Esters-buliding-blocks

Clarke, Joshua A. published the artcileBase-Catalyzed Hydrosilylation of Nitriles to Amines and Esters to Alcohols, Synthetic Route of 10287-53-3, the publication is European Journal of Organic Chemistry (2021), 2021(31), 4434-4439, database is CAplus.

Base-catalyzed hydrosilylation of nitriles to amines and esters to silylated alcs. is reported. This protocol tolerates electron-rich and electron-neutral olefins and works in the presence of basic functional groups (e. g. tertiary amines) but fails for acidic substrates, such as phenols and NH anilines. This catalytic system does not tolerate carbonyl groups, such as aldehydes, ketones, esters and carbamides, which are reduced to corresponding alcs. and amines. With the exact amount of silane, esters can be selectively reduced in the presence of nitriles, but the selectivity drops for the pairs ester/carboxamide and carboxamide/nitrile. Through competition experiments, the following preference in functional group reactivity was determined: ester > carboxamide > nitrile.

European Journal of Organic Chemistry published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Synthetic Route of 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Van Kerckhoven, Christel published the artcileDithiocarbamate telechelic polymers: synthesis and block copolymerization, Related Products of esters-buliding-blocks, the publication is Makromolekulare Chemie (1991), 192(1), 101-14, database is CAplus.

The iniferter method was studied for the synthesis of polyvinyl block copolymers of relatively low mol. weight using tetramethylthiuram disulfide (I) and benzyl diethyldithiocarbamate (II) as initiator. Considering the low quantum yield of dissociation (ϕ_d) of I (2.5·10^-3 in cyclohexane), I was used as a thermal initiator (95°) for the synthesis of dithiocarbamate-polystyrene telechelics. ¹³C-NMR anal. of these telechelics showed 2 ¹³C=S signals corresponding to 2 different end groups: Et₂NCSS₂CHPhCH₂– and Et₂NCSS₂CH₂CHPh-. Several styrene polymerizations were also carried out in the presence of AIBN as thermal initiator and I as chain-transfer agent. Depending on the AIBN-I mole ratio, mono- and difunctional telechelics were formed, as evidenced by NMR anal. These telechelics were used for the photochem. initiations of Et acrylate (III), acrylic acid, and Me methacrylate (IV). It was assumed that ϕ_d of the dithiocarbamate end group was equal to that of II (0.06). Nonfunctional polymers were also prepared, either photochem. by dissociation of II, or thermally in presence of AIBN and II as transfer agent. They were used for block copolymerization with IV. Inversely, telechelics were prepared in a first step; in this case ϕ_d = 0.026. They were then used for the polymerization of III. The block copolymers were fractionated; their composition and mol. weights were determined by ¹H NMR and gel-permeation chromatog., resp.

Makromolekulare Chemie published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C17H16O2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Reid, Tony published the artcilePhase II trial of the histone deacetylase inhibitor pivaloyloxymethyl butyrate (Pivanex, AN-9) in advanced non-small cell lung cancer., Computed Properties of 122110-53-6, the publication is Lung cancer (Amsterdam, Netherlands) (2004), 45(3), 381-6, database is MEDLINE.

This multicenter phase II trial evaluated the therapeutic activity and safety profile of pivaloyloxymethyl butyrate (Pivanex, AN-9) as a single agent in refractory non-small cell lung cancer (NSCLC). Pivanex (2.34 g/m2 per day) was administered as a 6-h continuous intravenous infusion, daily for 3 days, and repeated every 21 days until disease progression. Forty-seven patients were treated. More than 90% of patients had received both a platinum compound and a taxane and 32% had received three or more prior chemotherapy regimens. The most common toxicities were transient grade 1-2 fatigue (34%), nausea (17%), and dysgeusia (11%). Three patients had partial responses (6.4 and 95%; CI 1.4-18.7%) and 14 patients had stable disease for > or =12 weeks (30%). Median survival for all patients was 6.2 months with 1-year survival of 26%. For patients who received fewer than three prior chemotherapy regimens, median survival was 7.8 months and 1-year survival was 31%. Pivanex is well tolerated and appears to be active as a single agent in patients with advanced NSCLC refractory to previous chemotherapy. Based on its therapeutic activity and favorable safety profile, further studies of Pivanex in NSCLC, particularly in combination with current chemotherapeutic agents, are warranted.

Lung cancer (Amsterdam, Netherlands) published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Computed Properties of 122110-53-6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Selvakumar, Kumaravel published the artcileCatalytic and Structural Studies on Complexes of a Binaphthyl-Phosphino-Oxazoline Auxiliary: The Meta Dialkyl Effect on Enantioselectivity, Quality Control of 126613-06-7, the publication is Organometallics (2000), 19(7), 1299-1307, database is CAplus.

The chiral phosphino-oxazoline ligand (S,R)-2-(4,5-dihydro-4-isopropyloxazol-2-yl)-2′-bis(3,5-dimethylphenyl)phosphino-1,1′-binaphthyl, 6b, its Pd-dichloro complex, 9, the p-cyanoaryl complex [PdBr(p-NCC₆H₄)(6b)], 10, a model for the Heck reaction, the cationic 1,3-diphenylallyl derivative [Pd(η³-PhCHCHCHPh)(6b)]OTf, 11, a model for the allylic allylation, and the Rh- and Ir-1,5-COD compounds [M(1,5-COD)(6b)]BF₄, 12 and 13, resp., were prepared In enantioselective Heck arylation and allylic allylation catalytic experiments, the presence of the 3,5-dimethylphenyl groups generally increases the observed ee. The solid-state structure of PdCl₂(6b), 9, was determined 2-Dimensional and variable-temperature NMR experiments suggest that one of the two 3,5-di-Me P-aryl rings interacts selectively with the remaining ligands. Consequently, the entire chiral pocket becomes slightly more rigid and the correlation with substrate improves.

Organometallics published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C10H10O2, Quality Control of 126613-06-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tekeste, Teame published the artcileModeling Zinc Enzyme Inhibition with Functional Thiolate Ligands, Safety of Ethyl 2-mercaptopropanoate, the publication is Inorganic Chemistry (2006), 45(26), 10799-10806, database is CAplus and MEDLINE.

The blocking of zinc enzymes by thiolate-containing inhibitors was modeled by treating Tp^Ph,MeZn-OH with functional thiols. The latter were chosen such that they contain an addnl. donor function (COOH, COOR, NH₂, NHR, OH) in a position favorable for chelation. Of them, mercapto carboxylic acid esters were incorporated as thiolates. The corresponding mercapto carboxylic acids, however, used only their carboxylate function for coordination. Various mercapto amines, mercapto alcs., and mercaptophenol were exclusively converted to thiolate ligands. The two modes of inhibitor attachment, terminal or chelating, were observed equally frequently. As a rule, they occur as alternatives for similar ligands. In case of 2-mercaptophenol they coexist in the crystalline state and in solution Hydrogen bonding, both intra- and intermol., seems to be a decisive factor determining the inhibitor attachments. Its persistence in solution is underlined by the observation that Tp^Ph,MeZn-hydroxythiophenolates are methylated about 2 orders of magnitude slower than Tp^Ph,MeZn-SPh itself.

Inorganic Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C11H10O, Safety of Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Grichanov, I. published the artcileAttractivity of some synthetic compounds for male gray grain moth [Apamea anceps]., Application of (Z)-Dodec-9-en-1-yl acetate, the publication is Eesti NSV Teaduste Akadeemia Toimetised, Bioloogia (1989), 38(3), 185-8, database is CAplus.

Twenty-eight synthetic compounds of the formula H₃C-(CH₂)_n-CH=CH-(CH₂)_m-Y (where Y = OAc, CHO, or OH; m = 4, 6, 7, 8, or 10; and n = 1, 3, 5, or 7; double bond had cis or trans configuration) were tested for ability to attract male gray grain moth (A. anceps). Only cis-11-hexadecenal was attractive for this species, and its specificity was 93-100%.

Eesti NSV Teaduste Akadeemia Toimetised, Bioloogia published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Application of (Z)-Dodec-9-en-1-yl acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Giannoccaro, Maria Pia published the artcileDifference in safety and humoral response to mRNA SARS-CoV-2 vaccines in patients with autoimmune neurological disorders: the ANCOVAX study, Product Details of C6H8O4, the publication is Journal of Neurology (2022), 269(8), 4000-4012, database is CAplus and MEDLINE.

Assessing the safety of SARS-CoV-2 mRNA vaccines and the effect of immunotherapies on the seroconversion rate in patients with autoimmune neurol. conditions (ANC) is relevant to clin. practice. Our aim was to assess the antibody response to and safety of SARS-CoV-2 mRNA vaccines in ANC. This longitudinal study included ANC patients vaccinated with two doses of BNT162b2 or mRNA-1273 between March and August 2021. Side effects were assessed 2-10 days after each dose. Neurol. status and anti-spike receptor binding domain antibody levels were evaluated before vaccination and 4 wk after the second dose. Healthcare-workers served as controls for antibody levels. We included 300 ANC patients (median age 52, IQR 40-65), and 347 healthcare-workers (median age 45, IQR 34-54). mRNA-1273 vaccine was associated with an increased risk of both local (OR 2.52 95% CI 1.45-4.39, p = 0.001) and systemic reactions (OR 2.51% CI 1.49-4.23, p = 0.001). The incidence of relapse was not different before and after vaccine (Incidence rate ratio 0.72, 95% CI 0.29-1.83). Anti-SARS-CoV-2 IgG were detected in 268 (89.9%) patients and in all controls (p < 0.0001). BNT162b2 vaccine (OR 8.84 95% CI 2.32-33.65, p = 0.001), anti-CD20 mAb (OR 0.004 95% CI 0.0007-0.026, p < 0.0001) and fingolimod (OR 0.036 95% CI 0.002-0.628, p = 0·023) were associated with an increased risk of not developing anti-SARS-CoV-2 IgG. SARS-CoV-2 mRNA vaccines were safe in a large group of ANC patients. Anti-CD20 and fingolimod treatment, as well as vaccination with the BNT162b2 vaccine, led to a reduced humoral response. These findings could inform vaccine policies in ANC patients undergoing immunotherapy.

Journal of Neurology published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Product Details of C6H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hattori, Hideshi published the artcileSynthesis and characterization of polymerizable photochromic liquid crystals containing a spiro-oxazine group, Category: esters-buliding-blocks, the publication is Liquid Crystals (1999), 26(7), 1085-1095, database is CAplus.

Novel polymerizable photochromic liquid crystal materials containing either the 1,3-dihydro-1,3,3-trimethylspiro[2H-indole-2,3′-[3H]naphth[2,1-b][1,4]oxazine] group or the 1,3-dihydro-1,3,3-trimethylspiro[2H-indole-2,3′-[3H]pyrido[3,2-f][1,4]benzoxazine] group as the photochromic moiety, and the biphenylene unit as the mesogenic moiety, were synthesized. Thermal and phys. properties of the compounds were examined using DSC, optical polarizing microscopy, wide-angle x-ray diffractometry and UV-visible spectrophotometry. The photochromic compounds containing both photochromic and mesogenic moieties showed metastable mesophases; these tended to crystallize with time and on heating. The crystallization behaviors were strongly dependent on the structure of the terminal group of alkylene spacer and the position of the spiro-oxazine bound to the mesogen.

Liquid Crystals published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hattori, Hideshi published the artcileSynthesis and properties of photochromic liquid-crystalline polyacrylates containing a spirooxazine group, SDS of cas: 50670-76-3, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (1999), 37(17), 3513-3522, database is CAplus.

The novel photochromic liquid-crystalline polyacrylates containing a spirooxazine group were synthesized. The photochromic polymer containing (4-pentamethyleneoxy)biphenylene moiety at the 5-position of spironaphthoxazine showed nematic phase from 122.9 to 133.8°C. The photochromic polymer containing undecamethylene instead of pentamethylene showed smectic phase from 93.1 to 169.7°. On the other hand, the photochromic polymer containing both undecamethylene as a spacer and spironaphthoxazine-bound biphenylene moiety at 9′-position did not show any liquid crystallinity. All spirooxazine-containing liquid-crystalline polymers showed photochromism in the solid state at room temperature Because the shape of the absorption spectra of the photochromic quenched liquid-crystalline polymer films was almost the same as those of the photochromic amorphous polymer films, the photochromic properties did not depend on the mesophase in the polymers examined

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, SDS of cas: 50670-76-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Farhat, Hafiza published the artcileEvaluation of nematicidal potential of endophytic fungi associated with healthy plants and GC-MS profiling of metabolites of endophytic Fusarium solani, Recommanded Product: Isobutyl palmitate, the publication is South African Journal of Botany (2022), 146-161, database is CAplus.

Endophytic fungi are now recognized as an excellent source of widely occurring natural products. Fungi are wonderful producers of natural products, mostly secondary metabolites. The vital use of these fungi may provide benefit to current demand for novel biomols. in agriculture, medical and pharmaceutical industries. In this study, endophytic fungi Aspergillus terreus, Cephalosporium sp., Chaetomium sp., Curvularia lunata, Curvularia hawaiiensis, Macrophomina phaseolina, Fusarium solani, Talaromyces assiutensis and Talaromyces trachyspermus isolated from healthy plants and evaluated for nematicidal activity against Meloidogyne javanica, a root-knot nematode. In vitro culture filtrates of these fungi showed strong nematicidal activity by killing juveniles of nematode to varying degree, where F.solani caused 100% mortality after 48 h. n- Hexane fraction of culture filtrate and n-hexane extract of mycelium of F. solani were subjected to GC-MS anal., resulted in the identification of several compounds and some are not reported before from this fungus. Metabolites from endophytic F. solani could be used in the development of antimicrobial agents that can be used in medicine or agrochems. The use of fungal based products offers a unique opportunity to discover novel therapeutic agents to combat various infectious agents and agricultural pests.

South African Journal of Botany published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Recommanded Product: Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics