Esters-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 126430-46-4, name is Benzyl 4-bromobutanoate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Benzyl 4-bromobutanoate

Compound 11 was synthesized in accordance with the following scheme. Synthesis of compound 10 is disclosed in J. Le Notre et al.. Adv. Synth. Catal. 349, 432 (2007), and synthesis was carried out on the basis thereof. Compound 9 (102.8 mg, 0.347 mmol, 1 eq.) and compound 10 (756.9 mg, 2.94 mmol, 8.5 eq.) were dissolved in acetonitrile (4 mE), N,N-diisopropylethylamine (512 pL, 2.94 mmol, 8.5 eq.) and a small amount of potassium iodide were added, and the mixture was heated and refluxed for 5.5 hours at 80 C. Water was added and then extracted using dichloromethane, the organic phase was washed using water and a saturated sodium chloride solution and dried using anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The resulting residue was purified by medium-pressure silica gel chromatography (eluent:n-hexane/ethyl acetate=86/14 to 65/35) to obtain the objective compound 11(91.7 mg, 56%). 1H NMR (400 MHz, CDCl3): delta 0.45 (s, 6H), 1.93(quin, 2H, J=7.2 Hz), 2.41 (t, 2H, J=7.2 Hz), 2.90 (s, 3H),2.94 (s, 6H), 3.34 (t, 2H, J=7.2 Hz), 3.95 (s, 2H), 5.10 (s,2H), 6.68 (dd, 1H, J=8.4, 2.8 Hz), 6.74 (dd, 1H, J=8.4, 2.8Hz), 6.95 (d, 1H, J=2.8 Hz), 6.99 (d, 1H, J=2.8 Hz), 7.15 (d,1H, J=8.4 Hz), 7.18 (d, 1H, J=8.4 Hz), 7.31-7.36 (m, 5H); 13C NMR (100 MHz, CDCl3): delta-2.7, 22.4, 31.8, 38.6, 39.2,41.2, 52.4, 66.4, 113.8, 114.2, 117.2, 117.3, 117.7, 128.3,128.4, 128.5, 128.65, 128.67, 134.8, 136.0, 136.1, 136.2,147.3, 148.8, 173.2; HRMS (ESI+): Calcd for [M+H]+,473.26188, Found, 473.26185 (-0.0 mmu).

According to the analysis of related databases, 126430-46-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; The University of Tokyo; URANO, Yasuteru; KAMIYA, Mako; MOROZUMI, Akihiko; UNO, Shinnosuke; UMEZAWA, Keitaro; (37 pag.)US2018/52109; (2018); A1;,
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Reference of 1245643-11-1, A common heterocyclic compound, 1245643-11-1, name is Methyl 3,4-diamino-5-bromobenzoate, molecular formula is C8H9BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

TsOH?H20 (0.388 g, 2.04 mmol) was added to a mixture of triethylorthoformate (6.8 mL, 40.8 mmol) and methyl 3,4-diamino-5-bromobenzoate (5.0 g, 20.4 mmol) in THF (150 mL). The mixture was stirred at 20C for 5 hours. After cooling to room temperature, the mixturewas concentrated under reduced pressure. EtOAc (20 mL) was added to the crude residue and the mixture was filtered. The filter cake was collected to give methyl 7-bromo- 1H- benzo[d]imidazole-5-carboxylate (4.0 g, 77% Yield) as a pink solid. ?H NMR (400 MHz, DMSO) (5 13.10 (br s, 1H), 8.51 (s, 1H), 8.17 (s, 1H), 7.96 (s, 1H), 3.87 (s, 2H).

The synthetic route of 1245643-11-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; STIVALA, Craig; HEFFRON, Timothy; (243 pag.)WO2019/57946; (2019); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 126541-82-0, name is Methyl 3-amino-4-(trifluoromethyl)benzoate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 3-amino-4-(trifluoromethyl)benzoate

Step C: Methyl 3-cyano-4-(trifluoromethyl)benzoateTo a mixture of methyl 3-amino-4-(trifluoromethyl)benzoate (3.2 g, 15 mmol) and aqueous HC1 solution (12 M, 3.5 mL) in water (20 mL) was added dropwise a solution of NaN02 (1.2 g, 17 mmol) in water (7.0 mL) at 5 C. The resulting mixture was stirred for 30 min at 5 C and then added dropwise to a slurry of CuCN (1.3 g, 15 mmol) and KCN (1.6 g, 25 mmol) in water (4 mL), while maintaining the internal temperature between 5-10 C. The mixture was stirred at 10 C for 30 min and then heated at 80 C for 1 h. After cooling, the mixture was extracted with DCM (30 mL x 3). The combined organic layers were washed with brine, dried over Na2S04 and concentrated to afford the title compound. MS: m/z = 230 (M +1). 1H MR (400 MHz, CDC13) delta 8.45-8.53 (m, 1H), 8.33-8.40 (m, 1H), 7.91 (d, 1H, = 8.5 Hz), 4.01 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MITCHELL, Helen; FRALEY, Mark E.; COOKE, Andrew J.; STUMP, Craig A.; BESHORE, Douglas C.; MCCOMAS, Casey C.; SCHIRRIPA, Kathy; ZHANG, Xu-Fang; MCWHERTER, Melody; MERCER, Swati P.; MOORE, Keith; LIU, Chungsing; MAO, Qinghau; (79 pag.)WO2015/143652; (2015); A1;,
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Reference of 54535-22-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54535-22-7, name is Diethyl 2-((phenylamino)methylene)malonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Compound 23 (4.77 g, 47.7 mmol) was added dropwise to Compound 22 (10 g, 46.3 mmol) with subsurface N2 flow to drive out ethanol below 30 C for 0.5 hours. The solution was then heated to 100-110 C and stirred for 2.5 hours. After cooling the mixture to below 60 C, diphenyl ether was added. The resulting solution was added dropwise to diphenyl ether that had been heated to 228-232 C for 1.5 hours with subsurface N2 flow to drive out ethanol. The mixture was stirred at 228-232 C for another 2 hours, cooled to below 100 C and then heptane was added to precipitate the product. The resulting slurry was stirred at 30 C for 0.5 hours. The solids were then filtered, and the cake was washed with heptane and dried in vacuo to give Compound 25 as a brown solid. 1H NMR (DMSO-d6; 400 MHz) delta 12.25 (s), delta 8.49 (d), delta 8.10 (m), delta 7.64 (m), delta 7.55 (m), delta 7.34 (m), delta 4.16 (q), delta 1.23 (t).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diethyl 2-((phenylamino)methylene)malonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; VAN GOOR, Fredrick, F.; WO2013/67410; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 85953-29-3, name is Methyl 2-chloro-4-fluorobenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2-chloro-4-fluorobenzoate

A mixture of tert-butyl 4,4′-bipiperidine-l -carboxylate (1-2) (268 mg, 1 mmol, 1.0 eq), methyl 2- chloro-4-fluorobenzoate (5-1) (226 mg, 1.2 mmol, 1.2 eq) and K2CO3 (414 mg, 3 mmol, 3 eq) in NMP (5 ml) was stirred at 120 C for 3 h. After cooling to room temperature, the mixture was diluted with EtOAc (80 niL), washed with water (20 mL x3), brine (10 mL), dried over sodium sulfate and purified by column chromatography (PE:EA =5: 1-3: 1 ) to give tert-butyl l’-(3- chloro-4-(methoxycarbonyl)phenyl)-4,4′-bipiperidine-l-carboxylate (5-2). LRMS m/z (M+Na) 459.2 found, 459.2 required

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK SHARP & DOHME CORP.; STACHEL, Shawn, J.; BENNETT, David Jonathan; BRNARDIC, Edward, J.; LIVERTON, Nigel, J.; MANLEY, Peter, J.; MENG, Zhaoyang; NANDA, Kausik, K.; RUDD, Michael, T.; WAI, Jenny; (137 pag.)WO2017/83219; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2051-59-4, name is 6-Chloro-2H-chromen-2-one belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 6-Chloro-2H-chromen-2-one

General procedure: To a tube were added 1a (1.0 equiv), CF 3 SO 2 Na(4.0 equiv),K 2 HPO 4 , Acetone (2 mL). Then the tube was evacuated and backlledwith argon for three times. The tube around condensate water wasstirred at room temperature in argon with the irradiation of Xenon lampfor 12 h. After the reaction was nished, the mixture was washed withsaturated sodium chloride solution and then extracted with ethylacetate for three times. The combined organic layers were dried overNa 2 SO 4 and concentrated under reduced pressure, then puried bychromatography on silica gel.

The synthetic route of 2051-59-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lin, Na; Li, Yaming; Hao, Xinyu; Jin, Kun; Zhang, Rong; Duan, Chunying; Journal of Fluorine Chemistry; vol. 214; (2018); p. 42 – 47;,
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Electric Literature of 106614-28-2, The chemical industry reduces the impact on the environment during synthesis 106614-28-2, name is Methyl 2,4-difluorobenzoate, I believe this compound will play a more active role in future production and life.

To a mixture of methyl 2,4-difluoro benzoate (1.0 g) in 1,4-dioxane (20 mL), 5-hydroxypyrrolo[2,3-b]pyridine (779 mg) and K3P04 (1.47 g) were added at 34C and heated to90C. The reaction mixture is stirred at the same temperature for 23 hours. K3P04 (396mg) was added at 90C to the reaction mixture and stirred for another 24 hours at thesame temperature. Cooled the reaction mixture to 32C and filtered on a celite bed.Washed the celite bed with ethyl acetate (20 mL) and evaporated the solvent in the filtrateto obtain crude product. The crude product was purified by column chromatography using60-120 silica gel mesh and 10-50% ethyl acetate- hexane as eluent to obtain the titlecompound as white solid. Yield: 588 mg; Purity by HPLC: 98.73%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,4-difluorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DR. REDDY?S LABORATORIES LIMITED; PEDDIREDDY, Subba Reddy; KOTTUR, Mohan Kumar; JURUPULA, Ramprasad; BAIG, Mohammed Azeezulla; CHAKKA, Ramesh; THIPPARABOINA, Rajesh; PEDDY, Vishweshwar; RAO, Pallavi; ORUGANTI, Srinivas; DAHANUKAR, Vilas Hareshwar; (88 pag.)WO2017/212431; (2017); A1;,
Ester – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 1678-68-8, name is trans-Ethyl 4-aminocyclohexanecarboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1678-68-8, name: trans-Ethyl 4-aminocyclohexanecarboxylate

Preparation 62 Ethyl trans-4-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}cyclohexanecarboxylate Ethyl trans-4-aminocyclohexanecarboxylate has been prepared previously, see: Skaric, V.; Kovacevic, M.; Skaric, D. J. Chem. Soc., Perkin Trans.1 1976, 1199-1201. A mixture of ethyl trans-4-aminocyclohexanecarboxylate (168 mg, 0.81 mmol), NEt3 (0.22 mL, 1.6 mmol) and 1,4-dichloro-7-isoquinolinesulphonyl chloride (200 mg, 0.67 mmol) in CH2Cl2 (8 mL) was stirred at 0 C for 1 h. The mixture was diluted with CH2Cl2 (100 mL), was washed with dilute HCl (50 mL, I M), water, dried (MgSO4) and evaporated in vacuo to give ethyl trans-4-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}cyclohexanecarboxylate (232 mg, 0.54 mmol) as a white solid. 1H (CDCl3, 400 MHz) delta 1.15-1.3 (5H, m), 1.4-1.55 (2H, m), 1.9-2.0 (4H, m), 2.1-2.2 (1H, m), 3.2-3.3 (1H, m), 4.1 (2H, t), 4.55 (1H, d), 8.25 (1H, d), 8.35 (1H, d), 8.5 (1H, s), 8.9 (1H, s) LRMS 431 (MH+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, trans-Ethyl 4-aminocyclohexanecarboxylate, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; Pfizer Limited; EP1077945; (2003); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 454-31-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 454-31-9, name is Ethyl 2,2-difluoroacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of intermediate 2 (20 g, 0.088 mol) in benzene (200 mL) was stirred at 0 C under nitrogen atmosphere. Potassium tert-butoxide (12 g) followed by ethyl difluoroacetate (13.14 g, 0.106 mol) were added at 0-5 C. The reaction mixture was stirred at rt for 5 h. Then 10% H2SO4 (10 mL) was added dropwise until pH = 7 keeping the temperature at 15-20 C by cooling. The mixture was extracted with EtOAc (2 x 50 mL). The organic layer was separated and washed with brine (2 x 20 mL), dried (MgS04), filtered and evaporated in vacuo yielding intermediate 13 (26 g, 97%).

The synthetic route of Ethyl 2,2-difluoroacetate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres Avelino; ALCAZAR-VACA, Manuel Jesus; (192 pag.)WO2018/154133; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 15448-76-7, name is Dimethyl bicyclo[2.2.1]heptane-1,4-dicarboxylate, A new synthetic method of this compound is introduced below., SDS of cas: 15448-76-7

A mixture of dimethyl bicyclo[2.2.1]heptane-l ,4-dicarboxylate (1.0 g, 4.71 mmol) and lithium hydroxide monohydrate (0.593 g, 14.13 mmol) in methanol (20 mL) and water (40 mL) was stirred at ambient temperature for 3 days. Volatiles were removed under vacuum, and the residue was acidified with 1 N HC1 solution. The white suspension was then extracted with ethyl acetate (100 mL). The organic layer was dried over magnesium sulfate, filtered and concentrated to give 0.85 g of the title compound as a white solid that was used without further purification.JH NMR (400 MHz, DMSO-

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; PLIUSHCHEV, Marina, A.; FROST, Jennifer, M.; TONG, Yunsong; BLACK, Lawrence, A.; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; CHUNG, Seungwon; XIONG, Zhaoming; SWEIS, Ramzi, Farah; DART, Michael, J.; BROWN, Brian, S.; MURAUSKI, Kathleen; (673 pag.)WO2019/90069; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics