Esters-buliding-blocks

Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones was written by Skiles, Jerry W.;Fuchs, Victor;Miao, Clara;Sorcek, Ronald;Grozinger, Karl G.;Mauldin, Scott C.;Vitous, Jana;Mui, Philip W.;Jacober, Stephen. And the article was included in Journal of Medicinal Chemistry in 1992.Category: esters-buliding-blocks This article mentions the following:

A series of tripeptides possessing trifluoromethyl or aryl kinase residues at P₁ were prepared and evaluated both in vitro and in vivo as potential inhibitors of human leukocyte elastase (HLE). Tripeptides containing nonnaturally occurring N-substituted glycine residues at the P₂-position have been demonstrated to be potent in vitro inhibitors of HLE, with IC₅₀ values in the submicromolar range. Sterically demanding substituents on the P₂-nitrogen have no detrimental effect on in vitro potency. The inhibition process presumably acts via hemiketal formation with the active site Ser¹⁹⁵ of HLE, and is facilitated by the strongly electron withdrawing trifluoromethyl functionality. Deletion of the amino acid at the P³-subsite region affords inactive compounds Valine is the preferred residue at the P₁-position, whereas the corresponding glycine, alanine, α,α-dimethylglycine, or phenylalanine analogs are all inactive. The compounds described herein all confer a high degree of in vitro specificity when tested against representing cysteine, aspartyl, metallo, and other serine proteases. One of the most potent in vitro inhibitors is tripeptide trifluoromethyl ketone I (IC₅₀ = 0.084 μM). I was also tested in hamsters in an elastase-induced pulmonary hemorrhage (EPH) model. In this model, intratracheal (it) administration of I, 5 min prior to HLE challenge, effectively inhibited hemorrhage in a dose-dependent manner with an ED₅₀ of 4.8 μg. The administration of 20 μg (i.t.) of I 24, 48 and 72 h prior to HLE challenge exhibits significant inhibition against hemorrhage at all time points (97%, 64% and 49%, resp.). In a 21-day chronic model of emphysema in hamsters, 200 μg of HLE administered i.t. caused an elastase-induced emphysema in the lungs which can be quantitated histol. utilizing image anal. In this assay, I significantly inhibited pulmonary lesions associated with septal destruction and increased alveolar spaces, when dosed at 20 μg i.t. 5 min prior to challenge with HLE. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Category: esters-buliding-blocks).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Influence of acrylonitrile butadiene elastomer as polymeric co-agent for crosslinking poly(vinyl chloride) by gamma radiation was written by Gupta, Neeraj K.;Gupta, Shivani;Tedesse, Aschalew. And the article was included in Journal of Polymer Research in 2022.Name: 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) This article mentions the following:

Plasticized filled poly(vinyl chloride) (PVC) blends incorporating acrylonitrile-butadiene rubber (NBR) as an elastomeric crosslinking co-agent were subjected to gamma radiation by a Co₆₀ source for total doses 25 to 100 kGy. Changes in total insoluble contents, physicomech. properties (before and after thermal aging), morphol., spectroscopy, and dynamic mech. behavior as a function of NBR loading and total dose were investigated. An increase in total insoluble contents with both NBR loading and total dose indicates that within the parameters of the study, the blends underwent crosslinking as the predominant effect with an increase of hardness. Unaged mech. properties (tensile strength, Young’s modulus, and elongation at break) of the blends were significantly modified. These same properties, after aging at 90°C, 168 h are again modified due to further crosslinking reactions above the glass transition temperatures The obtained results indicate that there exists a loading range for NBR for which an optimal combination of room temperature and aged mech. properties may be obtained. Abrasion resistance of the blends improves due to the formation of chem. bonded networks. The mechanism of the crosslinking reaction was elucidated by Fourier transform IR spectroscopy. Electron scanning microscopy shows single-phase blend morphologies for all blends and reveals a reduction in matrix ductility on crosslinking. Dynamic mech. anal. conducted to study the change in loss tangent, storage modulus, and loss modulus at 100 kGy total dose shows an increase in these parameters and that the modification of physicomech. properties are due to both crosslinking as well as enhanced interaction between PVC and NBR. In the experiment, the researchers used many compounds, for example, 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8Name: 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)).

2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) (cas: 6683-19-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: 2,2-Bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Selective monomethyl esterification of dicarboxylic acids by use of monocarboxylate chemisorption on alumina was written by Ogawa, Haruo;Chihara, Teiji;Taya, Kazuo. And the article was included in Journal of the American Chemical Society in 1985.HPLC of Formula: 3903-40-0 This article mentions the following:

The application of alumina as a solid support affords a new procedure for selective monoesterification of dicarboxylic acids. Thus, terephthalic acid (I), isophthalic acid, cis– and trans-1,4-cyclohexanedicarboxylic acids, and aliphatic dicarboxylic acids give the corresponding monomethyl esters quant. with diazomethane. Selective monomethyl esterification of phthalic acid is not successful on alumina, probably as a consequence of the close proximity of the two carboxyl groups and the forced orientation of the second group when one is adsorbed. Me₂SO₄ and p-MeC₆H₄N:NNHMe were also effective for the selective monomethyl esterification of I by this procedure. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0HPLC of Formula: 3903-40-0).

12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 3903-40-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Phytochemical profiling of Coryphantha macromeris (cactaceae) growing in greenhouse conditions using ultra-high-performance liquid chromatography-tandem mass spectrometry was written by Cabanas-Garcia, Emmanuel;Areche, Carlos;Jauregui-Rincon, Juan;Cruz-Sosa, Francisco;Balch, Eugenio Perez-Molphe. And the article was included in Molecules in 2019.SDS of cas: 106-79-6 This article mentions the following:

Chromatog. separationcombined with mass spectrometry is a powerful tool for the characterization of plant metabolites because of its high sensitivity and selectivity. In this work, the phytochem.profile of aerial and radicular parts of Coryphantha macromeris (Engelm.) Britton & Rose growing under greenhouse conditions was qual.investigated for the first time by means of modern ultra-high-performance liquid chromatog. tandem mass spectrometry (UHPLC-PDA-HESI-Orbitrap-MS/MS). The UHPLC-PDA-HESI-Orbitrap-MS/MS anal. indicated a high complexity in phenolic metabolites. In our investigation, 69 compounds were detected and 60 of them were identified. Among detected compounds, several phenolic acids, phenolic glycosides, and organic acids were found. Within this diversity, 26 metabolites were exclusively detected in the aerial part, and 19 in the roots. Twenty-four metabolites occurred in both plant parts. According to the relative abundance of peaks in the chromatogram, ferulic and piscidic acids and their derivatives may correspond to one of the main phenolic compounds of C.macromeris. Our results contribute to the phytochem.knowledge regarding C.macromeris and its potential applications in the pharmaceutical and cosmetic industries. Besides, some metabolites and their fragmentation patterns are reported here for the first time for cacti species. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6SDS of cas: 106-79-6).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 106-79-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Analogs of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain “C-region” was written by Walpole, Christopher S. J.;Wrigglesworth, Roger;Bevan, Stuart;Campbell, Elizabeth A.;Dray, Andy;James, Iain F.;Masdin, Kay J.;Perkins, Martin N.;Winter, Janet. And the article was included in Journal of Medicinal Chemistry in 1993.Safety of 12-Methoxy-12-oxododecanoic acid This article mentions the following:

Structural variants of the hydrophobic side chain (C region) of the capsaicin mol. have been incorporated into a series of vanillylamides and vanillylthioureas. These compounds have been tested in an in vitro assay for agonism (⁴⁵Ca²⁺ influx into dorsal root ganglia neurons), previously shown to be predictive of analgesic activity. The results of this study have established the requirement for a hydrophobic substituent of limited size (molar refractivity, MR, <55) in order to obtain high potency. Combination of the information about the C-region of the capsaicin mol. with studies of the other parts of the mol. provides a rational basis for the design of compounds of increased potency. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0Safety of 12-Methoxy-12-oxododecanoic acid).

12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of 12-Methoxy-12-oxododecanoic acid

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The carboxyl group. Infrared absorption and ionization was written by Peltier, Daniel;Pichevin, Annick. And the article was included in Bulletin de la Societe Chimique de France in 1960.Application of 81245-24-1 This article mentions the following:

PK, ν_OH(monomeric), and ν_C:O (monomeric and dimeric) values of 17 substituted benzoic, 34 o-toluic, 17 m-toluic, and 12 p-toluic acids, as well as the ν_C:O values of 55 Me and Et esters were tabulated. For all the acids except the 6-substituted o-toluic acids (6-NO₂, I, Br, Cl, OH, NH₂), ν_OH (cm.^-1) = 3498 + 9pK. The ν_C:O (monomeric) of the o-OH and o-NH₂ acids were on the average 55 cm.^-1 lower and those of nonchelated, 6-substituted o-toluic acids were approx. 5 cm.^-1 higher than calculated from the appropriate equations (CA 53, 17954e). For acids free of chelation and steric effects, ν_OH = 5,028 – 0.857 ν_C:O (monomeric) (cm.^-1). For 3-, 4-, and 5-substituted o-toluic acids, ν_OH = 5053 – 0.874 ν_C:O. The carbonyl frequencies of the Et esters were approx. 5 cm.^-1 lower than those of the corresponding Me esters. These results are explained by electronic effects of H or alkyl group on the carbonyl group. 6-HO(or H₂N)-2-MeC₆H₃CO₂Me exhibited 2 carbonyl frequencies related to chelated and nonchelated forms. Similar data were presented for 2,3- (I), 2,4-, and 2,6-(MeO)MeC₆H₃CO₂H, and o-MeOC₆H₄CO₂H. The dimeric carbonyl absorptions were weak, the ν_OH were lower, and the ν_C:O were higher, based on the relations with pK, than expected for nonchelated acids. I was exceptional, as it gave a strong dimeric carbonyl absorption. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Application of 81245-24-1).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application of 81245-24-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Facile synthesis of δ-ketoesters via formal two-carbon insertion into β-ketoesters was written by Jiang, Yan;Xi, Song;Wang, Qi;Fu, Lin;He, Ling;Wang, Zhen;Zhang, Min. And the article was included in Tetrahedron Letters in 2022.Category: esters-buliding-blocks This article mentions the following:

A formal two-carbon insertion into β-ketoesters with vinylmetal has been developed for the rapid synthesis of δ-ketoesters. This method features high efficiency, simple operation, and mild conditions without the usage of bases and catalysts. The reaction is postulated to proceed via a tandem process in volving nucleophilic addition of vinylmetal to ketone, retro-aldol reaction to give an enolate anion and an enone, and finally Michael addition of these two intermediates. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Category: esters-buliding-blocks).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Volatile components of Borassus aethiopum was written by Mahmout, Yaya;Mbaiguinam, Mbailao;Bessiere, Jean-Marie. And the article was included in Journal de la Societe Ouest-Africaine de Chimie in 2001.Recommanded Product: Ethyl 2-hydroxy-3-phenylpropanoate This article mentions the following:

The essential oil and the methylene chloride extract of the pulp of B. aethiopum of Chad were analyzed. The essential yield of the samples was 0.5-0.7%, while methylene chloride extracts gave 1.3% of the residue. The essential oil was characterized by (E)-Et cinnamate and geranylacetone (10.5%) with lesser amounts of 3-phenylpropanol (8.6%) and farnesylacetone (5%). The other main esters were Et 3-hydroxybutanoate (3.4%), Et 3-phenylpropanoate (2.7%), Et benzoate (1.7%), (E)-Me cinnamate (0.8%), Et 3-hydroxyisohexanoate (0.6%) and phenylethyl tiglate (0.6%). The richness of ester compounds may have contributed significantly to the pleasant odor of the ripe fruits of B. aethiopum. The presence of (E)-Et cinnamate in the oil of B. aethiopum was the most major difference noticed on comparison of the essential oil of samples from Sudan. Most of the identified components were not previously known to be present in the volatile extracts of B. aethiopum. These compositional differences may be chemotaxonomically significant. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Recommanded Product: Ethyl 2-hydroxy-3-phenylpropanoate).

Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: Ethyl 2-hydroxy-3-phenylpropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Highly efficient [2 + 2] intramolecular cyclizations of allenynes under microwave irradiation: construction of fused bicyclic compounds was written by Oh, Chang Ho;Gupta, Arun Kumar;Park, Dai In;Kim, Nakjoong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2005.Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate This article mentions the following:

A palladium [2 + 2] cycloaddition of 1,6- and 1,7- allenyne carboxylates and microwave-mediated [2 + 2] cycloaddition of various 1,n-allenynes were developed and, particularly, the microwave irradiated [2 + 2] cycloaddition of allenynes can provide a simple, general and eco-friendly synthetic method to fused bicyclo[m,2,0]alkadienes. E.g., microwave irradiation of allenyne CH₂:C:CHCH₂N(Ts)CH₂CCCO₂Et gave 89% bicyclo[m,2,0]alkadiene I. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate).

Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of novel photoactive enkephalin-like peptides was written by Sumbatyan, N. V.;Topin, A. N.;Taranenko, M. V.;Korshunova, G. A.. And the article was included in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya in 2001.Recommanded Product: 133467-01-3 This article mentions the following:

Two new analogs of enkephalin containing photoactive residue of N-azide-L-phenylalanine and N-[3-(trifluoromethyl)-3H-diazirin-3-yl]-L-phenylalanine were synthesized. The photochem. property of prepared enkephalin derivatives and their ability to bind opioid receptors were studied. In the experiment, the researchers used many compounds, for example, Boc-D-Leu-OMe (cas: 133467-01-3Recommanded Product: 133467-01-3).

Boc-D-Leu-OMe (cas: 133467-01-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 133467-01-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics