Esters-buliding-blocks

Runemark, August published the artcileAerobic Oxidative EDA Catalysis: Synthesis of Tetrahydroquinolines Using an Organocatalytic EDA Active Acceptor, Name: Ethyl 4-dimethylaminobenzoate, the publication is Journal of Organic Chemistry (2022), 87(2), 1457-1469, database is CAplus and MEDLINE.

A catalytic electron donor-acceptor (EDA) complex for the visible-light-driven annulation reaction between activated alkenes and N,N-substituted dialkyl anilines was reported. The key photoactive complex was formed in situ between dialkylated anilines as donors and 1,2-dibenzoylethylene as a catalytic acceptor. The catalytic acceptor was regenerated by aerobic oxidation Investigations into the mechanism were provided, revealing a rare example of a catalytic acceptor in photoactive EDA complexes that can give access to selective functionalization of aromatic amines under mild photochem. conditions.

Journal of Organic Chemistry published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Name: Ethyl 4-dimethylaminobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Parthasarathy, V. published the artcileMelt surface grafting of HDPE with mercaptoesters by thermolysis method, Name: Ethyl 2-mercaptopropanoate, the publication is Polymer Engineering & Science (2010), 50(3), 474-483, database is CAplus.

High-d. polyethylene (HDPE) was graft functionalized with 2 different mercapto esters in an inert atm. at 160°C under different exptl. conditions by thermolysis method. The order of functionalization, crosslinking, and C=C formation reactions were determined from the relative intensities of carbonyl stretching vibration and C-H bending vibrations. FTIR, DSC, and TGA anal. tools were used to characterize mercapto ester-functionalized HDPE. A plausible reaction mechanism is proposed here to explain the exptl. results obtained. POLYM. ENG. SCI., 2010. © 2009 Society of Plastics Engineers.

Polymer Engineering & Science published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Name: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dong, Lyu published the artcileAdvantage of Preserving Bi-orientation Structure of Isotactic Polypropylene through Die Drawing, Recommanded Product: Tris(2,4-di-tert-butylphenyl) phosphite, the publication is Chinese Journal of Polymer Science (2021), 39(1), 91-101, database is CAplus.

The isotactic polypropylene (iPP) usually shows a unique parent-daughter lamellae structure in which the parent and daughter lamellae are against each other with a near perpendicular angle (80° or 100°). Inducing a high fraction of oriented cross-hatched structure in iPP during processing is desirable for designing the bi-oriented iPP products. We processed a com. iPP via tensile-stretching and die-drawing to evaluate the structural evolution of oriented parent-daughter lamellae. It turned out that the die-drawing process had an advantage in attaining a high fraction of oriented cross-hatched structure of iPP, as compared to the free tensile stretching. Besides, the presence of α-nucleating agents affected the formation of oriented parent-daughter lamellae in the die-drawn samples, whereas such influence diminished in the free stretched ones. It was found that the confined deformation inside the die led to the well-preserved oriented cross-hatched structure in the die-drawn iPP.

Chinese Journal of Polymer Science published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C42H63O3P, Recommanded Product: Tris(2,4-di-tert-butylphenyl) phosphite.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tang, Shuqin published the artcilePrenatal Exposure to Emerging Plasticizers and Synthetic Antioxidants and Their Potency to Cross Human Placenta, Application of Dimethyl adipate, the publication is Environmental Science & Technology (2022), 56(12), 8507-8517, database is CAplus and MEDLINE.

Gestational exposure to environmental chems. and subsequent permeation through the placental barrier represents potential health risks to both pregnant women and their fetuses. In the present study, we explored prenatal exposure to a suite of 46 emerging plasticizers and synthetic antioxidants (including five transformation products of 2,6-di-tert-butyl-4-hydroxytoluene, BHT) and their potency to cross human placenta based on a total of 109 maternal and cord serum pairs. Most of these chems. have rarely or never been investigated for prenatal exposure and associated health risks. Eleven of them exhibited detection frequency greater than 50% in maternal blood, including di-Bu fumarate (DBF), 2,6-di-tert-butylphenol (2,4-DtBP), 1,3-diphenylguanidine (DPG), methyl-2-(benzoyl)benzoate (MBB), tri-Et citrate (TEC), BHT, and its five metabolites, with a median concentration from 0.05 to 3.1 ng/mL. The transplacental transfer efficiency (TTE) was determined for selected chems. with valid measurements in more than 10 maternal/cord blood pairs, and the mean TTEs exhibited a large variation (i.e., 0.29-2.14) between chems. The determined TTEs for some of the target chems. were comparable to the predicted values by our previously proposed models developed from mol. descriptors, indicating that their transplacental transfer potency could be largely affected by physicochem. properties and mol. structures. However, addnl. biol. and physiol. factors may influence the potency of environmental chems. to cross human placenta. Overall, our study findings raise concern on human exposure to an increasing list of plastic additives during critical life stages (e.g., pregnancy) and potential health risks.

Environmental Science & Technology published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C15H21BO3, Application of Dimethyl adipate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tang, Shuqin published the artcilePrenatal Exposure to Emerging Plasticizers and Synthetic Antioxidants and Their Potency to Cross Human Placenta, Related Products of esters-buliding-blocks, the publication is Environmental Science & Technology (2022), 56(12), 8507-8517, database is CAplus and MEDLINE.

Gestational exposure to environmental chems. and subsequent permeation through the placental barrier represents potential health risks to both pregnant women and their fetuses. In the present study, we explored prenatal exposure to a suite of 46 emerging plasticizers and synthetic antioxidants (including five transformation products of 2,6-di-tert-butyl-4-hydroxytoluene, BHT) and their potency to cross human placenta based on a total of 109 maternal and cord serum pairs. Most of these chems. have rarely or never been investigated for prenatal exposure and associated health risks. Eleven of them exhibited detection frequency greater than 50% in maternal blood, including di-Bu fumarate (DBF), 2,6-di-tert-butylphenol (2,4-DtBP), 1,3-diphenylguanidine (DPG), methyl-2-(benzoyl)benzoate (MBB), tri-Et citrate (TEC), BHT, and its five metabolites, with a median concentration from 0.05 to 3.1 ng/mL. The transplacental transfer efficiency (TTE) was determined for selected chems. with valid measurements in more than 10 maternal/cord blood pairs, and the mean TTEs exhibited a large variation (i.e., 0.29-2.14) between chems. The determined TTEs for some of the target chems. were comparable to the predicted values by our previously proposed models developed from mol. descriptors, indicating that their transplacental transfer potency could be largely affected by physicochem. properties and mol. structures. However, addnl. biol. and physiol. factors may influence the potency of environmental chems. to cross human placenta. Overall, our study findings raise concern on human exposure to an increasing list of plastic additives during critical life stages (e.g., pregnancy) and potential health risks.

Environmental Science & Technology published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C5H10Cl3O3P, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wu, Jianxiang published the artcileNovel amphiphilic ABC 3-miktoarm star azo-copolymer with polypeptide chain: Synthesis, self-assembly and photo-responsive behavior, Quality Control of 135529-02-1, the publication is European Polymer Journal (2020), 109930, database is CAplus.

Well-defined amphiphilic ABC 3-miktoarm star terpolymer containing hydrophilic methoxy poly(ethylene glycol) (MPEG), hydrophobic poly[6-(4-methoxy-azobenzene-4′-oxy) hexyl methacrylate] (PAzoMA) and poly(γ-benzyl-L-glutamic acid) (PBLG) was synthesized by a combination of copper-mediated atom transfer radical polymerization (ATRP) and ring opening polymerization (ROP). MPEG was modified to bear two different functional groups, which were further modified to the initiator of ATRP and ROP for the preparation of the amphiphilic ABC-type 3-miktoarm star terpolymers (MPEG) (PAzoMA) (PBLG). The spindle-like micelles were formed from the amphiphilic 3-miktoarm star terpolymer through a solution self-assembly due to the rigid α-helical conformation of PBLG block and the π-π interaction between PBLG block with PAzoMA block in the star terpolymer. The investigation of the photo-isomerization behavior of (MPEG) (PAzoMA) (PBLG) in solution and in micellar solution showed that trans-cis isomerization in solution was quicker than that in micellar solution, and H- or J-aggregates of the azobenzene groups in the aggregates did not be observed On the basis of the exptl. results, the formation mechanisms of the spindle-like micelles were suggested and the obtained results may expand the self-assembly research field.

European Polymer Journal published new progress about 135529-02-1. 135529-02-1 belongs to esters-buliding-blocks, auxiliary class azo,Alkenyl,Benzene,Ester,Ether, name is 6-(4-((4-Methoxyphenyl)diazenyl)phenoxy)hexyl methacrylate, and the molecular formula is C27H39ClN2, Quality Control of 135529-02-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhao, Chen published the artcileDesign of a New Histamine H₃ Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure-Activity Relationships, HPLC of Formula: 370880-09-4, the publication is Journal of Medicinal Chemistry (2009), 52(15), 4640-4649, database is CAplus and MEDLINE.

A new histamine H₃ receptor (H₃R) antagonist chemotype I (R¹ = aryl, R² = alkyl) was designed by combining key pharmacophoric elements from two different precursor structural series and then simplifying and optimizing the resulting combined structural features. First, analogs were made based on a previously identified conessine-based H₃R antagonist series. While the first analogs II and 4b-epi-II showed no antagonistic activity to H₃R, the mere addition of a key 4-cyanophenyl moiety, found in a reference compound (ABT-239), in place of the methoxyl group elevated the series to high potency at H₃R. The resulting hybrid structure was judged too synthetically demanding to enable an extensive SAR study, thus forcing a strategy to simplify the chem. structure. The resulting (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrrole series proved to be highly potent, as exemplified by III having a human H₃K_i of 0.54 nM, rat H₃K_i of 4.57 nM, and excellent pharmacokinetics (PK) profile in rats (oral bioavailability of 39% and t_1/2 of 2.4 h).

Journal of Medicinal Chemistry published new progress about 370880-09-4. 370880-09-4 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amide, name is (3aR,6aR)-tert-Butyl hexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxylate, and the molecular formula is C8H15NO, HPLC of Formula: 370880-09-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhao, Xiao-hui published the artcileSeparation of activated compounds from Synechococcus sp. and the bioactivity study, SDS of cas: 110-34-9, the publication is Tianran Chanwu Yanjiu Yu Kaifa (2013), 25(1), 12-16, 70, database is CAplus.

Marine microalga Synechococcus was one of Cyanobacteria. In order to investigate the bioactivity components of Synechococcus, three organic solvents, including petroleum ether, Et acetate and n-butanol, were used to extract the ethanol extract of Synechococcus, resp., and three kinds of organic phase crude extracts were obtained. Then the antibiosis and antioxidant activities of crude extracts were detected. The chem. components of crude extracts were analyzed by GC-MS chromatogram, and 20 components of petroleum ether phase and n-butanol phase were determined, resp. The activity tracking results showed that the best antibacterial and antioxidant effects of crude extracts were observed in petroleum ether phase, followed by Et acetate phase and n-butanol phase. The aqueous extracts had no bioactivities. Subsequently, silica gel column chromatog., gel Sephadex LH-20 chromatog. and preparative thin layer chromatog. were used to sep. and purify the compounds from petroleum ether phase, and a monomeric compound was obtained, the structure of compound was elucidated as β-sitosterol by the means of ¹H NMR, ¹³C NMR etc. spectrum technol.

Tianran Chanwu Yanjiu Yu Kaifa published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C7H13BrSi, SDS of cas: 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xu, Shujing published the artcileDesign, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability, Product Details of C9H8O4, the publication is European Journal of Medicinal Chemistry (2022), 113903, database is CAplus and MEDLINE.

Further clin. development of I, a lead compound targeting HIV-1 capsid, is impeded by low antiviral activity and inferior metabolic stability. By modifying the benzene (region I) and indole of I, we identified two potent compounds II [R = propargyl, 4-NH₂Ph] with significantly improved metabolic stability. Compared to PF74, II [R = 4-NH₂Ph] displayed greater metabolic stability in human liver microsomes (HLMs) with half-life (t_1/2) 109-fold that of PF74. Moreover, mechanism of action (MOA) studies demonstrated that II [R = propargyl, 4-NH₂Ph] effectively mirrored the MOA of compounds that interact within the I interprotomer pocket, showing direct and robust interactions with recombinant CA, and 7u displaying antiviral effects in both the early and late stages of HIV-1 replication. Furthermore, MD simulation corroborated that II [R = 4-NH₂Ph] was bound to the I binding site, and the results of the online molinspiration software predicted that II [R = propargyl, 4-NH₂Ph] had desirable physicochem. properties. Unexpectedly, this series of compounds exhibited better antiviral activity than I against HIV-2, represented by compound II [R = propargyl] whose anti-HIV-2 activity was almost 5 times increased potency over I. Therefore, we have rationally redesigned the I chemotype to inhibitors with novel structures and enhanced metabolic stability in this study. We hope that these new compounds can serve as a blueprint for developing a new generation of HIV treatment regimens.

European Journal of Medicinal Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C20H28B2O4S2, Product Details of C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cui, Bin published the artcileMn(OAc)₃-Mediated Hydrotrifluoromethylation of Unactivated Alkenes Using CF₃SO₂Na as the Trifluoromethyl Source, Quality Control of 5205-11-8, the publication is Journal of Organic Chemistry (2018), 83(11), 6015-6024, database is CAplus and MEDLINE.

Unfunctionalized alkenes such as alkenyl ethers, amides, sulfonamides, and esters underwent regioselective hydrotrifluoromethylation with F₃CSO₂Na (Langlois’s reagent) mediated by Mn(OAc)₃ in AcOH at ambient temperature under Ar. TEMPO inhibited the hydrotrifluoromethylation (yielding TEMPO-CF₃), and hydrotrifluoromethylation of N,N-diallyl-p-toluenesulfonamide yielded a trifluoroethyl-substituted pyrrolidine, consistent with a radical mechanism for the hydrotrifluoromethylation reaction; deuteration experiments with O- and C-deuterated acetic acid were performed to determine the source of hydrogen atoms.

Journal of Organic Chemistry published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Quality Control of 5205-11-8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics