiquimod. These results indicate that compound 4 is superior to Imiquimod with respect to efficacy and safety. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2SDS of cas: 587-88-2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.SDS of cas: 587-88-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification of volatile components from oviposition and non-oviposition plants of Gasterophilus pecorum (Diptera: Gasterophilidae) was written by Zhou, Ran;Zhang, Ke;Zhang, Tiange;Zhou, Tong;Chu, Hongjun;Ge, Yan;Wang, Chen;Li, Kai. And the article was included in Scientific Reports in 2020.Synthetic Route of C6H10O2 This article mentions the following:

Abstract: Oviposition by Gasterophilus pecorum on shoot tips of Stipa caucasica is a key determinant of its severe infection of the reintroduced Przewalskis horse (Equus przewalskii). Volatiles in shoots of grasses on which Przewalskis horse feeds, including S. caucasica at preoviposition, oviposition, and postoviposition stages of G. pecorum, S. caucasica, Stipa orientalis, and Ceratoides latens at the oviposition stage, and S. caucasica in various growth periods, were collected by dynamic headspace adsorption and analyzed by automatic thermal desorption gas chromatog.-mass spectrometry. Caprolactam was highest in C. latens at oviposition stage of G. pecorum and lowest in S. caucasica at postoviposition stage, and that of 3-hexen-1-ol,(Z)- was lowest in C. latens and highest in S. caucasica at its oviposition stage. Furthermore, substances specific to S. orientalis and C. latens were also present in S. caucasica, except at oviposition stage. Our findings will facilitate studies on G. pecorums adaptation to the arid desert steppe and its future control. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Synthetic Route of C6H10O2).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C6H10O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

CoCl(PPh₃)₃ as Cyclotrimerization Catalyst for Functionalized Triynes under Mild Conditions was written by Jungk, Phillip;Fischer, Fabian;Thiel, Indre;Hapke, Marko. And the article was included in Journal of Organic Chemistry in 2015.Recommanded Product: 17920-23-9 This article mentions the following:

The ubiquitary Co(I) complex CoCl(PPh₃)₃ was found to be a convenient catalyst for the [2+2+2] cycloaddition of functionalized triynes, e.g., I [R, R’ = 1-naphthyl, 2-methoxy-1-naphthyl, 9-phenanthryl, substiuted aryl, hetreoaryl, Ph, Me; X = O, C(CO₂Et)₂] under mild reaction conditions and devoid of any addnl. additive, yielding the substituted arene compounds, e.g., II. Successful development of synthetic routes to various triynes and the subsequent cyclotrimerization key step gave systematic access to a variety of different bi- and triaryls with good to excellent yields for the cyclization. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Recommanded Product: 17920-23-9).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Recommanded Product: 17920-23-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design, Synthesis, and Biological Evaluation of Novel, Highly Active Soft ROCK Inhibitors was written by Boland, Sandro;Bourin, Arnaud;Alen, Jo;Geraets, Jacques;Schroeders, Pieter;Castermans, Karolien;Kindt, Nele;Boumans, Nicki;Panitti, Laura;Fransen, Silke;Vanormelingen, Jessica;Stassen, Jean Marie;Leysen, Dirk;Defert, Olivier. And the article was included in Journal of Medicinal Chemistry in 2015.Product Details of 1195768-18-3 This article mentions the following:

ROCK1 and ROCK2 play important roles in numerous cellular functions, including smooth muscle cell contraction, cell proliferation, adhesion, and migration. Consequently, ROCK inhibitors are of interest for treating multiple indications including cardiovascular diseases, inflammatory and autoimmune diseases, lung diseases, and eye diseases. However, systemic inhibition of ROCK is expected to result in significant side effects. Strategies allowing reduced systemic exposure are therefore of interest. In a continuing effort toward identification of ROCK inhibitors, we here report the design, synthesis, and evaluation of novel soft ROCK inhibitors displaying an ester function allowing their rapid inactivation in the systemic circulation. Those compounds, e.g. I, display subnanomolar activity against ROCK and strong differences of functional activity between parent compounds and expected metabolites. The binding mode of a representative compound was determined exptl. in a single-crystal X-ray diffraction study. Enzymes responsible for inactivation of these compounds once they enter systemic circulation are also discussed. In the experiment, the researchers used many compounds, for example, Methyl 3-amino-2-fluorobenzoate (cas: 1195768-18-3Product Details of 1195768-18-3).

Methyl 3-amino-2-fluorobenzoate (cas: 1195768-18-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 1195768-18-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Multivariate optimization of dual-sorbent dynamic headspace extraction of volatiles in wine analysis was written by Vyviurska, Olga;Hanobikova, Maria;Gomes, Adriano A.;Spanik, Ivan. And the article was included in Food Chemistry in 2021.Computed Properties of C6H10O2 This article mentions the following:

The main critical point of newly developed miniaturized sample preparation techniques is a limited extraction capacity. Dynamic headspace extraction offers increased volume of sorbent which is commonly used in environmental anal. Application of two sorbents (Carbopack B/Carbopack X and Tenax TA) at different extraction temperatures allows enhancing a range of volatile organic compounds available for anal. Such approach was applied in our research for quantification of volatile organic compounds in botrytized wines with gas chromatog. The central composite design was included to anal. simultaneous effects of incubation time, incubation temperature, purge volume and purge flow. In attempt to properly assess results, the data evaluation involved Pareto charts, surface response methodol. and principal component anal. Multivariate exptl. design revealed statistical significance of purge volume and quadratic terms of incubation time and temperature, for response of volatiles. The quantification method with 0.2-2.0μg/L LOD and 0.5-5.0μg/L LOQ values, was developed under simultaneously optimized exptl. conditions such as a 54°C incubation temperature, a 20.18 min incubation time, a 344.3 mL purge volume and a 16.0 mL/min purge flow. The increased levels of linalool oxide, Et phenylacetate, γ-hexalactone and α-terpineol were observed in the samples, that correlated with botrytized wine technol. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Computed Properties of C6H10O2).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C6H10O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics