Esters-buliding-blocks

Kumari, Aruna published the artcileGC-MS analysis of the methanol fraction of Ailanthus excelsa Roxb. fruit, Application of 3-Acetyldihydrofuran-2(3H)-one, the publication is Asian Journal of Pharmaceutical and Clinical Research (2022), 15(6), 51-55, database is CAplus.

The objective of the study was to evaluate the phytochem. compounds present in the methanolic fruit extract of Ailanthus excelsa. Phytochem. screening was carried out using the GC-MS instrument following the standard protocol. GC-MS studies revealed the presence of 65 compounds in fruit extract of Ailanthus excelsa. Among them, highest peak area (37.67%) was obtained for Mome Inositol (Six hydroxyl group polysaccharide) (Retention time 14.873). This study identifies the presence of pharmacol. active compounds which can be constructive for the formulation of novel drugs.

Asian Journal of Pharmaceutical and Clinical Research published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Application of 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sharma, Amit Kumar published the artcileProduction of a sustainable fuel from microalgae Chlorella minutissima grown in a 1500 L open raceway ponds, Application In Synthesis of 121-79-9, the publication is Biomass and Bioenergy (2021), 106073, database is CAplus.

Energy demand is increasing continuously due to the progress of industrialization, the vehicular population of the world, and modernization in lifestyle. In the present study, Chlorella minutissima microalgae were cultured in a 1500 L raceway open pond using com. fertilizer under semi-continuous mode. About 19.98 wt % lipid was extracted by the soxhlet extraction method from this microalgae biomass. To optimize the input reaction parameters (temperature, lipid to methanol ratio, microwave power, and reaction time) for improving transesterification yield, Response Surface Methodol. (RSM) was employed. The output responses of the experiments were biodiesel yield along with d., kinematic viscosity, calorific value, cold flow properties, and oxidation stability. To validate the model, confirmation trials were carried out. All the fuel properties were found to be satisfying ASTM D6751 and EN 14214 standard specifications except for oxidation stability at 3.0 h. The oxidation stability was further improved by using appropriate antioxidants and improved up to 10.5 h with the addition of 1000 ppm Pr gallate.

Biomass and Bioenergy published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H11N3O3S, Application In Synthesis of 121-79-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Aminkhani, Ali published the artcileChemical Constituent, Antimicrobial Activity, and Synergistic Effect of the Stem, Leaf, and Flower Essential Oil of the Artemisia fragrans Willd. from Khoy, Quality Control of 103-26-4, the publication is Chemistry & Biodiversity (2021), 18(8), e2100241, database is CAplus and MEDLINE.

Artemisia fragrans is commonly used as a folk medicine as antispasmodic, anti-pyretic, anti-inflammatory, and abortifacient agents. The villagers use its pungent odor to repel rodents, mites, and pests, as well as its essential oil and smoke after burning to treat lung infections after uprooting the plant. Herein, we extracted the essential oils (EOs) of different parts of the plant and analyzed their chem. compositions and antibacterial activities. The chem. anal. led to the identification of 73, 59, and 57 compounds in the EOs of the stem, leaf, and flower, resp. All of the EOs exhibited antibacterial activities against both G+ and G- bacteria. The EOs of the leaf and flower were more effective against tested bacteria, except B. anthracis and P. aeruginosa, compared to that of the stem. The binary combination of the EOs (stem and flower) or (stem and leaf) showed a synergistic effect. Statistical anal. indicated EOs of leaf and flower are more potent than that of the stem. These findings suggest the application of leaf and flower of the plant, which not only can prevent its uprooting but also ensure better therapeutic function.

Chemistry & Biodiversity published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Quality Control of 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Yantao published the artcileHighly selective synthesis of all-carbon tetrasubstituted alkenes by deoxygenative alkenylation of carboxylic acids, COA of Formula: C9H8O4, the publication is Nature Communications (2022), 13(1), 10, database is CAplus and MEDLINE.

The synthesis of all-carbon tetrasubstituted olefins under mild reaction conditions is challenging because of the inevitable issues including significant steric hindrance and the uncontrolled Z/E stereoselectivity. In this paper, authors report the synthesis of all-carbon tetrasubstituted alkenes from readily available carboxylic acids and alkenyl triflates with the synergistic catalysis of cyclo-octa-1,5-diene(tetramethyl-1,4-benzoquinone)nickel and visible light under an air atm., thus avoiding the need for a glovebox or a Schlenk line. A wide range of aromatic carboxylic acids and cyclic and acyclic alkenyl triflates underwent the C-C coupling process smoothly, forming structurally diverse alkenes stereospecifically in moderate to good yields. The practicality of the method is further illustrated by the late-stage modification of complex mols., the one pot synthesis and gram-scale applications. This is an important step towards the valuable utilization of carboxylic acids, and it also simplifies the exptl. operation of metallophotoredox catalysis with moisture sensitive nickel(0) catalysis.

Nature Communications published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, COA of Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Batova, Ayse published the artcileThe histone deacetylase inhibitor AN-9 has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines, Formula: C10H18O4, the publication is Blood (2002), 100(9), 3319-3324, database is CAplus and MEDLINE.

The novel prodrug of butyric acid, pivaloyloxymethyl butyrate (AN-9), a histone deacetylase inhibitor, shows great promise as an effective and relatively nontoxic anticancer agent for solid malignancies. However, little is known about its effects on hematopoietic malignancies. In this study, the authors show that 21 primary samples of acute leukemia were sensitive to the antiproliferative effects of AN-9, with a 50% inhibitory concentration (IC₅₀) of 45.8 μM. In colony-forming assays, primary T-cell acute lymphoblastic leukemia (T-ALL) cells were 3-fold more sensitive to AN-9 than the normal hematopoietic progenitors, erythroid burst-forming units, and granulocyte/monocyte colony-forming units. AN-9 induced apoptosis in the T-ALL cell line CEM. A common problem with cancer is chemoresistance, which is often typical of relapsed cancers. Remarkably, a T-ALL sample at diagnosis and an acute myeloid leukemia sample at relapse that were resistant to doxorubicin in vitro were sensitive to AN-9, with an IC₅₀ of 50 μM for both samples. More strikingly, samples from 2 infants with t(4;11) ALL obtained at diagnosis and relapse each were the most sensitive to AN-9, with IC₅₀ values of 25 and 17 μM, resp. Furthermore, a doxorubicin-resistant clone of HL60, HL60/ADR, obtained by the transfection of the MDR-1 gene, was equally sensitive to AN-9 cytotoxicity as the parental cells. AN-9 induced the expression of p21 in an infant leukemia sample with 11q23 rearrangement, but not in T- or B-precursor ALL. Collectively, the authors’ results suggest that AN-9 is a selective agent for hematopoietic malignancies that can circumvent the mechanisms of chemoresistance limiting most conventional chemotherapy.

Blood published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Formula: C10H18O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Jie published the artcileCu-Catalyzed Decarboxylative Borylation, Application of tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate, the publication is ACS Catalysis (2018), 8(10), 9537-9542, database is CAplus and MEDLINE.

A simple method for the conversion of carboxylic acids to boronic esters via redox-active esters (RAEs) is reported using copper catalysis. The scope of this transformation is broad, and compared with the known protocols available, it represents the most inexpensive, rapid, and operationally simple option. In addition to a full exploration of the scope, a kinetic study was performed to elucidate substrate and reagent concentration dependences.

ACS Catalysis published new progress about 1850305-80-4. 1850305-80-4 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate, and the molecular formula is C20H19NO4, Application of tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Song, Qiuyan published the artcileMacrocyclic Photoinitiator Based on Prism[5]arene Matching LEDs Light with Low Migration, Application of Ethyl 4-dimethylaminobenzoate, the publication is Macromolecular Rapid Communications (2021), 42(17), 2100299, database is CAplus and MEDLINE.

In this work, a naphthalene-based macrocycle prism[5]arene (NP₅OCH₃) is developed as a novel kind of photoinitiator. When NP₅OCH₃ is irradiated under light, the bond between methylene and naphthalene can be quickly broken owning to the existence of ring tension. The macrocycle is cleaved to linear oligomer biradicals, which can effectively initiate the free radical photopolymerization of acrylate monomers. Compared with conventional photoinitiators, NP₅OCH₃ has strong light absorption in the wavelength range of 365-405 nm, so it can well match the environment-friendly light-emitting diodes (LEDs) light source to realize highly efficient initiation. In addition, there is no small mol. fragment generated during NP₅OCH₃ fracture, and the resulted linear oligomer biradicals can be immobilized in the polymer after initiating polymerization, so NP₅OCH₃ photoinitiators show much lower migration rate and cytotoxicity. Cleavable macrocycle prismarene may provide a new idea for the design of safe and efficient photoinitiators matching long wavelength light.

Macromolecular Rapid Communications published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C2H4ClNO, Application of Ethyl 4-dimethylaminobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Hiari, Yusuf M. published the artcileSynthesis and biological evaluation of substituted tetrahydro-1H-quino[7,8-b][1,4]benzodiazepine-3-carboxylic derivatives, Computed Properties of 924-99-2, the publication is Farmacia (Bucharest, Romania) (2014), 62(3), 570-588, database is CAplus.

This research paper aims the preparation of substituted tetrahydroquino[7,8-b][1,4]benzodiazepine-3-carboxylic acids I (R = F, Me, H₂N). Reaction of 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-1,4-dihydroquinoline-3-carboxylic acid with each of 2-amino-5-methylbenzoic acid, 2-amino-5-flourobenzoic acid, and 2-amino-5-nitrobenzoic acid yielded 8-nitro-7-substituted anilino-1,4-dihydroquinoline-3-carboxylic acids with low yields. Reduction of 8-nitro-7-substituted anilino-1,4-dihydroquinoline-3-carboxylic acids with sodium dithionite or stannous chloride resulted in the production of 8-amino-7-substituted aniline-1,4-dihydro-quinoline-3-carboxylic acids II. Polyphosphoric acid (PPA) catalyzed thermal lactamization of 8-amino-7-substituted aniline-1,4-dihydro-quinoline-3-carboxylic acids resulted in the production of I. The prepared targets and the intermediates have shown interesting antibacterial activity mainly against gram pos. strains. In particular, the reduced intermediates II showed good activity against standard S. aureus (MIC = 0.05 – 0.19 μg/mL). Intermediates II have also shown reasonable activity against resistant gram pos. strains. The targets I (R = F, H₂N) have comparable activity to the reference against standard gram pos. strains.

Farmacia (Bucharest, Romania) published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rabizadeh, Ester published the artcileRapid alteration of c-myc and c-jun expression in leukemic cells induced to differentiate by a butyric acid prodrug, Product Details of C10H18O4, the publication is FEBS Letters (1993), 328(3), 225-9, database is CAplus and MEDLINE.

The novel prodrug of butyric acid (BA), pivaloyloxymethyl butyrate, has been shown, in vitro, to induce differentiation and inhibit leukemic cell proliferation. The prodrug affects the cells in vitro at lower concentration and at least 100 times faster than does BA. The authors have compared the ability of BA with that of its prodrug AN-9 to modulate the expression of the early regulating genes, c-myc and c-jun, in HL-60 cells. Exposure of HL-60 cells to the prodrug resulted in a decrease of c-myc and an increase of c-jun expression. The prodrug elicited this effect at lower concentrations and at least 100 times faster than BA. Since changes in the expression of c-myc and c-jun occur minutes after exposure of the cells to the prodrug, these genes are likely to play a major role in the early stages of the differentiation pathway.

FEBS Letters published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Product Details of C10H18O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rabizadeh, E published the artcileEsterase inhibitors diminish the modulation of gene expression by butyric acid derivative, pivaloyloxymethyl butyrate (AN-9)., Safety of (Pivaloyloxy)methyl butyrate, the publication is Israel journal of medical sciences (1996), 32(12), 1186-91, database is MEDLINE.

Pivaloyloxymethyl butyrate (AN-9) belongs to the family of acyloxyalkyl ester prodrugs of carboxylic acids which undergo intracellular hydrolysis to yield butyric acid (BA). We have previously shown that AN-9 and BA reduce the level of c-myc and enhance c-jun transcripts in HL-60 cells, and that the differentiation of these cells, induced by AN-9, is dependent on the presence of intracellular esterases. In this study we show that esterase inhibitors abolish the changes induced by AN-9 on c-myc and c-jun expression. In contrast, esterase inhibitors do not change the effects of BA on c-myc or c-jun. Interestingly, these inhibitors affect the modulation induced by both AN-9 and BA on the retinoblastoma tumor suppressor gene. These data suggest that AN-9 is indeed a prodrug of BA and that prior intracellular hydrolysis by esterases is material for AN-9 activity.

Israel journal of medical sciences published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Safety of (Pivaloyloxy)methyl butyrate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics