Esters-buliding-blocks

Jenic, Darko published the artcileReversal of Tetracycline Resistance by Cepharanthine, Cinchonidine, Ellagic Acid and Propyl Gallate in a Multi-drug Resistant Escherichia coli, Application of Propyl 3,4,5-trihydroxybenzoate, the publication is Natural Products and Bioprospecting (2021), 11(3), 345-355, database is CAplus and MEDLINE.

Bacterial resistance to antibiotics is an increasing threat to global healthcare systems. We therefore sought compounds with potential to reverse antibiotic resistance in a clin. relevant multi-drug resistant isolate of Escherichia coli (NCTC 13400). 200 natural compounds with a history of either safe oral use in man, or as a component of a traditional herb or medicine, were screened. Four compounds; ellagic acid, Pr gallate, cinchonidine and cepharanthine, lowered the min. inhibitory concentrations (MICs) of tetracycline, chloramphenicol and tobramycin by up to fourfold, and when combined up to eightfold. These compounds had no impact on the MICs of ampicillin, erythromycin or trimethoprim. Mechanistic studies revealed that while cepharanthine potently suppressed efflux of the marker Nile red from bacterial cells, the other hit compounds slowed cellular accumulation of this marker, and/or slowed bacterial growth in the absence of antibiotic. Although cepharanthine showed some toxicity in a cultured HEK-293 mammalian cell-line model, the other hit compounds exhibited no toxicity at concentrations where they are active against E. coli NCTC 13400. The results suggest that phytochems. with capacity to reverse antibiotic resistance may be more common in traditional medicines than previously appreciated, and may offer useful scaffolds for the development of antibiotic-sensitizing drugs.

Natural Products and Bioprospecting published new progress about 121-79-9. 121-79-9 belongs to esters-buliding-blocks, auxiliary class Natural product, name is Propyl 3,4,5-trihydroxybenzoate, and the molecular formula is C10H12O5, Application of Propyl 3,4,5-trihydroxybenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Krascsenicsova, Katarina published the artcileStereoconservative Negishi arylation and alkynylation as an efficient approach to enantiopure 2,2′-diarylated 1,1′-binaphthyls, Product Details of C22H12F6O6S2, the publication is Chemical Communications (Cambridge, United Kingdom) (2004), 2606-2607, database is CAplus and MEDLINE.

Negishi arylation and alkynylation of easily synthesized chiral 2,2′-diiodo-1,1′-binaphthyl rapidly proceeds in refluxing THF under microwave irradiation conditions affording enantiopure 2,2′-R₂-1,1′-binaphthyls (R = Ph, 4-MeC₆H₄, 2-MeOC₆H₄, 2-furyl, 3-pyridyl, Me₃SiCC, PhCC, etc.) in good to excellent yields.

Chemical Communications (Cambridge, United Kingdom) published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, Product Details of C22H12F6O6S2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Greenway, A. R. published the artcileCompounds modifying the activity of two sex attractants for males of the pea moth, Cydia nigricana (F.), Quality Control of 16974-11-1, the publication is Journal of Chemical Ecology (1982), 8(2), 397-408, database is CAplus and MEDLINE.

(E)-10-Dodecen-1-yl acetate (R10-12:Ac) [112-42-5] and (E,E)-8,10-dodecadien-1-yl acetate (E,E8,10-12:Ac) [53880-51-6] are sex attractants for males of the pea moth (C. nigricana). Thirty-two structurally related compounds with chain lengths were exposed with E10-12:Ac or C_9-14 E,E8,10-12:Ac in traps in the field to investigate their influence on the activity of the attractants. Only alcs. and acetates unsaturated at C-8, -9, or -10 greatly influenced moth captures; (Z)- [40642-40-8] and (E)-8-dodecen-1-ol  [42513-42-8] were weak synergists for E10-12:Ac, but not synergists for E,E8,10-12:Ac were found. (Z)- [28079-04-1] And (E)-8-dodecen-1-yl acetate  [38363-29-0] and (E,E)-8,10-dodecadien-1-ol  [33956-49-9] inhibited both E10-12:Ac and E,E8,10-12:Ac, while (E)-10-dodecen-1-ol  [35237-63-9], 10-dodecyn-1-ol  [69221-99-4], (Z) [16974-11-1] and (E)-9-dodecen-1-yl acetate  [35148-19-7], (Z)-10-dodecen-1-yl acetate  [35148-20-0], and undecyl acetate  [1731-81-3] inhibited only the former attractant.

Journal of Chemical Ecology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Quality Control of 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhu, Di published the artcileTerthiophene Derivative-Based Photoinitiating Systems for Free Radical and Cationic Polymerization under Blue LEDs, HPLC of Formula: 10287-53-3, the publication is Industrial & Engineering Chemistry Research (2021), 60(24), 8733-8742, database is CAplus.

Terthiophene derivatives were prepared and utilized as photoinitiators of photopolymerization reactions upon exposure to LEDs (410 and 445 nm). The photochem. mechanisms of the terthiophene-based photoinitiating systems were investigated and confirmed by steady-state photolysis, fluorescence quenching, and ESR spin-trapping techniques. The photoinitiation ability of terthiophene derivatives in combination with the iodonium salt and optionally with a tertiary amine in the free radical polymerization of multifunctional acrylates and cationic polymerization of epoxides under mild light irradiation was investigated. Exceptionally, a sodium salt form of a terthiophene derivative presented exceeding water solubility and admirable efficiency in rapid hydrogel formation from the 2-hydroxy Et acrylate and water blend. The storage stability of the effective photoinitiating systems in the formulations was also studied under moderate conditions.

Industrial & Engineering Chemistry Research published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C12H15ClO3, HPLC of Formula: 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kantlehner, Willi published the artcileOrthoamides. XXXII. Reaction of tert-butoxy-N,N,N’,N’-tetramethylmethanediamine with NH- and CH-acidic compounds, Computed Properties of 924-99-2, the publication is Liebigs Annalen der Chemie (1980), 344-57, database is CAplus.

Me₃COCH(NMe₂)₂ (I) reacted with OHCNHCH₂(CH₂)_nCO₂Et to give OHCNH(CH₂)_nC(CO₂Et):CHNMe₂, whereas H₂NCH₂CO₂Et reacted with I to give Me₂NCH:NCH₂CO₂Et, which reacted with I to give Me₂NCH:NC(CO₂Et):CHNMe₂. HCONHR (R = Me, Et, Ph, Pr, PhCH₂) were transformed by I into Me₂NCH:NR. Reaction of EtO₂CCH₂NC with I gave EtO₂CC(NC):CHNMe₂, whereas reaction of PhCH₂NC with I gave Me₂NCH:CPhN:CHNMe₂. The oxazolines II (R = H, Me), R¹N:C(OEt)CH₂R² (R¹, R² = Me, Ph; Ph, H), and Me₂NCMe:NR³ (R³ = Me, Ph) were aminomethylated by I to give III, Me₂NCH:CR²C(OEt):NR¹, and R³N:C(NMe₂)CH:CHNMe₂, resp. MeC⁺(NMe₂)₂BF₄^– reacted with I to give Me₂NCH:CHC⁺(NMe₂)₂BF₄^–, whereas R⁴CH₂P(O)(OEt)₂ (R⁴ = Ph, CO₂Et, cyano) reacted with I to give Me₂NCH:CR⁴P(O)(OEt)₂. Reaction of I with Me₃SiCH₂CO₂Et yielded Me₂NCH:CHCO₂Et.

Liebigs Annalen der Chemie published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Arndt, Daniel published the artcileA complex matrix characterization approach, applied to cigarette smoke, that integrates multiple analytical methods and compound identification strategies for non-targeted liquid chromatography with high-resolution mass spectrometry, Quality Control of 517-23-7, the publication is Rapid Communications in Mass Spectrometry (2020), 34(2), e8571, database is CAplus and MEDLINE.

Rationale : For the characterization of the chem. composition of complex matrixes such as tobacco smoke, containing more than 6000 constituents, several anal. approaches have to be combined to increase compound coverage across the chem. space. Furthermore, the identification of unknown mols. requiring the implementation of addnl. confirmatory tools in the absence of reference standards, such as tandem mass spectrometry spectra comparisons and in silico prediction of mass spectra, is a major bottleneck. Methods : We applied a combination of four chromatog./ionization techniques (reversed-phase (RP) – heated electrospray ionization (HESI) in both pos. (+) and neg. (-) modes, RP – atm. pressure chem. ionization (APCI) in pos. mode, and hydrophilic interaction liquid chromatog. (HILIC) – HESI pos.) using a Thermo Q Exactive® liquid chromatog./high-resolution accurate mass spectrometry (LC/HRAM-MS) platform for the anal. of 3R4F-derived smoke. Compound identification was performed by using mass spectral libraries and in silico predicted fragments from multiple integrated databases. Results : A total of 331 compounds with semi-quant. estimates â‰?00 ng per cigarette were identified, which were distributed within the known chem. space of tobacco smoke. The integration of multiple LC/HRAM-MS-based chromatog./ionization approaches combined with complementary compound identification strategies was key for maximizing the number of amenable compounds and for strengthening the level of identification confidence. A total of 50 novel compounds were identified as being present in tobacco smoke. In the absence of reference MS² spectra, in silico MS² spectra prediction gave a good indication for compound class and was used as an addnl. confirmatory tool for our integrated non-targeted screening (NTS) approach. Conclusions : This study presents a powerful chem. characterization approach that has been successfully applied for the identification of novel compounds in cigarette smoke. We believe that this innovative approach has general applicability and a huge potential benefit for the anal. of any complex matrixes.

Rapid Communications in Mass Spectrometry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Quality Control of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ashor, Almabrok A. published the artcileOptimization of modifier deposition on the alumina surface to enhance mechanical properties and cavitation resistance, Name: Dimethyl itaconate, the publication is Polymer Bulletin (Heidelberg, Germany) (2020), 77(7), 3603-3620, database is CAplus.

Composites based on poly(Me methacrylate), di-Me itaconate matrix and alumina particles were prepared Ferrous oxide-doped alumina particles (Al₂O₃ Fe) and com. alumina nanoparticles (Al₂O₃ n) modified with (3-aminopropyl)trimethoxysilane (AM) and Me esters of linseed oil fatty acids (biodiesel-BD) were used as reinforcement. The mech. properties of the prepared composites, containing 1, 3 and 5 weight% of surface-modified alumina particles, are compared to a neat polymer matrix. The particles were characterized by single-beam Fourier transform IR spectroscopy, thermogravimetry and differential scanning calorimetry. The mech. properties of the composites were determined by micro-Vickers hardness and impact testing. The morphol. of the surface of the composites exposed to cavitation was observed through a field emission scanning electron microscope. AFM anal. was used to compare surface features seen using the SEM and to interpret the surface degradation properties. The hardness, cavitation resistance and high-impact energy resistance of the composites are better in the case of AM surface modification of alumina fillers, but biodiesel modified particles have comparable mech. properties and a stabilized Al-O-Si bond that could be important when a composite is exposed to humidity or a wet environment.

Polymer Bulletin (Heidelberg, Germany) published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Name: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lebedeva, K. V. published the artcileIsolation, identification, and synthesis of pheromone components of a Tashkent population of cutworm (Mamestra suasa), Product Details of C14H26O2, the publication is Agrokhimiya (1990), 115-25, database is CAplus.

Major constituents of the volatile fraction of the M. suasa pheromone were decanal, dodedecenyl acetate, tridecanol, hexadecanol, and Z-11-hexadecenyl acetate (I) (1.66:1.00:1.34:0.01:176). I was also the main component of leachates from female glands. After the removal of the volatile fraction the electroantennog.-active fraction of the glands contained Z–11-hexadecenal, I, hexadecanyl acetate, octadecanal, Z-6,Z-11-hexadecadienal, and Z-6,Z-11-hexadecadienyl acetate (1.5:742.5:123:100:1:3). Thus, only I was common for all the 3 sources of the pheromone. It was used as the main component of attractants tested in the Asian and European USSR. I + Z-11-hexadecenal (100:10) was especially effective in the Voronezh area in summer, I + hexadecanyl acetate (200:20) and several other compounds were effective in the Tashkent area in spring. Different combinations were effective in the Issyk-Kul area in spring and in summer. None of these mixtures had an adequate selectivity.

Agrokhimiya published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Product Details of C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Siu, Lillian L. published the artcileActivity of pivaloyloxymethyl butyrate, a novel anticancer agent, on primary human tumor colony-forming units, Recommanded Product: (Pivaloyloxy)methyl butyrate, the publication is Investigational New Drugs (1998), 16(2), 113-119, database is CAplus and MEDLINE.

The anti-proliferative effects of pivaloyloxymethyl butyrate (AN-9), a butyric acid (BA) derivative with potent tumor-differentiating properties both in vitro and in vivo, was evaluated against colorectal, breast, lung, ovarian, renal cell, bladder, and other types of tumor colony-forming units in a human tumor cloning assay. A total of 76 evaluable specimens were exposed to AN-9 continuously, 48 of these were also exposed to BA continuously for direct comparison of the two agents, and 20 specimens were exposed to AN-9 for two hours. An in vitro inhibitory response was defined as a â‰?50% decrease in tumor colony formation in treated cells compared to untreated controls. Superior anti-tumor activity was observed with the continuous exposure to AN-9 (39% in vitro response at 100 μM and 70% at 200 μM) than with the two-hour exposure (20% at 100 μM and 25% at 200 μM). At a continuous concentration of 200 μM, AN-9 demonstrated greater tumor-specific activity than BA against melanoma (100% vs. 67%), ovarian (67% vs. 40%), breast (63% vs. 0%), non-small cell lung (60% vs. 10%), and colorectal tumor colony-forming units (62% vs. 20%). AN-9 is a novel differentiating agent with activity against colony-forming units derived from a variety of primary human tumors, including those that are considered relatively chemoresistant, and may thus provide a therapeutic alternative or addition to standard cytotoxic agents, if appropriate drug concentrations can be achieved in patients.

Investigational New Drugs published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C17H14F3N3O2S, Recommanded Product: (Pivaloyloxy)methyl butyrate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Schmidt-Busser, Daniela published the artcileIdentification of host-plant chemical stimuli for the European grape berry moth Eupoecilia ambiguella, Application In Synthesis of 16974-11-1, the publication is Physiological Entomology (2011), 36(2), 101-110, database is CAplus.

The present study aims to identify host-plant stimuli for the European grape berry moth Eupoecilia ambiguella, a major pest of vine in Europe. Headspace volatiles from Vitis vinifera L. cv. Pinot Noir, Vitis vinifera subsp. sylvestris, and 5 other host-plant species comprising 5 different families are analyzed by gas chromatog. linked to electroantennogram (EAG) recording from male E. ambiguella antennae and by gas chromatog.-mass spectrometry. This procedure identifies 32 EAG-active compounds, among them the aliphatic compounds 1-hexanol, (Z)-3-hexenol, (Z)-3-hexenyl acetate, and 1-octen-3-ol; the terpenes limonene, β-caryophyllene, and (E)-4,8-dimethyl-1,3,7-nonatriene; and the aromatic compounds benzaldehyde and Me salicylate. Male and female E. ambiguella show similar EAG response amplitudes to individual chem. stimuli and also to mixtures of plant volatiles, as represented by essential oils from 10 other plant species. This possibly indicates a common role for plant compounds in the sensory ecol. of the 2 sexes of E. ambiguella.

Physiological Entomology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Application In Synthesis of 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics