Esters-buliding-blocks

Marsh, Alexandra M. R. published the artcileHistone deacetylase inhibitors: recent outcomes from clinical trials and the implications for oncology treatment approaches, Product Details of C10H18O4, the publication is Clinical Investigation (London, United Kingdom) (2013), 3(6), 571-594, database is CAplus.

A review. Histone deacetylases play an important role in multiple processes, including gene expression, proliferation, apoptosis, cytoskeletal organization, migration and angiogenesis. Histone deacetylase inhibitors are able to induce cell death and growth arrest as targeted anticancer agents. While only two, vorinostat and romidepsin, are licensed in oncol., several have reached Phase III trials and many more are in Phase I and II. In addition to this, multiple novel drugs, including more targeted agents, are emerging from preclin. studies. This paper examines the outcomes of recent clin. trials in 11 key histone deacetylase inhibitors, both as monotherapy and in combination with other antitumor drugs. An overview of the advantages and disadvantages between the different classes and individual drugs is discussed, as well as a brief outlook on the future developments in the field.

Clinical Investigation (London, United Kingdom) published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Product Details of C10H18O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Takizawa, Toshiya published the artcileSynthetic studies on spiruchostatin A, a potent histone deacetylase inhibitor, Quality Control of 106391-88-2, the publication is Journal of Tohoku Pharmaceutical University (2007), 33-47, database is CAplus.

Spiruchostatin A (I), isolated from a culture broth of Pseudomonas sp., has been shown to be a potent histone deacetylase (HDAC) inhibitor. HDAC inhibitors can suppress the growth of human tumor xenografts, this natural product, therefore, is expected to be a promising candidate for novel mol.-targeted anticancer agents. We envisioned that I would be synthesized through twofold macrolactam/macrolactone cyclization of a fully elaborated acyclic disulfide. The key segments, required for the preparation of the advanced key intermediate, were initially synthesized, and the two segments were subsequently subjected to the critical cross S-S coupling reaction to produce a desired key intermediate. Upon deprotection of the N-Boc and the Me ester groups, the crucial cyclization formation was achieved using PyBOP to provide a desired macrolactam, a potential key precursor for I. Further investigations concerning the transformation of 16 to the target mol. I were also described.

Journal of Tohoku Pharmaceutical University published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C8H11NO, Quality Control of 106391-88-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sayar, Noel published the artcileFacile total synthesis of thailandepsins D-F: Novel bicyclic depsipeptide histone deacetylase inhibitors isolated from a microorganism, Safety of (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, the publication is Synthesis (2019), 51(6), 1419-1426, database is CAplus.

The naturally occurring bicyclic depsipeptide histone deacetylase inhibitors thailandepsins D-F were efficiently synthesized for the first time in 49-61% overall yield over five steps, starting from known amine and carboxylic acid segments. The synthesis includes the condensation of the two known starting materials to directly assemble the corresponding seco-acids, which are the key precursors for macrolactonization. The seco-acids are then macrolactonized using the Shiina method to construct the requisite 15-member macrocycles.

Synthesis published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, Safety of (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zapol’skii, Viktor A. published the artcileChemistry of polyhalogenated nitrobutadienes, 14: efficient synthesis of functionalized (Z)-2-allylidenethiazolidin-4-ones, Name: Ethyl 2-mercaptopropanoate, the publication is Beilstein Journal of Organic Chemistry (2014), 1638-1644, 7 pp., database is CAplus and MEDLINE.

The reaction of mercaptoacetic acid esters with pentachloro-2-nitro-1,3-butadiene provides an appropriate precursor for the synthesis of special thiazolidin-4-ones. Applying different anilines as the second constituent for the requisite cyclization step, a series of (Z)-2-allylidenethiazolidin-4-ones I (Ar = 4-ClC₆H₄, 4-MeOC₆H₄, 4-MeC₆H₄) was obtained in yields up to 81%. Some subsequent reactions have been examined too, such as the formation of perfunctionalized 1H-pyrazoles upon treatment with hydrazine. Thiazolidinones are as well known for their physiol. activities as for their application in optoelectronics.

Beilstein Journal of Organic Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C16H29BO2, Name: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Florit, Federico published the artcileDesign of dynamic trajectories for efficient and data-rich exploration of flow reaction design spaces, Category: esters-buliding-blocks, the publication is Reaction Chemistry & Engineering (2021), 6(12), 2306-2314, database is CAplus.

Batch and continuous reactors both enable exploration of a chem. design space. The former rely on transient experiments, thus experiencing a wide variety of operating conditions over time, whereas the latter are usually operated at steady state and are representative of only one set of conditions. Operating a continuous reactor under dynamic conditions allows more efficient exploration of the underlying reaction space for extraction of kinetics and optimization of performance. We present a methodol. to efficiently explore a design space using a tubular flow reactor installed on an automatic platform (equipped with FTIR and HPLC anal.) operated in a transient regime using sinusoidal variations of the parameters. This data-dense method proves to be quicker with respect to steady-state operations because of the larger amount of information collected during a single experiment A computational anal. provides a simple criterion for the design of dynamic experiments in order for them to be representative of steady-state conditions. The methodol. is applied exptl. to the synthesis of a pharmaceutical intermediate via an esterification reaction in the presence of base. In the experiments, up to three parameters (reaction time, base equivalent, and temperature) are changed simultaneously. Proper design of the trajectories in the design space allows verification of the consistency of the results by exploiting the self-crossings within each trajectory and crossings between different trajectories. The experiments further validate the developed criterion for dynamic operations.

Reaction Chemistry & Engineering published new progress about 59721-16-3. 59721-16-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Phenol,Ester,Amide, name is 2-(Dimethylamino)-2-oxoethyl 2-(4-hydroxyphenyl)acetate, and the molecular formula is C12H15NO4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hayashi, Keitaro published the artcileAntitumor effect of dimethyl itaconate on thymic carcinoma by targeting LDHA-mTOR axis, Safety of Dimethyl itaconate, the publication is Life Sciences (2021), 119847, database is CAplus and MEDLINE.

Thymic carcinoma is a rare type of cancer without an established standard pharmaceutical treatment. This study investigated the antitumor effect of di-Me itaconate (DI), a cell-permeable derivative of itaconate, on human thymic carcinoma cell line. Human thymic carcinoma cell line Ty82 was used to evaluate the effect of DI on cell viability. Western blotting and immunohistochem. were performed to determine the mol. mechanism of antitumor effects of DI on Ty82. DI suppressed cell growth and promoted apoptosis of Ty82. The suppressive effect of DI on Ty82 was mediated by the downregulation of lactate dehydrogenase A (LDHA), and the subsequent decrease in the activity of mechanistic target of rapamycin (mTOR). DI exhibited synergistic antitumor effects with a specific inhibitor of large neutral amino acid transporter 1 (LAT1), an amino acid transporter currently being investigated as a novel target for cancer therapy. Our findings demonstrate that DI is a novel potential strategy for thymic carcinoma treatment.

Life Sciences published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Safety of Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yanagisawa, Akira published the artcileCatalytic asymmetric aldol reaction of trimethoxysilyl enol ethers using 2,2′-bis(di-p-tolylphosphino)-1,1′-binaphthyl·AgF complex, Quality Control of 126613-06-7, the publication is Bulletin of the Chemical Society of Japan (2001), 74(8), 1477-1484, database is CAplus.

Catalytic asym. Mukaiyama-type aldol reaction using MeO₃Si enol ethers was achieved using 2,2′-bis(di-p-tolylphosphino)-1,1′-binaphthyl (p-Tol-BINAP)·AgF complex as a catalyst. The chiral Ag(I) catalyst was easily generated by mixing p-Tol-BINAP and AgF in MeOH at room temperature High syn- and enantioselectivities were obtained from both the E- and Z-silyl enol ethers. Use of a 1:1 mixture of MeOH and acetone as a solvent in the reaction of cyclohexanone-derived MeO₃Si enol ethers resulted in higher enantioselectivity.

Bulletin of the Chemical Society of Japan published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H32O2, Quality Control of 126613-06-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tanaka, Shinji published the artcileEpoxide as precatalyst for metal-free catalytic transesterification, Related Products of esters-buliding-blocks, the publication is Tetrahedron Letters (2019), 60(30), 2009-2013, database is CAplus.

Transesterification of Me-esters was accelerated by an in situ-generated metal-free catalyst comprising a quaternary alkylammonium salt and an epoxide was developed. The combination of a quaternary alkylammonium acetate and glycidol was optimal, and various esters R¹CO₂R² [R¹ = 2-thiophenyl, Ph, Bn, etc.; R² = 2-Bu, n-C₆H₁₃, Bn, prenyl] were synthesized from Me-esters with alcs. in good to excellent yield. Anal. of the catalyst solution revealed that basic species were generated by the ring-opening reaction of epoxide.

Tetrahedron Letters published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H9N3O4, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yamashita, Keiji published the artcilePreparation of photoresist polymer by a photoreactive monomer containing N,N-diethyldithiocarbamate group, Computed Properties of 3052-61-7, the publication is Journal of Applied Polymer Science (1988), 35(2), 465-73, database is CAplus.

The title monomer, 4-vinylbenzyl diethyldithiocarbamate (I), was synthesized and copolymerized with some vinyl monomers by AIBN. The copolymers obtained had efficient photocrosslinking abilities, and were thermally stable. There was no loss of the dithiocarbamoyl group during radical polymerization, and the polymerization proceeded through the vinyl group. The degree of photocrosslinking was proportional to the concentration of the photosensitive group, but the photosensitivity of the polymer was not. Water-soluble photoreactive copolymers, of I with acrylamide (II) or methacrylic acid were also prepared The I–II copolymer had good photosensitivity at 3% I incorporation. Photocrosslinking yields of these polymers depended on the viscosity of the original polymers except for low I amounts The relation between copolymer composition and glass transition temperature (T_g) indicated that the copolymer structure largely depended on ΔT_g. The mechanism of photocrosslinking was studied by photodecomposition of benzyl diethyldithiocarbamate, showing that decreases of S content were clearly related to the photocrosslinking points.

Journal of Applied Polymer Science published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C7H3BrF3I, Computed Properties of 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yamashita, Keiji published the artcilePreparation of photoresist polymer by a photoreactive monomer containing N,N-diethyldithiocarbamate group, Application of Benzyl diethylcarbamodithioate, the publication is Journal of Applied Polymer Science (1988), 35(2), 465-73, database is CAplus.

p-Et₂NCS₂CH₂C₆H₄CH:CH₂ (I) was synthesized and copolymerized with styrene, Me methacrylate, acrylonitrile, and vinyl acetate by AIBN initiation. The copolymers obtained had efficient photocrosslinking abilities, and were thermally stable. Therefore, there was no loss of dithiocarbamoyl group during radical polymerization, and the polymerization proceeded through vinyl groups. The degree of UV photocrosslinking was proportional to the concentration of the photosensitive group, but photosensitivity of the polymer was not. Water-soluble photoreactive copolymers of I with acrylamide (II) and methacrylic acid were also prepared I–II copolymer had good photosensitivity at only 3 mol% I incorporation. Photocrosslinking yields of these polymers depends on the viscosity of the original polymers except in the case of low concentration of I. The relation between copolymer composition and glass transition temperature (T_g) was also investigated. Investigation of T_g, showed that the copolymer structure largely affected the ΔT_g. The mechanism of photocrosslinking was studied by photodecomposition of benzyl N,N-diethyldithiocarbamate, and the decreases of sulfur content was clearly related to photocrosslinking points.

Journal of Applied Polymer Science published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C8H10BNO3, Application of Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics