Esters-buliding-blocks

Takahashi, Daisuke published the artcileCompound screening identified gossypetin and isoquercitrin as novel inhibitors for amyloid fibril formations of Vλ6 proteins associated with AL amyloidosis, COA of Formula: C10H12O5, the publication is Biochemical and Biophysical Research Communications (2022), 22-28, database is CAplus and MEDLINE.

AL amyloidosis is a life-threatening disease characterized by the deposition of amyloidogenic Ig light chain secreted from clonal plasma cells. Here we established an in-vitro screening system of amyloid inhibition of a variable domain in λ6 light chain mutant (Vλ6), Wil, and screened a food-additive compound library to identify compounds inhibiting the fibril formation. We found gossypetin and isoquercitrin as novel inhibitors. NMR anal. showed that both compounds directly interacted with natively-folded Wil, and proteolysis experiments demonstrated that these compounds conferred proteolytic resistance, suggesting that the compounds enhance the kinetic stability of Wil. Since gossypetin and isoquercitrin specifically interacted with the protein at micromolar concentrations, these compounds could be used as lead to further develop inhibitors against AL amyloidosis.

Biochemical and Biophysical Research Communications published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C15H20O6, COA of Formula: C10H12O5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Doi, Toru published the artcileRadical polymerization of methyl acrylate by use of benzyl N,N-diethyldithiocrbamate in combination with tetraethylthiuram disulfide as a two-component iniferter, Formula: C12H17NS2, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (1994), 32(15), 2911-18, database is CAplus.

Polymerization of Me acrylate with benzyl N,N-diethyldithiocarbamate (BDC) was carried out in bulk or in benzene under UV irradiation The polymerization proceeded to give high yield of polymer, however it was found that BDC did not function as an iniferter in the MA polymerization Bimol. termination leading to deactivation of the iniferter site was observed during the polymerization in preference to chain transfer and primary radical termination which reproduce the iniferter site. The deactivation was successfully prevented by combining BDC and tetraethylthiuram disulfide as a two-component iniferter. This two-component iniferter system was also applied to synthesis of a star polymer with 1,2,4,5-tetrakis(N,N-diethyldithiocarbamylmethyl)benzene as a tetrafunctional photoiniferter.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Formula: C12H17NS2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Doi, Toru published the artcileElucidation of mechanism for living radical polymerization of styrene with N,N-diethyldithiocarbamate derivatives as iniferters by the use of spin trapping technique, Name: Benzyl diethylcarbamodithioate, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (1994), 32(12), 2241-9, database is CAplus.

The photodissociation of several N,N-diethyldithiocarbamate derivatives (RDC), i.e., benzyl, 1-phenylethyl, 2-phenylethyl, Bu, sec-, and tert-Bu N,N-diethyldithiocarbamates, was investigated by the spin trapping technique to elucidate the polymerization mechanism of styrene (I) with RDC as iniferters. The scission of RDC occurred at two different C-S bonds depending on the structure of the alkyl groups of RDC and the cleavage manner was dominated by both resonance and steric effects. RDC generating an N,N-diethyldithiocarbamyl radical acts as an effective iniferter and induces the living radical polymerization of I in homogeneous system. The polymerizations of I with tetraethylthiuram disulfide and p-xylylene bis(N,N-diethyldithiocarbamate) were also discussed on the basis of the results of the spin trapping for RDC as the model compounds of the polystyrene chain ends.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Name: Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lee, Heung Jae published the artcileSurface photograft polymerization on segmented polyurethane using the iniferter technique, Product Details of C12H17NS2, the publication is Journal of Biomedical Materials Research (1999), 47(4), 564-567, database is CAplus and MEDLINE.

A segmented polyurethane (SPU) film was chloromethylated and subsequently dithiocarbamated. The treated films were immersed in solutions containing poly(ethylene glycol) methacrylate (PEGMA) or N,N-dimethylacryl amide (DMAAm) and irradiated with UV light. The resultant surfaces were highly wettable with water. The surface chem. compositions, as determined by XPS, indicated that surface graft polymerization, initiated from surface-derivatized dithiocarbamate, had occurred and had altered the surface properties and the composition of SPU. The platelet adhesion test using platelet-rich plasma showed minimal adhesion for the poly(PEGMA)-grafted surface, followed by the poly(DMAAm)-grafted surface.

Journal of Biomedical Materials Research published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Product Details of C12H17NS2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Trisovic, N. published the artcileMesomorphism of novel stilbene-based bent-core liquid crystals, Formula: C15H14O3, the publication is Liquid Crystals (2021), 48(7), 1054-1064, database is CAplus.

A series of asym. bent-core liquid crystals I (X = COO; Y = H, Cl), bearing the stilbene moiety in the side wing, was synthesized and characterised. Structural modifications of the non-stilbene wing resulted in formation of various mesophases. Compounds I (X = COO; Y = H) and I (X = COO; Y = Cl) with an ester linking group between the Ph rings in this wing have an enantiotropic non-polar smectic-type mesophase, while compound I (Y = H), incorporating the biphenyl moiety, has a ferroelec. SmC_aP_F phase. The mols. of I (Y = H) undergo photoisomerisation in solution under UV irradiation, while the mesophases are unstable and UV irradiation leads to irreversible changes. The mesophases of I (X = COO; Y = H) and I (X = COO; Y = Cl) do not show any electro-optical switching and polarisation current. Applying low frequency AC voltage on a planarly aligned film of compound I (Y = H), smectic domains grow, while the birefringence and an image flickering increase. The observed features of these compounds identify stilbene as an attractive moiety in the design of advanced materials based on bent-core mols.

Liquid Crystals published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C13H19Br2ClN2O, Formula: C15H14O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Borrelli, S. published the artcileDelayed and recurrent dimethyl fumarate induced-lymphopenia in patients with multiple sclerosis, HPLC of Formula: 624-49-7, the publication is Multiple Sclerosis and Related Disorders (2022), 103887, database is CAplus and MEDLINE.

Early lymphopenia is a known side effect of di-Me fumarate, a disease-modifying therapy for MS. However, the long-term effects on immune response and the impact on lymphocyte counts when another disease-modifying treatment is introduced, remain unknown. To better understand these specific aspects, we reviewed cases that develop prolonged grade 2 to 4 lymphopenia under di-Me fumarate in Lausanne MS clinic. Retrospective anal. of the 12 patients (10.1%) who discontinued di-Me fumarate because of prolonged lymphopenia amongst the 119 patients treated with di-Me fumarate. We reviewed their demographics, as well as their clin., biol. and MRI characteristics compared to the non-lymphopenic patients, during di-Me fumarate therapy, and within a timeframe of up to 18 mo after switching to another disease-modifying treatment. We also focused on lymphocyte subsets in a subgroup of patients. Compared to non-lymphopenic patients, lymphopenic patients were older at di-Me fumarate initiation (51.4 yo vs 39.7, p = 0.0003) and the majority were male (p = 0.037). Three of them (25%) developed delayed lymphopenia, more than one year after treatment onset. Despite persistent lymphopenia, three patients experienced disease activity. Amongst the nine patients (75%) who were switched to another therapy, five (55.6%) presented recurrent lymphopenia, predominantly with a CD8⁺ T cell decrease. Di-Me fumarate has a long-term impact on lymphocyte biol., even after its discontinuation, with a sustained reduction in CD8+ T cells that may increase opportunistic infection risk, and should be taken in consideration when switching therapies after di-Me fumarate.

Multiple Sclerosis and Related Disorders published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, HPLC of Formula: 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Knothe, Gerhard published the artcileCetane numbers of branched and straight-chain fatty esters determined in an ignition quality tester, Quality Control of 110-34-9, the publication is Fuel (2003), 82(8), 971-975, database is CAplus.

The cetane number, a widely used diesel fuel quality parameter related to the ignition delay time (and combustion quality) of a fuel, has been applied to alternative diesel fuels such as biodiesel and its components. In this work, the cetane numbers of 29 samples of straight-chain and branched C₁-C₄ esters as well as 2-ethylhexyl esters of various common fatty acids were determined The cetane numbers of these esters are not significantly affected by branching in the alc. moiety. Therefore, branched esters, which improve the cold-flow properties of biodiesel, can be employed without greatly influencing ignition properties compared to the more common Me esters. Unsaturation in the fatty acid chain was again the most significant factor causing lower cetane numbers Cetane numbers were determined in an ignition quality tester (IQT) which is a newly developed, automated rapid method using only small amounts of material. The IQT is as applicable to biodiesel and its components as previous cetane-testing methods.

Fuel published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Quality Control of 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Stimac, Vlado published the artcileInitial Scale-Up and Process Improvements for the Preparation of a Lead Antibacterial Macrolone Compound, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Organic Process Research & Development (2010), 14(6), 1393-1401, database is CAplus.

Macrolones are a novel class of potent antimicrobial agents that consist of a macrolide scaffold to which a quinolone unit is tethered by various linkers to the 4”-O-position of the cladinose sugar. In this paper is described a modified 13-step route to a lead compound in the series. Critical reaction steps in the medicinal chem. route were modified for an initial scale-up process, and as a result, a synthetic procedure suitable for preparation of multi-hundred gram quantities of the final product, with 98% purity, has been developed. The new procedure does not require any purification by column chromatog. for any of the reaction steps. The overall yield was increased from 5-8% in the medicinal chem. route to 27% in the improved procedure.

Organic Process Research & Development published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C12H10FeO4, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Huang, Pin-Chi published the artcileMorphology-Mediated Photoresponsive and Fluorescence Behaviors of Azobenzene-Containing Block Copolymers, Related Products of esters-buliding-blocks, the publication is Langmuir (2018), 34(25), 7416-7427, database is CAplus and MEDLINE.

We investigated the relationship between the self-assembled morphol. of poly(tert-Bu acrylate)-block-poly(6-[4-(4′-methoxyphenylazo)phenoxy]hexyl methacrylate) (PtBA-b-PAzoMA) block copolymers and their photoresponsive and fluorescence behaviors. The morphol. of PtBA-b-PAzoMA copolymers was manipulated by dissolving them in mixed DMF (DMF)/hexanol solvents. When PtBA-b-PAzoMA was dissolved in DMF-rich (neutral) solvents, a favorable interaction between the DMF mols. and both blocks resulted in a random-coiled conformation. The unconfined morphol. facilitated the formation of both nonassocd. and head-to-head organized azobenzene mesogens, which promoted fluorescence emission. When hexanol, a PtBA-selective solvent, was added to DMF, the solvency of PtBA-b-PAzoMA worsened, leading to its assembly into micelles, with PAzoMA in the micelle core. The confinement of azobenzene moieties in the micelle core hindered their trans-to-cis photoisomerization, thereby considerably decreasing the kinetics of photoisomerization and the population of cis isomers. Addnl., a nanoconfined geometry resulted in compactly packed chromophores, causing fluorescence loss. When PtBA-b-PAzoMA was exposed to UV light, the increased number of cis isomers hampered the closely packed mesogens, resulting in a substantial enhancement of fluorescence emission. When the mole fraction of the PAzoMA block was increased, PtBA-b-PAzoMA formed clusters, causing the slow kinetics of photoisomerization and fluorescence quenching.

Langmuir published new progress about 135529-02-1. 135529-02-1 belongs to esters-buliding-blocks, auxiliary class azo,Alkenyl,Benzene,Ester,Ether, name is 6-(4-((4-Methoxyphenyl)diazenyl)phenoxy)hexyl methacrylate, and the molecular formula is C23H28N2O4, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nakayama, Yasuhide published the artcileHigh performance gene delivery polymeric vector: Nano-structured cationic star polymers (star vectors), Recommanded Product: Benzyl diethylcarbamodithioate, the publication is Current Drug Delivery (2005), 2(1), 53-57, database is CAplus and MEDLINE.

Nano-structured hyperbranched cationic star polymers, called star vectors, were molecularly designed for a novel gene delivery non-viral vector. The linear and 3, 4 or 6 branched water-soluble cationic polymers, which had same mol. weight of ∼18,000, were synthesized by iniferter (initiator-transfer agent-terminator)-based photo-living-radical polymerization of 3-(N,N-dimethylamino)propyl acrylamide, initiated from resp. multi-dithiocarbamate-derivatized benzenes as an iniferter. All polymers produced polyion complexes ‘polyplexes’ by mixing with pDNA (pGL3-control plasmid), in which the particle size was ∼250 nm in diameter [the charge ratio < 2/1 (vector/pDNA)] and ∼150 nm (the charge ratio > 2.5/1), and the ζ-potential was ∼+10 mV (the charge ratio > 1/1). When COS-1 cells were incubated with the polyplexes 12h after preparation under the charge ratio of 5/1, higher gene expression was obtained as an increase in branching, with a little cytotoxicity. The relative gene expression to the linear polymer was about 2, 5, and 10 times in 3-, 4-, and 6-branched polymers, resp. The precise change in branching of polymers enabled the control of the gene transfer activity.

Current Drug Delivery published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Recommanded Product: Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics