Esters-buliding-blocks

Jahan, Israt published the artcileGC-MS phytochemical profiling, pharmacological properties, and in silico studies of Chukrasia velutina leaves: a novel source for bioactive agents, Category: esters-buliding-blocks, the publication is Molecules (2020), 25(15), 3536, database is CAplus and MEDLINE.

Chukrasia velutina is a local medicinal plant commonly known as chikrassy in Bangladesh, India, China, and other South Asian countries. The leaves, bark, and seeds are vastly used as herbal medicine for fever and diarrhea, and its leaves essential oils are used for antimicrobial purposes. In this study, we discuss the neuropsychiatric properties of C. velutina leaves through several animal models, quant. and qual. phytochem. anal., and computational approaches. Neuropsychiatric effects were performed in rodents on the methanolic extract of C. velutina leaves (MECVL). Antidepressant, anxiolytic, and sedative effects experimented through these rodent models were used such as the force swimming test (FST), tail suspension test (TST), hole board test (HBT), elevated plus maze test (EPMT), light/dark box test (LDBT), open field test (OFT), and hole cross test (HCT). In these rodent models, 200 and 400 mg/kg doses were used which exhibited a significant result in the force swimming and tail suspension test (p < 0.001) for the antidepressant effect. In the anxiolytic study, the results were significant in the hole board, elevated plus maze, and light/dark box test (p < 0.001) for doses of 200 and 400 mg/kg. The result was also significant in the open field and hole cross test (p < 0.001) for sedative action in the sake of similar doses. Moreover, qual. and quant. studies were also performed through phytochem. screening and GC-MS anal., and fifty-seven phytochem. compounds were found. These compounds were analyzed for pharmacokinetics properties using the SwissADME tool and from them, thirty-five compounds were considered for the mol. docking anal. These phytoconstituents were docking against the human serotonin receptor, potassium channel receptor, and crystal structure of human beta-receptor, where eight of the compounds showed a good binding affinity towards the resp. receptors considered to the reference standard drugs. After all of these analyses, it can be said that the secondary metabolite of C. velutina leaves (MECVL) could be a good source for inhibiting the neuropsychiatric disorders which were found on animal models as well as in computational studies.

Molecules published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tsukamoto, Takamasa published the artcileHighly Accurate Synthesis of Quasi-sub-nanoparticles by Dendron-assembled Supramolecular Templates, Formula: C15H14O3, the publication is Angewandte Chemie, International Edition (2022), 61(8), e202114353, database is CAplus and MEDLINE.

Quasi-sub-nanomaterials (1-3 nm) have been predicted to exhibit unique properties originating from the gray structures considered both bulk solids and mols., while their synthesis is extremely difficult. The present study describes a new template synthesis method for quasi-sub-nanosized materials using a combination of coordination chem. and polymer chem. Utilizing self-assembly of guest basic phenylazomethine dendron units onto host acidic core units with six tritylium cations, the dendron-assembled supramols. were constructed easily and quant. without costly techniques. This huge supramol. capsule accumulating multiple acidic rhodium salts in its basic ligands enabled a precise synthesis of rhodium particles via formation of multinuclear complexes. The obtained particles (Rh₈₄, â‰?.5 nm) have particle sizes within 1-3 nm range and were larger than conventional sub-nanoparticles (Rh₁₄, âˆ?.85 nm), therefore the precise template synthesis of quasi-sub-nanoparticles was successfully demonstrated.

Angewandte Chemie, International Edition published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C12H6NNaO4, Formula: C15H14O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fujii, Kohei published the artcileDesign of Phosphinic Acid Catalysts with the Closest Stereogenicity at the α-Position: Synthesis and Application of α-Stereogenic Perfluoroalkyl Phosphinic Acid Catalysts, Name: (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), the publication is Organic Letters (2019), 21(9), 3387-3391, database is CAplus and MEDLINE.

Chiral C₂-sym. phosphinic acids I (17a,b; R = CF₃, C₂F₅) were designed as chiral Bronsted acid organocatalysts, based on sterically demanding and helical chiral perfluoroalkyl groups at the closest α-position advancing asym. reaction environment and catalytic activity. The perfluoroalkyl catalysts, [(CF₃)₂F₂] and [(C₂F₅)₂F₂] phosphinic acids, were synthesized via a stereoselective addition/cyclization sequence of Me phosphinate and deoxofluorination. These new classes of Bronsted acid catalysts were applied to an asym. Friedel-Crafts reaction to give up to 89% yield and 82% R-enantioselectivity, which is higher than those obtained with the parent phosphoric acid (42% and 55.5% S).

Organic Letters published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, Name: (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate).

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Medina, Scott H. published the artcileTargeting Hepatic Cancer Cells with PEGylated Dendrimers Displaying N-Acetylgalactosamine and SP94 Peptide Ligands, Recommanded Product: (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, the publication is Advanced Healthcare Materials (2013), 2(10), 1337-1350, database is CAplus and MEDLINE.

Poly(amidoamine) (PAMAM) dendrimers are branched water-soluble polymers defined by consecutive generation numbers (Gn) indicating a parallel increase in size, mol. weight, and number of surface groups available for conjugation of bioactive agents. In this article, we compare the biodistribution of N-acetylgalactosamine (NAcGal)-targeted [¹⁴C]₁-G5-(NH₂)₅-(Ac)₁₀₈-(NAcGal)₁₄ particles to non-targeted [¹⁴C]₁-G5-(NH₂)₁₂₇ and PEGylated [¹⁴C]₁-G5-(NH₂)₄₄-(Ac)₇₃-(PEG)₁₀ particles in a mouse hepatic cancer model. Results show that both NAcGal-targeted and non-targeted particles are rapidly cleared from the systemic circulation with high distribution to the liver. However, NAcGal-targeted particles exhibited 2.5-fold higher accumulation in tumor tissue compared to non-targeted ones. In comparison, PEGylated particles showed a 16-fold increase in plasma residence time and a 5-fold reduction in liver accumulation. These results motivated us to engineer new PEGylated G5 particles with PEG chains anchored to the G5 surface via acid-labile cis-aconityl linkages where the free PEG tips are functionalized with NAcGal or SP94 peptide to investigate their potential as targeting ligands for hepatic cancer cells as a function of sugar conformation (α vs. β), ligand concentration (100-4000 nM), and incubation time (2 and 24 h) compared to fluorescently (Fl)-labeled and non-targeted G5-(Fl)₆-(NH₂)₁₂₂ and G5-(Fl)₆-(Ac)₁₀₇-(cPEG)₁₅ particles. Results show G5-(Fl)₆-(Ac)₁₀₇-(cPEG[NAcGal_β])₁₄ particles achieve faster uptake and higher intracellular concentrations in HepG2 cancer cells compared to other G5 particles while escaping the non-specific adsorption of serum protein and phagocytosis by Kupffer cells, which make these particles the ideal carrier for selective drug delivery into hepatic cancer cells.

Advanced Healthcare Materials published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, Recommanded Product: (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kuruvilla, Sibu P. published the artcileN-Acetylgalactosamine-Targeted Delivery of Dendrimer-Doxorubicin Conjugates Influences Doxorubicin Cytotoxicity and Metabolic Profile in Hepatic Cancer Cells, HPLC of Formula: 10378-06-0, the publication is Advanced Healthcare Materials (2017), 6(5), n/a, database is CAplus and MEDLINE.

This study describes the development of targeted, doxorubicin (DOX)-loaded generation 5 (G5) polyamidoamine dendrimers able to achieve cell-specific DOX delivery and release into the cytoplasm of hepatic cancer cells. G5 is functionalized with poly(ethylene glycol) (PEG) brushes displaying N-acetylgalactosamine (NAcGal) ligands to target hepatic cancer cells. DOX is attached to G5 through one of two aromatic azo-linkages, L3 or L4, achieving either P1 ((NAcGal_β-PEGc)_16.6-G5-(L3-DOX)_11.6) or P2 ((NAcGal_β-PEGc)_16.6-G5-(L4-DOX)_13.4) conjugates. After confirming the conjugatesâ€?biocompatibility, flow cytometry studies show P1/P2 achieve 100% uptake into hepatic cancer cells at 30-60 × 10^-9 M particle concentration This internalization correlates with cytotoxicity against HepG2 cells with 50% inhibitory concentration (IC₅₀) values of 24.8, 1414.0, and 237.8 × 10^-9 M for free DOX, P1, and P2, resp. Differences in cytotoxicity prompted metabolomics anal. to identify the intracellular release behavior of DOX. Results show that P1/P2 release alternative DOX metabolites than free DOX. Stable isotope tracer studies show that the different metabolites induce different effects on metabolic cycles. Namely, free DOX reduces glycolysis and increases fatty acid oxidation, while P1/P2 increase glycolysis, likely as a response to high oxidative stress. Overall, P1/P2 conjugates offer a platform drug delivery technol. for improving hepatic cancer therapy.

Advanced Healthcare Materials published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, HPLC of Formula: 10378-06-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kuruvilla, Sibu P. published the artcileEffect of N-acetylgalactosamine ligand valency on targeting dendrimers to hepatic cancer cells, COA of Formula: C14H19NO8, the publication is International Journal of Pharmaceutics (Amsterdam, Netherlands) (2018), 545(1-2), 27-36, database is CAplus and MEDLINE.

The display of N-acetylgalactosamine (NAcGal) ligands has shown great potential in improving the targeting of various therapeutic mols. to hepatocellular carcinoma (HCC), a severe disease whose clin. treatment is severely hindered by limitations in delivery of therapeutic cargo. We previously used the display of NAcGal on generation 5 (G5) polyamidoamine (PAMAM) dendrimers connected through a poly(ethylene glycol) (PEG) brush (i.e. G5-cPEG-NAcGal; monoGal) to effectively target hepatic cancer cells and deliver a loaded therapeutic cargo. In this study, we were interested to see if tri-valent NAcGal ligands (i.e. NAcGal₃) displayed on G5 dendrimers (i.e. G5-cPEG-NAcGal₃; triGal) could improve their ability to target hepatic cancer cells compared to their monoGal counterparts. We therefore synthesized a library of triGal particles, with either 2, 4, 6, 8, 11, or 14 targeting branches (i.e. cPEG-NAcGal₃) attached. Conventional flow cytometry studies showed that all particle formulations can label hepatic cancer cells in a concentration-dependent manner, reaching 90-100% of cells labeled at either 285 or 570 nM G5, but interestingly, monoGal labeled more cells at lower concentrations To elucidate the difference in internalization of monoGal vs. triGal conjugates, we turned to multi-spectral imaging flow cytometry and quantified the amount of internalized (I) vs. surface-bound (I⁰) conjugates to determine the ratio of internalization (I/I⁰) in all treatment groups. Results show that regardless of NAcGal valency, or the d. of targeting branches, all particles achieve full internalization and diffuse localization throughout the cell (I/I⁰ âˆ?3.0 for all particle compositions). This indicates that while tri-valent NAcGal is a promising technique for targeting nanoparticles to hepatic cancer cells, mono-valent NAcGal is more efficient, contrary to what is observed with small mols.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, COA of Formula: C14H19NO8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Han, Chunyu published the artcileTetrasubstituted 1,3-Enynes by Gold-Catalyzed Direct C(sp²)-H Alkynylation of Acceptor-Substituted Enamines, Application In Synthesis of 30414-53-0, the publication is Organic Letters (2021), 23(12), 4764-4768, database is CAplus and MEDLINE.

A gold-catalyzed synthesis of tetrasubstituted 1,3-enynes from hypervalent iodine(III) reagents and activated alkenes is reported. This reaction involves an in situ formed alkynyl Au(III) species and a subsequent direct C(sp²)-H functionalization of alkenes, offering 26 enynes in 62-92% yield with excellent functional group tolerance.

Organic Letters published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Application In Synthesis of 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Han, Chunyu published the artcileTetra-substituted furans by a gold-catalysed tandem C(sp³)-H alkynylation/oxy-alkynylation reaction, SDS of cas: 30414-53-0, the publication is Organic Chemistry Frontiers (2021), 8(23), 6546-6552, database is CAplus.

A gold-catalyzed cascade C(sp³)-H alkynylation/oxy-alkynylation of acceptor-substituted carbonyl compounds with hypervalent iodine(III) reagents for the synthesis of tetra-substituted furans is described. This reaction involves two Au(I)/Au(III) catalytic cycles and proceeds through a C(sp³)-H alkynylation of a substituted ketone and a subsequent oxy-alkynylation of the generated 2-alkynyl ketone. This mild and simple method can tolerate a wide range of functionalities, offering distinct advantages over previous methods using PIDA as the external oxidant. Furthermore, a gram-scale synthesis is feasible and the synthesized furan product was readily transformed into other related compounds

Organic Chemistry Frontiers published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, SDS of cas: 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Vang, Le published the artcileSex Pheromones of Three Citrus Leafrollers, Archips atrolucens, Adoxophyes privatana, and Homona sp., Inhabiting the Mekong Delta of Vietnam, HPLC of Formula: 16974-11-1, the publication is Journal of Chemical Ecology (2013), 39(6), 783-789, database is CAplus and MEDLINE.

Archips atrolucens, Adoxophyes privatana, and Homona sp. are serious defoliators of citrus trees in the Mekong Delta of Vietnam. To establish a sustainable pest-management program for the 3 species, their female-produced sex pheromones were investigated by GC-EAD and GC-MS analyses, and the following multi-component pheromones were identified: (Z)-11-tetradecenyl acetate (Z11-14:OAc), (E)-11-tetradecenyl acetate (E11-14:OAc), and tetradecyl acetate (14:OAc) in a ratio of 64:32:4 for A. atrolucens; Z11-14:OAc and (Z)-9-tetradecenyl acetate (Z9-14:OAc) in a ratio of 92:8 for A. privatana; and Z11-14:OAc and (Z)-9-dodecenyl acetate (Z9-12:OAc) in a ratio of 96:4 for Homona sp. Each lure baited with synthetic components as a mimic of the natural pheromone attracted males of the target species specifically, indicating that each monounsaturated minor component plays a significant role for mating communication and reproductive isolation of the three species inhabiting the same citrus orchards. In an extract of the pheromone glands of A. atrolucens females, the content of 14:OAc was very low, but a synergistic effect was observed clearly when the saturated compound was mixed at the same level as the E11-14:OAc. The synthetic lures will provide useful tools for monitoring flights of adults of the 3 species.

Journal of Chemical Ecology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C20H12N2O2, HPLC of Formula: 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rajalakshmi, K. published the artcileVibrational assignments of α-acetyl -γ- butyrolactone by ab initio Hartree-Fock and density functional methods, Application of 3-Acetyldihydrofuran-2(3H)-one, the publication is International Journal of ChemTech Research (2018), 11(6), 145-159, database is CAplus.

The Fourier transform IR and FT-Raman spectra of α-acetyl-γ-butyrolactone have been recorded in region 4,000-400 and 4,000-100 cm^-1 resp. A complete assignment and anal. of fundamental vibration modes of the mol. have been carried out. The observed fundamental modes have been compared with harmonic vibration frequencies computed using d. functional theory calculations by employing B3LYP functional at 6-311 + G(d,p) level. UV-Visible spectrum of the compound has been recorded and electronic properties, such as HOMO (HOMO) and LUMO (LUMO) energies have been calculated with B3LYP/6-311 + + G(d,p) level. These calculated energies show that charge transfer occurs within mol. Mulliken population anal. and thermodn. properties of title compound have also been calculated

International Journal of ChemTech Research published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Application of 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics