Esters-buliding-blocks

Petrov, Rostislav A. published the artcileSynthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates, Safety of (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(3), 382-387, database is CAplus and MEDLINE.

Asialoglycoprotein receptor (ASGP-R) is a promising biol. target for drug delivery into hepatoma cells. Nevertheless, there are only few examples of small-mol. conjugates of ASGP-R selective ligand equipped by a therapeutic agent for the treatment of hepatocellular carcinoma (HCC). In the present work, we describe a convenient and versatile synthetic approach to novel mono- and multivalent drug-conjugates containing N-acetyl-2-deoxy-2-aminogalactopyranose and anticancer drug – paclitaxel (PTX). Several mols. have demonstrated high affinity towards ASGP-R and good stability under physiol. conditions, significant in vitro anticancer activity comparable to PTX, as well as good internalization via ASGP-R-mediated endocytosis. Therefore, the conjugates with the highest potency can be regarded as a promising therapeutic option against HCC.

Bioorganic & Medicinal Chemistry Letters published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, Safety of (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Saleh, Balkis published the artcileStudies with functionally substituted enamines: the reactivity of enaminals and enamino esters toward naphthoquinone, hydrazonoyl halides, aminoazoles and hippuric acid, Application of Ethyl 3-(dimethylamino)acrylate, the publication is Synthesis (2006), 59-62, database is CAplus.

Whereas enamines react with naphthoquinone to yield naphthofuran (i.e., naphtho[1,2-b]furan) aldehyde and carboxylic acid ester derivatives, enamine ester react with naphthoquinone to yield benzindole derivatives Et 3-(dimethylamino)-2-propenoate reacts with hydrazonoyl halides to yield 3,4-disubstituted pyrazole derivatives On the other hand, and enaminal, 3-(dimethylamino)-2-propenal, failed to react with hydrazonoyl halides, while an enamine ester, Et 3-(anilino)acrylate, afforded a hydrazone derivative on treatment with hydrazonoyl halide. An enamino ester, Et 3-(dimethylamino)-2-propenoate, afforded tri-Et 1,3,5-benzenetricarboxylic acid esters on refluxing in acetic acid.

Synthesis published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Application of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ivanenkov, Yan A. published the artcileSynthesis and biological evaluation of novel doxorubicin-containing ASGP-R-targeted drug-conjugates, HPLC of Formula: 10378-06-0, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(3), 503-508, database is CAplus and MEDLINE.

Asialoglycoprotein receptor (ASGP-R) belongs to a wide family of C-type lectins and it is currently regarded as an attractive protein in the field of targeted drug delivery (TDD). It is abundantly expressed in hepatocytes and can be found predominantly on the sinusoidal surface especially of HepG2 cells. Therefore, ASGP-R can be used for the TDD of anticancer therapeutics against HCC and mol. diagnostic tools. To date, a variety of mono- and multivalent selective ASGP-R ligands have been discovered. Although many of these compounds have demonstrated a relatively high binding affinity towards the target, the reported synthetic schemes are not handled, complicated and include many non-trivial steps. In the current study, we describe a convenient and versatile synthetic approach to novel monovalent drug-conjugates containing N-acetyl-2-deoxy-2-aminogalactopyranose fragment as an ASGP-R-recognition “core-head” and well-known nonselective cytostatic – Doxorubicin (Dox). This is the first example of the direct conjugation of a drug mol. to the ASGP-targeted warhead by a really convenient manner via a simple linker sequence. The performed MTS-based biol. evaluation in HepG2 cells revealed the novel conjugates as having anticancer activity. Confocal microscopy showed that the mols. readily penetrated HepG2 membrane and were mainly localized within the cytoplasm instead of the nucleus. Per contra, Dox under the same conditions demonstrated good anticancer activity and was predominantly concentrated in the nucleus. Therefore, we speculate that the amide “trigger” that we have used in this study for linker attachment is a sufficiently stable inside the cells to be enzymically or spontaneously degraded. As a consequence, we did not observe the release of the drug. Ligands containing triggers that are more liable towards endogenous hydrolysis within the tissue of targeting are strongly required.

Bioorganic & Medicinal Chemistry Letters published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, HPLC of Formula: 10378-06-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Charfeddine, Ilhem published the artcileSurface tension and interfacial tension of polyolefins and polyolefin blends, Quality Control of 31570-04-4, the publication is Journal of Applied Polymer Science (2022), 139(14), 51885, database is CAplus.

This paper focuses on the calculation of the interfacial tension of two systems: low-d. polyethylene with isotactic polypropylene and high-d. polyethylene with syndiotactic polypropylene. For this, three methods to measure the interfacial tension are compared: the use of Palierne’s model, and Gramespacher and Meissner’s model, both based on addnl. elasticity or long relaxation times brought by shape recovery of dispersed phase, and ab-initio calculation, which requires the knowledge of the surface tension of the neat polymer measured at the same temperature For that, a database collected from the literature is built in the first section of this paper, whether for the studied systems or for other systems of various olefinic homopolymers or copolymers with polypropylene. The results show the effectiveness of the Gramespacher and Meissner’s model to calculate the interfacial tension of the studied systems for which the results were in agreement with ab-initio calculation and Palierne’s model. Extension of the ab-initio calculation to olefinic copolymers was proposed.

Journal of Applied Polymer Science published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C42H63O3P, Quality Control of 31570-04-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Reetz, Manfred T. published the artcileGeneral synthesis of active antiviral α-adamantyl carbonyl compounds, Safety of Ethyltert-butylacetate, the publication is Angewandte Chemie (1979), 91(1), 78-9, database is CAplus.

Silyl enol ethers R¹(Me₃SiO)C:CR²R³ [R¹ = MeO, Et, Me₂CH, EtO, Me₃C, R² = H, Me, Et, Me₃C, R¹R² = (CH₂)_n (n = 3, 4, 6), (CH₂)₂CHMeCH₂; R³ = H, Me] and 1-(trimethylsilyloxy)-4-methyl-3,4-dihydronaphthalene, easily obtained from R¹COCHR²R³ and Me₃SiCl, reacted with 1-bromoadamantane and TiCl₄ at -40 to -50° to give 62-89% α-adamantyl ketones I, useful as virucides. I (R¹R² = CH₂CH₂CHMeCH₂, R³ = H) was 3 times as active against the virus of Newcastle disease as 1-aminoadamantane, but only half as toxic.

Angewandte Chemie published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Safety of Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ramesh, C. published the artcileA simple, mild and efficient procedure for selective cleavage of prenyl esters using silica-supported sodium hydrogen sulphate as a heterogeneous catalyst, Name: 3-Methylbut-2-en-1-yl benzoate, the publication is Tetrahedron Letters (2003), 44(7), 1465-1467, database is CAplus.

Prenyl esters were selectively and efficiently cleaved under slightly acidic reaction conditions using silica-supported sodium hydrogen sulfate as a heterogeneous catalyst at room temperature to regenerate the parent carboxylic acids in very high yields.

Tetrahedron Letters published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Name: 3-Methylbut-2-en-1-yl benzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Heidari, Ali Akbar published the artcileThin film composite solvent resistant nanofiltration membrane via interfacial polymerization on an engineered polyethylene membrane support coated with polydopamine, Quality Control of 31570-04-4, the publication is Journal of Membrane Science (2021), 119406, database is CAplus.

In this work, a thin film composite (TFC) membrane possessing outstanding properties for solvent resistant nanofiltration (SRNF) membrane application was fabricated. For this purpose, high d. polyethylene (HDPE)-polystyrene (PS)-styrene-ethylene-butylene-styrene (SEBS) blends were fabricated in the first step with different compositions by using an internal mixer machine and hot press technique, resp. Then, the fabrication of a novel HDPE support was conducted by etching the PS phase out of the as-prepared HDPE-PS-SEBS blends through solvent extraction method (Etched HDPE). In the next step, the prepared Etched HDPE membrane support was dipped in a dopamine solution, by which auto-oxidization and self-polymerization of dopamine monomers onto the Etched HDPE membrane supports surface was done, leading to the formation of an ultrathin polydopamine (PDA) layer with a strong chem. binding force. By the formation of the polydopamine layer, hydrophilic functional groups were introduced onto the HDPE membranes surface_, causing the attraction of m-phenylenediamine (MPD) monomers onto the membrane surface and the formation of a uniform ultrathin PA top layer. Finally, the TFC layer was formed on the as-prepared membrane supports with different m-phenylenediamine and trimesoyl chloride (TMC) concentrations The performance and properties of the prepared TFC-PE@PDA membrane was investigated for rejection of different dyes including Reactive Red, Direct Yellow, Methyl blue, Rhodamine B, Crystal Violet and Methyl orange in SRNF applications, based on which outstanding separation performance (dye rejections of 99.8, 99.5, 99.2, 98.5, 96.8 and 94.4 for RR, DY, MB, RDB, CV and MO, resp., under the pressure of 9 bar), methanol flux as high as 1.8 L/m² h bar along with excellent methanol flux as high as 3.7 L/m² h bar after DMF activation, were obtained. Furthermore, it is noteworthy that an outstanding solvent resistance (dye rejections of more than 99.2, 98.8, 98.5, 97.9, 96 and 93.8% for RR, DY, MB, RDB, CV and MO, resp., being dipped in DMF at 70°C for 90 days) was also shown by the prepared TFC-PE@PDA membrane.

Journal of Membrane Science published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C42H63O3P, Quality Control of 31570-04-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Das, Sanjib Kumar published the artcileIdentification of phytocompounds from Houttuynia cordata Thunb. as potential inhibitors for SARS-CoV-2 replication proteins through GC-MS/LC-MS characterization, molecular docking and molecular dynamics simulation, Application In Synthesis of 624-49-7, the publication is Molecular Diversity (2022), 26(1), 365-388, database is CAplus and MEDLINE.

The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a massive viral disease outbreak of international concerns. The present study is mainly intended to identify the bioactive phytocompounds from traditional antiviral herb Houttuynia cordata Thunb. as potential inhibitors for three main replication proteins of SARS-CoV-2, namely Main protease (Mpro), Papain-Like protease (PLpro) and ADP ribose phosphatase (ADRP) which control the replication process. A total of 177 phytocompounds were characterized from H. cordata using GC-MS/LC-MS and they were docked against three SARS-CoV-2 proteins (receptors), namely Mpro, PLpro and ADRP using Epic, LigPrep and Glide module of Schrodinger suite 2020-3. During docking studies, phytocompounds (ligand) 6-Hydroxyondansetron (A104) have demonstrated strong binding affinity toward receptors Mpro (PDB ID 6LU7) and PLpro (PDB ID 7JRN) with G-score of – 7.274 and – 5.672, resp., while Quercitrin (A166) also showed strong binding affinity toward ADRP (PDB ID 6W02) with G-score -6.788. Mol. Dynamics Simulation (MDS) performed using Desmond module of Schrodinger suite 2020-3 has demonstrated better stability in the ligand-receptor complexes A104-6LU7 and A166-6W02 within 100 ns than the A104-7JRN complex. The ADME-Tox study performed using SwissADMEserver for pharmacokinetics of the selected phytocompounds 6-Hydroxyondansetron (A104) and Quercitrin (A166) demonstrated that 6-Hydroxyondansetron passes all the required drug discovery rules which can potentially inhibit Mpro and PLpro of SARS-CoV-2 without causing toxicity while Quercitrin demonstrated less drug-like properties but also demonstrated as potential inhibitor for ADRP. Present findings confer opportunities for 6-Hydroxyondansetron and Quercitrin to be developed as new therapeutic drug against COVID-19.

Molecular Diversity published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Application In Synthesis of 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pathiranage, Taniya M. S. K. published the artcileSynthesis and characterization of side-chain thermotropic liquid crystalline copolymers containing regioregular poly(3-hexylthiophene), Recommanded Product: 6-(4-((4-Methoxyphenyl)diazenyl)phenoxy)hexyl methacrylate, the publication is Polymer (2015), 317-326, database is CAplus.

An azobenzene liquid crystalline mesogen, 6-(4-((4-methoxyphenyl)diazenyl)phenoxy)hexyl methacrylate (MMAZO) was incorporated into a block copolymer with regioregular poly(3-hexylthiophene) (P3HT). The synthesis was performed by a combination of Grignard metathesis (GRIM) and atom transfer radical polymerization (ATRP) techniques. The composition of synthesized copolymers was determined from ¹HNMR anal. The P3HT block/random copolymers containing thermotropic liquid crystalline segments were expected to bring unique self-assembly and opto-electronic properties. The field-effect mobility of the P3HT copolymers was measured in organic thin film transistors (OTFT). The surface morphol. of the P3HT copolymer films upon annealing was investigated by tapping mode at. force microscopy (TMAFM). Finally, the transition of liquid crystalline mesophase in response to the temperature in the P3HT copolymers was investigated by differential scanning calorimetry (DSC) and polarizing optical microscopy (POM).

Polymer published new progress about 135529-02-1. 135529-02-1 belongs to esters-buliding-blocks, auxiliary class azo,Alkenyl,Benzene,Ester,Ether, name is 6-(4-((4-Methoxyphenyl)diazenyl)phenoxy)hexyl methacrylate, and the molecular formula is C23H28N2O4, Recommanded Product: 6-(4-((4-Methoxyphenyl)diazenyl)phenoxy)hexyl methacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dotta, Pascal published the artcileDialkyl Effect on Enantioselectivity: π-Stacking as a Structural Feature in P,N Complexes of Palladium(II), Category: esters-buliding-blocks, the publication is Organometallics (2002), 21(14), 3033-3041, database is CAplus.

A phosphino,oxazoline P,N-bidentate ligand, 4, containing 3,5-di-tert-butylphenyl groups was prepared In the Heck arylation of dihydrofuran, 4 affords higher ee’s than either 2 or 3, the unsubstituted and m-dimethylphenyl analogs, resp. Several Pd(0) complexes of 4 are reported. The exchange dynamics of Pd(4)(dba) involve an interconversion of diastereomers via an intramol. process. The x-ray structure for PdCl₂(4), 8, was determined by x-ray diffraction methods. Comparison of data with PdCl₂(2), 9, and PdCl₂(3), 10, suggests that differing amounts of π-π stacking influence the structures of these relatively simple Pd complexes, with 9 and 10 revealing the strongest π-π interactions. An estimation of the van der Waals energies involved in the interaction supports a ∼ 4 kcal/mol stabilization via π-π stacking.

Organometallics published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics