Esters-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89-71-4, name is Methyl 2-methylbenzoate, This compound has unique chemical properties. The synthetic route is as follows., Formula: C9H10O2

To a solution of methyl 2-methylbenzoate (5g, 0. 033mol) in carbon tetrachloride (85ml) was added n-bromosuccinimide (5.93g, 0. 033mol) and benzoyl peroxide (0.22g, 0. 9mol). The reaction was refluxed for 4 hr. The reaction was cooled to room temperature. The white precipitate was filtered and the solvent removed. The oil was dissolved in ET2O and cooled to-78C The product precipitated and collected yielding v (5. 86G, 77%).

According to the analysis of related databases, 89-71-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHROMA THERAPEUTICS LIMITED; WO2004/101506; (2004); A1;,
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Related Products of 23680-40-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 23680-40-2, name is Methyl 3-bromopropiolate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Methyl 3-bromopropiolate 2 (0.5 mmol), furan 1 (0.6 mmol) and distilled toluene (1.5 mL) were added to atwo-necked flask, and the mixture was stirred at reflux for 24 h under nitrogen atmosphere. After completion ofthe initial DielsAlder reaction, silica gel (150 mg) was added under flow of nitrogen and the mixture wasstirred at reflux for 2 h. After removal of the solvent and filtration, a product 4 was purified by silica gelcolumn chromatography or PTLC using a mixture of ethyl acetate and n-hexane as an eluent.

The synthetic route of Methyl 3-bromopropiolate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shinohara, Hiroyuki; Sonoda, Motohiro; Hayagane, Naoya; Kita, Shota; Tanimori, Shinji; Ogawa, Akiya; Tetrahedron Letters; vol. 55; 38; (2014); p. 5302 – 5305;,
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Synthetic Route of 29263-94-3,Some common heterocyclic compound, 29263-94-3, name is Diethyl 2-bromo-2-methylmalonate, molecular formula is C8H13BrO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a 7 mL vial equipped with magnetic stir bar was added bromomalonate (1.0 equiv,0.40 mmol), 2,6-lutidine (1.0 equiv, 0.40 mmol), tris[2-phenylpyridinato-C2,N]iridium(III) (1 mol %, 4.0 mumol), and heterocycle (5.0 equiv, 2.0 mmol). Dryacetonitrile or DMA (0.5 mL, 0.8 M) was then added and the reaction was sparged withN2 for 15 min. The reaction was set to stir under nitrogen at room temperature surroundedby a string of 1W or two strings of 4W blue LEDs for 24 h. The reaction mixture wasthen diluted with ethyl acetate and extracted with water. The aqueous layer was extractedwith ethyl acetate (2 x 10 mL). The combined organic layers were washed with brine,dried over Na2SO4, and concentrated in vacuo. The residue was purified bychromatography on silica gel, using the solvent system indicated.

The synthetic route of 29263-94-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Swift, Elizabeth C.; Williams, Theresa M.; Stephenson, Corey R. J.; Synlett; vol. 27; 5; (2016); p. 754 – 758;,
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Synthetic Route of 17994-94-4, These common heterocyclic compound, 17994-94-4, name is Methyl 7-aminoheptanoate hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

7-(4-Butyl-benzylamino)-heptanoic acid methyl ester. A solution of 7-amino-heptanoic acid methyl ester hydrochloride, prepared of Preparation 1, (1.12 g, 5.9 mmol), 4-butyl-benzaldehyde (0.915 g, 5.65 mmol), and triethylamine (0.83 mL, 5.98 mmol) in 20 mL MeOH was stirred at room temperature for 3 hours. After cooling to 0 C., NaBH4 (0.342 g, 9.04 mmol) was added and the reaction was stirred for 15 minutes at room temperature. The mixture was quenched with 1:1 NaHCO3:H2O and the MeOH was removed in vacuo. The resulting residue was diluted with CH2Cl2 and the organic solution was washed with water and brine, dried over MgSO4, filtered, and concentrated in vacuo to afford the title compound of Step A (1.4 g). 1H NMR (400 MHz, CDCl3) delta 7.08-7.38 (m, 4H), 3.62 (s, 2H), 3.29 (s, 3H), 2.52-2.66 (m, 4H), 2.25 (t, 2H), 1.53-1.63 (m, 6H), 1.25-1.40 (m, 6H), 0.85 (t, 3H); MS 306 (M+1).

Statistics shows that Methyl 7-aminoheptanoate hydrochloride is playing an increasingly important role. we look forward to future research findings about 17994-94-4.

Reference:
Patent; Pfizer Inc.; US2005/203086; (2005); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 40876-98-0, name is Sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of Sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate

To a stirred solution of (E)-5-((4-chlorobenzylidene)amino)-1,3-dimethylpyridin-2(1H)-one (Step 73.1) (4 g, 15.34 mmol) in AcOH (40 mL) was added diethyl oxaloacetate sodium salt (6.45 g,30.7 mmol) and the resulting mixture was heated up and stirred at 110 00 for 1 hr. The reactionwas concentrated under reduced pressure, diluted with CH2CI2 and water and both phases separated. The aqueous layer was extracted twice with CH2CI2, combined organic layers were washed with brine, dried over Na2504, filtered and concentrated under reduced pressure. The crude product was triturated in Et20 to afford the title product (4.42 g, 8.34 mmol, 54% yield) as beige solid. tR: 0.86 mm (LC-MS 2); ESl-MS: 403 [M+H], ESl-MS: 401 [M-H] (LC-MS 2).

According to the analysis of related databases, 40876-98-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; BLANK, Jutta; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUEEGER, Heinrich; VAUPEL, Andrea; WO2014/191896; (2014); A1;,
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Synthetic Route of 35120-18-4, A common heterocyclic compound, 35120-18-4, name is Ethyl 1-bromocyclobutanecarboxylate, molecular formula is C7H11BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

7-bromoquinoline-4-thiol 31b (220 mg, 0.90 mmol), ethyl 1-bromocyclobutanecarboxylate (227 mg, 1.10 mmol) and cesium carbonate (896 mg, 2.70 mmol) were added to 5 mL of NA-dimethylformamide, successively. The reaction solution was heated to 60 C. and stirred for 2 hours, then mixed with 50 mL of water, stirred uniformly, and extracted with ethyl acetate (50 mL*3). The organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, and the residue was purified by thin layer chromatography with elution system C to obtain the title compound ethyl 1-((7-bromoquinolin-4-yl)thio)cyclobutanecarboxylate 31c (100 mg, a colorless oil) yield: 30%. MS m/z (ESI): 368.1 [M+1]

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shanghai Hengrui Pharmaceutical Co., Lt.d; PENG, Jianbiao; SUN, Piaoyang; LAN, Jiong; GU, Chunyan; LI, Xiaotao; LIU, Bonian; HAN, Chunzhou; HU, Qiyue; JIN, Fangfang; DONG, Qing; CAO, Guoqing; (57 pag.)US2016/108035; (2016); A1;,
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Electric Literature of 124-06-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 124-06-1, name is Ethyl tetradecanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(Example 4) Synthesis of N-[2-(1-methylpyrrolidin-2-yl)ethyl]myristamide (Compound 4) toluene (1.00 ml), dried using MS 4A, was mixed with 1.00 ml of a n-hexane solution of 15% Me3Al. With the mixture being cooled in an ice-methanol bath, 0.17 ml (0.78 mmol) of 2-(2-aminoethyl)-1-methylpyrrolidine was added dropwise over about 2 minutes.. After stirring for 20 minutes, the temperature was raised to room temperature, and 0.5 ml of a toluene solution of 0.2 g (0.78 mmol) of myristic acid ethyl ester was added dropwise over 1 minute.. After stirring for 2 hours at 70C, the mixture was cooled with ice, and a 1N NaOH solution was added dropwise.. The mixture was stirred for 10 minutes, and water and ethyl acetate were added.. Then, the mixture was separated into respective layers, and the organic layer was washed twice with 20 ml of a saturated aqueous solution of sodium chloride.. After this layer was dried over anhydrous magnesium sulfate, it was concentrated under reduced pressure on a 30C water bath to obtain the captioned compound (yield 0.25 g).. This compound was subjected to silica gel column chromatography (mobile phase: CHCl3:MeOH (19:19:1)) for purification. NMR and mass spectrum confirmed the purified compound to have the following structure:

The synthetic route of Ethyl tetradecanoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Maruha Corporation; EP1408030; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 115913-32-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115913-32-1, name is Dimethyl bicyclo[1.1.1]pentane-1,3-dicarboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

50 Ml three-mouth bottle added 1.48 g bicyclo [1.1.1] pentane – 1, 3 – dicarboxylic acid dimethyl ester, its use 20 ml methanol dissolved, slowly dropping NaOH at room temperature (324 mg) in methanol (5 ml) solution, after adding up to 80 C reaction 2 h. After the reaction is finished concentrated to dry, add 40 ml water, dichloromethane is used for extraction (50 ml * 3), the water layer to adjust the PH dilute hydrochloric acid, adding dichloromethane extraction (40 ml * 4), the combined organic layer, drying the concentrated white solid 925 mg, yield 68%.

The synthetic route of Dimethyl bicyclo[1.1.1]pentane-1,3-dicarboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sichuan Bai Li Pharmaceutical Co., Ltd.; Zhu Yi; Li Jie; Liu Weijia; Wan Weili; Zhuo Shi; (26 pag.)CN109180681; (2019); A;,
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These common heterocyclic compound, 4492-02-8, name is Ethyl 4,5,6,7-tetrahydro-1H-indazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C10H14N2O2

Example 1 IndazoLe-3-Carboxylic Acid A mixture of 4,5,6,7-tetrahydroindazole-3-carboxylic acid ethyl ester (21.0 g, 108 mmol), 5% palladium on carbon (7.0 g solid, 3.29 mmol of Pd), and 210 mL of cymene was heated to reflux for 38 hours. At this point complete conversion to the indazole-3-carboxylic acid ethyl ester was shown by TLC (silica gel, 3:1 ethyl acetate-heptane). The reaction was cooled to 120 C. and the 5% palladium on carbon was removed by filtration.

The synthetic route of Ethyl 4,5,6,7-tetrahydro-1H-indazole-3-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eli Lilly and Company; US5914405; (1999); A;,
Ester – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 151583-29-8, name is Methyl 3-(3-bromophenyl)propanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C10H11BrO2

Example 37B: 3-(3-methoxy-3-oxopropyl)phenylboronic acid j00413j DMSO (6.86 mL) and dioxane (6.86 mL) were degassed for 15 mm bybubbling with argon. Meanwhile, Example 37A (400 mg, 1.645 mmol), KOAc (404 mg,4.11 mmol), and bis(neopentyl glycolato)diboron (520 mg, 2.304 mmol) were placed in amicrowave tube. To these compounds was added the degassed solvents. The tube was sealed and degassed for an additional 15 mi [1,1?-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (135 mg, 0.165 mmol) was subsequently added, the tubesealed, and heated to 90 C and allowed to stir overnight. The reaction was diluted withEtOAc and washed twice with brine, dried (Na2SO4), filtered, and concentrated in vacuo.The crude reaction mixture was purified by Prep LC (Axia Luna 5 t Cl 8 3 Ox 100 mmcolumn, 10 mm gradient from 40 to 100% B in A, A = 10:90:0.1 MeCN:H20:TFA, B =90:10:0.1 MeCN:H20:TFA) to yield Example 37B (O.224g, 64%) which was usedimmediately after purification.

The synthetic route of 151583-29-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; RICHTER, Jeremy; BATES, J. Alex; CHENEY, Daniel L.; WO2014/201073; (2014); A1;,
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