Esters-buliding-blocks

Porter, Jacob published the artcileA novel, unusual acid catalyzed route to substituted 1,4-dihydropyridine via double decarboxylation, HPLC of Formula: 924-99-2, the publication is Letters in Organic Chemistry (2011), 8(9), 610-613, database is CAplus.

A simple and high yield route to 3,4,5-trisubstituted 1,4-dihydropyridine systems via an interesting intermol. condensation and double decarboxylation is described. Thus, in presence of AcOH, reaction of (E)-EtO₂CCH:CHNHBn and di-Et (ethoxymethylene)malonate gave 1,4-dihydropyridine derivative (I).

Letters in Organic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, HPLC of Formula: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Blanchard, Lucien published the artcileMelt polycondensation for the synthesis of polyester amides using kneader reactor technology, Name: Dimethyl adipate, the publication is Chimia (2020), 74(12), 1024-1025, database is CAplus and MEDLINE.

In this work, we discuss the process development and scale-up of the melt polycondensation of polyester amides from a laboratory scale to kg-scale in a kneader reactor. We identified and optimized the most important critical parameters and produced kg-quantities of polyester amides with Mn up to 25’000 g/mol and reproducible thermal and mech. properties. The special kneader reactor allows safe and efficient scale-up of polymerization reactions at high temperature and viscous melts due to good mixing and efficient mass transfer.

Chimia published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Name: Dimethyl adipate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rephaeli, Ada published the artcileDerivatives of butyric acid as potential anti-neoplastic agents, COA of Formula: C10H18O4, the publication is International Journal of Cancer (1991), 49(1), 66-72, database is CAplus and MEDLINE.

A novel derivative of butyric acid, pivalyloxymethyl butyrate (AN-9) was shown, in vitro, to: (a) induce cytodifferentiation and inhibit the proliferation of leukemic cells; (b) inhibit the growth and formation of Lewis lung carcinoma colonies in semi-solid agar. AN-9 affect cells at about 10-fold lower concentration and at a faster rate than does butyric acid. The pivalyloxymethyl esters of propionic, isobutyric and valeric acids do not elicit effects similar to those of AN-9, while the isobutyryloxymethyl butyrate does, which strongly suggests that the activity of AN-9 stems from intracellular metabolic degradation of the pro-drug to butyric acid. In vivo, AN-9, increased the survival of mice in Lewis lung carcinoma primary cancer model and significantly decreased the number of lung lesions of the animals inoculated with highly metastatic cells, but did not affect their life span. Acute LD₅₀ studies showed that AN-9 possesses low toxicity. AN-9 is a potential antineoplastic agent as well as a tool for investigation of the differentiation induction mechanism.

International Journal of Cancer published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, COA of Formula: C10H18O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ulven, Elisabeth Rexen published the artcileStructure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators, Formula: C6H10O3, the publication is Journal of Medicinal Chemistry (2020), 63(7), 3577-3595, database is CAplus and MEDLINE.

Free fatty acid receptor 3 (FFA3, previously GPR41) is activated by short-chain fatty acids, mediates health effects of the gut microbiota, and is a therapeutic target for metabolic and inflammatory diseases. The shortage of well-characterized tool compounds has however impeded progress. Herein, we report structure-activity relationship of an allosteric modulator series and characterization of physicochem. and pharmacokinetic properties of selected compounds, including previous and new tools. Two representatives, 57 (TUG-1907) and 63 (TUG-2015), showed improved solubility and preserved potency. Of these, 57, with EC₅₀ = 145 nM and a solubility of 33μM, showed high clearance in vivo but is a preferred tool in vitro. In contrast, 63, with EC₅₀ = 162 nM and a solubility of 9μM, showed lower clearance and seems better suited for in vivo studies. Using 57, we demonstrate for the first time that FFA3 activation leads to calcium mobilization in murine dorsal root ganglia.

Journal of Medicinal Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C9H5Cl2F3, Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zerin, Nagma published the artcileOptimum formulation design of natural fiber-reinforced composites (NFRC) for automotive applications, Computed Properties of 31570-04-4, the publication is Journal of Composite Materials (2022), 56(9), 1407-1415, database is CAplus.

Natural fiber-reinforced composites (NFRC) are cheaper and more eco-friendly alternatives compared to synthetic composites for automotive applications. As there is limited understanding about the balance of different phys. properties in NFRC, optimizing these properties is an important consideration for a more widespread application of NFRC. The goal of this research was to statistically develop an optimum formulation for oat-hull-reinforced polypropylene composite. Mech. properties of the composites were first exptl. measured. Then, the mixture design experiment approach was utilized to generate response models for different properties, and diagnostic tools were utilized to validate the models. In addition to optimizing the desired material properties, the overall cost of the composite was minimized, which adds novelty to the work.

Journal of Composite Materials published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C9H5ClO2, Computed Properties of 31570-04-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yin, Xiumei published the artcileSynthesis of camostat mesilate, Recommanded Product: 2-(Dimethylamino)-2-oxoethyl 2-(4-hydroxyphenyl)acetate, the publication is Huaxue Yanjiu Yu Yingyong (2004), 16(6), 859-860, database is CAplus.

Camostat mesilate was synthesized from 4-aminobenzoic acid by adding cyanamide to obtain 4-guanidinobenzoic acid HCl, esterifying 4-hydroxyphenylacetic acid 2-dimethylamino-2-oxoethyl ester that was prepared from 4-hydroxyphenylacetic acid and N,N-dimethylchloroacetamide, neutralizing, and converting to the salt. The structures of the intermediates and product were confirmed by MS, IR, and ¹H-NMR. The overall yield of the improved procedure was 56%.

Huaxue Yanjiu Yu Yingyong published new progress about 59721-16-3. 59721-16-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Phenol,Ester,Amide, name is 2-(Dimethylamino)-2-oxoethyl 2-(4-hydroxyphenyl)acetate, and the molecular formula is C15H21BO2, Recommanded Product: 2-(Dimethylamino)-2-oxoethyl 2-(4-hydroxyphenyl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shin, Junhwa published the artcileAn Efficient New Route to Plasmenyl-type Lipids: Synthesis and Cytotoxicity of a Plasmenylcholine Analog of the Antitumor Ether Lipid ET-18-OMe, COA of Formula: C9H9NO6S, the publication is Journal of the American Chemical Society (2001), 123(3), 508-509, database is CAplus and MEDLINE.

Glycerolipid I has been prepared via a facile reaction sequence with use of an acrolein acetal derivative and 1-iodo-tridecane as precursors under Barbier-type reaction conditions. The observed regioselectivities and high Z:E ratios of the lithiated 4,4-di-tert-butylbiphenyl (DBB)-mediated coupling reaction are likely due to a lithiated allylic anion that undergoes stereoselective γ-coupling with electrophiles via lithium ion-acetal chelation. The resulting racemic I shows cytotoxic properties similar to the clin. relevant ATL analog 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OMe); however, it is not presently known whether the cytotoxic mechanism for I is apoptotic in nature as it is for ET-18-OMe. Experiments designed to adapt this method for the preparation of plasmalogens and the pure R-I/S-I stereoisomers are in progress. Addnl. experiments aimed at probing the relative cytotoxicity of R-I, S-I, and racemic I, as well as the mechanism of cell death upon exposure to these ATL, are also planned.

Journal of the American Chemical Society published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C7H3Cl2F3O2S, COA of Formula: C9H9NO6S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Guo-Xing published the artcileA microfluidics-dispensing-printing strategy for Janus photonic crystal microspheres towards smart patterned displays, Recommanded Product: Trimethylolpropane triacrylate, the publication is Journal of Polymer Science (Hoboken, NJ, United States) (2022), 60(11), 1710-1717, database is CAplus.

From the implementation point of view, the printable magnetic Janus colloidal photonic crystals (CPCs) microspheres are highly desirable. Herein, we developed a dispensing-printing strategy for magnetic Janus CPCs display via a microfluidics-automatic printing system. Monodisperse core/shell colloidal particles and magnetic Fe₃O₄ nanoparticles precursor serve as inks. Based on the equilibrium of three-phase interfacial tensions, Janus structure is successfully formed, followed by UV irradiation and self-assembly of colloid particle to generate magnetic Janus CPCs microspheres. Notably, this method shows distinct superiority with highly uniform Janus CPCs structure, where the TMPTA/Fe₃O₄ hemisphere is in the bottom side while CPCs hemisphere is in the top side. Thus, by using Janus CPCs microspheres with two different structural colors as pixel points, a pattern with red flower and green leaf is achieved. Moreover, 1D linear Janus CPCs pattern encapsulated by hydrogel is also fabricated. Both the color and the shape can be changed under the traction of magnets, showing great potentials in flexible smart displays. We believe this work not only offers a new feasible pathway to construct magnetic Janus CPCs patterns by a dispensing-printable fashion, but also provides new opportunities for flexible and smart displays.

Journal of Polymer Science (Hoboken, NJ, United States) published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Recommanded Product: Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wei, Ping published the artcileGC-MS analysis of essential oil from flowers of Melia toosendan, Application In Synthesis of 110-34-9, the publication is Xibei Yaoxue Zazhi (2014), 29(3), 241-244, database is CAplus.

The aim is to analyze the chem. constituents of the essential oil from the fresh and the dried flowers of Melia toosendan. The chem. components of the essential oil were analyzed by GC-MS. 22 Peaks were separated totally, and 16 compounds were identified from the fresh flowers, which accounted for 72.73%. The oil contained mainly alkanes, also contained nitrogen and chlorine compounds 41 Peaks were separated totally, and 33 compounds were identified from the dried ones, which accounted for 80.49%. The oil contained mainly alc. and acid compounds, and didn’t contain nitrogen and chlorine compounds The relative content of each component was calculated by peak area normalization method. It was the first time to extract and analyze the essential oil from the dried and the fresh flowers of Melia toosendan.

Xibei Yaoxue Zazhi published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C4H4N2O2, Application In Synthesis of 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shi, Shuai published the artcileThree-component radical homo Mannich reaction, Synthetic Route of 19788-49-9, the publication is Nature Communications (2021), 12(1), 1006, database is CAplus and MEDLINE.

By employing a radical process, enolizable aldehydes were utilized as substrates in the three-component radical homo-Mannich reaction for the streamlined synthesis of γ-amino-carbonyl compounds. The electrophilic radicals were generated from thiols HSCHR¹C(O)R² (R¹ = H, Me; R² = Me, EtO, PhCH₂O, 1-adamantyl, Et₂N, etc.) via the desulfurization process facilitated by visible-light, and then added to the electron-rich double bonds of enamines, formed in-situ from aldehydes or ketones R³CH₂C(O)R⁴ [R³ = H, Et, MeSCH₂, Ph, PhCH₂, etc., R⁴ = H; R³ = H, R⁴ = Ph, 3-FC₆H₄, etc.; R³R⁴ = (CH₂)₅, CH₂CHPhCH₂CH₂, CH₂N(CH₂Ph)CH₂CH₂, etc.] and amines R⁵NHR⁶ [R⁵ = Me, R⁶ = H₂C:CHCH₂, PhCH₂, cyclohexyl, etc.; R⁵ = PhCH₂, R⁶ = PhCH₂, EtO₂CCH₂, etc.; R⁵R⁶ = (CH₂)₄, CHPh(CH₂)₃, etc.] to provide the products I in a single step. The broad scope, mild conditions, high functional group tolerance, and modularity of this metal-free approach for the synthesis of complex tertiary amine scaffolds will likely be of great utility to chemists in both academia and industry.

Nature Communications published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C6H13N3O2, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics