Esters-buliding-blocks

Karmel, Caleb published the artcileIridium-Catalyzed Silylation of Five-Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl-Imidazoline Ligand, Formula: C13H19BO4S, the publication is Angewandte Chemie, International Edition (2020), 59(15), 6074-6081, database is CAplus and MEDLINE.

The steric effects of substituents on five-membered rings are less pronounced than those on six-membered rings because of the difference in bond angles. Thus, the regioselectivities of reactions of five-membered heteroarenes that occur with selectivities dictated by steric effects, such as the borylation of C-H bonds, were poor in many cases. The authors report that the silylation of five-membered-ring heteroarenes occurs with high sterically derived regioselectivity when catalyzed by the combination of [Ir(cod)(OMe)]₂ (cod = 1,5-cyclooctadiene) and a phenanthroline ligand or a new pyridyl-imidazoline ligand that further increases the regioselectivity. The silylation reactions with these catalysts produce high yields of heteroarylsilanes from functionalization at the most sterically accessible C-H bonds of these rings under conditions that the borylation of C-H bonds with previously reported catalysts formed mixtures of products or products that are unstable. The heteroarylsilane products undergo cross-coupling reactions and substitution reactions with ipso selectivity to generate heteroarenes that bear halogen, aryl, and perfluoroalkyl substituents.

Angewandte Chemie, International Edition published new progress about 960116-27-2. 960116-27-2 belongs to esters-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ester,Thiophene,Boronate Esters,Boronic Acids,Boronic acid and ester,, name is Ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate, and the molecular formula is C13H19BO4S, Formula: C13H19BO4S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Patnaik, Amita published the artcileA phase I study of pivaloyloxymethyl butyrate, a prodrug of the differentiating agent butyric acid, in patients with advanced solid malignancies, Safety of (Pivaloyloxy)methyl butyrate, the publication is Clinical Cancer Research (2002), 8(7), 2142-2148, database is CAplus and MEDLINE.

Pivaloyloxymethyl butyrate (AN-9), an acyloxyalkyl ester prodrug of butyric acid (BA), has demonstrated greater potency than BA at inducing malignant cell differentiation and tumor growth inhibition and has demonstrated more favorable toxicol., pharmacol., and pharmaceutical properties than BA in preclin. studies. The principal objective of this study was to determine the feasibility of administering AN-9 as a 6-h i.v. infusion daily for 5 days every 3 wk in patients with advanced solid malignancies. The study also sought to determine the principal toxicities and maximum tolerated dose of AN-9 on this intermittent schedule, as well as the effects of AN-9 on fetal Hb production, a parameter indicative of RBC differentiation. None of the 28 patients treated with 85 total courses of AN-9 at dosages ranging from 0.047 to 3.3 g/m²/day every 3 wk experienced dose limiting toxicity. Mild to moderate nausea, vomiting, hepatic transaminase elevation, hyperglycemia, fever, fatigue, anorexia, injection site reaction, diarrhea, and visual complaints were observed Dose escalation of AN-9 was limited by the maximum feasible volume of its intralipid formulation vehicle that could be administered safely on this schedule, resulting in a maximum deliverable dose of 3.3 g/m²/day. There was no consistent increase in fetal Hb with AN-9 treatment. A partial response was observed in a previously untreated patient with metastatic non-small cell lung cancer. Addnl. disease-directed clin. evaluations of AN-9 are necessary to establish the breadth of its antitumor activity and to assess its role as an effective differentiating agent.

Clinical Cancer Research published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Safety of (Pivaloyloxy)methyl butyrate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Treacy, Sean M. published the artcileCopper Catalyzed C(sp³)-H Bond Alkylation via Photoinduced Ligand-to-Metal Charge Transfer, Recommanded Product: Dimethyl adipate, the publication is Journal of the American Chemical Society (2021), 143(7), 2729-2735, database is CAplus and MEDLINE.

The functionalization of numerous feedstock chems. via the coupling of unactivated C(sp³)-H bonds with electron-deficient olefins was reported. The active cuprate catalyst undergoes ligand-to-metal charge transfer enabled the generation of a chlorine radical which acted as a powerful hydrogen atom transfer reagent capable of abstracting strong electron-rich C(sp³)-H bonds. Of note is that the chlorocuprate catalyst was an exceedingly mild oxidant (0.5 V vs SCE) and that a proposed protodemetalation mechanism offered a broad scope of electron-deficient olefins, offered high diastereoselectivity in the case of endocyclic alkenes. The coupling of chlorine radical generation with Cu reduction through LMCT enabled the generation of a highly active HAT reagent in an operationally simple and atom economical protocol.

Journal of the American Chemical Society published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C12H17NO2, Recommanded Product: Dimethyl adipate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lawer, Aggie published the artcileInternal Nucleophilic Catalyst Mediated Cyclisation/Ring Expansion Cascades for the Synthesis of Medium-Sized Lactones and Lactams, COA of Formula: C15H21BO4, the publication is Angewandte Chemie, International Edition (2019), 58(39), 13942-13947, database is CAplus and MEDLINE.

A strategy for the synthesis of medium-sized lactones and lactams from linear precursors is described in which an amine acts as an internal nucleophilic catalyst to facilitate a novel cyclisation/ring expansion cascade sequence. This method obviates the need for the high-dilution conditions usually associated with medium-ring cyclisation protocols, as the reactions operate exclusively via kinetically favorable “normal”-sized cyclic transition states. This same feature also enables biaryl-containing medium-sized rings to be prepared with complete atroposelectivity by point-to-axial chirality transfer.

Angewandte Chemie, International Edition published new progress about 956229-86-0. 956229-86-0 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Benzene,Ester,Boronate Esters,Boronic acid and ester, name is Methyl 2-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate, and the molecular formula is C15H21BO4, COA of Formula: C15H21BO4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gridelli, Cesare published the artcileThe potential role of histone deacetylase inhibitors in the treatment of non-small-cell lung cancer., Synthetic Route of 122110-53-6, the publication is Critical reviews in oncology/hematology (2008), 68(1), 29-36, database is MEDLINE.

Non-small-cell lung cancer (NSCLC) arises from a complex series of genetic and epigenetic changes leading to uncontrolled cell growth and metastases. The exponential growth in the level of research about the histone deacetylase (HDAC) enzymes, responsible for deacetylating core nucleosomal histones and other proteins, has been driven by the ability of HDAC inhibitors to modulate transcriptional activity. As a result, this therapeutic class is able to block angiogenesis and cell cycling, and promote apoptosis and differentiation. The mechanisms resulting in the antiproliferative biologic effects of these agents are not yet known. Clinical experience indicates these agents generally well tolerated, and active in several haematological and solid tumours. HDAC inhibitors, under clinical evaluation in the treatment of NSCLC patients, are pivanex, CI-994, vorinostat, and LBH589. Here, we discuss about the potential role of HDAC inhibitors focusing on their activity, tolerability, efficacy and future development, in the treatment of NSCLC.

Critical reviews in oncology/hematology published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Synthetic Route of 122110-53-6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nesterova, I. P. published the artcileDetermination of isomer composition of insect sex pheromones using capillary gas-liquid chromatography, Application of (Z)-Dodec-9-en-1-yl acetate, the publication is Zhurnal Analiticheskoi Khimii (1982), 37(8), 1491-3, database is CAplus.

A 50 m long 0.25 mm diameter steel column, coated on the inside with 1,2,3-tris(β-cyanethoxy)propane, was used for determining the geometric and position isomer composition of 21 insect pheromones, consisting of mono- and diene alcs. and their acetates. N was the carrier gas and the column. temperature was 160°. The coefficient of discrimination depended on the presence of functional group, mol. length, the degree of unsaturation, and position and configuration of the double bond. Alcs. were eluted after acetates, and cis-isomers of monounsaturated alcs. and their acetates were eluted after trans-isomers. trans-7-cis-9-dodecadien-1-ol  [54364-60-2] And trans-7-cis-9-dodecadien-1-yl acetate  [54364-62-4] were eluted before trans-7-trans-9-dodecadien-1-ol  [54364-61-3] and trans-7-trans-9-dodecadien-1-yl acetate  [54364-63-5].

Zhurnal Analiticheskoi Khimii published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Application of (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Artal, C. published the artcileSHG Characterization of Different Polar Materials Obtained by in Situ Photopolymerization, Recommanded Product: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, the publication is Macromolecules (2001), 34(12), 4244-4255, database is CAplus.

The structural, thermal, and nonlinear optical (NLO) parameters of chiral polyacrylates containing biphenyl moieties and various polar groups were studied. The side-chain polymers, anisotropic networks, and gels, were prepared by in situ photopolymerization of the precursors in the ferroelec. SmC* liquid crystal phase. The effects of structure, crosslinker content, and degree of mobility of a common NLO-phore on the second harmonic generation (SHG) activity were studied to identify the best mol. structure toward practical applications. Slight improvements in the SHG d_ij coefficient of the polymeric materials was observed, compared to that of the low mol. weight precursor. The side-chain polymers and low crosslinking polymers are the most interesting materials from the point of view of both the NLO-activity and the ease of synthesis. These two types of materials provide stable room temperature thin films displaying SHG and electrooptic (EO) responses without the application of a poling field.

Macromolecules published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Recommanded Product: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Vandyck, Koen published the artcileSynthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV), Recommanded Product: 3-(Methoxycarbonyl)benzoic acid, the publication is Journal of Medicinal Chemistry (2018), 61(14), 6247-6260, database is CAplus and MEDLINE.

Small mol. induced hepatitis B virus (HBV) capsid assembly modulation is considered an attractive approach for new antiviral therapies against HBV. Here we describe efforts toward the discovery of a HBV capsid assembly modulator in a hit-to-lead optimization, resulting in JNJ-632, a tool compound used to further profile the mode of action. Administration of JNJ-632 (54) in HBV genotype D infected chimeric mice resulted in a 2.77 log reduction of the HBV DNA viral load.

Journal of Medicinal Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C7H13NO2, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Korblova, Eva published the artcilePreparation of (Z)- and (E)-9-dodecenyl acetates, Formula: C14H26O2, the publication is Collection of Czechoslovak Chemical Communications (1985), 50(10), 2284-8, database is CAplus.

The pheromones (Z)- and (E)-EtCH:CH(CH₂)₈OAc were synthesized via the acetylenic precursor, 9-decyn-1-ol, prepared from tetrahydrofurfuryl chloride and Me(CH₂)₅Br. The OH groups of the intermediates in the subsequent steps were protected by the ethoxyethyl group.

Collection of Czechoslovak Chemical Communications published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Formula: C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gudesblatt, Mark published the artcileHealth-Related Quality of Life with Diroximel Fumarate in Patients with Relapsing Forms of Multiple Sclerosis: Findings from Qualitative Research Using Patient Interviews, COA of Formula: C6H8O4, the publication is Advances in Therapy (2022), 39(7), 3199-3213, database is CAplus and MEDLINE.

Abstract: Introduction: Diroximel fumarate (DRF) is an oral fumarate for relapsing multiple sclerosis (MS). Clin. and real-world studies of DRF have demonstrated improved gastrointestinal (GI) tolerability and low (< 1%) GI-related treatment discontinuation vs. di-Me fumarate (DMF) and high rates of treatment adherence. Our aim was to conduct a concept elicitation study to identify treatment-related concepts most meaningful to patients and to evaluate how these concepts shape the patient perspective of DRF. Methods: In-depth qual. interviews were conducted with patients from Oct. to Dec. 2020. US adults who had been prescribed DRF through routine clin. care and had taken DRF for ≥ 3 wk in the past 6 mo were eligible to participate. Semi-structured interviews explored patient perceptions on treatment selection and impact. Results: Seventeen patients participated in the study. Mean (SD) age was 49.3 (12.0) years. Sixteen patients reported prior disease-modifying therapy, while 10 (58.8%) had prior DMF. DRF treatment duration ranged from ∼ 6 wk to 10 mo. Four key concepts emerged: (1) overall wellness and quality of life, (2) ease of administration, (3) minimal and manageable side effects, and (4) patient optimism due to MS treatments. Mode of administration (82.4%), no/mild side effects (70.6%), convenience over injectable/infusion medications (58.8%), and effectiveness (64.7%) were cited as pos. aspects of DRF treatment. Frequent dosing (52.9%) and food requirements (41.2%) were cited as neg. attributes; however, 94.1% had no dietary changes since starting treatment. Conclusion: The patient perspective is a key aspect when considering a disease-modifying therapy for MS, given the multitude of options currently available. Overall wellness, ease of administration, and minimal and manageable side effects were DRF-related concepts most meaningful to patients on therapy. Acknowledging these patient perceptions in shared decision-making may lead to greater patient adherence and optimal treatment outcomes.

Advances in Therapy published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, COA of Formula: C6H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics