Esters-buliding-blocks

Li, Shuangshuang published the artcilePractical allylation with unactivated allylic alcohols under mild conditions, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one, the publication is Organic Chemistry Frontiers (2021), 8(13), 3354-3359, database is CAplus.

A practical palladium/calcium catalytic system was developed for dehydrative allylation with unactivated allylic alcs. EtOH solvent with a H₂O additive was identified as powerful medium to accelerate proton transfer. This catalytic system and environmentally benign medium enabled a variety of soft carbonic nucleophiles and allylic alcs. to react smoothly at room temperature with water as the only byproduct. A wide spectrum of allylic compounds bearing a variety of functional groups I [R = Me, CN, CO₂Et, etc.; R¹ = CO₂Me, CO₂Et; R² = CN, NO₂, CO₂Me, CO₂Et; R³ = H, Me; R⁴ = H, Me; R⁵ = Ph, 2-FC₆H₄, 2-thienyl, etc.] could be obtained with high to excellent yields.

Organic Chemistry Frontiers published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xu, Yan-Li published the artcileHighly enantioselective one-pot sequential synthesis of valerolactones and pyrazolones bearing all-carbon quaternary stereocentres, Quality Control of 517-23-7, the publication is Organic & Biomolecular Chemistry (2021), 19(7), 1610-1615, database is CAplus and MEDLINE.

Highly enantiopure and bioactive δ-valerolactones I (R = Me, Ph, 1-naphthyl, 2-chlorophenyl, etc.; R¹ = Ph, 1-naphthyl, 2-methylphenyl, etc.; n = 0, 1), and pyrazolones II, bearing α-all-carbon quaternary stereocentres, were successfully and sequentially prepared via a one-pot procedure starting from readily available, inexpensive materials, catalyzed by a new chiral squaramide III under mild reaction conditions. An organocatalytic Michael reaction afforded the valerolactones I, while a one-pot Michael-hydrazinolysis-imidization cascade yielded the pyrazolones II. This procedure is economically efficient and environmentally benign.

Organic & Biomolecular Chemistry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C10H14O, Quality Control of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Chengwei published the artcileHighly-chemoselective step-down reduction of carboxylic acids to aromatic hydrocarbons via palladium catalysis, COA of Formula: C9H8O4, the publication is Chemical Science (2019), 10(22), 5736-5742, database is CAplus and MEDLINE.

The highly selective method for the direct step-down reduction of carboxylic acids RCOOH (biphenyl-4-yl, 1-naphthyl, 1-methyl-1H-indole-3-yl, etc.) to arenes RH, proceeding via well-defined Pd(0)/(II) catalytic cycle was described. The method shows a remarkably broad substrate scope, enabling to direct the classical acyl reduction towards selective decarbonylation by a redox-neutral mechanism. The utility of this reaction is highlighted in the direct defunctionalization of pharmaceuticals and natural products, and further emphasized in a range of traceless processes using removable carboxylic acids under mild, redox-neutral conditions orthogonal to protodecarboxylation. Extensive DFT computations were conducted to demonstrate preferred selectivity for the reversible oxidative addition and indicated that a versatile hydrogen atom transfer (HAT) pathway is operable.

Chemical Science published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, COA of Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wu, Xiaolu published the artcileMicro-Nanometer Particle Composition and Functional Design of Surface Nano-Structured Ammonium Polyphosphate and Its Application in Intumescent Flame-Retardant Polypropylene, Quality Control of 31570-04-4, the publication is Nanomaterials (2022), 12(4), 606, database is CAplus and MEDLINE.

A novel composite and functional micro-nanometer particle is designed by the hydrolysis of aluminum isopropoxide on the surface of ammonium polyphosphate (APP) to prepare surface nanostructured ammonium polyphosphate (NSAPP). NSAPP is characterized by XPS, XRF, SEM, water solubility tests, and TGA. Results indicate that nanosized aluminum hydroxide is deposited on the surface of NSAPP, which enhanced its water resistance and thermostability. Then, APP and NSAPP coupled with dipentaerythritol (DPER) is used for the flame retardant of polypropylene (PP). The limiting oxygen index value of the PP/DPER/NSAPP composite is higher than that of PP/DPER/APP. Besides, the UL 94 vertical burning test of PP/DPER/NSAPP composites can reach the V-0 rating easily. According to the study of the combustion behavior of FR-PP composites, NSAPP contributes to form a dense and multi-layered char in the combustion process. Thus, such an intumescent char with a ceramic-like, continuous, and dense structure over the PP matrix protects the underlying matrix and enhances the thermal stability of the condensed phase, thereby improving the flame retardant performance of FR-PP.

Nanomaterials published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C14H28O5S, Quality Control of 31570-04-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

He, Ying-Jie published the artcileMigration of (non-) intentionally added substances and microplastics from microwavable plastic food containers, Safety of Tris(2,4-di-tert-butylphenyl) phosphite, the publication is Journal of Hazardous Materials (2021), 126074, database is CAplus and MEDLINE.

Microwavable plastic food containers (MPFCs) are extensively used for food storage, cooking, rapid heating and as take-out containers. There is an urgent need to investigate whether MPFCs pose potential health risks, as a result of the migration of chems. into foods. Herein, 42 intentionally added substances (IAS) and > 100 non-IAS (NIAS) migrating from MPFCs were identified in food simulants according to Regulation (EU). The migration of major IAS and NIAS was higher in 95% ethanol compared to other simulants, and gradually decreased following repeated use. NIAS, including Cramer class III toxic compounds, such as PEG oligomers of N,N-bis(2-hydroxyethyl) alkyl(C8-C18)amines, isomers of hexadecanamide and oleamide, and Irgafos 168 OXO were detected and exceeded the recommended limits in some MPFCs. Furthermore, microplastics (MPs) were detected with high values of over one million particles/L in some MPFCs in a single test, and migration behaviors of MPs in different MPFCs were diverse. Surprisingly, this rigorous migration might result in an annual intake of IAS/NIAS up to 55.15 mg and 150 million MPs particles if take-out food was consumed once a day. Multi-safety evaluation studies on the migration of various chems. from MPFCs to foodstuffs during food preparation should be assessed.

Journal of Hazardous Materials published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C42H63O3P, Safety of Tris(2,4-di-tert-butylphenyl) phosphite.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gao, Ya published the artcileDefluorinative Alkylation of Trifluoromethyl Alkenes with Soft Carbon Nucleophiles Enabled by a Catalytic Amount of Base, Formula: C6H8O3, the publication is Advanced Synthesis & Catalysis (2022), 364(13), 2241-2247, database is CAplus.

Direct manipulation of readily accessible trifluoromethyl alkenes (TAs) represents an attractive approach to the preparation of diversified fluorine-containing compounds In this study, defluorinative alkylation reactions of TAs with a broad array of soft carbon nucleophiles have been documented. Nucleophilic substitutions occur enabled by a catalytic amount of base, providing access to tertiary alkyl substituted gem-difluoroalkenes and 2-fluoro-4H-pyrans. By extending the nucleophiles to silyl enol ethers, defluorination can be achieved in the absence of base to give gem-difluoroalkenes. This process, which eliminates the requirement of organometallic reagents, transition metals, or strong bases for the C-F bond cleavage, is applicable to late-stage modification of complex mols.

Advanced Synthesis & Catalysis published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wu, Tianxiao published the artcileRational drug design to explore the structure-activity relationship (SAR) of TRK inhibitors with 2,4-diaminopyrimidine scaffold, Quality Control of 350-19-6, the publication is European Journal of Medicinal Chemistry (2022), 114096, database is CAplus and MEDLINE.

Tropomyosin receptor kinase (TRK) is an ideal target for treating cancers caused by the NTRK gene fusion. In this study, more than 60 2,4-diaminopyrimidine derivatives were prepared to understand the structure-activity relationship and confirm the rationality of the pharmacophore model reported previously. Among them, compound I was found to be a potent pan-TRK inhibitor that inhibits the proliferation of Km-12 cell lines. Addnl., compound I induced the apoptosis of Km-12 cells in a concentration-dependent manner. Western blot anal. revealed that compound I inhibited the phosphorylation of TRK to block downstream pathways. Compound I also possessed outstanding plasma stability and liver microsomal stability in vitro, with half-lives greater than 289.1 min and 145 min, resp. Pharmacokinetic studies indicated that the oral bioavailability of compound I is 17.4%. These results demonstrate that compound I could serve as a novel lead compound for overcoming NTRK-fusion cancers.

European Journal of Medicinal Chemistry published new progress about 350-19-6. 350-19-6 belongs to esters-buliding-blocks, auxiliary class Fluoride,Benzene,Ester, name is Ethyl 3,5-difluorobenzoate, and the molecular formula is C19H14Cl2, Quality Control of 350-19-6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Peng published the artcileUV Curable Robust Durable Hydrophobic Coating Based on Epoxy Polyhedral Oligomeric Silsesquioxanes (EP-POSS) and Their Derivatives, Recommanded Product: Trimethylolpropane triacrylate, the publication is ACS Omega (2022), 7(20), 17108-17118, database is CAplus and MEDLINE.

Hydrophobic coatings have considerable potential applications in many fields. Easy-to-operate and high durability are essential for practical use, fast cured and solvents-free are plus, and if possessed of characteristics (antigraffiti, good adhesion, high hardness, heat resistance, wide range of applicability, etc.) at the same time, which is a dream solution Herein, a facile one-step approach with the above features was reported for a UV curable robust hydrophobic coating based on Epoxy Polyhedral Oligomeric Silsesquioxanes (EP-POSS). The structure and surface morphol. of these EP-POSS and their derivatives were systematically studied. Because of the core-in-cage structure which was constructed by repeating units R-Si(O_1/2)₃– and the strong covalent bond of Si-C and Si-O, the coatings displayed high pencil hardness (6-8H), high thermal stability with initial decomposition temperature around 350-400°C, and high water contact angle (up to 108.06°) even after outdoor exposure for a month. These POSS and their derivatives are expected to find uses in various applications such as stain resistance, self-cleaning, scratch resistance, and cigarette moxibustion resistance of wood furniture, kitchenware, medical and industrial appliances.

ACS Omega published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C7H8BrClFN, Recommanded Product: Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Chenglong published the artcilePreparation and Characterisation of Polyurethane Acrylate-Based Titanium Dioxide Pigment for Blue Light-Curable Ink, Computed Properties of 10287-53-3, the publication is Polymers (Basel, Switzerland) (2021), 13(22), 3977, database is CAplus and MEDLINE.

Herein, a polyurethane acrylate-based TiO₂ (PU-TiO₂ ) was fabricated using a two-step method. First, a polyurethane prepolymer was prepared Second, PU-TiO₂ was prepared using amino-modified TiO₂ (A-TiO₂ ). The best synthesis process of the polyurethane prepolymer was when the reaction temperature was 80°C, the reaction time was 3h and the R-value of the polyurethane acrylate was 2. Next, the influence of the A-TiO₂ content on the structure and performance of PU-TiO₂ was examined The anal. of the rheol. properties of the PU-TiO₂ ink indicated that its viscosity gradually increased as the A-TiO₂ content increased. The tensile performance of film improved because of the presence of A-TiO₂ . The photo-polymerization and photo-rheol. performance indicated that the PU-TiO₂ structure changed from a hyperbranched structure with TiO₂ as the core to a segmented structure, as the A-TiO₂ content was 3%.

Polymers (Basel, Switzerland) published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C8H8O3, Computed Properties of 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Ze-Shui published the artcilePalladium/Norbornene Cooperative Catalysis To Access Tetrahydronaphthalenes and Indanes with a Quaternary Center, Safety of 3-Acetyldihydrofuran-2(3H)-one, the publication is ACS Catalysis (2018), 8(6), 4783-4788, database is CAplus.

A cooperative catalytic system comprising a palladium/XPhos complex and 5-norbornene-2-carboxylic acid was developed. This system promotes a two-component annulation reaction, allowing the construction of tetrahydronaphthalenes and indanes that contain quaternary centers through consecutive Catellani-type C-H activation and redox-relay Heck reaction. Inexpensive 5-norbornene-2-carboxylic acid acts as a catalytic mediator (20 mol %) in this process. This mild, scalable, and chemoselective protocol is compatible with a wide variety of readily available aryl iodides and alkylating reagents. Application of this method in a 4-step synthesis of opioid analgesic eptazocine is demonstrated. Preliminary studies underscore the future promise of rendering this Catellani/redox-relay Heck cascade enantioselective.

ACS Catalysis published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Safety of 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics