Esters-buliding-blocks

Sun, Zikai published the artcileImmunosuppressive effects of dimethyl fumarate on dendritic cell maturation and migration: a potent protector for coronary heart disease, Recommanded Product: Dimethyl fumarate, the publication is Immunopharmacology and Immunotoxicology (2022), 44(2), 178-185, database is CAplus and MEDLINE.

Dendritic cells (DCs), as a bridge between innate and adaptive immunity, play key roles in atherogenesis, particularly in plaque rupture, the underlying pathophysiol. cause of myocardial infarction. Targeting DC functions, including maturation and migration to atherosclerotic plaques, may be a novel therapeutic approach to atherosclerotic disease. Di-Me fumarate (DMF), an agent consisting of a combination of fumaric acid esters, in current study were found to be able to suppress DC maturation by reducing the expression of costimulatory mols. and MHC class II and by blocking cytokine secretion. In addition, DMF efficiently inhibited the migration of activated DCs in vitro and in vivo by reducing the expression of chemokine receptor 7 (CCR7). Addnl., DMF efficiently inhibited the expression of the costimulatory mol. CD86, as well as the chemokine receptor CCR7 and the C-XC motif chemokine receptor 4 (CXCR4), in healthy donor-derived purified DCs that had been stimulated by ST-segment elevation myocardial infarction (STEMI) patient serum. This study points to the potent therapeutic value of DMF for protecting against cardiovascular disease by suppressing DC functions.

Immunopharmacology and Immunotoxicology published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C25H29N9O3, Recommanded Product: Dimethyl fumarate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xie, Haopu published the artcileNovel titin-inspired high-performance polyurethanes with self-healing and recyclable capacities based on dual dynamic network, Category: esters-buliding-blocks, the publication is Polymer (2021), 124096, database is CAplus.

It is still a huge challenge that integrating excellent mech. performance and high healing efficiency into self-healing materials at the same time, even if numerous dynamic bonds have been explored in preparing of self-healing materials in the last 20 years. Herein, we reported a novel titin-inspired strategy to prepare the polyurethanes via introducing dual dynamic network which contained the phys. crosslinking of quadruple hydrogen bonds formed by 5-(2-hydroxyethyl)-6-methyl-2-aminouracil (UPy) dimers and the covalent crosslinking of Diels-Alder (D-A) bonds. Specially, relying on the synergistic effect of the dual dynamic network, the resulting polyurethane F50U50-PU exhibited admirable mech. performance, such as a super-high strength of 51.9 MPa, a superb toughness of 166.7 MJ/m3 and a large elongation at break of 930%. Meanwhile, on account of the dynamic feature of quadruple hydrogen bonds and D-A bonds, the resulting polyurethane showed a high heat-induced healing efficiency of 91.2%. More importantly, the polyurethanes could be recycled by hot-pressing process to regain their initial mech. properties and integrity. And it was also used as substrate to construct self-healing conductive device, which displayed splendid self-healing of elec. conductivity after damage. It can be envisioned that the polyurethanes with both superior mech. performance and high healing efficiencies have great application prospect in multifarious fields.

Polymer published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C15H21BO3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ren, Xiaozhen published the artcileA UV-LED excited photoinitiator with low toxicity and low migration for photocurable inks, Recommanded Product: Trimethylolpropane triacrylate, the publication is Dyes and Pigments (2022), 110133, database is CAplus.

With the improvement of public environmental protection awareness, the market share of LED in the photocuring field is also expanding rapidly, so it is necessary to develop matching photoinitiators. Here, we prepared a mol. (ND-1) possessing both co-initiating and polymerizable groups, and it exhibits a good initiation effect on acrylate monomers under UV-LED irradiation The double bond conversion rate reaches up to 80% especially for tripropylene glycol diacrylate (TPGDA). Due to excellent photocuring effect of ND-1, it can initiate monomer polymerization in the presence of color paste and was successfully applied to photocurable inks. In addition, ND-1 exhibits low migration and low toxicity, which is very important to promote the application of packaging with photocurable inks in the food, medical, personal care and tobacco fields. Finally, the photoinitiation mechanism of ND-1 was explored. The free radicals not only come from the cleavage of C-O bond, but also intermol. hydrogen abstraction.

Dyes and Pigments published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Recommanded Product: Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sun, Ming Yang published the artcilePreparation the composite with high toughness and strength by recycled cyclic olefin copolymer, Formula: C42H63O3P, the publication is Polymer Engineering & Science (2022), 62(5), 1427-1434, database is CAplus.

At present, it is of great significance to develop an effective method of recycling cyclic olefin copolymers (rCOC) due to its increasing application. But, its poor toughness is still an important difficulty to limit its effective recycling. In this article, we introduced PA6 into the POE-g-MAH/rCOC composites. Because of the good compatibility of POE-g-MAH between PA6 and rCOC, it just led to an overall improvement in mech. properties of PA6/POE-g-MAH/rCOC (45/15/40) composites. Its tensile strength reached 42.3 MPa, which was more than 41.9% compared with that of POE-g-MAH/rCOC composites. Its notched impact strength was 11.7 kJ/m², which was higher than 875.0% compared with rCOC. Furthermore, the component of PA6 was wrapped by nonpolar rCOC and POE-g-MAH, resulting in a low water absorption rate (1.0%). So, the strength of the composites only dropped a little after water adsorption. In summary, the addition of PA6 helped the composites effectively utilize the toughness of POE-g-MAH. Thus, we developed an easy method to recycle rCOC and prepare the responding composites with high strength and toughness.

Polymer Engineering & Science published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C4H8Cl2S2, Formula: C42H63O3P.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yang, Chongzhe published the artcileTherapeutic potential of tricarboxylic acid cycle metabolite itaconate in cardiovascular diseases, Application In Synthesis of 617-52-7, the publication is EBioMedicine (2020), 102938, database is CAplus and MEDLINE.

Tricarboxylic acid cycle (TCA cycle) produces metabolites in the mitochondria under various pathophysiol. conditions. LPS and interferons induce IRG1 expression and itaconate production from the TAC cycle. Itaconate and its derivatives DI and OI contribute to (1) succinate dehydrogenase inhibition and succinate accumulation; (2) KEAP1 cysteine alkylation, Nrf2 expression and nucleus translocation, and pro- and anti-inflammatory mol. expression regulation; (3) ATF3 expression; and (4) M2 macrophage polarization. Adeno-associated virus (AAV)-mediated overexpression of Nrf2 reduced AAA growth and lesion inflammation, but shRNA-mediated Nrf2 knockdown revealed the opposite phenotypes. Instead of using the Irg1 mice to test a role for itaconate in AAA, this study used AAV-mediated KEAP1 overexpression to increase AAA growth and lesion inflammation. OI treatment reversed these KEAP1 adverse activities, likely via KEAP1 alkylation and disassocn. from Nrf2, although this study did not explore the details. This is the first study of TCA cycle metabolites in AAA that extends the concept of using OI or DI as a therapeutic regimen to slow murine and human AAA growth and associated lesion and systemic inflammation. The demonstrated beneficial effects of OI and DI in sepsis, hepatic, cerebral, and cardiac IR injuries support this potential.

EBioMedicine published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C6H4ClNO2, Application In Synthesis of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ding, Huina published the artcileEffect of microbial community structures and metabolite profile on greenhouse gas emissions in rice varieties, Application In Synthesis of 121-79-9, the publication is Environmental Pollution (Oxford, United Kingdom) (2022), 119365, database is CAplus and MEDLINE.

Rice paddy fields are major sources of atm. methane (CH4) and nitrous oxide (N2O). Rice variety is an important factor affecting CH4 and N2O emissions. However, the interactive effects of rice metabolites and microorganisms on CH4 and N2O emissions in paddy fields are not clearly understood. In this study, a high greenhouse gas-emitting cultivar (YL 6) and a low greenhouse gas-emitting cultivar (YY 1540) were used as exptl. materials. Metabolomics was used to examine the roots, root exudates, and bulk soil metabolites. High-throughput sequencing was used to determine the microbial community composition YY 1540 had more secondary metabolites (flavonoids and isoflavonoids) in root exudates than YL 6. It was enriched with the uncultured members of the families Gemmatimonadanceae and Rhizobiales_Incertae_Sedis in bulk soil, and genera Burkholderia-Caballeronia-Paraburkholderia, Magnetospirillum, Aeromonas, and Anaeromyxobacter in roots, contributing to increased expression of pmoA and nosZ genes and reducing CH4 and N2O emissions. YL 6 roots and root exudates contained higher contents of carbohydrates [e.g., 6-O- acetylarbutin and 2-(3- hydroxyphenyl) ethanol 1-glucoside] than those of YY 1540. They were enriched with genera RBG-16-58-14 in bulk soil and Exiguobacterium, and uncultured member of the Kineosporiaceae family in roots, which contributed to increased expression of mcrA, ammonia-oxidizing archaea, ammonia-oxidizing bacteria, nirS, and nirK genes and greenhouse gas emissions. In general, these results established a link between metabolites, microorganisms, microbial functional genes, and greenhouse gas emissions. The metabolites of root exudates and roots regulated CH4 and N2O emissions by influencing the microbial community composition in bulk soil and roots.

Environmental Pollution (Oxford, United Kingdom) published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Application In Synthesis of 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Liang published the artcileHydroxymethylation of active methenyl compounds: DMSO as methylene source and H₂O as oxygen source, HPLC of Formula: 517-23-7, the publication is Tetrahedron Letters (2022), 153663, database is CAplus.

A mild and efficient method for hydroxymethylation of active methenyl compounds was described. In this transformation, the widely available solvents DMSO and water served as methylene and oxygen sources, resp. Under promotion of activator and base, the reaction could be used for the construction of a series of α-hydroxymethylated carbonyl compounds R¹COC(CH₂OH)R²R³ [R¹ = Me, Ph, Bn, 2-furyl, 2-thienyl; R² = CN, MeCO, MeO₂C, EtO₂C, t-BuO₂C, PhNHCO; R³ = Me, Et, Bn, etc.; R¹R³ = (CH₂)₃, H₂COCH₂, (CH₂)₄, etc.] with all-carbon quaternary carbon center in good to excellent yield.

Tetrahedron Letters published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C12H6NNaO4, HPLC of Formula: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Luan, Xuezhu published the artcileExperimental study on toughening of porous cordierite ceramic prepared by particle-stabilized emulsions, Name: Propyl 3,4,5-trihydroxybenzoate, the publication is Materials Today Communications (2022), 103674, database is CAplus.

The majority of work has focused on the toughening of porous cordierite ceramics (PCC), which has a uniform and homogeneous porous structure prepared by the particle-stabilized emulsions after sintering at ∼1300°C for 2 h. The particle sizes of raw materials were adjusted to 20 nm to ensure that all samples maintained the same porous structure, which prevented crack propagation from separating PCC’s bending strength increased by up to ∼214% at ∼4 wt% ZrO₂ content, which absorb energy to improve fracture toughness. The addition of mullite fibers created new intermol. forces between colloidal particles and filler parameters, which played a neg. impact on the stability of the micelle shape, resulting in unsuccessful foaming and toughening. Rod-shaped cordierite crystals with a large aspect ratio were formed on the inner wall of PCC with 3 wt% AlF₃ and created a short network in situ, which improved the bending strength of the tensile structure by strengthening crack deflection and crack bridging.

Materials Today Communications published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Name: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Kejie published the artcileSiC paste with high curing thickness for stereolithography, Recommanded Product: Trimethylolpropane triacrylate, the publication is Ceramics International (2022), 48(S19), 28692-28703, database is CAplus.

In this study, the method and mechanism of the improvement of the curing thickness of SiC by stereolithog. (SLA) were investigated, the rheol. properties of SiC paste were optimized, and the problem of cracking problem during debinding was solved. The best molding process for preparing SiC ceramics with the Ceramaker 900 equipment was studied. Oxidation at 1180°C for 1 h and hydroxylation with 0.6 mol/L H₂O₂ were the best modification processes for SiC powder. SiC paste with good rheol. properties and high curing thickness was prepared using a resin system of BPA, HDDA, TPGDA, TMPTA, DPHA, and A-BPEF (mass ratio = 9:7:5:20:15:6). The best debinding process for SLA SiC was segmented debinding. The bulk d., total porosity, and room temperature bending strength of the SiC ceramics obtained are 2.13 g/cm³, 10.2%, 229 MPa, resp. The nanoindentation elastic modulus and hardness of SLA SiC ceramics were found to be 18.7 and 1.66 GPa, resp. Through this process, a lattice structure of SiC parts with good surface quality was prepared

Ceramics International published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C18H23OP, Recommanded Product: Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wan, Yiqian published the artcileChemical studies on soft coral Lobophytum catelai. II., Quality Control of 110-34-9, the publication is Redai Haiyang (1997), 16(3), 78-82, database is CAplus.

The chem. constituents of the soft coral Lobophytum catelai collected from Xisha Islands were studied by spectroscopies and GC/MS. Eight compounds were isolated and identified, which were palmitic acid, iso-Bu palmicate, Bu alc., Pr palmitate, 2,3-dihydroxypropyloctadecaicate, 2β,3β-epoxy-5α-androsta-17-ol, 14-methyl-5α-cholesta-8-ene-3-one, and 2α,3α-epoxy-5α-androsta- 17-β-ol.

Redai Haiyang published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C7H11N, Quality Control of 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics