Esters-buliding-blocks

Korrapati, Vinodh K. published the artcileBilayer coatings for temporary and long-term corrosion protection of magnesium-AZ31 alloy, Formula: C15H20O6, the publication is Progress in Organic Coatings (2022), 106608, database is CAplus.

Phosphate and silane containing organic self-assembled (SA) layers serve as pre-treatments on magnesium alloy sheet materials. A reliable protection was achieved in this work via application of alkyd-based coatings on the pretreated surface. The idea of adopting SA pre-treatments as functional layers at metal-polymer interface is to influence the adhesive properties between solid metal substrate and alkyd-based coating. Hexadecyltrimethoxysilane (HDTMS) deposited metal surfaces exhibit stronger adhesive strength, while a near homogeneous distribution of the octadecylphosphonic acid (ODPA) and perfluorodecylphosphonic acid (PFDPA) exhibit low adhesive phenomenon, when placed as pre-layers in bilayer coatings. Electrochem. impedance results after 168 h of immersion reveal that the organophosphate and organosilane deposited bilayer films demonstrate protective properties with almost no interface defects. Moreover, organophosphate treated bilayer coatings enhance easy peeling of alkyd coat after protecting the surface from corrosive electrolytes. Bilayer coatings developed on AZ31 sheets can confer temporary or long-term corrosion protection depending on further processing strategy and offer efficient alloy protection for both purposes.

Progress in Organic Coatings published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Formula: C15H20O6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pietrasiak, Ewa published the artcileSynthesis of 2-Substituted Aziridine-2-Carboxylic Esters via Michael-Induced Ring-Closure Strategy, Computed Properties of 19788-49-9, the publication is Synlett (2017), 28(16), 2115-2120, database is CAplus.

A Michael-induced ring-closure (MIRC) strategy allowing the synthesis of 2-substituted aziridine-2-carboxylic esters was presented. A broad spectrum of nucleophiles was applied, leading to large diversity of products which were subjected to further structural modifications. Diastereoselective ring closure was observed in the case of chiral substrates.

Synlett published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Computed Properties of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

McCourt, Ruairi O. published the artcileAtmospheric Oxygen Mediated Radical Hydrothiolation of Alkenes, HPLC of Formula: 5205-11-8, the publication is Chemistry – A European Journal (2020), 26(68), 15804-15810, database is CAplus and MEDLINE.

A mild, metal-free, atm. oxygen-mediated radical hydrothiolation of alkenes (and alkyne) was reported. A variety of sulfur containing motifs including alkanethiols, thiophenols and thioacids undergo an atm. oxygen-mediated radical hydrothiolation reaction with a plethora of alkenes in good yield with excellent functional group compatibility, typically with short reaction times to furnished a range of functionalized products. Biomols. proved tolerant to the conditions and the procedure was robust and easily executable requiring no specialized equipment. Concise mechanistic studies confirmed that the process proceeded through radical intermediates in a thiol-ene reaction manifold. The methodol. offered an efficient “green” approach for thiol-ene mediated “click” ligation and a milder alternative to thermally initiated hydrothiolation processes.

Chemistry – A European Journal published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, HPLC of Formula: 5205-11-8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

La-ongthong, Kannika published the artcileCyclization of o-Alkynylisocyanobenzenes with 1,3-Dicarbonyl Compounds, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one, the publication is Synlett (2022), 33(14), 1411-1418, database is CAplus.

A facile and convenient reaction of o-alkynylisocyanobenzenes with various active-methylene compounds, including 1,3-diesters, 1,3-diketones,β-keto esters, and β-keto amides, under Bronsted basic conditions, had been developed. Di-Et malonate reacted smoothly with a collection of o-alkynylisocyanobenzenes to provide the corresponding 2-quinolin-2-yl malonates in excellent yields. Acetylacetone gave a mixture of quinolin-4-yl and quinolin-2-yl derivatives Acetoacetate esters and acetoacetyl amide derivative initially gave 2-quinolin-2-yl adducts that underwent partial deacetylation under the reaction conditions.

Synlett published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yamamoto, Tsuyoshi published the artcileSerial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides, SDS of cas: 10378-06-0, the publication is Bioorganic & Medicinal Chemistry (2016), 24(1), 26-32, database is CAplus and MEDLINE.

The targeting of abundant hepatic asialoglycoprotein receptors (ASGPR) with trivalent N-acetylgalactosamine (GalNAc) is a reliable strategy for efficiently delivering antisense oligonucleotides (ASOs) to the liver. The authors here exptl. demonstrate the high systemic potential of the synthetically-accessible, phosphodiester-linked monovalent GalNAc unit when tethered to the 5′-terminus of well-characterized 2′,4′-bridged nucleic acid (also known as locked nucleic acid)-modified apolipoprotein B-targeting ASO via a bio-labile linker. Quant. anal. of the hepatic disposition of the ASOs revealed that phosphodiester is preferable to phosphorothioate as an interunit linkage in terms of ASGPR binding of the GalNAc moiety, as well as the subcellular behavior of the ASO. The flexibility of this monomeric unit was demonstrated by attaching up to 5 GalNAc units in a serial manner and showing that knockdown activity improves as the number of GalNAc units increases. The authors’ study suggests the structural requirements for efficient hepatocellular targeting using monovalent GalNAc and could contribute to a new mol. design for suitably modifying ASO.

Bioorganic & Medicinal Chemistry published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C7H5Cl2NO, SDS of cas: 10378-06-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Morozzi, Chiara published the artcileSynthesis and cellular evaluation of click-chemistry probes to study the biological effects of alpha, beta-unsaturated carbonyls, Product Details of C6H8O4, the publication is Redox Biology (2022), 102299, database is CAplus and MEDLINE.

Humans are commonly exposed to α,β-unsaturated carbonyls as both environmental toxins (e.g. acrolein) and therapeutic drugs (e.g. dimethylfumarate, DMFU, a front-line drug for the treatment of multiple sclerosis and psoriasis). These compounds undergo rapid Michael addition reactions with amine, imidazole and thiol groups on biol. targets, with reaction at protein Cys residues being a major reaction pathway. However, the cellular targets of these species (the ‘adductome’) are poorly understood due to the absence of readily identifiable tags or reporter groups (chromophores/fluorophores or antigens) on many α,β-unsaturated carbonyls. Here we report a ‘proof of concept’ study in which we synthesize novel α,β-unsaturated carbonyls containing an alkyne function introduced at remote sites on the α,β-unsaturated carbonyl compounds (e.g. one of the Me groups of dimethylfumarate). The presence of this tag allows ‘click-chem.’ to be used to visualize, isolate, enrich and characterize the cellular targets of such compounds The probes show similar selectivity and reactivity to the parent compounds and compete for cellular targets, yielding long-lived (stable) adducts that can be visualized in intact cells (such as primary human coronary artery smooth muscle cells), and extracted and enriched for subsequent target anal. It is shown using this approach that dimethylfumarate forms adducts with multiple intracellular targets including cytoskeletal, organelle and nuclear species, with these including the rate-limiting glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH). This approach should be amenable to use with multiple α,β-unsaturated carbonyls and a wide variety of targets containing nucleophilic sites.

Redox Biology published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Product Details of C6H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fu, Niankai published the artcileElectrocatalytic Radical Dichlorination of Alkenes with Nucleophilic Chlorine Sources, Related Products of esters-buliding-blocks, the publication is Journal of the American Chemical Society (2017), 139(43), 15548-15553, database is CAplus and MEDLINE.

We report a Mn-catalyzed electrochem. dichlorination of alkenes with MgCl₂ as the chlorine source. This method provides operationally simple, sustainable, and efficient access to a variety of vicinally dichlorinated compounds In particular, alkenes with oxidatively labile functional groups, such as alcs., aldehydes, sulfides, and amines, were transformed into the desired vicinal dichlorides with high chemoselectivity. Mechanistic data are consistent with metal-mediated Cl atom transfer as the predominant pathway enabling dual C-Cl bond formation and contradict an alternative pathway involving electrochem. evolution of chlorine gas followed by Cl₂-mediated electrophilic dichlorination.

Journal of the American Chemical Society published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Maeta, Takahiro published the artcileDimethyl fumarate induces apoptosis via inhibiting NF-κB and STAT3 signaling in adult T-cell leukemia/lymphoma cells, Product Details of C6H8O4, the publication is Anticancer Research (2022), 42(5), 2301-2309, database is CAplus and MEDLINE.

Adult T-cell leukemia (ATL) is a peripheral T lymphocytic malignancy caused by human T-cell leukemia virus type 1 (HTLV-1) infection. Despite treatment that includes novel agents that have been developed, most of ATL patients relapse and acquire multidrug resistance. As a result, the creation of newer agents is critical Di-Me fumarate (DMF) has several effects in cancer cells, including cell signaling, proliferation and cell death. However, its antitumor effects on ATL cells remain unknown. In this study, we looked at DMF′s antitumor effects on ATL cells.Materials and methods: We examined the effects of DMF on proliferation and apoptosis using the trypan blue exclusion assay and annexin V/propidium iodide staining in HTLV-1-infected and transformed T-cell lines, MT-1 and MT-2 cells. We also evaluated the effects of DMF on the nuclear factor-kappa B (NF-κB) and signal transducers and activators of transcription 3 (STAT3) signaling pathways and anti-apoptotic proteins by immunoblotting.Results: DMF inhibited proliferation and induced apoptosis in MT-1 and MT-2 cells by activating poly ADP-ribose polymerase (PARP). Furthermore, DMF inhibited the constitutive activation of both canonical and non-canonical NF-κB pathways in MT-2 cells and the non-canonical NF-κB pathway in MT-1 cells. DMF also inhibited the constitutive tyrosine phosphorylation of STAT3 and the expression of anti-apoptotic proteins, c-IAP2 and survivin in both cells.Conclusion: These results indicate that DMF inhibits proliferation and induces apoptosis in HTLV-1-infected and transformed T-cells by suppressing NF-κB and STAT3 signaling pathways. DMF should be investigated further as a novel agent for ATL.

Anticancer Research published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Product Details of C6H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mashima, Kiyomi published the artcileDimethyl fumarate ameliorates graft-versus-host disease by inhibiting T-cell metabolism and immune responses through a reactive oxygen species-dependent mechanism, Quality Control of 624-49-7, the publication is British Journal of Haematology (2022), 197(6), e78-e82, database is CAplus and MEDLINE.

Acute graft-vs.-host disease (GVHD) is among the leading causes of non-relapse mortality and morbidity after allogeneic haematopoietic stem cell transplantation. Di-Me fumarate (DMF), a fumaric acid derivative, is a novel therapeutic agent for relapsing multiple sclerosis and psoriasis. For instance, DMF succinates a key glycolytic enzyme, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and irreversibly inactivates its enzymic activity, thereby downregulating aerobic glycolysis in CD4+ T cells. This study investigated whether, and if so, how DMF impairs the metabolism and immune responses of antigen-activated Tcells both in vitro and in vivo using a xenogeneic GVHD mouse model. While the number of CD4+ T cells decreased, the proportion of CD25+ FoxP3+ regulatory T cells (Treg) was higher in DMF-treated mice, and thus the total number of Tregs was equivalent in both groups. Given that DMF depletes intracellular GSH levels by forming succinated glutathione, causing dysregulated ROS accumulation in diverse immune cells and cancer cells, we investigated the redox status of T-cell receptor (TCR)- stimulated T cells after DMF treatment and evaluated the association between their metabolic profiles and effector T-cell function. Furthermore, NAC almost completely restored viability (Figure 2F), proliferation (Figure 2G), and interferon gamma (IFN-γ) production (Figure 2H) of TCR-stimulated T cells following DMF treatment. Clin. relevant GVHD model, which show better disease control and prolonged survival by DMF treatment, can be readily translated to clin. settings. Our findings will provide a mol. basis for potential future clin. applications of DMF for the prevention and treatment of GVHD.

British Journal of Haematology published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Quality Control of 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Watanabe, Michiko published the artcileApplication of cytochrome P450 reactivity on the characterization of chemical compounds and its association with repeated-dose toxicity, Related Products of esters-buliding-blocks, the publication is Toxicology and Applied Pharmacology (2020), 114854, database is CAplus and MEDLINE.

Repeated-dose toxicity (RDT) studies are one of the critical studies to assess chem. safety. There have been some studies attempting to predict RDT endpoints based on chem. substructures, but it remains very difficult to establish such a method, and a more detailed characterization of chem. compounds seems necessary. Cytochrome P450s (P450s) comprise multiple forms with different substrate specificities and play important roles in both the detoxification and metabolic activation of xenobiotics. In this study, we investigated possible use of P 450 reactivity of chem. compounds to classify the compounds A total of 148 compounds with available rat RDT test data were used as test compounds and subjected to inhibition assays against 18 human and rat P450s. Among the tested compounds, 82 compounds inhibited at least one P 450 form. Hierarchical clustering analyses using the P 450 inhibitory profiles divided the 82 compounds into nine groups, some of which showed characteristic chem. and biol. properties. Principal component analyses of the P 450 inhibition data in combination with the calculated chem. descriptors demonstrated that P 450 inhibition data were plotted differently than most chem. descriptors in the loading plots. Finally, association analyses between P 450 inhibition and RDT endpoints showed that some endpoints related to the liver, kidney and hematol. were significantly associated with the inhibition of some P450s. Our present results suggest that the P 450 reactivity profiles can be used as novel descriptors for characterizing chem. compounds for the investigation of the toxicity mechanism and/or the establishment of a toxicity prediction model.

Toxicology and Applied Pharmacology published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C18H24N6O6S4, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics