Esters-buliding-blocks

Heath, R. R. published the artcileCorrelation of retention times on liquid crystal capillary column with reported vapor pressures and half-lives of compounds used in pheromone formulations, Product Details of C14H26O2, the publication is Journal of Chemical Ecology (1986), 12(11), 2081-8, database is CAplus and MEDLINE.

A method was developed to determine by capillary gas chromatog. on liquid crystal stationary phases the relative vapor pressures and half-lives of many compounds used as insect pheromones. The retention time of 7 acetates on a liquid crystal column (cholesteryl-p-chlorocinnamate) was correlated closely to the reported vapor pressures of the compounds For 13 addnl. pheromonal acetates and alcs., reported half-lives showed a high degree of correlation with their retention times on the liquid crystal column. Thus, chromatog. on capillary liquid crystal gas chromatog. columns is a useful method for determining the relative volatiles of many pheromones to facilitate the development of more precise formulations.

Journal of Chemical Ecology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Product Details of C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ryabchenko, Boris published the artcileInvestigation of anticancer and antiviral properties of selected aroma samples, Quality Control of 5205-11-8, the publication is Natural Product Communications (2008), 3(7), 1085-1088, database is CAplus.

Antitumor and antiviral activities of various aroma samples, including cinnamic acid, β-caryophyllene, caryophyllene oxide, nerolidol (synthetic and natural samples), trans,trans-farnesol, farnesol (isomeric mixture), longifolene, geranic acid and a farnesol-rich ylang-fraction were investigated using HeLa and Jurkat cell lines. Using a CytoTox-96-Assay we observed strong antitumor effects of natural- and synthetic nerolidol-samples at concentrations less than 5 μM. Furthermore, synthetic nerolidol reduced the number of HeLa and Jurkat cells to 50% (CC₅₀) at concentrations which were more than ten times lower compared with the EDs required to achieve 50% cytotoxicity (ED₅₀). Antiviral studies were performed to investigate inhibitory effects of the compounds on mouse polyomavirus propagation in 3T6 cells. Remarkable inhibition of viral activity was demonstrated by synthetic nerolidol at CC₅₀ 3.2±1.5 μM and natural nerolidol at CC₅₀ 1.2±0.4 μM All other compounds, however, did not show any inhibition against this virus.

Natural Product Communications published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Quality Control of 5205-11-8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dodgson, K. S. published the artcileMetabolic fate of the ester sulfate group of potassium p- nitrophenylsulfate-S³⁵, Application In Synthesis of 6217-68-1, the publication is Biochemical Journal (1960), 154-9, database is CAplus and MEDLINE.

After intraperitoneal injection of K p-nitrophenyl sulfate-S³⁵ (I) to male and female rats, the bulk of the S³⁵ appears in the urine within 24 hrs. Up to 30% of the S³⁵ of the original dose appears in the urine as inorganic sulfate-S³⁵, most of the remainder appearing as ester sulfate-S³⁵. Chromatographic examination of the urines shows the presence of at least 10 radioactive sulfate esters in addition to I. The chromatographic pattern is very similar to that obtained with the urines of rats receiving Na₂S³⁵O₄ by intraperitoneal injection. After 48 hrs. the S³⁵ is still present in the tissues. Incorporation of S³⁵ into chondroitinsulfate of skin and cartilage and into liver taurine has been demonstrated.

Biochemical Journal published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Application In Synthesis of 6217-68-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tanaka, Yuji published the artcileGallic Acid Derivatives Propyl Gallate and Epigallocatechin Gallate Reduce rRNA Transcription via Induction of KDM2A Activation, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate, the publication is Biomolecules (2022), 12(1), 30, database is CAplus and MEDLINE.

We previously reported that lysine-demethylase 2A (KDM2A), a Jumonji-C histone demethylase, is activated by gallic acid to reduce H3K36me2 levels in the rRNA gene promoter and consequently inhibit rRNA transcription and cell proliferation in the breast cancer cell line MCF-7. Gallic acid activates AMP-activated protein kinase (AMPK) and increases reactive oxygen species (ROS) production to activate KDM2A. Esters of gallic acid, Pr gallate (PG) and epigallocatechin gallate (EGCG), and other chems., reduce cancer cell proliferation. However, whether these compounds activate KDM2A has yet to be tested. In this study, we found that PG and EGCG decreased rRNA transcription and cell proliferation through KDM2A in MCF-7 cells. The activation of both AMPK and ROS production by PG or EGCG was required to activate KDM2A. Of note, while the elevation of ROS production by PG or EGCG was limited in time, it was sufficient to activate KDM2A. Importantly, the inhibition of rRNA transcription and cell proliferation by gallic acid, PG, or EGCG was specifically observed in MCF-7 cells, whereas it was not observed in non-tumorigenic MCF10A cells. Altogether, these results suggest that the derivatization of gallic acid may be used to obtain new compounds with anti-cancer activity.

Biomolecules published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C6H13I, Recommanded Product: Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Vandevoorde, Severine published the artcileEsters, retroesters, and a retroamide of palmitic acid: pool for the first selective inhibitors of N-palmitoylethanolamine- selective acid amidase, Application In Synthesis of 110-34-9, the publication is Journal of Medicinal Chemistry (2003), 46(21), 4373-4376, database is CAplus and MEDLINE.

Cyclohexyl hexadecanoate, hexadecyl propionate, and N-(3-hydroxypropionyl)pentadecanamide, resp. ester, retroester, and retroamide derivatives of N-palmitoylethanolamine, represent the first selective inhibitors of “N-palmitoylethanolamine hydrolase” described so far. These compounds are devoid of affinity for CB₁ and CB₂ receptors and characterized by high percentages of inhibition of N-palmitoylethanolamine-selective acid amidase (84.0, 70.5, and 76.7% inhibition at 100 μM, resp.) with much lower inhibitory effect on either fatty acid amide hydrolase or the uptake of anandamide.

Journal of Medicinal Chemistry published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C9H7NO2, Application In Synthesis of 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tsurushima, Katsumasa published the artcileDimethyl Fumarate Induces Apoptosis via Inhibition of NF-κB and Enhances the Effect of Paclitaxel and Adriamycin in Human TNBC Cells., Recommanded Product: Dimethyl fumarate, the publication is International journal of molecular sciences (2022), 23(15), database is MEDLINE.

Triple-negative breast cancer (TNBC) has the poorest prognosis of all breast cancer subtypes. Recently, the activation of NF-κB, which is involved in the growth and survival of malignant tumors, has been demonstrated in TNBC, suggesting that NF-κB may serve as a new therapeutic target. In the present study, we examined whether dimethyl fumarate (DMF), an NF-κB inhibitor, induces apoptosis in TNBC cells and enhances the apoptosis-inducing effect of paclitaxel and adriamycin. Cell survival was analyzed by the trypan blue assay and apoptosis assay. Protein detection was examined by immunoblotting. The activation of NF-κB p65 was correlated with poor prognosis in patients with TNBC. DMF induced apoptosis in MDA-MB-231 and BT-549 cells at concentrations that were non-cytotoxic to the normal mammary cell line MCF-10A. Furthermore, DMF inhibited NF-κB nuclear translocation and Survivin, XIAP, Bcl-xL, and Bcl-2 expression in MDA-MB-231 and BT-549 cells. Moreover, DMF enhanced the apoptosis-inducing effect of paclitaxel and adriamycin in MDA-MB-231 cells. These findings suggest that DMF may be an effective therapeutic agent for the treatment of TNBC, in which NF-κB is constitutively active. DMF may also be useful as an adjuvant therapy to conventional anticancer drugs.

International journal of molecular sciences published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O6, Recommanded Product: Dimethyl fumarate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hillert, Jan published the artcileA comparative study of teriflunomide and dimethyl fumarate within the Swedish MS Registry, Related Products of esters-buliding-blocks, the publication is Multiple Sclerosis Journal (2022), 28(2), 237-246, database is CAplus and MEDLINE.

Teriflunomide and di-Me fumarate (DMF) are first-line disease-modifying treatments for multiple sclerosis with similar labels that are used in comparable populations. The objective of this study was to compare the effectiveness and persistence of teriflunomide and DMF in a Swedish real-world setting. All relapsing-remitting multiple sclerosis (RRMS) patients in the Swedish MS registry initiating teriflunomide or DMF were included in the anal. The primary endpoint was treatment persistence. Propensity score matching was used to adjust comparisons for baseline confounders. A total of 353 teriflunomide patients were successfully matched to 353 DMF. There was no difference in the rate of overall treatment discontinuation by treatment group across the entire observation period (hazard ratio (HR) = 1.12; 95% confidence interval (CI) = 0.91-1.39; p = 0.277; reference = teriflunomide). Annualised relapse rate (ARR) was comparable (p = 0.237) between DMF (0.07; 95% CI = 0.05-0.10) and teriflunomide (0.09; 95% CI = 0.07-0.12). There was no difference in time to first on-treatment relapse (HR = 0.78; 95% CI = 0.50-1.21), disability progression (HR = 0.55; 95% CI = 0.27-1.12) or confirmed improvement (HR = 1.17; 95% CI = 0.57-2.36). This population-based real-world study reports similarities in treatment persistence, clin. effectiveness and quality of life outcomes between teriflunomide and di-Me fumarate.

Multiple Sclerosis Journal published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sahlen, F. published the artcileSynthesis and Characterization of Bifunctional Liquid-Crystalline Monomers Showing Smectic C Phase. Photopolymerization and Crosslinking, SDS of cas: 50670-76-3, the publication is Chemistry of Materials (1996), 8(2), 382-8, database is CAplus.

Novel syntheses of bifunctional liquid-crystalline acrylate and methacrylate monomers are described. Thermal and microstructural characterization of the monomers using small-angle X-ray scattering, differential scanning calorimetry, and optical microscopy revealed the presence of smectic A, smectic C, and smectic E phases. Photopolymerization of the bifunctional monomers conducted at different temperatures preserved the monomeric liquid-crystalline structure in the crosslinked polymers. The densely crosslinked polymers showed thermal reversibility. Mixtures of these monomers and chiral monofunctional liquid-crystalline monomers exhibited chiral smectic C mesomorphism that was made permanent by photopolymerization and subsequent crosslinking.

Chemistry of Materials published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, SDS of cas: 50670-76-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Moinuddin, Ovase published the artcileStudy on thermal storage properties of microencapsulated organic ester as phase change material for cooling application, Application of Dimethyl adipate, the publication is International Journal of Environmental Analytical Chemistry (2021), 101(12), 1662-1671, database is CAplus.

The phase change materials (PCMs) are latent thermal energy storage materials to store and release energy in the form of latent heat with a change in internal energy. The microencapsulation technique overcomes the limitations faced by the PCMs during energy storage and release. In this study, the new ester-based non-paraffin PCM was microencapsulated into an organic shell using in-situ polymerization technique. The as-prepared MPCMs was characterised using the field emission electron microscope (FESEM), fourier transform IR spectroscopy (FTIR), differential scanning calorimetry (DSC) and thermogravimetric anal. (TGA) techniques. The results show that the MPCM characterised using FESEM has exhibited a good morphol. The chem. stability studies carried using FTIR spectroscopy also confirmed the formation of microcapsules was only by phys. interaction. The DSC test results also signify that microcapsules have a latent heat of enthalpy of 65.32 kJ/kg, with onset melting temperature of 8.57°C. Thus, this ensures the MPCM to be considered as a potential candidate for the CTES application.

International Journal of Environmental Analytical Chemistry published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Application of Dimethyl adipate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Srivastava, Arvind K. published the artcileGlutathione-S-transferase activity in Setaria cervi females and effect of new antifilarial compounds, Quality Control of 3052-61-7, the publication is Indian Journal of Parasitology (1994), 18(2), 127-133, database is CAplus.

Glutathione-s-transferase(s) (EC 2.5.1.18; GST) activity was detected in both cytosol and microsomal fractions of bovine filarial parasites S. cervi females. However, they were different in their pH optima and substrate specificity. Cytosolic S. cervi GST was sensitive to inhibition by certain new classes of antifilarial compounds i.e. diethyldithiocarbamates, α-cyanoethylcinnamates, and benzo-pyran-2-ones. This suggests that GST in filariids may serve as a biochem. target for designing more potent and effective antifilarial mols. of these series.

Indian Journal of Parasitology published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H23N3S, Quality Control of 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics