Esters-buliding-blocks

Tiwari, Vinod K. published the artcileOne-pot convenient and high yielding synthesis of dithiocarbamates, HPLC of Formula: 3052-61-7, the publication is Monatshefte fuer Chemie (2007), 138(7), 653-658, database is CAplus.

A convenient and high yielding method for the synthesis of diverse dithiocarbamates having various substituents including alkyl, aryl, heteroaryl, and alkylaryl at the thiol chain or at the amine chain or at both thiol and amine chains were developed by the one-pot reaction of mercaptans, amines, and bis(benzotriazolyl)methanethione in presence of amidine base under mild reaction conditions.

Monatshefte fuer Chemie published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C19H14Cl2, HPLC of Formula: 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Aquino, Fernanda Lima Torres de published the artciletrans-Cinnamic acid, but not p-coumaric acid or methyl cinnamate, induces fibroblast migration through PKA- and p38-MAPK signalling pathways., COA of Formula: C10H10O2, the publication is Journal of tissue viability (2021), 30(3), 363-371, database is MEDLINE.

AIM: Hydroxycinnamic acids their derivatives have various pharmacological properties. The hydroxycinnamic acid derivatives, methyl cinnamate, trans-cinnamic, and p-coumaric acids have been the object of study in the treatment of skin wounds. However, it is unclear whether these derivatives exert a direct beneficial effect on fibroblast function. In this study, we evaluated the effects of methyl cinnamate, trans-cinnamic, and p-coumaric acids on fibroblast migration in vitro. MATERIALS AND METHODS: NIH 3T3 and L929 fibroblast cell lines were exposed to each drug at several concentrations and the effect on cell viability, cell cycle, and extracellular matrix production were assessed by MTT assay, flow cytometry, and immunofluorescence staining, respectively. The effect on cell migration was examined using scratch assay. RESULTS: The results showed that hydroxycinnamic acid derivatives not affect cell viability, but increase fibroblast migration in the in vitro scratch-wound healing assay. They also induced an increase in S and G2/M phases accompanied by a decrease in the G0/G1 phase of the cell cycle. The cell proliferation inhibitor mitomycin C abolished the effect induced by p-coumaric acid and methyl cinnamate, indicating that only the trans-cinnamic acid stimulated migration. A transwell migration assay confirmed that trans-cinnamic acid-treated fibroblasts exhibited increased migration compared with untreated cells. trans-Cinnamic acid-induced fibroblast migration was decreased by PKA inhibitor and p38-MAPK inhibitor but not by JNK inhibitor. Additionally, trans-cinnamic acid-treated fibroblasts showed an increase in the production of laminin and collagen type I. CONCLUSION: Our study showed that trans-cinnamic acid improves fibroblast migration and modulates extracellular matrix synthesis, indicating its potential for accelerating the healing process.

Journal of tissue viability published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, COA of Formula: C10H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ficks, Arne published the artcileEfficient multigram syntheses of air-stable, chiral primary phosphine ligand precursors via palladium-catalyzed phosphonylation of aryltriflates, Recommanded Product: (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), the publication is Synthesis (2013), 45(2), 265-271, database is CAplus.

Aryl monotriflates, derived from (R)-BINOL, were alkylated or reduced to give 2′-alkoxy-1,1′-binaphthyl 2-triflates and 1,1′-binaphthyl 2-triflates, resp., which were phosphonylated with HP(O)(OEt)₂ and reduced to the corresponding primary arylphosphines by reaction with LiAlH₄/Me₃SiCl. The prepared 1,1′-binaphthalen-2-ylphosphines are air-stable, chiral primary phosphines, being produced on a multigram scale. The key synthetic step is an optimized palladium-catalyzed phosphonylation reaction of aryl triflates, which opens up a valuable synthetic route to a chiral scaffold that is easily derivatized into novel phosphines.

Synthesis published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, Recommanded Product: (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate).

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wilds, A. L. published the artcileSteroid analogs lacking ring C. II. Some analogs of progesterone and desoxycorticosterone, Safety of Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, the publication is Journal of the American Chemical Society (1950), 2388-95, database is CAplus.

cf. C.A. 44, 1086c; 45, 140g. Procedures were developed for the synthesis of some analogs of progesterone (I) and desoxycorticosterone lacking ring C and with a 6-membered ring D. The method involved the Robinson-Mannich base procedure for synthesizing α,β-unsaturated cyclic ketones, modified for application to hydroxymethylene ketones. The I analogs were physiologically inactive. p-MeOC₆H₄Ph, obtained in 95-7% yield from p-HOC₆H₄Ph and Me₂SO₄, was converted to p-(p-MeOC₆H₄)C₆H₄COMe (II), m. 155-6°, in 56% yield (cf. C.A. 40, 7172.1). Oxidation of 174 g. II with NaOBr and demethylation of the resulting 176 g. crude MeO acid with 460 ml. 48% HBr and 2200 ml. AcOH by refluxing 14 hrs. with exclusion of air gave 95% 4′-hydroxy-4-biphenylcarboxylic acid (III), m. 292-4° after sublimation and recrystallization from AcOH. The Me ester of III, colorless cubes, m. 227-8° (from Me₂CO), was obtained in 92-5% yield by refluxing III 2 hrs. with MeOH saturated at 50° with HCl gas. The Et ester, m. 142-3° (from Me₂CO-CCl₄), was similarly prepared in 87% yield after refluxing 24 hrs. A suspension of 40 g. Me ester in 85 ml. absolute MeOH was hydrogenated 12 hrs. with 10 g. W-6 Raney Ni at 85° and an initial H pressure of 4500 lb./sq. in., the catalyst filtered off, and washed with MeOH (500 ml. total MeOH), 50 ml. 45% KOH added, the solution refluxed 2 hrs., diluted with 2 l. H₂O, extracted with 3 portions of CHCl₃, and the extract evaporated, giving 8.5 g. semisolid neutral material. The alk. solution was acidified, extracted with 3 portions of CHCl₃, the extract dried over Na₂SO₄, and the solvent removed, leaving 28.0 g. (70%) of a mixture of acids. Recrystallization from Me₂CO gave 1 of the stereoisomers of 4-(4-carboxycyclohexyl)cyclohexanol (IV), colorless prisms, m. 194-5°. Attempts to sep. the mixture of acids by fractional acidification of their Na₂CO₃ solution failed, yielding a mixture m. 115-205°. When the reduced ester mixture was not hydrolyzed but crystallized from Et₂O-petr. ether, recrystallization from CCl₄ of the solid (18%, m. 90-5°) gave 1 of the isomeric Me esters of IV, m. 98-100°, hydrolyzed by alkali to the same stereoisomer, m. 194-5°, of IV as above. The crude mixture of isomers of IV (28 g.) was dissolved in 500 ml. AcOH, cooled to 16°, stirred with 23 g. Cr₂O₃ in 20 ml. H₂O, 50 ml. AcOH slowly added over 1 hr., the mixture kept at 16-20° 1 addnl. hr., then treated with 25 ml. MeOH, poured into 2 l. H₂O containing 50 ml. HCl, the mixture extracted several times with CHCl₃, the extract washed with dilute HCl and H₂O, dried over Na₂SO₄, the solvent removed, and the residue recrystallized from Me₂CO, giving in 2 crops 8.7 g. (31%) of a crude isomer A of 4-(4-carboxycyclohexyl)cyclohexanone (V), m. 174-5°. From the filtrate, by crystallization from petr. ether-Et₂O, was obtained 14.1 g. (50%) of a mixture (m. 84-90°), largely a 2nd isomer B of V. The Me ester of isomer A, obtained in 99% yield with CH₂N₂ in Et₂O, from petr. ether, colorless prisms, m. 39-40° (2,4-dinitrophenylhydrazone, prepared in 57% yield in MeOH containing a trace of HCl, from AcOMe, orange prisms, m. 197-8°). Partial purification of the crude isomer B of V by fractional acidification of its solution in Na₂CO₃ or adsorption of the Me ester on alumina and fractional elution, resulting in each case in concentration of isomer B in the 1st fraction. The best method was to remove as much of isomer A as possible, then seed a solution in C₆H₆ with pure isomer B, and cool, giving a product m. 96-6.5° (from C₆H₆ and Et₂O-petr. ether). The solid isomer m. 194-5°, of IV, oxidized with Cr₂O₃, gave isomer B, m. 96-6.5°, of V. The Me ester was an oil, yielding 55% 2,4-dinitrophenylhydrazone, orange needles, m. 107-9° (from MeOH), resolidifying, and m. 131-2°. A suspension of 5 g. Et ester of III was hydrogenated 30 min. with 2 g. W-6 Raney Ni at a pressure of 2400 lb./sq.in. and 110°, the catalyst and solvent removed, and the residue dissolved in Et₂O and extracted with 3 portions of cold 5% KOH; from the Et₂O was obtained 3.80 g. oil which partially solidified, and on recrystallization from Et₂O-petr. ether gave one isomer of the Et ester of 4-(p-carboxyphenyl)cyclohexanol (VI), fine colorless needles, m. 134-5°. The remainder of the neutral product was hydrolyzed by refluxing 2 hrs. with 60 ml. MeOH and 10 ml. 45% KOH, diluted, and extracted with CHCl₃, yielding 0.17 g. neutral material. The alk. layer, acidified and extracted with warm CHCl₃ yielded 3.20 g. mixture of acids, m. 195-217°. Recrystallization from Me₂CO gave one isomer of VI, stout prisms, m. 236-7°; conversion of this acid to the Et ester with alc. HCl gave the same isomer, m. 134-5°, as above. Me ester, prepared by addition of CH₂N₂ in Et₂O to the acid in CHCl₃, colorless needles from CCl₄, m. 137-8°. From the KOH washings of the crude hydrogenation mixture was obtained 1.0 g. oily acidic material which was converted into the Me ester with MeOH and H₂SO₄; from this was isolated some unreduced Me ester of III, m. 224-6°, and a small amount of the Me ester, m. 137-38°, of IV. None of the compound with only the ring containing the carbomethoxy group reduced was isolated. The crude acid (m. 195-217°) above was oxidized in 80 ml. AcOH with 2.00 g. Cr₂O₄ in 2 ml. H₂O and 10 ml. AcOH at 15-18°; a portion of the solid keto acid from the CHCl₃ extracts recrystallized from Me₂CO as stout prisms, m. 228-30°. The remaining crude acid treated in CHCl₃ with excess CH₂N₂ in Et₂O yielded the Me ester of 4-(4-carboxyphenyl)cyclohexanone (VII), colorless platelets from Et₂O, m. 93-4.5°; 2,4-dinitrophenylhydrazone of the Me ester (92% from AcOMe), orange prisms, m. 223-4°.

Journal of the American Chemical Society published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C12H14IN, Safety of Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Failli, Amedeo A. published the artcilePyridobenzodiazepines: A novel class of orally active, vasopressin V₂ receptor selective agonists, Product Details of C9H6F4O2, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(4), 954-959, database is CAplus and MEDLINE.

Our efforts in seeking low mol. weight agonists of the antidiuretic peptide hormone arginine vasopressin (AVP) have led to the identification of the clin. candidate WAY-151932 (VNA-932). Further exploration of the structural requirements for agonist activity has provided another class of potent, orally active, non-peptidic vasopressin V₂ receptor selective agonists exemplified by the 5,11-dihydro-pyrido[2,3-b][1,5]benzodiazepine as a candidate for further development.

Bioorganic & Medicinal Chemistry Letters published new progress about 220141-23-1. 220141-23-1 belongs to esters-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Benzene,Ester, name is Methyl 4-fluoro-2-(trifluoromethyl)benzoate, and the molecular formula is C9H6F4O2, Product Details of C9H6F4O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Jian published the artcileA direct HPLC method for the determination of enantiomeric excess of some highly enantiomerically enriched derivatives of chiral glycidols, COA of Formula: C9H9NO6S, the publication is Tetrahedron Letters (1993), 34(48), 7663-6, database is CAplus.

A newly developed HPLC method which requires no derivatization is used to determine accurately the enantiomeric purity of some glycidol-based derivatives that were enantiomerically enriched by recrystallization or lipase-catalyzed kinetic resolution after the Sharpless asym. epoxidation

Tetrahedron Letters published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, COA of Formula: C9H9NO6S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tkachuk, Volodymyr V. published the artcile2-Carbamimidoylbenzoic Acid as a New Effective and Available Precursor for the Synthesis of Substituted 2-(Pyrimidin-2-yl)-benzoic Acids, COA of Formula: C6H10O3, the publication is Synthesis (2021), 53(2), 371-382, database is CAplus.

A new approach to the synthesis of 2-(pyrimidin-2-yl)benzoic acids I (R = Me, Et, Ph, OH, NH₂) based on the ring contraction of the 2-carbamimidoylbenzoic acid with 1,3-dicarbonyl compounds R¹CH₂C(O)OR² (R¹ = C(O)Me, C(O)Et, C(O)Ph, C(O)OEt, CN; R² = Me, Et), and their synthetic equivalent has been developed. The intramol. condensation of the obtained acids with 1,3-dielectrophiles proceeds with the formation of the 4,6-dihydropyrimido[2,1-a]isoindole-4,6-diones II (R = Me, Et, Ph, NH₂), the pyrrolidone ring of which is easily opened under the action of weak nucleophiles. The reaction of 2-carbamimidoylbenzoic acid with chromones III (R³ = H, CF₃; R⁴ = 4-chlorophenyl, 2-nitrophenyl), which have an aryloxy group at 3-position does not stop at the step of pyrimidine ring formation and undergoes further spontaneous cyclization into 2-(benzo[4,5]furo[3,2-d]pyrimidin-2-yl)benzoic acids IV.

Synthesis published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C18H10F3NO3S2, COA of Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sugiyama, Kazuo published the artcileSynthesis and properties of macromonomer having azobenzene moieties as a mesogenic group, Product Details of C23H28N2O4, the publication is Kinki Daigaku Kogakubu Kenkyu Hokoku (1988), 31-5, database is CAplus.

4-Methoxy-4′-(6-methacryloyloxyhexyloxy)azobenzene was telomerized radically in the presence of HSCH₂CO₂H to give a telomer which was treated with glycidyl methacrylate to give the title macromonomer. DSC and polarization microscopy showed that the telomer was a nematic liquid crystal. Photoreversible cis-trans isomerization of the telomer was studied.

Kinki Daigaku Kogakubu Kenkyu Hokoku published new progress about 135529-02-1. 135529-02-1 belongs to esters-buliding-blocks, auxiliary class azo,Alkenyl,Benzene,Ester,Ether, name is 6-(4-((4-Methoxyphenyl)diazenyl)phenoxy)hexyl methacrylate, and the molecular formula is C9H9NO, Product Details of C23H28N2O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sugiyama, Kazuo published the artcileThermal properties of liquid-crystalline polyitaconates with paired mesogens, COA of Formula: C23H28N2O4, the publication is Bulletin of the Chemical Society of Japan (1991), 64(5), 1715-17, database is CAplus.

2-Methylenesuccinates (itaconates) (I) having 2 4-methoxyazobenzene moieties as paired mesogenic groups were prepared I was radically homopolymerized and copolymerized with non-mesogenic monomer, dioctadecyl itaconate (DOI). Paired mesogenic homopolyitaconate exhibits a nematic phase and the copolymers of I with DOI also show a mesomorphic phase up to 25 mol% of DOI content. The enhancement of mesophase formation by paired mesogens is discussed.

Bulletin of the Chemical Society of Japan published new progress about 135529-02-1. 135529-02-1 belongs to esters-buliding-blocks, auxiliary class azo,Alkenyl,Benzene,Ester,Ether, name is 6-(4-((4-Methoxyphenyl)diazenyl)phenoxy)hexyl methacrylate, and the molecular formula is C10H15ClO3S, COA of Formula: C23H28N2O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yang, Feng V. published the artcileParallel synthesis of N-biaryl quinolone carboxylic acids as selective M₁ positive allosteric modulators, SDS of cas: 924-99-2, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(2), 531-536, database is CAplus and MEDLINE.

An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M₁ pos. allosteric modulators, and strategies for improving potency and plasma free fraction were identified.

Bioorganic & Medicinal Chemistry Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C18H10F3NO3S2, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics