The important role of 139102-34-4

The synthetic route of Methyl 4-bromo-2-methoxybenzoate has been constantly updated, and we look forward to future research findings.

139102-34-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 139102-34-4, name is Methyl 4-bromo-2-methoxybenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

L1BH4 (0.66 g) was added portion- wise to a solution of methyl 4-bromo-2- methoxybenzoate (5 g) in dry THF (50 mL) and EtOH (10 mL) was added. The reaction was stirred for 18h. The mixture was then poured into aq. NaOH (1M, 300 mL) and extracted with EtOAc. The organics were combined, washed with water then sat. brine before being dried (MgS04), and concentrated in vacuo to give the sub-title compound (4.4 g) as a gum; 1H NMR: 7.30 (d, 1H), 7.17-7.11 (m, 2H), 5.10 (t, 1H), 4.43 (d, 2H), 3.79 (s, 3H).

The synthetic route of Methyl 4-bromo-2-methoxybenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; DAINIPPON SUMITOMO PHARMA CO., LTD.; ASTRAZENECA UK LIMITED; BAILEY, Andrew; HIGHTON, Adrian John; MCINALLY, Thomas; MOCHEL, Tobias; URABE, Daisuke; WO2012/66335; (2012); A1;,
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Simple exploration of 18013-97-3

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Diethyl 2,5-dibromoterephthalate.

Adding some certain compound to certain chemical reactions, such as: 18013-97-3, name is Diethyl 2,5-dibromoterephthalate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18013-97-3. 18013-97-3

To the crude was added anhydrous Lambda/,/V-dimethylformamide (100 cm3), 2,5-dibromo-terephthalic acid diethyl ester (1 1 .0 g, 29 mmol) and bis(triphenylphosphine)palladium(ll) dichloride (612 mg, 0.87 mmol) and the mixture heated at 100 C for 2 hours. The mixture allowed to cool to 23 C, concentrated in vacuo and passed through a plug of silica (dichloromethane) to give a solid which was triturated in methanol. The solid collected by filtration to give 2,5-bis-thieno[2,3-b]thiophen-2-yl- terephthalic acid diethyl ester (1 1 .68 g, 81 %) as a yellow solid. 1H-NMR (400 MHz, CDCIs) 1 .13 (6H, t, J 7.1 ), 4.24 (4H, q, J 7.1 ), 7.24 (2H, d, J 5.2), 7.26 (2H, s), 7.37 (2H, d, J 5.2), 7.88 (2H, s).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Diethyl 2,5-dibromoterephthalate.

Reference:
Patent; MERCK PATENT GMBH; MORSE, Graham; HEARD, Kane; MITCHELL, William; KROMPIEC, Michal; D’LAVARI, Mansoor; PRON, Agnieszka; (260 pag.)WO2019/52935; (2019); A1;,
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Some scientific research about tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate

According to the analysis of related databases, tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, the application of this compound in the production field has become more and more popular.

581065-95-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 581065-95-4 as follows.

The preparation of compound D is disclosed in Cheng et al. 2013 (compound 108, FIG. 19). The preparation of compound E is disclosed in Cong et al. 2015 (compound 21, FIG. 2b). Compound F was prepared from tert-butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate (CAS Reg. No. 581065-95-4) by treatment with Fmoc-Cl to attach the Fmoc protecting group, followed by treatment with trifluoroacetic acid to cleave the t-butyl ester.

According to the analysis of related databases, tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; Young, Ian S.; Lou, Sha; Gangwar, Sanjeev; (16 pag.)US2019/388553; (2019); A1;,
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The important role of Methyl 2-(bromomethyl)acrylate

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4224-69-5, and friends who are interested can also refer to it.

4224-69-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4224-69-5 as follows.

General procedure: To a solution of 2a (0.30 g, 0.89 mmol) in a mixture of THF: H2O (20 mL, 2:1, v/v) were added allyl bromide (0.161 mL, 1.33 mmol) and indium powder (0.153 g, 1.33 mmol) and the reaction was continued for 3 h. On completion as monitored by TLC, the excess solvent was removed from the reaction to obtain a residue which was extracted with EtOAc (40 mL) and water (30 mL). The water layer was separated and further extracted with EtOAc (2 x 20 mL) and the organic layers were pooled, dried over anhyd. Na2SO4, and evaporated in vacuum to afford 3d (0.318 g, 93%) which was used further without purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4224-69-5, and friends who are interested can also refer to it.

Reference:
Article; Yadav, Veena D.; Srivastava, Kumkum; Tripathi, Renu; Batra, Sanjay; Tetrahedron; vol. 73; 38; (2017); p. 5680 – 5689;,
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Some scientific research about Methyl cyclohex-1-enecarboxylate

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18448-47-0, name is Methyl cyclohex-1-enecarboxylate, A new synthetic method of this compound is introduced below., 18448-47-0

(4) Take 3.9g of 0.8g potassium carbonate (K2CO3),0.6g palladium on carbon (Pd (OH) 2 / C) and23mL tert-butyl hydroperoxide (TBHP),0 C was sequentially added to 80 mL of dichloromethane (DCM),The temperature was naturally raised to room temperature until the reaction was completed, and the allyl site was oxidized to form a carbonyl group.The reaction solution was then extracted with DCM, and the extract was separated by silica gel column chromatography.It is obtained that when R = H,4.1 g of product were obtained; when R = CH3,4.15 g of product was obtained.The reaction yield was 85%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shenzhen Elderly Medical Institute; Wu Zhengzhi; Tao Cheng; Liu Jieren; Li Limin; (6 pag.)CN110229064; (2019); A;,
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New downstream synthetic route of 1-Bromo-2-(2-methoxyethoxy)ethane

According to the analysis of related databases, 54149-17-6, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 54149-17-6 as follows. 54149-17-6

Compound 1 (2.2 g, 8.7 mmol) was dissolved in DMSO (50 ml), potassium carbonate (3.6 g, 26.1 mmol) was added, and the mixture was stirred at room temperature for 30 minutes.Next, 2- (2-methoxyethoxy) ethyl bromide (manufactured by Tokyo Chemical Industry Co., Ltd.: 4.8 g, 26.1 mmol) was added and the mixture was stirred at room temperature for 12 hours.After the reaction solution was extracted with diisopropyl ether (250 ml), the organic solvent was washed with water.After distilling off the solvent, it was isolated and purified by silica gel column chromatography using hexane and ethyl acetate to obtain Compound 3 (2.4 g, yield 56%)

According to the analysis of related databases, 54149-17-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KURARAY COMPANY LIMITED; SHIBUYA, HIROMASA; MORIHARA, YASUSHI; INAGAKI, TAKUYA; MIURA, MASANORI; FUJITA, AKIO; (25 pag.)JP2015/17052; (2015); A;,
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The important role of (2,4-Dimethoxyphenyl)methanamine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (2,4-Dimethoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 20781-20-8, name is (2,4-Dimethoxyphenyl)methanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20781-20-8, 20781-20-8

Example 162: 3-Fluoro-8-isopropyl-10-methyl-11-oxo-/V-piperidin-4-yl-10,11- dihydrodibenzo[6,f][1 ,4]thiazepine-7-sulfonamide 5,5-dioxide hydrochlorideStep 1. te/f-Butyl 4-(2,4-dimethoxybenzylamino)piperidine-1-carboxylate[0492] A mixture of terf-butyl 4-oxopiperidine-1-carboxylate (21.0 g, 0.105 mol), 2,4-dimethoxybenzylamine (17.6 g, 0.105 mol), and sodium triacetoxyborohydride (55.8 g, 0.263 mol) were stirred in ethanol (500 ml_) 2 hours at room temperature. Aqueous sodium bicarbonate was added, and the mixture was extracted with dichloromethane. The organic phase was washed with brine, dried over magnesium sulfate and concentrated to a volume of 325 ml_ to afford an approximately 0.323 M solution in dichloromethane of terf-butyl 4-(2,4-dimethoxybenzylamino)piperidine-1- -carboxylate which was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (2,4-Dimethoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; WYETH; WO2008/61029; (2008); A1;,
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Some scientific research about 3-Benzyloxyaniline

According to the analysis of related databases, 1484-26-0, the application of this compound in the production field has become more and more popular.

1484-26-0, Adding a certain compound to certain chemical reactions, such as: 1484-26-0, name is 3-Benzyloxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1484-26-0.

A mixture OF TRIETHYL ORTHOFORMATE (92 mL, 0.55 mol) and 2, 2-DIMETHYL- [1, 3] – dioxane-4,6-dione (75.3 g, 0.522 mol) (MELDRUMS acid) was heated at 55 ¡ãC for 90 minutes and then cooled to 45 ¡ãC. A solution of 3-benzyloxyaniline (100.2 g, 0.5029 mol) in methanol (200 mL) was slowly added to the reaction over a period 45 minutes while maintaining the reaction temperature below 50 ¡ãC. The reaction was then heated at 45 ¡ãC for one hour, allowed to cool to room temperature, and stirred overnight. The reaction mixture was cooled to 1 ¡ãC, and the product was isolated by filtration and washed with cold ethanol (-400 mL) until the filtrate was colorless. 5-1 [ (3- Benzyloxy) phenylimino] methyl}-2, 2-DIMETHYL- [1, 3] -dioxane-4,6-dione (170.65 g) was isolated as a tan, powdery solid. IH NMR (300 MHz, DMSO-d6) 8 11.21 (d, J= 14. 2 Hz, 1H), 8.61 (d, J= 14. 2 Hz, 1H), 7.49-7. 30 (M, 7H), 7.12 (dd, J= 8.1, 1.96 Hz, 1H), 6.91 (dd, J= 8.4, 2.1 Hz, 1H), 5.16 (s, 2H), 1.68 (s, 6H).

According to the analysis of related databases, 1484-26-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2005/32484; (2005); A2;,
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Continuously updated synthesis method about 1-Bromo-3,5-dimethoxybenzene

According to the analysis of related databases, 20469-65-2, the application of this compound in the production field has become more and more popular.

20469-65-2, Adding a certain compound to certain chemical reactions, such as: 20469-65-2, name is 1-Bromo-3,5-dimethoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20469-65-2.

the mixture 1-bromo-3,5-dimethoxybenzene 1c (6.51g, 30mmol), trimethylsilylacetylene (8.8g, 90mmol), bis (triphenylphosphine) palladium chloride (1.05g, 1.5mmol), cuprous iodide (0.56g, 3.0mmol), triethylamine (80 mL) and N, N-dimethylformamide (150 mL) were heated to 80 C. and stirred under nitrogen protection for 12 hours.The reaction mixture was cooled to room temperature, concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether) to obtain the target product ((3,5-dimethoxyphenyl) ethynyl) trimethylsilane 1d (6.2 g, brown solid), yield: 88%.

According to the analysis of related databases, 20469-65-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BEIJING TIANCHENG PHARMA CO., LTD.; CHEN, XIANGYANG; GAO, YINGXIANG; KONG, NORMAN XIANGLONG; (118 pag.)TW2019/38538; (2019); A;,
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Sources of common compounds: 456-49-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Fluoro-3-methoxybenzene, its application will become more common.

456-49-5,Some common heterocyclic compound, 456-49-5, name is 1-Fluoro-3-methoxybenzene, molecular formula is C7H7FO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of -butyllithium (5.0 mL, 7.93 mmol, 1.6 M in -hexane) in freshly distilled THF (20 mL) at -70 C were added a solution of compound 1-1 (1.0 g, 7.93 mmol) in THF (10 mL) and a solution of I2 (2.32 g, 9.12 mmol) in THF (15 mL) dropwise respectively. At the end of the addition, the mixture was stirred for 20 mins and allowed to warm up to -60 C and then an aqueous solution of sodium thiosulfate (3.0 mL, 10%) was added to the mixture. After the reaction was completed, the mixture was quenched by adding an aqueous ammonium chloride solution (10 mL) slowly. The THF was removed in vacuo and the aqueous phase was extracted with -hexane (50 mL x 3). The combined organic layers were washed with an aqueous sodium thiosulfate solution (10%) and water, dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 10/1) to give the title compound as oil (1.6 g, 80%). The compound was characterized by the following spectroscopic data: lli NMR (400 MHz, CDCI3): delta 6.79, 6.77, 6.75 (d, dd, d, 1H), 6.63, 6.62, 6.60, 6.58 (s, d, d, s, 1H), 6.53-6.52, 6.51-6.50 (m, m, 1H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Fluoro-3-methoxybenzene, its application will become more common.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; HU, Bailin; LI, Shifeng; WU, Xiwei; TANG, Changhua; WANG, Chenglin; FANG, Qinghong; YU, Quanxing; ZHANG, Zhikeng; WO2014/131315; (2014); A1;,
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