Esters-buliding-blocks

Ciampi, Ethel published the artcileSafety and humoral response rate of inactivated and mRNA vaccines against SARS-CoV-2 in patients with Multiple Sclerosis, COA of Formula: C6H8O4, the publication is Multiple Sclerosis and Related Disorders (2022), 103690, database is CAplus and MEDLINE.

Safety and effectiveness outcomes in Multiple Sclerosis (MS) patients receiving different disease-modifying therapies (DMT) and different types of vaccines against SARS-CoV-2 are limited. Growing evidence coming mainly from Israel, Europe and North America using mRNA and adenoviral vector vaccines has been published. To assess the safety and humoral response of inactivated virus and mRNA vaccines against SARS-CoV-2 in patients with MS. Ongoing, multicentric, prospective, observational study performed between Feb. and Sept. 2021. Humoral response (antibodies against spike-1 protein) was determined at least 4 wk after the complete schedule of anti-SARS-CoV-2 vaccines. Categorical outcome (pos./neg.) and total antibody titers were recorded. Adverse events supposedly attributable to vaccination (AESAV) were collected. 178 Patients, 68% women, mean age 39.7 ± 11.2 years, 123 received inactivated (Coronavac-Sinovac), 51 mRNA (Pfizer-BioNtech), and 4 adenoviral vector vaccines (CanSino n = 2, Jonhson&Johnson-Jannsen n = 1, Oxford-AstraZeneca n = 1). Six patients had a history of COVID-19 before vaccination. Overall humoral response was observed in 66.9% (62.6% inactivated vs. 78.4% mRNA, p = 0.04). Pos. anti-S1-antibodies were observed in 100% of patients with no DMT (n = 3), 100% with interferon/glatiramer-acetate (n = 11), 100% with teriflunomide/dimethyl-fumarate (n = 16), 100% with natalizumab (n = 10), 100% with alemtuzumab (n = 8), 90% with cladribine (n = 10), and 88% with fingolimod (n = 17), while 43% of patients receiving antiCD20 (n = 99) were pos. (38% inactivated vaccine vs. 59% mRNA vaccine, p = 0.05). In the multivariate anal. including antiCD20 patients, the predictors for a pos. humoral response were receiving the mRNA vaccine (OR 8.11 (1.79-36.8), p = 0.007) and a lower number of total infusions (OR 0.44 (0.27-0.74) p = 0.002). The most frequent AESAV was local pain (14%), with 4 (2.2%) patients experiencing mild-moderate relapses within 8 wk of first vaccination compared to 11 relapses (6.2%) within the 8 wk before vaccination (Chi-squared 3.41, p = 0.06). A higher humoral response rate was observed using the mRNA compared to the inactivated vaccine, while patients using antiCD20 had a significantly lower response rate, and patients using antiCD20 and fingolimod had lower antibody titers. In this MS patient cohort, inactivated and mRNA vaccines against SARS-CoV-2 appear to be safe, with no increase in relapse rate. This information may help guidelines including booster shots and types of vaccines in selected populations.

Multiple Sclerosis and Related Disorders published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, COA of Formula: C6H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Setnicka, Vladimir published the artcileVibrational Circular Dichroism of 1,1′-Binaphthyl Derivatives: Experimental and Theoretical Study, Safety of (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), the publication is Journal of Physical Chemistry A (2001), 105(39), 8931-8938, database is CAplus.

Absorption and vibrational CD (VCD) spectra of six 1,1′-binaphthyl derivatives were measured and analyzed from ab initio modeling. The spectra of both enantiomers were recorded with a high signal-to-noise ratio. The BPW91/6-31G^** d. functional theory level and the gauge invariant AOs were used for the simulations of VCD intensities. The binaphthyl moiety behaves as a chiral chromophore with a strong VCD signal because the 1,1′-substitution hinders its rotation. Most of the VCD bands were assigned, and the contributions of the binaphthyl skeleton and the functional groups could be clearly distinguished. Distinct VCD characteristics were found for the compounds exhibiting C₂ and C₁ symmetry. A very good agreement between the calculated and exptl. spectra was observed Apart from indication of enantiomeric purity, the spectra contain readable information about mol. conformation. The dihedral angle between the naphthyls planes, equal to âˆ?5° when naphthyl residues were connected with PO₄ covalent bridge, was found close to 90° for all the other derivatives

Journal of Physical Chemistry A published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C4H6N2, Safety of (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate).

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Palaniswamy, P. published the artcileResponses of male redbacked cutworm, Euxoa ochrogaster (Lepidoptera:Noctuidae), to sex pheromone components in a flight tunnel, Formula: C14H26O2, the publication is Environmental Entomology (1983), 12(3), 748-52, database is CAplus.

Of 4 components of the title pheromone, individually only Z5-12:Ac ((Z)-5-dodecenyl acetate; I) [16676-96-3] and Z7-12:Ac ((Z)-5-dodecenyl acetate; II) [14959-86-5] stimulated activation responses of the E. ochrogaster males, but neither initiated upwind flight in the flight tunnel. Of all possible binary combinations only I + II elicited responses from activation to landing. Z5-10:Ac ((Z)-5-decenyl acetate) [67446-07-5] increased activation, upwind flight responses, and prolonged flight, but only when it was added to blends containing I + II. Addition of Z9-12:Ac((Z)-9-dodecyl acetate) [16974-11-1] as a 4th component increased initiation of landing response on the source. In moth pheromone systems utilizing several components, the sequence of male responses in locating and mating with a female depends upon specific combination of pheromone components and concentrations

Environmental Entomology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Formula: C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Palaniswamy, P. published the artcileMechanisms of orientation disruption by sex pheromone components in the redbacked cutworm, Euxoa ochrogaster (Guenee) (Lepidoptera: Noctuidae), Application of (Z)-Dodec-9-en-1-yl acetate, the publication is Environmental Entomology (1988), 17(3), 432-41, database is CAplus.

Disruption of orientation of E. ochrogaster males to synthetic bait was studied in a flight tunnel and in small field plots in cereals, using synthetic pheromone components as disruptants. Field tests showed that increasing the dose from 0 to 100 μg per dispenser of the blend of all 4 components (Z)-5-dodecenyl acetate (Z5-12:Ac) + (Z)-7-dodecenyl acetate (Z7-12:Ac) + (Z)-9-dodecenyl acetate (Z9-12:Ac) + (Z)-5-decenyl acetate (Z5-10:Ac) or that of Z5-12:Ac and Z7-12:Ac, individually, resulted in a sharp increase in disruption up to a maximum of 75%; a further increase in the dose to 1000 μg per dispenser resulted in only a small and gradual increase in disruption, reaching a maximum of 88%. Z5-10:Ac caused approx. 78% disruption at levels of 100 μg and 1,000 μg per dispenser, and Z9-12:Ac was least effective at these doses. Flight tunnel and field observations showed that with blends, the mechanisms of disruption varied in relation to the concentrations used. The primary cause of disruption was competitive attraction at low dose levels and reduction in searching effort at high dose levels. With single components, irresp. of concentrations used, the cause of disruption was primarily reduction in searching effort. Based on these studies and those on Euxoa messoria and Malacosoma disstria, it is suggested that in moths, depending upon the species, functional nature of the pheromone components, concentrations used, and the method of disruptant dispenser placements, individual or blends of components can cause orientation disruption by competitive attraction and by modulating the behavior of males, particularly by reducing the searching effort.

Environmental Entomology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Application of (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dix, M. E. published the artcileSex pheromone of Retinia metallica (Busck) (Lepidoptera: Tortricidae): identification and field studies, COA of Formula: C14H26O2, the publication is Canadian Entomologist (1988), 120(8-9), 721-6, database is CAplus.

The major sex pheromone component from female moths of R. metallica was identified as Z7,E9-dodecadienyl acetate (Z7,E9:Ac) by a combination of electroantennog. (EAG), gas chromatog. (GC), and mass spectrometric analyses. In field tests, males of R. metallica were strongly attracted to Z7,E9-12:Ac. Addition of Z7,Z9-12:Ac, Z7,E9-dodecadienol (Z7,E9-12:OH), and Z7-dodecenyl acetate (Z7-12:Ac) to Z7,E9-12:Ac did not significantly alter trap catch. However, the addition of E9-dodecenyl acetate (E9-12:Ac) and Z9-12:Ac reduced trap catch. Trap catch was affected by height of placement; traps placed in the upper third of the tree (6 m) caught significantly more males than traps placed at lower heights.

Canadian Entomologist published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, COA of Formula: C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ahmad, Sajjad published the artcileChemical composition, antioxidant and anticholinesterase potentials of essential oil of Rumex hastatus D. Don collected from the North West of Pakistan, Application In Synthesis of 5340-78-3, the publication is BMC Complementary and Alternative Medicine (2016), 29/1-29/11, database is CAplus and MEDLINE.

Background: Ethnomedicinally Rumex hastatus D. Don has been used since long for various ailments especially in neurol. disorders. The reported data and the importance of Rumex genus demonstrate the vital medicinal value of R. hastatus. Methods: In the current investigational study, isolation of essential oil and its antioxidant and anticholinesterase assays were performed. The essential oil of R. hastatus was analyzed by GC-MS for the first time. The essential oil was evaluated for anticholinesterase and antioxidant assays. The anticholinesterase assay was conducted at various concentrations (62.5 to 1000 μg/mL) against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Similarly, the antioxidant potential was determined using DPPH and ABTS free radicals. Results: The GC-MS anal. of essential oil showed 123 components. The result recorded for the anticholinesterase assays demonstrated a marked potential against AChE and BChE with IC50 values of 32.54 and 97.38 μg/mL resp. which were comparable with the pos. control i.e., galanthamine (AChE, IC50 = 4.73 μg/mL and BChE, IC50 = 11.09 μg/ ml). The antioxidant assays against DPPH and ABTS free radicals also exhibited significant scavenging potential with IC50 values of 3.71 and 6.29 μg/mL resp., while for ascorbic acid the IC50 value was <0.1 μg/mL against both free radicals. Conclusions: Based on the current investigational studies, it may be concluded that R. hastatus is an effective source of essential oil’s components having anticholinesterase and antioxidant potentials, which after subjecting to drug development may lead to novel drug candidates against neurodegenerative disorders.

BMC Complementary and Alternative Medicine published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application In Synthesis of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kitazaki, Yuki published the artcilePrimary diffuse large B-cell lymphoma of the central nervous system with rapidly progressing lesions after dimethyl fumarate treatment, showing relapsing and remitting symptoms: A case report, Synthetic Route of 624-49-7, the publication is Clinical & Experimental Neuroimmunology (2022), 13(1), 60-65, database is CAplus.

Background : We present a case of B-cell type primary central nervous system lymphoma that rapidly progressed after di-Me fumarate (DMF) administration. Case presentation : An asymptomatic white matter lesion of the left frontal lobe was observed in a 56-yr-old Japanese man on magnetic resonance imaging during a medical checkup. For the subsequent 5 mo, the sporadic white matter lesion showed no change and no contrast effect. He suddenly presented with right upper limb paralysis on day 74. After improvement, he had a recurrence of right upper limb paralysis and diminished vision loss. Based on the 2017 revised McDonald criteria, two attacks, objective clin. evidence of one lesion and cerebrospinal fluid oligoclonal band assay positivity, he was diagnosed with relapsing-remitting multiple sclerosis and administered DMF. Three months after DMF administration, he developed new brain lesions that progressed rapidly; addnl. immunotherapy was ineffective. He was pathol. diagnosed with B-cell type primary central nervous system lymphoma using brain biopsy on day 301. Conclusion : Patients with rapidly progressing white matter lesions after DMF administration should be suspected for B-cell type primary central nervous system lymphoma and pathol. diagnosed using brain biopsy.

Clinical & Experimental Neuroimmunology published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Synthetic Route of 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Aydinoglu, Aysu published the artcileDevelopment of Biomimetic Hydroxyapatite Containing Dental Restorative Composites, Recommanded Product: Ethyl 4-dimethylaminobenzoate, the publication is Arabian Journal for Science and Engineering (2022), 47(5), 6667-6678, database is CAplus.

The aim of the study was to evaluate the incorporation effect of biomimetic hydroxyapatite (BHA) particles on the mech. properties of exptl. dental composites. Two exptl. composites were produced from the same organic matrix, Si/Zr nanocluster, and SiO2/silane as main inorganic reinforcing fillers. 7wt% BHA was added to one of the groups to evaluate its effect on mech. properties. The BHA was also modified with 3-MPTMS to improve chem. bonding. Chem. structures and phys. properties of the fillers were identified by XRD, FTIR, XPS, TGA, SEM, BET, and Zeta-Sizer. According to ISO 4049 and DIN 50,133 the mech. properties, and to ISO 10993-5:2009 the biocompatibility was investigated. Anal. of variance (ANOVA) was used for the statistical anal. of acquired data. The BHA was synthesized by the biomimetic method in simulated body media (SBF). The SEM images of BHA/Silane particles demonstrated rod-like shapes and similar dimensions with natural hydroxyapatite present in tooth enamel. The modification by using 3-MPTMS was decreased the mean particle size of the fillers due to a lower agglomeration tendency. Moreover, the addition of small mass fractions of the BHA into the dental resins can substantially meet the ISO 4049 requirements. Consequently, the BHA was not adversely decreasing the mech. properties of the dental composites. Also, the biocompatibility of the BHA-containing composites was found better than the samples without BHA-containing composites. The incorporation of the BHA can meet the mech. requirements of dental resins and composites. Addnl., it may show regenerative properties against small lesions.

Arabian Journal for Science and Engineering published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Recommanded Product: Ethyl 4-dimethylaminobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gao, Xin published the artcilePhotoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent “Ene”-Reductases, Related Products of esters-buliding-blocks, the publication is Journal of the American Chemical Society (2021), 143(47), 19643-19647, database is CAplus and MEDLINE.

α-Tertiary amines are a common motif in pharmaceutically important mols. but are challenging to prepare using asym. catalysis. Here, author demonstrate engineered flavin-dependent ‘ene’-reductases (EREDs) can catalyze radical additions into oximes to prepare this motif. Two different EREDs were evolved into competent catalysts for this transformation with high levels of stereoselectivity. Mechanistic studies indicate that the oxime contributes to the enzyme templated charge-transfer complex formed between the substrate and cofactor. These products can be further derivatized to prepare a variety of motifs, highlighting the versatility of ERED photoenzymic catalysis for organic synthesis.

Journal of the American Chemical Society published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Karagoz, Idris published the artcileEffect of melt temperature on product properties of injection-molded high-density polyethylene, Related Products of esters-buliding-blocks, the publication is Polymer Bulletin (Heidelberg, Germany) (2021), 78(10), 6073-6091, database is CAplus.

Abstract: Recently, injection molding process has generated growing interest, exhibiting great potential to easily fabricate unique polymeric materials for industrial applications. To increase the sustainability of the process, determinative parameters and their effects should be examined This study focuses on the effect of melt temperature on as-injection molded product, thereby high-d. polyethylene samples were fabricated by performing three different melt temperatures (180, 190, and 200°C), and subsequently, their mech., thermal, and morphol. and surface quality properties were examined The results showed that higher melting temperature lowered crystallization rate and decreased the strength of tensile and bending; however, it increased crystal lamellar thickness and impact strength. Moreover, the type of fibrillation changed with the temperature Moreover, defects formation increased with the temperature For further application, the effect of the temperature on surface quality was discussed. This work will provide a guide for manufacturing injection-molded products at desired properties by arranging melt temperature

Polymer Bulletin (Heidelberg, Germany) published new progress about 31570-04-4. 31570-04-4 belongs to esters-buliding-blocks, auxiliary class Mono-phosphine Ligands, name is Tris(2,4-di-tert-butylphenyl) phosphite, and the molecular formula is C42H63O3P, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics