Esters-buliding-blocks

Tabarrini, Oriana published the artcileStructure Modifications of 6-Aminoquinolones with Potent Anti-HIV Activity, COA of Formula: C7H13NO2, the publication is Journal of Medicinal Chemistry (2004), 47(22), 5567-5578, database is CAplus and MEDLINE.

It was recently discovered that 6-aminoquinolone derivatives could be valid leads for the development of new anti-HIV agents because of their new and diversified mode of action. The studies carried out on the lead compound WM5 showed that this derivative is able to inhibit the Tat-mediated long terminal repeat driven transcription, an essential step in the HIV-1 replication cycle. Thus, starting from lead WM5, the design and synthesis of an enlarged series of 6-aminoquinolones, e.g. I (R¹ = Me, 2-benzothiazolyl, biphenyl, 4-FC₆H₄, etc.; R² = 2-MeOC₆H₄, 2-thiazolyl, 2-pyridyl, 5-methyl-1,3,4-thiadiazol-2-yl, etc.), was performed and their structure-activity relationship was studied. I (R¹ = Me; R² = 3-F₃CC₆H₄, 2-thiazolyl, 2-pyrazinyl, 2-benzoxazolyl) proved to be highly effective in inhibiting HIV replication at 50% inhibitory concentration in the range of 0.0087-0.7 μg/mL in MT-4, PBMCs and CEM cell lines coupled with pos. selectivity indexes that reach values higher than 1000 on CEM cell lines for I (R¹ = Me; R² = 2-thiazolyl, 2-pyrazinyl). Time-of-addition experiments clearly confirm that the new, potent 6-aminoquinolones interact at a postintegration step in the replication cycle of HIV.

Journal of Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C12H15NO, COA of Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Masschelein, Kurt G. R. published the artcileExploiting the regioselectivity of pyroglutamate alkylations for the synthesis of 6-azabicyclo[3.2.1]octanes and 4-azabicyclo[3.3.0]octanes, HPLC of Formula: 942603-91-0, the publication is Tetrahedron (2007), 63(22), 4712-4724, database is CAplus.

The preparation of 6-azabicyclo[3.2.1]octanes and 4-azabicyclo[3.3.0]octanes via regioselective alkylation and ring closure of pyroglutamates is described. Depending on the N-protecting group of pyroglutamates, the reactivity can be directed to the formation of 6-azabicyclo[3.2.1]octanes, e.g. I, or 4-azabicyclo[3.3.0]octanes, e,.g. II, which are conformationally restricted glutamate analogs. The stereoselectivity is also discussed.

Tetrahedron published new progress about 942603-91-0. 942603-91-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Fused-Heterocycles, name is Ethyl 2-methylene-5-oxohexahydro-1H-pyrrolizine-7a-carboxylate, and the molecular formula is C11H15NO3, HPLC of Formula: 942603-91-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nugent, Jeremy published the artcileSynthesis of α-quaternary bicyclo[1.1.1]pentanes through synergistic organophotoredox and hydrogen atom transfer catalysis, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one, the publication is Organic Letters (2021), 23(21), 8628-8633, database is CAplus and MEDLINE.

Bicyclo[1.1.1]pentanes (BCPs) are of importance in drug design as sp3-rich bioisosteres of arenes and tert-Bu groups, however the preparation of BCPs with adjacent quaternary carbons is barely known. Authors report a facile synthesis of α-quaternary BCPs using organophotoredox and hydrogen atom transfer catalysis in which α-keto radicals, generated through oxidation of β-ketocarbonyls, underwent efficient addition to [1.1.1]propellane. The BCP products can be transformed into a variety of useful derivatives including enantioenriched BCPs featuring α-quaternary stereocenters.

Organic Letters published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hayrapetyan, Davit published the artcileFacile Synthesis of Spirocyclic Lactams via [3+2] and [3+3] Aza-Annulation Reactions, COA of Formula: C6H8O3, the publication is European Journal of Organic Chemistry (2021), 2021(14), 2121-2125, database is CAplus.

Spirocyclic pyrrolidones and piperidones such as I and II were synthesized starting from readily available α-ketolactones and α-ketolactams employing [3+2]- and [3+3]-aza-annulation reactions. Tandem reactions of enamino lactams and lactones with maleic and itaconic anhydride yielded alkylidenespirolactams in good yields; further reduction of the exocyclic C=C double bond of the enamino moiety proceeded with excellent diastereoselectivity. Overall, one C-C and two C-N bonds, as well as three new stereocenters were created in a diastereoselective manner resulting in a fast upbuild of mol. complexity.

European Journal of Organic Chemistry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, COA of Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Batista-Pereira, Luciane G. published the artcileIsolation, Identification, Synthesis, and Field Evaluation of the Sex Pheromone of the Brazilian Population of Spodoptera frugiperda, Application of (Z)-Dodec-9-en-1-yl acetate, the publication is Journal of Chemical Ecology (2006), 32(5), 1085-1099, database is CAplus and MEDLINE.

Several studies have shown intraspecific geog. variation in the composition of sex pheromones. Pheromone lures from North America and Europe were not effective against the fall armyworm Spodoptera frugiperda (Smith, 1797) (Lepidoptera: Noctuidae) in Brazil, so the authors examined the composition of the sex pheromone produced by females from Brazilian populations. Virgin female gland extracts contained (Z)-7-dodecenyl acetate (Z7-12:Ac), (E)-7-dodecenyl acetate (E7-12:Ac), dodecyl acetate, (Z)-9-dodecenyl acetate, (Z)-9-tetradecenyl acetate (Z9-14:Ac), (Z)-10-tetradecenyl acetate, tetradecyl acetate/(Z)-11-tetradecenyl acetate (Z11-16:Ac), and (Z)-11-hexadecenyl acetate. The relative proportions of each acetate were 0.8:1.2:0.6:traces:82.8:0.3:1.5:12.9, resp. This is the first time that E7-12:Ac has been reported from the pheromone gland of S. frugiperda. Only three compounds, Z9-14:Ac, Z7-12:Ac, and E7-12:Ac, elicited antennal responses, and there were no differences in catch between traps baited with either Z7-12:Ac + Z9-14:Ac or Z7-12:Ac + Z9-14:Ac + Z11-16:Ac blends. However, the Z7-12:Ac + Z9-14:Ac + E7-12:Ac blend was significantly better than Z7-12:Ac + Z9-14:Ac, indicating that E7-12:Ac is an active component in the sex pheromone of the Brazilian populations of S. frugiperda.

Journal of Chemical Ecology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Application of (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Knothe, Gerhard published the artcileKinematic viscosity of biodiesel fuel components and related compounds. Influence of compound structure and comparison to petrodiesel fuel components, Application In Synthesis of 110-34-9, the publication is Fuel (2005), 84(9), 1059-1065, database is CAplus.

Biodiesel, defined as the mono-alkyl esters of vegetable oils and animal fats is an alternative diesel fuel that is steadily gaining attention and significance. One of the most important fuel properties of biodiesel and conventional diesel fuel derived from petroleum is viscosity, which is also an important property of lubricants. Ranges of acceptable kinematic viscosity are specified in various biodiesel and petrodiesel standards In this work, the kinematic viscosity of numerous fatty compounds as well as components of petrodiesel were determined at 40 °C (ASTM D445) as this is the temperature prescribed in biodiesel and petrodiesel standards The objective is to obtain a database on kinematic viscosity under identical conditions that can be used to define the influence of compound structure on kinematic viscosity. Kinematic viscosity increases with chain length of either the fatty acid or alc. moiety in a fatty ester or in an aliphatic hydrocarbon. The increase in kinematic viscosity over a certain number of carbons is smaller in aliphatic hydrocarbons than in fatty compounds The kinematic viscosity of unsaturated fatty compounds strongly depends on the nature and number of double bonds with double bond position affecting viscosity less. Terminal double bonds in aliphatic hydrocarbons have a comparatively small viscosity-reducing effect. Branching in the alc. moiety does not significantly affect viscosity compared to straight-chain analogs. Free fatty acids or compounds with hydroxy groups possess significantly higher viscosity. The viscosity range of fatty compounds is greater than that of various hydrocarbons comprising petrodiesel. The effect of dibenzothiophene, a sulfur-containing compound found in petrodiesel fuel, on viscosity of toluene is less than that of fatty esters or long-chain aliphatic hydrocarbons. To further assess the influence of the nature of oxygenated moieties on kinematic viscosity, compounds with 10 carbons and varying oxygenated moieties were investigated. A reversal in the effect on viscosity of the carboxylic acid moiety vs. the alc. moiety is noted for the C10 compounds compared to unsaturated C18 compounds Overall, the sequence of influence on kinematic viscosity of oxygenated moieties is COOH≈C-OH>COOCH₃≈C=O>C-O-C> no oxygen.

Fuel published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Application In Synthesis of 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Van Es, Theodorus published the artcileN,1-Dialkyl-7-(alkylamino)-4-(alkylimino)-1,4-dihydroquinoline-3-carboxamides and their 4-oxo derivatives: synthesis and properties, Computed Properties of 924-99-2, the publication is South African Journal of Chemistry [online computer file] (2001), 1-16, database is CAplus.

Methods are described for accessing the little known class of 4-alkyliminoquinoline-3-carboxamide title compounds; viz., from 4-oxoquinoline-3-carboxylic acids treated successively with thionyl chloride and amine, from 4-oxoquinoline-3-carboxylic esters treated likewise, and from the hydrogen chloride salt of a 4-alkyliminoquinoline-3-carboxylic ester and amine. Mechanistic aspects of the syntheses are discussed, and some spectroscopic and chem. properties of the title compounds are presented.

South African Journal of Chemistry [online computer file] published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C13H9FO, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mahmoud, Engy published the artcileDetermination of volatiles, antioxidant activity, and polyphenol content in the postharvest waste of Ocimum basilicum L, SDS of cas: 103-26-4, the publication is Food Chemistry (2022), 131692, database is CAplus and MEDLINE.

The treatment of postharvest wastes is an integral part of the food value chain. Therefore, Ocimum basilicum L. residues were dried in an oven and a microwave. Volatiles were extracted using hydrodistillation, headspace solid-phase microextraction (HS-SPME) and then analyzed by Gas Chromatog.-Mass Spectrometry (GC-MS). Thirty volatiles were identified in raw material, with β-linalool, methyleugenol, methylcinnamate, and estragole predominating. Meanwhile, 24 and 18 volatiles were detected in the oven- and microwave-dried samples, with a significant decrease of methyleugenol content. The highest radical scavenging ability and total phenolic content were achieved for microwaved wastes using photochemiluminescence, DPPH, and Folin-Ciocalteu test. Moreover, 8 phenolic acids and 9 flavonoids were identified in the LC-MS/MS anal., with significant contents of rosmarinic acid and luteolin (1042.45 and 11.68μg/g of dry matter, resp.) in the microwaved basil. This experiment pointed out that microwaved basil wastes could be re-used in the food, pharmacy and/or cosmetic industries.

Food Chemistry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, SDS of cas: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shah, Parag K. published the artcilePhotopolymerization shrinkage-stress reduction in polymer-based dental restoratives by surface modification of fillers, Computed Properties of 10287-53-3, the publication is Dental Materials (2021), 37(4), 578-587, database is CAplus and MEDLINE.

This research explores the use of polymer brushes for surface treatment of fillers used in polymer-based dental restoratives with focus on shrinkage stress reduction The influence of interfacial reactive groups on shrinkage stress is explored. Oligomers of varying lengths and with varying number of reactive groups along the length were synthesized by modifying com. oligomers. Surface of silica fillers (OX50) was treated with methylaminopropyltrimethoxysilane and this was further reacted with the synthesized oligomers to obtain a series of polymer brushes on the surface. Fillers modified with -methacryloxypropyltrimethoxysilane were used as a control. Filler surface treatment was confirmed using diffuse reflectance spectroscopy and thermogravimetric anal. Fillers were added at 30 wt% to a resin made of BisGMA/TEGDMA and polymerization kinetics, shrinkage stress, volumetric shrinkage, flexural strength and modulus, viscosity were measured. Composites with polymer brush functionalized fillers showed up to a 30% reduction in shrinkage stress as compared to the control, with no reduction in flexural strength and modulus. Shrinkage stress reduced with increasing length of the polymer brush and increased with increase in number of reactive groups along the length of the polymer brush. The interface between inorganic fillers and an organic polymer matrix has been utilized to reduce shrinkage stress in a composite with no compromise in mech. properties. This study gives insights into the stress development mechanism at the interface.

Dental Materials published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C9H6N2O2, Computed Properties of 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Julia, Marc published the artcileSyntheses via sulfones. XXXVII. Synthesis of three pheromones with a Z double bond: (Z)-8-DDA, (Z)-9-DDA, and (Z)-9-TDA, Application of (Z)-Dodec-9-en-1-yl acetate, the publication is Tetrahedron (1986), 42(9), 2469-74, database is CAplus.

The title compounds, Z-8-dodecen-1-yl acetate, Z-9-dodecen-1-yl acetate, and Z-9-tetradecen-1-yl acetate, have been synthesized in 3 efficient steps. The reaction mixture from lithiated HO(CH₂)_nSO₂Ph (n = 8, 9) and Me(CH₂)_mCHO (m = 1-3) was quenched with Ac₂O yielding a diastereoisomeric mixture of β-acetoxy sulfones. Convergent elimination with powd. NaOH led to E-Me(CH₂)_mCH:C(SO₂Ph)(CH₂)_n-1OAc. Stereospecific hydrogenolysis of the sulfonyl group was carried out with sodium dithionite leading to the unsaturated alcs. (>99% Z), which were reesterified.

Tetrahedron published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Application of (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics