Esters-buliding-blocks

Kargbo, Robert published the artcileReadily Accessible, Modular, and Tuneable BINOL 3,3′-Perfluoroalkylsulfones: Highly Efficient Catalysts for Enantioselective In-Mediated Imine Allylation, SDS of cas: 126613-06-7, the publication is Journal of the American Chemical Society (2007), 129(13), 3846-3847, database is CAplus and MEDLINE.

Thia-Fries rearrangement of BINOL perfluoroalkylsulfonates affords readily derivatized novel perfluoroalkyl mono- and disulfone BINOL ligands in just two steps from enantiomerically pure BINOL. These electron-demanding BINOLs were successfully applied as catalysts for indium-mediated allylation of N-acylhydrazones. A general and highly enantioselective catalytic process is described, in which the presence of two perfluoroalkylsulfone (SO₂R^F, R^F = CF₃, n-C₄F₉, n-C₈F₁₇) groups is crucial for activity and selectivity. The allylation process affords the corresponding homoallylic amines in up to 99% yield and 99% ee. E.g., allylation of 3-{2-ClC₆H₄CH:N}oxazol (oxazol = 2-oxazolidinonyl) with allyl bromide in the presence of indium and (R)-3,3′-bis(trifluoromethanesulfonyl)-2,2′-dihydroxy-1,1′-binaphthalene gave 3-{2-ClC₆H₄(H₂C:CHCH₂)CHNH}oxazol in 99% yield and 99% ee.

Journal of the American Chemical Society published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, SDS of cas: 126613-06-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Suzuki, Sakaru published the artcileEnzymic transsulfation from a phenol to carbohydrates, Quality Control of 6217-68-1, the publication is Biochimica et Biophysica Acta (1957), 444-5, database is CAplus and MEDLINE.

cf. C.A. 51, 2184c. Although charoninsulfuric acid (I) (a glucan polysulfate present in the mucous gland of Charonia lampas) did not incorporate S³⁵O₄^— in the presence of an Me₂CO powder of mucous gland alone, sulfation of I occurred in the presence of this Me₂CO powder when p-nitrophenylsulfuric acid was present as sulfate donor in a suitable incubation mixture From this and other results it was concluded that S³⁵O₄^— was incorporated into carbohydrate from p-nitrophenylsulfate by enzymic transsulfation, and no incorporation took place from inorganic S³⁵O₄^—.

Biochimica et Biophysica Acta published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C19H34ClN, Quality Control of 6217-68-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nakano, Ayako published the artcileβ-Isocupreidine-Catalyzed Baylis-Hillman Reaction of Chiral N-Boc-α-Amino Aldehydes, Product Details of C10H19NO3, the publication is Organic Letters (2006), 8(23), 5357-5360, database is CAplus and MEDLINE.

β-Isocupreidine (β-ICD)-catalyzed Baylis-Hillman reaction of chiral N-Boc-α-amino aldehydes BocNR¹CHR²CHO [Boc = Me₃CO₂C; R¹ = H, R² = Me, Me₂CH, Me₂CHCH₂; R¹R² = (CH₂)₃, CMe₂OCH₂] and 1,1,1,3,3,3-hexafluoroisopropyl acrylate (HFIPA) takes place without racemization and exhibits the match-mismatch relationship between the substrate and the catalyst. In the case of acyclic amino aldehydes, L-substrates show excellent syn selectivity and high reactivity in contrast to D-substrates. On the other hand, in the case of cyclic amino aldehydes, D-substrates rather than L-substrates show excellent anti selectivity and high reactivity. The Baylis-Hillman adducts obtained were transesterified and further converted into carboxyvinyl-substituted oxazolidines and (hydroxy)(methylene)pyrrolidinones.

Organic Letters published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, Product Details of C10H19NO3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Robinson, Emma J. published the artcileAqueous Metabolite Trends for the Progression of Nonalcoholic Fatty Liver Disease in Female Bariatric Surgery Patients by Targeted 1H-NMR Metabolomics, Formula: C6H10O3, the publication is Metabolites (2021), 11(11), 737, database is CAplus and MEDLINE.

Determining biomarkers and better characterizing the biochem. progression of nonalcoholic fatty liver disease (NAFLD) remains a clin. challenge. A targeted 1H-NMR study of serum, combined with clin. variables, detected and localized biomarkers to stages of NAFLD in morbidly obese females. Pre-surgery serum samples from 100 middle-aged, morbidly obese female subjects, grouped on gold-standard liver wedge biopsies (non-NAFLD; steatosis; and fibrosis) were collected, extracted, and analyzed in aqueous (D2O) buffer (1H, 600 MHz). Profiled concentrations were subjected to exploratory statistical anal. Metabolites varying significantly between the non-NAFLD and steatosis groups included the ketone bodies 3-hydroxybutyrate (� p = 0.035) and acetone (� p = 0.012), and also alanine (� p = 0.004) and a putative pyruvate signal (� p = 0.003). In contrast, the steatosis and fibrosis groups were characterized by 2-hydroxyisovalerate (� p = 0.023), betaine (� p = 0.008), hypoxanthine (� p = 0.003), taurine (� p = 0.001), 2-hydroxybutyrate (� p = 0.045), 3-hydroxyisobutyrate (� p = 0.046), and increasing medium chain fatty acids. Exploratory classification models with and without clin. variables exhibited overall success rates ca. 75-85%. In the study conditions, inhibition of fatty acid oxidation and disruption of the hepatic urea cycle are supported as early features of NAFLD that continue in fibrosis. In fibrosis, markers support inflammation, hepatocyte damage, and decreased liver function. Complementarity of NMR concentrations and clin. information in classification models is shown. A broader hypothesis that standard-of-care sera can yield metabolomic information is supported.

Metabolites published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cecchetti, Violetta published the artcileStudies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-ethyl- and 6-amino-8-methoxyquinolones, Computed Properties of 924-99-2, the publication is Bioorganic & Medicinal Chemistry (1999), 7(11), 2465-2471, database is CAplus and MEDLINE.

From our quant. structure-activity relationship (QSAR) study on a large set of 6-aminoquinolones, which indicated that a group larger than Me could be allocated at C-8 position, we have synthesized two new series of 6-aminoquinolones characterized by the presence of an Et or a methoxy group at C-8 position. The antibacterial evaluation shows that, while the 8-Et derivatives were devoid of any antibacterial activity, the introduction of methoxy group gave compounds with good antibacterial activity, especially against Gram-pos. bacteria. A tentative explanation of the different behaviors among the 8-substituted analogs is given taking into account both the length and electronic properties of the C-8 groups.

Bioorganic & Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chretien, Jacques R. published the artcileGas chromatography of homologous esters. XXX. Unexpected predominancy of polar effects over steric effects in crowded aliphatic esters: a gas-liquid chromatographic appraisal of specific interactions, Application of Ethyltert-butylacetate, the publication is Journal of Chromatography (1985), 324(2), 355-62, database is CAplus.

The chromatog. behavior of sixteen hindered α,α-disubstituted or α,α,α-trisubstituted aliphatic Et or Me esters containing C_4-9 acyl groups is presented. Kovats index increments, on height stationary phases of increasing polarity and the contributions of the Me groups, obtained by progressive substitution are discussed. The polar and steric effects are separated by use of IR and an extended Taft scale (-E‘_s) ranging over 8 powers of 10 for the considered acyl groups. Predominancy of polar effects over steric effects is demonstrated for the congested α,α,α-trisubstituted esters containing C_7-9 acyl groups.

Journal of Chromatography published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application of Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Okinczyc, Piotr published the artcileProfile of polyphenolic and essential oil composition of polish propolis, black poplar and aspens buds, Application In Synthesis of 5205-11-8, the publication is Molecules (2018), 23(6), 1262/1-1262/18, database is CAplus and MEDLINE.

In this work, we studied similarities and differences between 70% ethanol in water extract (70EE) and essential oils (EOs) obtained from propolis, black poplars (Populus nigra L.) and aspens (P. tremula L.) to ascertain which of these is a better indicator of the plant species used by bees to collect propolis precursors. Composition of 70EE was analyzed by UPLC-PDA-MS, while GC-MS was used to research the EOs. Principal component analyses (PCA) and calculations of Spearman’s coefficient rank were used for statistical anal. Statistical anal. exhibited correlation between chem. compositions of propolis and Populus buds’ 70EE. In the case of EOs, results were less clear. Compositions of black poplars, aspens EOs and propolises have shown more variability than 70EE. Different factors such as higher instability of EOs compared to 70EE, different degradation pattern of benzyl esters to benzoic acid, differences in plant metabolism and bees’ preferences may be responsible for these phenomena. Our research has therefore shown that 70EE of propolis reflected the composition of P. nigra or complex aspen-black poplar origin.

Molecules published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Application In Synthesis of 5205-11-8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Chengwei published the artcileDecarbonylative sulfide synthesis from carboxylic acids and thioesters via cross-over C-S activation and acyl capture, Synthetic Route of 1877-71-0, the publication is Organic Chemistry Frontiers (2021), 8(17), 4805-4813, database is CAplus and MEDLINE.

A method for the synthesis of sulfides from carboxylic acids via thioester C-S activation and acyl capture has been developed, wherein thioesters serve as dual electrophilic activators of carboxylic acids and S-nucleophiles through the merger of decarbonylative palladium catalysis and sulfur coupling. This new concept employs readily available carboxylic acids as coupling partners to directly intercept sulfur reagents via redox-neutral thioester-enabled cross-over thioetherification. The scope of this platform is demonstrated in the highly selective decarbonylative thioetherification of a variety of carboxylic acids and thioesters, including late-stage derivatization of pharmaceuticals and natural products. This method operates under mild, external base-free, and operationally practical conditions, providing a powerful new framework to unlock aryl electrophiles from carboxylic acids and increase the reactivity by employing common building blocks in organic synthesis.

Organic Chemistry Frontiers published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Synthetic Route of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kozma, Viktoria published the artcileConjugate addition of 1,3-dicarbonyl compounds to maleimides using bifunctional primary amine-(thio)phosphoramide organocatalysts, COA of Formula: C6H8O3, the publication is Molecular Catalysis (2022), 112089, database is CAplus.

Asym. Michael additions of 1,3-dicarbonyl compounds to N-substituted maleimides were carried out using primary amine-(thio)phosphoramide bifunctional chiral organocatalysts derived from optically pure C2-sym. 1,2-diamines. The addition of Et 2-fluoroacetoacetate using the 1,2-diphenylethane-1,2-diamine derived thiophosphoramide catalyst afforded various succinimides substituted with fluorine bearing quaternary carbon in high yields, good diastereomeric ratios and excellent enantiomeric excesses. Alicyclic β-ketoesters provided the diastereomerically pure Michael adducts in good yields and high enantioselectivities, whereas 2,4-pentanedione afforded products with slightly lower enantiomeric excesses. The bulkiness of the N-substituent of the maleimide ring influenced mostly the conversions. The thiophosphoramide catalyst was found also efficient in the addition of Et 2-fluoroacetoacetate to β-nitrostyrenes. Unprecedentedly, during this work the highly enantioselective addition of 1,3-dicarbonyl compounds to maleimides were catalyzed by a primary amine-hydrogen-bond donor groups containing bifunctional organocatalyst. These reactions occurred through enamine intermediate, as evidenced by electrospray-ionization mass spectrometry and NMR spectroscopy.

Molecular Catalysis published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, COA of Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Isidorov, Valery A. published the artcileRapid GC/MS determination of botanical precursors of Eurasian propolis, Category: esters-buliding-blocks, the publication is Food Chemistry (2014), 101-106, database is CAplus and MEDLINE.

In this work, ether extracts of propolises from 11 countries of Europe and Asia together with extracts of the buds of their principal plant precursors were prepared and investigated by gas chromatog.-mass spectrometry. For the first time, chem. compositions of the exudates of aspen, white birch and silver birch buds were determined Basing on the data on the content of individual components and their groups, the method of rapid examination of plant precursors of propolis was developed. This new method is based on the use of a chromatogram for one extracted ion m/z = 219, characteristic for a group of similar substances: phenylpropenoids. The I^T retention indexes of silylated derivatives of 449 substances registered in the buds of 6 species of trees and 37 samples of propolis extracts were calculated These useful anal. parameters (majority of which are absent in the available databases) are attached in Supplementary information.

Food Chemistry published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics