Esters-buliding-blocks

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35613-44-6, name is Methyl 2-(2-aminophenyl)acetate, A new synthetic method of this compound is introduced below., COA of Formula: C9H11NO2

Methyl 2- (2-aminophenyl) acetate (0.71 g, 4.3 mmol) andSodium carbonate (0.16g, 1.6mmol)Dissolved in tetrahydrofuran (10mL),Reduce the temperature to -78 and stir for 1h.2-bromopropionyl chloride (0.77g, 4.5mmol) andTetrahydrofuran (5mL) was mixed slowly and completely within 0.5 hours.After the addition is complete, move to room temperature and stir for 5h.Methyl 2- (2- (2-bromopropionamide) phenyl) acetate (white solid, 1.16 g) was obtained in a yield of 90%.

The synthetic route of 35613-44-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhangzhou Sanitation Profession College; Zheng Lulu; Luo Jinhong; Yang Lina; Chen Tongjun; (7 pag.)CN110272351; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 653-92-9, name is Methyl 2-bromo-4-fluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 653-92-9, Product Details of 653-92-9

a) 2-Bromo-4-dimethylamino-benzoic acid methyl ester (7a) To a stirred solution of 5,24 g (22.5 mmol) 2-Bromo-4-fluoro-benzoic acid methyl ester (Rarechemicals) and 60.0 ml dimethylsulphoxid are added 2.23 g (27.0 mmol) dimethylamine hydrochloride and 6.54 g (47.3 mmol) potassium carbonate. The reaction mixture is stirred for 11h at 70C in an autoclave and is concentrated with high vacuum rotation evaporator at 65C. The residue is diluted with dichloromethane, washed twice with water. The combined water phases are extracted with dichloromethane. The combined dichloromethane phases are washed with diluted sodium hydrogen carbonate solution, dried with sodium sulphate and concentrated. The oily crude is purified by column chromatography and the desired product 7a is obtained in 70 % yield (4,08 g, 15.8 mmol). MS-ESI: 258/560 (M+ +1, 88/83).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Bayer Schering Pharma Aktiengesellschaft; EP1897885; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99548-54-6, name is Methyl 3-bromo-2-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 99548-54-6

A mixture of 3-Bromo-2-methyl benzoic acid methyl ester (2.4 g, 10.29 mmol), NBS (1.83 g, 10.29 [MMOL)] and AIBN (4 mg) in [CHLOROBENZENE] (40 mi) was heated to [80C] under nitrogen for 18 hours. The mixture was cooled in an ice-bath, filtered and the solvent removed by evaporation under reduced pressure. The orange residue was purified by flash chromatography on silica gel eluting with a solvent gradient of heptane: ethyl acetate (40: 1) to give the title compound (2.74 g, 86 %) as a colourless oil. [1H-NMR] (400 MHz, [CDCI3)] : [ES] = 3.88 (s, 3H), 5.06 (s, 2H), 7.22 (dd, 1H), 7.68 (d, [1H),] 7. 89 (d, [1 H).] Microanalysis : Found: C, 35.21 ; H, 2.67 ; N, 0.00. [C9H8BR202] requires C, 35.10 ; H, 2.62 ; N, 0.00%.

The synthetic route of 99548-54-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/14357; (2004); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 35065-86-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35065-86-2, name is 3-Bromophenyl acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A stirred solution of the appropriate bromophenyl alkanoic acid(1 eq) in MeOH (25 mL)was treated with H2SO4 (0.1 eq of a conc. aq.solution) and heated at reflux for 18 h. The resultant solution wascooled to room temperature and concentrated under reducedpressure. The resultant oil was diluted with NaHCO3 (50 mL of a sat.aq. solution) and subsequently extracted with diethyl ether(3 25 mL). The combined organics were washed with brine(1 100 mL), dried (MgSO4), filtered and concentrated underreduced pressure to give the desired methyl ester:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromophenyl acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jorgensen, William T.; Gulliver, Damien W.; Katte, Timothy A.; Werry, Eryn L.; Reekie, Tristan A.; Connor, Mark; Kassiou, Michael; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 1644 – 1656;,
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Reference of 927-68-4, These common heterocyclic compound, 927-68-4, name is 2-Bromoethyl acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Dissolve ethyl imidazole-2-carboxylate (200 mg, 1.43 mmol) in 5 ml of N,N-dimethylformamide, add cesium carbonate (931 mg, 2.85 mmol) and activate for 0.5 h, then add2-bromoethyl acetate(385mg, 2.14mmol), warmed to 80C for 2h, complete reaction by TLC, stop reaction, cooled to room temperature, diluted with water, extracted with ethyl acetate (3¡Á20ml), combined organic layers, washed with saturated brine, anhydrous Dry over sodium sulfate, filter, and concentrate to obtain crude product. Purified by column chromatography (PE:EA=3:1) to give a pale yellow liquid, namely compound 1-(2-acetoxyethyl)-1H-imidazole-2-carboxylic acid ethyl ester 26b (300mg, yield 92.8 %).

The synthetic route of 927-68-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sichuan University; Li Guobo; Wang Zhenling; (40 pag.)CN111187218; (2020); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50413-30-4, name is Methyl 2-amino-4-methoxylbenzoate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Methyl 2-amino-4-methoxylbenzoate

Example 1 : methyl 4-methoxy-2-[(3-UQ-methgammal-lH-imidazol-4-yl)sulfonyllamino} quinoxalin-2-yl)aminolbenzoate; N-(3-chloroquinoxalin-2-yl)-l -methyl- lH-imidazole-4-sulfonamide (2 g; 6.2 mmol; 1 eq) and methyl 2-amino-4-methoxybenzoate (1.2 g; 6.8 mmol; 1.1 eq) are taken up in water (60 mL) and acetic acid (160 muL; 3.65 mmol; 0.6 eq) is added. The suspension is heated up to 1700C in the microwave under normal absorption for 20 min. The reaction is stopped by filtration of the solid and washing with water until neutral. The orange powder obtained is dried under vaccum at 400C overnight then taken up in DCM. Triethylamine (1.72 mL) is added. After sonication, the solvents are removed under reduced pressure and the residue obtained is washed with water then dried under vacuum at 400C overnight. The powder is taken up in MeOH and refluxed then the suspension is left at 4C for Ih. The precipitate is filtered and washed with MeOH then dried under vacuum at 4O0C for 2 days, to afford 1.68 g (58%) of the title compound as a yellow powder. 1H NMR (DMSO-Ci6) O 11.77 (s, IH), 9.05 (d, J= 2.3 Hz, IH), 8.10-7.95 (m, 2H), 7.90 (s, IH), 7.85-7.76 (m, IH), 7.73-7.60 (m, IH), 7.55-7.35 (m, 2H), 6.73 (dd, J= 8.6, 2.2 Hz, IH), 3.91 (s, 6H), 3.72 (s, 3H). HPLC (max plot) 100%; Rt 4.12 min. LC/MS: (ES+): 469.0, (ES-): 467.1 .

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 50413-30-4.

Reference:
Patent; LABORATOIRES SERONO SA; WO2008/101979; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 428-97-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 428-97-7 name is Diethyl 2,2-difluoropentanedioate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 126 Ethyl 4,4-Difluoro-5-hydroxypentanoate (c) Diethyl 2,2-difluoroglutarate (2.50 g, 11.1 mmol) was dissolved in 400 ml of absolute ethanol. Sodium borohydride (0.53 g, 13.73 mmol) was added and the resulting solution was stirred vigorously under N2 at room temperature for 7 hrs as the solution turned yellow. The ethanol was evaporated in vacuo, and the residue taken up in water EtOAc and acidified with 5% HCl. The ethyl acetate extract yielded after workup 1.50 g of the hydroxy-ester. It was filtered through a short column (50 g) of silica gel (eluted with ether) to give 1.30 g (64% yield) of the title compound as a colorless oil. Tlc on silica gel: Rf 0.44 in EtOAc:hexane 1:3

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diethyl 2,2-difluoropentanedioate, and friends who are interested can also refer to it.

Reference:
Patent; The University of Chicago; US4324730; (1982); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 25597-16-4, A common heterocyclic compound, 25597-16-4, name is Ethyl 4,4,4-trifluorocrotonate, molecular formula is C6H7F3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0832] A mixture of 10 g (72.5 mmol) of 2, 4-dihydroxybenzaldehyde, 15.3 mL (101. 4 mmol) of ethyl 4-triflouromethylcrotonate, and 20 g (145 mmol) of potassium carbonate in 25 ML of anhydrous DIMETHYLFORMMAMIDE was heated to 90C for three h. After cooling to room temperature, the reaction was added to 500 mL of ethyl acetate. The organic phase was washed with brine three times, dried over anhydrous magnesium sulfate and CONCD in vacuo. Silica chromatography with EtOAc/hexane (3: 7) gave 19.0 g (98%) of a yellow solid: 1H NMR (CDC13/400 MHz) 7.63 (s, 1H), 6.85 (d, J=8. 8 Hz, 1H), 6.79 (dd, J=8.8Hz, 2.8Hz, 1H), 6.70 (d, J=2. 8 Hz, 1H), 5.63 (q, J=6. 8 Hz, 1H), 4. 31 (m, 2H), 1.34 (t, J=7. 2 Hz, 3H). MS (ESI+) 289. 1 (M+1, 100).

The synthetic route of 25597-16-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACIA CORPORATION; WO2004/87686; (2004); A2;; ; Patent; PHARMACIA CORPORATION; WO2004/87687; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6933-47-7, name is Methyl 4-amino-2-methylbenzoate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks

General procedure: To a stirred solution of tert-butyl 2-formyl-6-azaspiro[3.4]octane-6-carboxylate (CAS: 203662-55-9) (225 mg, 1.0 mmol) and 2-(3-aminopheny])acetonitrile (CAS: 4623-249) (136 mg, 1.03 mmol) in MeOH (10 mL) at room temperature was added decaborane (43 mg, 0.35 mmol). The reaction mixture was stirred at room temperature overnight. The reaction mixture was concentrated. The residue was purified bysilica gel chromatography eluted with PE/EtOAc(3/1,v/v) to afford intermediate 119 (340 mg, 99% yield) as a yellow solid. Intermediate 178 was prepared via an analogous reaction protocol as described forthe preparation of intermediate 119, starting from the respective starting materials.

The synthetic route of 6933-47-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; JOHNSON & JOHNSON (CHINA) INVESTMENT LTD.; DAI, Xuedong; QUEROLLE, Olivier Alexis Georges; KROSKY, Daniel Jason; CAI, Wei; FU, Liqiang; KONG, Linglong; LIU, Yingtao; WAN, Zhao-Kui; HERKERT, Barbara; PANDE, Vineet; EDWARDS, James Patrick; PATRICK, Aaron Nathaniel; ANGIBAUD, Patrick Rene; PONCELET, Virginie Sophie; (488 pag.)WO2019/120209; (2019); A1;,
Ester – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24812-90-6, name is Methyl 3-amino-4-methoxybenzoate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 24812-90-6

Anhydrous p-toluene sulfonic acid (41.99 g, 220.8 mmol) was melted at 120 C and 3-amino-4-methoxy benzoic acid methyl ester (20 g, 110.38 mmol) obtained in step 1 and benzonitrile (22.77 g, 220.8 mmol) were added thereto and stirred at 180 C for 5 hours. The resulting solution was cooled to room temperature and the reaction was stopped by adding NaHCO3 thereto. The resulting mixture was extracted with ethyl acetate, the extract was dried over MgS04 and concentrated under a reduced pressure. The concentrate was dissolved in 50 % methanol and 5 % NaOCl (56 ml, 37.65 mmol) was added dropwise thereto. After 5 min, the resulting mixture was extracted with ethyl acetate, the extract was dried over MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by silica gel column chlomatography (eluent-MeOH/CDCl3=5:95, Merck, Silicagel 60) to obtain the title compound (31 g, 25.10 mmol) in a yield of 88 %. 1H NMR (CDCl3): delta 7.78 (1H, d), 7.48 (1H, s), 7.37-7.24 (5H, m), 6.95 (1H, d), 3.78 (6H, s) MW: 318

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 24812-90-6.

Reference:
Patent; CRYSTALGENOMICS, INC.; YUYU INC.; WO2004/65370; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics