Tag: 0-100

Song, Yaoyao; Wang, Lei; Liu, Fengjuan; Jiao, Chengjin; Nan, Hao; Shen, Xiao; Chen, Hong; Li, Yifan; Lei, Beilei; Jiang, Jinglong; Chen, Peng; Xu, Quanle published their research in Journal of Agricultural and Food Chemistry in 2021. The article was titled 《β-Cyanoalanine Synthase Regulates the Accumulation of β-ODAP via Interaction with Serine Acetyltransferase in Lathyrus sativus》.Synthetic Route of C5H6O2 The article contains the following contents:

β-N-Oxalyl-L-α,β-diaminopropionic acid (β-ODAP), found in Lathyrus sativus at first, causes a neurol. disease, lathyrism, when over ingested in an unbalanced diet. Our previous research suggested that β-ODAP biosynthesis is related to sulfur metabolism In this study, β-cyanoalanine synthase (β-CAS) was confirmed to be responsible for β-ODAP biosynthesis via in vitro enzymic anal. LsCAS was found to be pyridoxal phosphate (PLP)-dependent via spectroscopic anal. and dual functional via enzymic activity anal. Generation of a M135T/M235S/S239T triple mutant of LsCAS, which are the key sites to control the ratio of CAS/cysteine synthase (CS) activity, switches reaction chem. to that of a CS. LsCAS interactions were further screened and verified via Y2H, BiFC and pull-down assay. It was suggested that LsSAT2 interacts and forms a cysteine regulatory complex (CRC) with LsCAS in mitochondria, which improves LsSAT while reduces LsCAS activities to affect β-ODAP content pos. These results provide new insights into the mol. regulation of β-ODAP content in L. sativus. In the experiment, the researchers used many compounds, for example, Ethyl propiolate(cas: 623-47-2Synthetic Route of C5H6O2)

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Synthetic Route of C5H6O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Surfactant Micelles Enable Metal-Free Spirocyclization of Keto-Ynamides and Access to Aza-Spiro Scaffolds in Aqueous Media》 was written by Beltran, Frederic; Vela-Gonzalez, Andrea V.; Knaub, Tatiana; Schmutz, Marc; Krafft, Marie Pierre; Miesch, Laurence. SDS of cas: 623-47-2This research focused onynamide keto sufactant micelle base spirocyclization; aza spirocycle preparation. The article conveys some information:

Micellar solutions of cetyltrimethylammonium bromide (CTAB) surfactant allow the spirocyclization of keto-ynamides in an aqueous medium without recourse to transition-metal catalysis, enabling access in water to naturally occurring aza-spiro compounds with potential in drug discovery. The reaction was monitored by dynamic light scattering (DLS) and cryogenic transmission electron microscopy (cryo-TEM), which determined the morphol. and change in size of the micelles before and after incorporation of the substrate and achievement of 5-endo-dig cyclization inside the micelles.Ethyl propiolate(cas: 623-47-2SDS of cas: 623-47-2) was used in this study.

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.SDS of cas: 623-47-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Osafune, Yukio; Toshida, Kenji; Han, Jinshun; Kishimoto, Toru; Iizuka-Furukawa, Sachiko; Isogai, Atsuko; Mukai, Nobuhiko published an article in Journal of Bioscience and Bioengineering. The title of the article was 《Identification of 2-furanmethanethiol contributing to roast aroma in honkaku shochu and awamori》.Reference of Ethyl propiolate The author mentioned the following in the article:

Honkaku shochu and awamori are traditional Japanese spirits. 2-Furanmethanethiol (2FM), a volatile thiol, was identified as a roast aroma compound in honkaku shochu and awamori. The detection threshold of 2FM in 25% (volume/volume) ethanol water solutions was determined as 1.6 ng/L. The odor activity values, calculated using the detection threshold suggested that 2FM affects the quality of honkaku shochu and awamori. The odor activity values of 2FM were higher in barley shochu distilled at atm. pressure than in sweet potato shochu, rice shochu and awamori; therefore, 2FM is considered to contribute to the characteristics of barley shochu. The experimental part of the paper was very detailed, including the reaction process of Ethyl propiolate(cas: 623-47-2Reference of Ethyl propiolate)

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Reference of Ethyl propiolate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Vinylene-bridged cyclic dipyrrin and BODIPY trimers》 was published in International Journal of Molecular Sciences in 2020. These research results belong to Xue, Songlin; Kuzuhara, Daiki; Aratani, Naoki; Yamada, Hiroko. SDS of cas: 872-36-6 The article mentions the following:

Vinylene-bridged cyclic boron-difluoride complex of dipyrrin (BODIPY) trimers were successfully prepared from expanded dimethyl-vinylene bridged hexaphyrin(2.1.2.1.2.1) Me-Hex that has the structure of alternate dipyrrins and vinylene bridges. The hexaphyrin(2.1.2.1.2.1) Me-Hex can coordinate with boron ions to afford five kinds of cyclic BODIPYs given by step-by-step boron complexations. Crystal structures of all cyclic BODIPYs except for 3BF2-Me-Hex(b) formed non-planar structures. The theor. calculation predicted that mono-/bis-boron cyclic BODIPYs show the intramol. charge transfer (ICT) characteristics, whereas tri-boron cyclic BODIPYs have no ICT characteristics. Reflecting these electronic properties, tri-boron cyclic BODIPYs exhibit weak fluorescence in the red region, but mono-/bis-boron cyclic BODIPYs exhibit no emission. Vinylene bridged cyclic dipyrrin trimer Me-Hex is the novel porphyrinoid ligand allowed to control the boron coordination under different reaction conditions to form various boron complexes. In the experiment, the researchers used many compounds, for example, Vinylene carbonate(cas: 872-36-6SDS of cas: 872-36-6)

Vinylene carbonate(cas: 872-36-6) belongs to esters. Alkyl carbonates find applications as solvents for lithium ion battery electrolytes and the use of high quality battery grade electrolytes having extremely low water (<10 ppm) and acid (<10 ppm) contents are critical for achieving high electrochemical performance.SDS of cas: 872-36-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Effect of film-forming additive in ionic liquid electrolyte on electrochemical performance of Si negative-electrode for LIBs》 were Yamaguchi, Kazuki; Domi, Yasuhiro; Usui, Hiroyuki; Shimizu, Masahiro; Morishita, Shota; Yodoya, Shuhei; Sakata, Takuma; Sakaguchi, Hiroki. And the article was published in Journal of the Electrochemical Society in 2019. Electric Literature of C3H2O3 The author mentioned the following in the article:

1-Ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)amide (EMI-TFSA) is one of the promising ionic liquids as electrolyte solvent to enhance the electrochem. performance of Si electrode for Li-ion batteries (LIBs) because of its low viscosity and high conductivity However, it has low stability against reduction and its reductive decomposition product inhibits Li+ insertion to electrodes, leading to poor cycling stability. To exert a potential of EMI-TFSA, we employed vinylene carbonate (VC) as film-forming additive. Si electrode exhibited very high cycling stability and rate capability in 20 volume% VC-added EMI-TFSA-based electrolyte. In addition, by replacing TFSA anion with bis(fluorosulfonyl)amide (FSA) for Li salt and ionic liquid solvent, an excellent cycling performance and outstanding rate capability was achieved. VC cannot only fabricate a good surface film but also lower the interaction between Li+ and FSA-, providing smooth desolvation of FSA- to obtain better high-rate performance. Non-flammability of the VC-added electrolytes was confirmed by fire resistance test in closed-system: no ignition was observed even at 300°C. Consequently, we found that mixture electrolyte consisted of EMI-based ionic liquid and VC, especially 1 M LiFSA/EMI-FSA with 20 volume% VC, is a prospective candidate for simultaneously enhancing the electrochem. performance of Si electrode as well as safety of LIBs. In the experiment, the researchers used many compounds, for example, Vinylene carbonate(cas: 872-36-6Electric Literature of C3H2O3)

Vinylene carbonate(cas: 872-36-6) belongs to esters. Alkyl carbonates find applications as solvents for lithium ion battery electrolytes and the use of high quality battery grade electrolytes having extremely low water (<10 ppm) and acid (<10 ppm) contents are critical for achieving high electrochemical performance.Electric Literature of C3H2O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson’s Disease》 was published in ACS Chemical Neuroscience in 2020. These research results belong to Di Martino, Rita Maria Concetta; Pruccoli, Letizia; Bisi, Alessandra; Gobbi, Silvia; Rampa, Angela; Martinez, Ana; Perez, Concepcion; Martinez-Gonzalez, Loreto; Paglione, Maria; Di Schiavi, Elia; Seghetti, Francesca; Tarozzi, Andrea; Belluti, Federica. Synthetic Route of C5H6O2 The article mentions the following:

Common copathogenic factors, including oxidative stress and neuroinflammation, are found to play a vital role in the development of neurodegenerative disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Nowadays, owing to the multifactorial character of the diseases, no effective therapies are available, thus underlying the need for new strategies. Overexpression of the enzyme GSK-3β and downregulation of the Nrf2/ARE pathway are responsible for a decrease in antioxidant defense effects. These pieces of evidence underline the usefulness of dual GSK-3β inhibitors/Nrf2 inducers. In this regard, to design a dual modulator, the structures of a curcumin-based analog, as GSK-3β inhibitor, and a di-Et fumarate fragment, as Nrf2 inducer, were combined. Among the hybrids, 5 and 6 proved to effectively inhibit GSK-3β, while 4 and 5 showed a marked ability to activate Nrf2 together to increase the neuronal resistance to oxidative stress. These last pieces of evidence translated into specific neuroprotective effects of 4 and 5 against PD pathol. events including neurotoxicity elicited by α-synuclein aggregates and 6-hydroxydopamine. Hybrid 5 also showed neuroprotective effects in a C. elegans model of PD where the activation of GSK-3β is intimately involved in Nrf2 regulation. In summary, 5 emerged as an interesting multitarget derivative, valuable to be exploited in a multitarget PD perspective. After reading the article, we found that the author used Ethyl propiolate(cas: 623-47-2Synthetic Route of C5H6O2)

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Synthetic Route of C5H6O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Tandem Reaction of 4-Halo-1,3-Dicarbonyl Compounds with Alkynes towards 4-Vinyl-3(2H)-Furanones and 3(2H)-Furanone fused 2-Pyridones》 was written by Omanakuttan, Vishnu K.; Santhini, P. V.; Shaludheen, S.; Varughese, Sunil; Hopf, Henning; John, Jubi. Safety of Ethyl propiolateThis research focused onvinyl furanone preparation; furanone fused pyridone preparation; halo dicarbonyl compound alkyne tandem Michael addition intramol cyclization. The article conveys some information:

A facile synthetic route of 4-vinyl-3(2H)-furanones I [R1 = OMe, OEt, OtBu, Ph; R2 = H, C(O)Ph, CO2Me, CO2tBu; R3 = H, Me; R4 = H, Me, Br; R5 = OMe, OEt, Ph] via tandem Michael addition and intramol. cyclization from the reaction of 4-halo-1,3-dicarbonyl compounds and alkynes was reported. The formation of a side-product (regioisomer) by a stepwise [2+2] cycloaddition between enolate (of the 4-halo-1,3-dicarbonyl compound) and activated alkyne followed by a sequential 4π-ring opening and an intramol. cyclization was also noted. Another interesting observation was the formation of 3(2H)-furanone fused 2-pyridone II [R6 = Me, Et; R7 = Ph, Bn, 4-MeC6H4, etc.] from the reaction of 4-bromo-3-oxo-N-alkyl(aryl)butanamides and activated alkynes with satisfactory to good yields. After reading the article, we found that the author used Ethyl propiolate(cas: 623-47-2Safety of Ethyl propiolate)

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Safety of Ethyl propiolate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 623-47-2In 2019 ,《2,7,12,17-Tetra(2,5-thienylene)-substituted porphycenes》 was published in Journal of Porphyrins and Phthalocyanines. The article was written by Kuzuhara, Daiki; Nakaoka, Haruka; Matsuo, Kyohei; Aratani, Naoki; Yamada, Hiroko. The article contains the following contents:

Syntheses of thiophene and dithiophene-substituted porphycenes (ThPc and DThPc) at 2,7,12,17-positions by McMurry coupling are reported. The crystal structure of ThPc revealed that the porphycene plane shows a highly planar structure, and the dihedral angles between the porphycene core and thiophene are relatively small at 21deg and 18deg. ThPc and DThPc exhibit red-shifted and broadened absorption because of the extension of π conjugations through porphycene to the substituted thiophenes. It was found that introduction of thiophene units onto porphycene results in decreasing the HOMO-LUMO differences effectively. The results came from multiple reactions, including the reaction of Ethyl propiolate(cas: 623-47-2HPLC of Formula: 623-47-2)

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.HPLC of Formula: 623-47-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Kasakado, Takayoshi; Fukuyama, Takahide; Nakagawa, Tomohiro; Taguchi, Shinji; Ryu, Ilhyong published an article in Beilstein Journal of Organic Chemistry. The title of the article was 《High-speed C-H chlorination of ethylene carbonate using a new photoflow setup》.Product Details of 872-36-6 The author mentioned the following in the article:

Reported the high-speed C-H chlorination of ethylene carbonate, which gives chloroethylene carbonate, a precursor to vinylene carbonate. A novel photoflow setup designed for a gas-liquid biphasic reaction turned out to be useful for the direct use of chlorine gas. The setup employed sloped channels so as to make the liquid phase thinner, ensured a high surface-to-volume ratio. When ethylene carbonate were introduced to the reactor, the residence time were measured to be 15 or 30 s, depending on the slope of the reactor set at 15 or 5°, resp. Such short time of exposition sufficed the photo C-H chlorination. The partial irradiation of the flow channels also sufficed for the C-H chlorination, which was consistent with the requirement of photoirradiation for the purpose of radical initiation. Near-complete selectivity for single chlorination required the low conversion of ethylene carbonate such as 9%, which were controlled by limited introduction of chlorine gas. At a higher conversion of ethylene carbonate such as 61%, the selectivity for monochlorinated ethylene carbonate over dichlorinated ethylene carbonate was 86%. Also found that the substrate contamination with water neg. influenced the performance of the C-H chlorination. The results came from multiple reactions, including the reaction of Vinylene carbonate(cas: 872-36-6Product Details of 872-36-6)

Vinylene carbonate(cas: 872-36-6) belongs to esters. Alkyl carbonates find applications as solvents for lithium ion battery electrolytes and the use of high quality battery grade electrolytes having extremely low water (<10 ppm) and acid (<10 ppm) contents are critical for achieving high electrochemical performance.Product Details of 872-36-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Hydrosulfonylation of Alkenes with Sulfonyl Chlorides under Visible Light Activation》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Hell, Sandrine M.; Meyer, Claudio F.; Misale, Antonio; Sap, Jeroen B. I.; Christensen, Kirsten E.; Willis, Michael C.; Trabanco, Andres A.; Gouverneur, Veronique. Formula: C5H6O2 The article mentions the following:

Sulfonyl chlorides are inexpensive reactants extensively explored for functionalization, but never considered for radical hydrosulfonylation of alkenes. Herein, the authors report that tris(trimethylsilyl)silane is an ideal hydrogen atom donor enabling highly effective photoredox-catalyzed hydrosulfonylation of electron-deficient alkenes with sulfonyl chlorides. To increase the generality of this transformation, polarity-reversal catalysis (PRC) was successfully implemented for alkenes bearing alkyl substituents. This late-stage functionalization method tolerates a remarkably wide range of functional groups, is operationally simple, scalable, and allows access to building blocks which are important for medicinal chem. and drug discovery. In addition to this study using Ethyl propiolate, there are many other studies that have used Ethyl propiolate(cas: 623-47-2Formula: C5H6O2) was used in this study.

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Formula: C5H6O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics