Esters-buliding-blocks

Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists was written by De Lucca, George V.;Kim, Ui T.;Johnson, Curt;Vargo, Brian J.;Welch, Patricia K.;Covington, Maryanne;Davies, Paul;Solomon, Kimberly A.;Newton, Robert C.;Trainor, George L.;Decicco, Carl P.;Ko, Soo S.. And the article was included in Journal of Medicinal Chemistry in 2002.Name: 3-Cyanophenylisocyanate This article mentions the following:

Structure-activity relationship (SAR) studies of initial screening hits from our corporate library of compounds and a structurally related series of CCR1 receptor antagonists were used to determine that an N-(alkyl)benzylpiperidine is an essential pharmacophore for selective CCR3 antagonists. Further SAR studies that introduced N-(ureidoalkyl) substituents improved the binding potency of these compounds from the micromolar to the low nanomolar range. This new series of compounds also displays highly potent, in vitro functional CCR3-mediated antagonism of eotaxin-induced Ca²⁺ mobilization and chemotaxis of human eosinophils. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Name: 3-Cyanophenylisocyanate).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: 3-Cyanophenylisocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chemoselective Deoxygenation of 2° Benzylic Alcohols through a Sequence of Formylation and B(C₆F₅)₃-Catalyzed Reduction was written by Richter, Sven C.;Oestreich, Martin. And the article was included in European Journal of Organic Chemistry in 2021.Electric Literature of C10H12O3 This article mentions the following:

A sequence of formylation and B(C₆F₅)₃-catalyzed reduction of the resulting formate with Et₃SiH enables the chemoselective deoxygenation of secondary benzylic alcs. Primary benzylic and tertiary non-benzylic alcs. are not reduced by this protocol. The formyl group fulfills a double role as activator and self-sacrificing protecting group. The deoxygenation of these formates is fast and can be carried out in the presence of other potentially reducible groups. Neighboring-group participation was found in the deoxygenation of certain diol motifs. In the experiment, the researchers used many compounds, for example, Methyl 2-(4-(hydroxymethyl)phenyl)acetate (cas: 155380-11-3Electric Literature of C10H12O3).

Methyl 2-(4-(hydroxymethyl)phenyl)acetate (cas: 155380-11-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C10H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chemical composition and antimicrobial activity of the essential oil and lipid content of Carduus pycnocephalus L. growing in Saudi Arabia was written by Al-Shammari, Latifa A.;Hassan, Wafaa H. B.;Al-Youssef, Hanan M.. And the article was included in Journal of Chemical and Pharmaceutical Research in 2012.COA of Formula: C12H22O4 This article mentions the following:

The essential oil of the air dried aerial parts of Carduus pycnocephalus L. F. Asteraceae was prepared by hydrodistillation GC/MS anal. revealed the presence of nineteen components representing 100% of the total oil. Hexadecanoic acid (39.62%) was the prominent component of the oil. GC/MS anal. of the unsaponifiable matter of the petroleum ether extract of the aerial parts of the plant revealed the presence of nineteen compounds; sixteen compounds were identified constituting 72.80% of total unsaponifiable matter. Olean-12-en-3-α-ol (20.39%), ursa-9(11), 12-dien-3-ol (17.74%) and hexadecanoic acid (17.62%) were the major components. GC/MS anal. of fatty acid Me ester showed the presence of twenty fatty acids Me esters (91.38%). The main known components were 1,2benzendicarboxylic acid dimethylester (31.08), palmitic acid Me ester (20.08%) and azelaic acid di-Me ester (7.60%). The antimicrobial, antispasmodic and anti-inflammatory effects were studied. The volatile oil and petroleum ether extract showed no antimicrobial activity, while the petroleum ether extract showed antispasmodic, anti-inflammatory effects. This is the first study on chem. composition and biol. activities of the volatile oil and lipid contents of Carduus pycnocephalus L. endemic for Saudi Arabia. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6COA of Formula: C12H22O4).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C12H22O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of biologically active 2-hydroxy-5-pyridinoyl amino acids and 2-(aminoacyl)aminopyridine-3-(or -5-)carboxylic acid derivatives was written by El-Naggar, A. M.;El-Haddad, A. F.;Badie, M. F.;Latif, M. S.;Gommaa, A. M.. And the article was included in Afinidad in 1983.Related Products of 14667-47-1 This article mentions the following:

6-Hydroxy-3-pyridinecarboxylate condensed with H-X-OMe.HCl (X = Gly, Ala, Ser, Val, Leu) in DMF containing DCC and Et₃N to give 55-69% pyridinecarbonyl amino acids I (R = OMe), which were treated with N₂H₄ to give 77-91% I (R = NHNH₂). I (X = Val, Leu; R = NHNH₂) were coupled with H-Ser-OMe.HCl by the azide method to give the corresponding dipeptides in 43-51% yield. Pyridinyl amino acid derivatives II and III [R¹ = tosyl (Tos), phthaloyl (Pht); X¹ = Ala, Ser, Val, Leu; R² = OMe] were prepared in 54-80% yields by condensing tosyl or phthaloyl amino acids with Me 2-amino-3-pyridinecarboxylate and Me 6-amino-3-pyridinecarboxylate, resp. II and III (R¹ = Tos; X¹ = Ser, Val, Leu; R² = OMe) were treated with N₂H₄ to give 55-80% II and III (R¹ = Tos, R² = NHNH₂), whereas II and III (R² = Pht; X¹ = Ala, Ser, Val, Leu; R² = OMe) underwent hydrazinolysis to give 52-66% II and III (R¹ = H, R² = NHNH₂). Dipeptides IV (X²-X³ = Val-Ser, Ala-Val, Ser-Leu) and V (X²-X³ = Ala-Ser, Ser-Val, Val-Leu) were also prepared Several of these compounds exhibited antimicrobial activity. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Related Products of 14667-47-1).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 14667-47-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design, Synthesis, and Structure-Activity Relationship of a Novel Series of GluN2C-Selective Potentiators [Erratum to document cited in CA160:398927] was written by Zimmerman, Sommer S.;Khatri, Alpa;Garnier-Amblard, Ethel C.;Mullasseril, Praseeda;Kurtkaya, Natalie L.;Gyoneva, Stefka;Hansen, Kasper B.;Traynelis, Stephen F.;Liotta, Dennis C.. And the article was included in Journal of Medicinal Chemistry in 2015.Safety of Methyl 2-methoxy-4-methylbenzoate This article mentions the following:

On page 2341, compound 162 in Table 4 should have an isonicotinoyl group in the R₁ position instead of a Me group. On page 2345, compounds 159 and 160 in Table 3 should have a Me group in the 2-position of the indole, and the R¹ should be a Me group instead of the nicotinoyl group shown. After rechecking the purity of all reported compounds, compounds 66-68, 85, 89, 90, 100, and 112 did not meet the J. Med. Chem. purity standards In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Safety of Methyl 2-methoxy-4-methylbenzoate).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of Methyl 2-methoxy-4-methylbenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ruthenium-Catalyzed Reductive Arylation of N-(2-Pyridinyl)amides with Isopropanol and Arylboronate Esters was written by Ronson, Thomas O.;Renders, Evelien;Van Steijvoort, Ben F.;Wang, Xubin;Wybon, Clarence C. D.;Prokopcova, Hana;Meerpoel, Lieven;Maes, Bert U. W.. And the article was included in Angewandte Chemie, International Edition in 2019.Recommanded Product: Methyl 2-aminonicotinate This article mentions the following:

A new three-component reductive arylation of amides with stable reactants (iPrOH and arylboronate esters), making use of a 2-pyridinyl (Py) directing group, is described. The N-Py-amide substrates are readily prepared from carboxylic acids and PyNH₂, and the resulting N-Py-1-arylalkanamine reaction products are easily transformed into the corresponding chlorides by substitution of the HN-Py group with HCl. The 1-aryl-1-chloroalkane products allow substitution and cross-coupling reactions. Therefore, a general protocol for the transformation of carboxylic acids into a variety of functionalities is obtained. The Py-NH₂ byproduct can be recycled. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Recommanded Product: Methyl 2-aminonicotinate).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: Methyl 2-aminonicotinate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Construction of [4.3.1]Propellanes via Molybdenum Fischer Carbene Complexes was written by Bertolini, Thomas M.;Nguyen, Que Huong;Harvey, Daniel F.. And the article was included in Journal of Organic Chemistry in 2002.Category: esters-buliding-blocks This article mentions the following:

Cyclization of molybdenum Fischer carbene complexes, e.g. I, with methyleneoctenynes, e.g. II, at 40° gave tricyclodecadienes, e.g. III, with yields of 24-54%, while the analogous chromium carbene complex gave no reaction. The range of dienyne substrates that participate in this reaction is explored and its mechanism is analyzed and discussed. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Category: esters-buliding-blocks).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

One-pot syntheses of 2,6-diiododiaryl ethers from para-EWG-substituted phenols by diacetoxyiodobenzene was written by Zhou, De-Jun;Yin, Shu-Qiang;Fan, Yun-Chang;Wang, Qiang. And the article was included in Research on Chemical Intermediates in 2016.Quality Control of Methyl 4-Hydroxy-2-methoxybenzoate This article mentions the following:

2,6-Diiododiaryl ethers are not only useful blocks for construction of substituted diaryl ethers but are also characteristic drug precursors. In this research, a one-pot tandem oxidation of phenols substituted with electron-withdrawing group at the para position by excess diacetoxyiodobenzene is proven as a novel and efficient method for preparing 2,6-diiododiaryl ethers. Using this method, three new 2,6-diiododiaryl ethers, namely, Me 3,5-diiodo-2-methoxy-4-phenoxybenzoate, Me 3,5-diiodo-4-phenoxybenzoate, and 1-(2,6-diiodo-4-nitrophenoxy)benzene were readily obtained from the corresponding phenols, and the yields were good. In the experiment, the researchers used many compounds, for example, Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8Quality Control of Methyl 4-Hydroxy-2-methoxybenzoate).

Methyl 4-Hydroxy-2-methoxybenzoate (cas: 28478-46-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Quality Control of Methyl 4-Hydroxy-2-methoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ultraviolet absorption spectra and dipole moments of substituted pyridines. IV. Aminopyridinecarboxylate esters was written by Gandolfo, Concetta;Buemi, Giuseppe;Favini, Giorgio. And the article was included in Gazzetta Chimica Italiana in 1971.Category: esters-buliding-blocks This article mentions the following:

Calculated electron transition energies and dipole moments are in good agreement with exptl. values for Me amino nicotinates, Me amino picolinates, and Me amino isonicotinates. The preferred conformation of the CO2Me group is Am for the nicotinates, Bo for the picolinates, and Ap or Bp for the isonicotinates. The Am conformation is favored in nicotinates when the NH2 group is ortho or meta with respect to CO2Me. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Category: esters-buliding-blocks).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lewis acid-catalyzed one-pot sequential reaction for the synthesis of α-halogenated β-keto esters was written by Cui, Han-Feng;Dong, Ke-Yan;Nie, Jing;Zheng, Yan;Ma, Jun-An. And the article was included in Tetrahedron Letters in 2010.Category: esters-buliding-blocks This article mentions the following:

A Lewis acid-catalyzed one-pot sequential transformation of β-keto esters, aromatic aldehydes, and NCS/NBS was reported. The reaction proceeds by way of Knoevenagel condensation/Nazarov cyclization/halogenation to give α-chloro- and α-bromo-β-keto esters in moderate yields with high diastereoselectivities. However, several aromatic aldehydes with electron-withdrawing substituents afforded unexpected α,β’-dichloro-β-keto esters in good to high yields. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Category: esters-buliding-blocks).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics