Esters-buliding-blocks

Gajare, Anil S. published the artcileMicrowave accelerated selective and facile deprotection of allyl esters catalyzed by Montmorillonite K-10, Name: 3-Methylbut-2-en-1-yl benzoate, the publication is Perkin 1 (2000), 639-640, database is CAplus.

Carboxylic acids are regenerated from their corresponding substituted allyl esters by Montmorillonite K-10 using microwave irradiation under solvent free conditions to afford enhanced yields and reduced reaction times compared to thermal conditions.

Perkin 1 published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Name: 3-Methylbut-2-en-1-yl benzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Swellmeen, Lubna published the artcileStructure based drug design of Pim-1 kinase followed by pharmacophore guided synthesis of quinolone-based inhibitors, Name: Ethyl 3-(dimethylamino)acrylate, the publication is Bioorganic & Medicinal Chemistry (2017), 25(17), 4855-4875, database is CAplus and MEDLINE.

Over expression of Human phosphatidylinositol mannoside kinases isoform 1 (Pim-1 kinase) has been reported in several leukemia and solid tumors. The authors’ continuous interest to reveal the secrecies of the mysterious Pim-1 kinase binding pocket has led the authors to employ a structure based drug design procedure based on receptor-ligand pharmacophore generation protocol implemented in Discovery Studio 4.5 (DS 4.5). Subsequently, the authors collected 104 crystal structures of Pim-1 kinase from the Protein Data Bank (PDB) and used them to generate pharmacophores based on the anticipated co-crystallized ligand-Pim 1 kinase receptor interactions. All selected pharmacophoric features were enumerated and only those that had corresponding valuable receptor-ligand interactions were retained. This was followed by modeling all pharmacophore combinations and scoring them according to their Receiver Operating Characteristic (ROC) curve anal. parameters as well as a DS.4.5 built-in Genetic Function Algorithm (GFA) validating model. Accordingly, 111 pharmacophores resulted with acceptable ROC performances; 1XWS_2_04, 2BIK_2_06, and 1XWS_2_06 (ROC AUC value of: 0.770, 0.743 and 0.741 resp.) were the best pharmacophores. These pharmacophores were employed to guide the synthesis of new series of 7-[(2-Carboxyethyl)amino]-1-substituted-6-fluoro-8-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid and their reduced 8-amino derivatives The synthesized compounds were later evaluated for their Pim-1 kinase inhibitory potencies. Of which the most potent illustrated an IC₅₀ value of 0.29 μM against Pim-1 kinase.

Bioorganic & Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C12H6NNaO4, Name: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jia, Mengxiao published the artcilePolymer stabilized isotropic phase liquid crystals with large Kerr constant, COA of Formula: C15H20O6, the publication is Liquid Crystals (2022), 49(3), 399-406, database is CAplus.

In this paper, we reported a polymer stabilized isotropic phase liquid crystal (PSILC). The influences of different content of chiral dopant and polymer monomer on PSILC were studied. Adding the proper proportion and total content of polymer monomer TMPTA and C12A into liquid crystal with 1.0 weight% chiral dopant R5011, and UV photo-polymerization at the isotropic phase, we obtain the Kerr constant greater than 10 nm/V2, hysteresis less than 2.0% and fast response in PSILC.

Liquid Crystals published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, COA of Formula: C15H20O6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Po-An published the artcileA Binaphthyl-Based Scaffold for a Chiral Dirhodium(II) Biscarboxylate Ligand with α-Quaternary Carbon Centers, Application In Synthesis of 126613-06-7, the publication is ACS Catalysis (2017), 7(9), 6155-6161, database is CAplus.

A nonracemic rhodium(II) paddlewheel complex has been synthesized from binaphthalenedibutanoate biscarboxylate ligands derived from BINOL, and the resulting complex has been used in enantioselective carbene/alkyne cascade reactions. The ligand design was guided by requirements for α,α-di-Me substituted carboxylates and bidentate ligands to ensure high levels of catalytic activity. Previously disclosed chiral complexes lack these features, resulting in low product yields. The design successfully replicated or exceeded the yields of the unusually effective achiral catalyst for the cascade reaction, Rh₂(esp)₂, which often shows unique reactivity. Promising enantioselectivity was observed for the tandem insertion-cyclization reactions of aldehyde-derived hydrazone substrates to give fused bicyclic ethers (29-96% ee), showing that the new scaffold has significant potential.

ACS Catalysis published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, Application In Synthesis of 126613-06-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Spasojevic, Pavle published the artcileOptimization of Reactive Diluent for Bio-Based Unsaturated Polyester Resin: A Rheological and Thermomechanical Study, Related Products of esters-buliding-blocks, the publication is Polymers (Basel, Switzerland) (2021), 13(16), 2667, database is CAplus and MEDLINE.

Nowadays, unsaturated polyester resins (UPR) are mainly obtained from non-renewable resources. The ever-increasing regulations and the continuous demand for more sustainability have led to extensive research towards more environmentally suitable alternatives to petroleum-based materials. However, one of the main disadvantages of bio-based UPR is their relatively high viscosity compared to petrochem. ones. In order to overcome this drawback, in this work, we investigated the possibility to lower the resin viscosity utilizing a mixture of di-Me itaconate (DMI) and Me methacrylate (MMA) as a reactive diluent. The effect of the DMI and MMA ratio on resin rheol. properties was investigated. The optimal curing parameters were determined and all UPRs had a high gel content, which was shown to be dependent on the DMI and MMA ratio in the formulation. Furthermore, thermomech. and mech. properties of the resulting network were also found to be affected by the used reactive diluent mixture A small substitution of DMI by MMA proved to be advantageous since it offers lower resin viscosity and improved mech. properties.

Polymers (Basel, Switzerland) published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C11H21BF4N2O2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gardner, Terrence G. published the artcileEnzymatic hydrolysis of an organic sulfur compound, Synthetic Route of 6217-68-1, the publication is Advances in Enzyme Research (2019), 7(1), 1-13, database is CAplus.

Sulfatases which cleave sulfate esters in biol. systems are key enzymes that deserve special attention due to their significant roles in organic sulfur (OS) mineralization and inorganic sulfur (SO2-4 ) release. In this study, in-vitro experiments were conducted to evaluate S bonded substrate hydrolysis by a com. available arylsulfatase (EC 3.1.6.1) from Aerobacter aerogenes. The enzyme-substrate interactions were assessed to determine: 1-rate of hydrolysis, 2-catalytic efficiency, 3-thermal stability, and 4-optimal pH of this enzyme. Arylsulfatase exhibited substrate hydrolysis with a high affinity for p-nitrophenyl sulfate (potassium 4-nitrophenyl sulfate (pNPS)). The optimum activity for the enzyme was observed to occur at a pH of 7.1. The optimal temperature was 37°C but ranged from 35°C – 45°C. The apparent Km and Kcat of the enzyme for pNPS hydrolysis at the optimal pH, and temperature were determined to be 1.03 mM and 75.73μM/min, resp. This work defines the catalytic and kinetic properties of arylsulfatase (EC 3.1.6.1) and confirms the optimal conditions for sulfatase activity testing. The resulting information is useful in elucidating the contributions that individual enzymes have for specific reactions rather than relying on traditional total enzyme activity measurements.

Advances in Enzyme Research published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Synthetic Route of 6217-68-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hayashi, Tamio published the artcileRhodium-Catalyzed Asymmetric 1,4-Addition to 1-Alkenylphosphonates, Safety of (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), the publication is Journal of the American Chemical Society (1999), 121(49), 11591-11592, database is CAplus.

Rhodium-catalyzed asym. 1,4-addition is successfully applied to α,β-unsaturated phosphonates by use of triarylcyclotriboroxanes as arylating reagents in place of arylboronic acids. Thus, reaction of (E)-MeCH:CHP(O)(OEt)₂ with phenylboroxine and 1 equivalent (to boron) of water in dioxane at 100° for 3 h gave 94% (S)-di-Et 2-phenylpropylphosphonate.

Journal of the American Chemical Society published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, Safety of (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate).

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yao, Xinle published the artcile3D printing of PTFE-filled polyimide for programmable lubricating in the region where lubrication is needed, Safety of Trimethylolpropane triacrylate, the publication is Tribology International (2022), 107405, database is CAplus.

Three-dimensional (3D) target-region-lubrication printing of photosensitive polyimide (PSPI) filled with polytetrafluoroethylene (PTFE), i.e., PSPI-PTFE, with excellent tribol. properties for self-lubricating devices was realized by digital light processing of PSPI-PTFE ink and thermal post-treatment. The 3D-printed PSPI-PTFE composites exhibited the friction coefficients and wear rates sharply reduced by 88% and 98%, resp., and good mech. properties, thermal stability and interlayer bonding as well. Importantly, the surfaces with lubricating only in regions where needed were readily realized due to the layer-by-layer manufacturing manner of 3D printing. As proof-of-concept, a target-region-lubricating bearing was demonstrated successfully, which run stably with a speed ranged from 60 to 180 rpm/min, indicating that the 3D-printed PSPI-PTFE composites are suitable for fabricating devices with complex and special shapes.

Tribology International published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C6H10F3NO, Safety of Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Jinhong published the artcileStudy on the Staged and Direct Fast Pyrolysis Behavior of Waste Pine Sawdust Using High Heating Rate TG-FTIR and Py-GC/MS, Computed Properties of 517-23-7, the publication is ACS Omega (2022), 7(5), 4245-4256, database is CAplus and MEDLINE.

To understand the fast pyrolysis kinetics and product evolution of waste pine sawdust, high heating rate thermogravimetry-Fourier transform IR (TG-FTIR) was used to obtain the kinetic parameters and the chem. groups formed during the pyrolysis process, while pyrolysis-gas chromatog./mass spectrometry (Py-GC/MS) was used to investigate the detailed compositions of products under the staged (seven stages from 300 to 600°C) and direct fast pyrolysis process. Spectral bands were identified for acids, alcs., aldehydes, aromatics, esters, ethers, hydrocarbons, ketones, phenols, and sugars. Research found that the apparent activation energy for fast pyrolysis is much higher than that of slow pyrolysis. The evolution of CO₂ is the major deoxygenation route. Cracking mainly occurred at the 450°C stage with phenols, ketones, aldehydes, and sugars as the main products. The product distributions for different stages are significantly different; the selectivity of aldehydes decreased, while phenols showed an upward trend with an increase in pyrolysis temperature Ketones and sugars reached their peak values at 450°C. The changes in the mol. composition of each stage helped to understand the pyrolysis process. Compared with the staged pyrolysis, the direct pyrolysis process had higher selectivity of acids, aldehydes, esters, and sugars and lower selectivity of phenols, ketones, and alcs.

ACS Omega published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C11H8N2O2, Computed Properties of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sathya, Elavarasan published the artcileNutritional and gas chromatography-mass spectrometry analysis of Andrographis lawsonii gamble, Formula: C10H10O2, the publication is Asian Journal of Pharmaceutical and Clinical Research (2022), 15(1), 47-51, database is CAplus.

Andrographis lawsonii Gamble is a medicinal herb species, Endemic to India: Karnataka (Dakshina kannada or south Canara district), Kerala (Palakkad district), and Tamil Nadu (Coimbatore and Nilgiris districts). The Andrographis is a large genus of the family Acanthaceae. This study focused to check the preliminary phytochem. nutritive anal., leaf stem and root and gas chromatog.-mass spectrometry (GC-MS) anal. leaf methanol extract The plant samples were subjected to Soxhlet extraction for phytochem. anal. and further exptl. studies. The test on phytochem. studies indicated the presence of alkaloids, saponins, glycosides, and flavonoids glycosides within the plant parts, resp. The estimation of carbohydrate protein starch methanol leaves extracts to have high activity compared to others. Preliminary phytochem. and Nutritional anal. in A. lawonii. Nutritional anal. in carbohydrate protein and starch content was found to be high in leaf methanol extract Highly medicinal compound anal. in this GC-MS Anal. 50 compound present in methanol leaf extract The leaf methanol extract of A. lawsonii has exhibited remarkable preliminary phytochem. anal. and nutritional anal. GC-MS anal. to the medicinal plant.

Asian Journal of Pharmaceutical and Clinical Research published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Formula: C10H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics