Esters-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 106614-28-2, name is Methyl 2,4-difluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106614-28-2, SDS of cas: 106614-28-2

Intermediate 28: Methyl 2-fluoro-4-(piperazin-1-yl)-benzoate Dimethyl sulfoxide (1.0 ml) was added to 544 mg of piperazine to prepare a suspension, and 368 mg of methyl 2,4-difluorobenzoate was added to the suspension. The mixture was stirred at 80 C. for 1 hr and was then cooled to room temperature. The reaction solution was concentrated under the reduced pressure. The residue was purified by column chromatography on silica gel (development system: methylene chloride-methanol-concentrated aqueous ammonia=900:100:1) to prepare 274 mg of the title compound. Physicochemical Properties of Intermediate 28

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Meiji Seika Kaisha, Ltd.; US6451800; (2002); B1;,
Ester – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 369-25-5, name is Methyl 3,4-difluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Methyl 3,4-difluorobenzoate

General procedure: 1,2-Dihydro-indazol-3-one (500 mg; 3.73 mmol; 1.00 eq.), cesium carbonate (3.64 g; 11.2 mmol; 3.00 eq.) and methyl 3,4-difluorobenzoate (1.28 g; 7.46 mmol; 2.00 eq.) were stirred at 120 C in a round bottom flask for 3 hours. 1,2-Dichloro-3-nitrobenzene (1.43 g; 7.46 mmol; 2.00 eq.) was added and the reaction mixture was heated at 120 C for an additional 2 hours. The reaction mixture was cooled and diluted in ethyl acetate (50 mL). The organic layer was washed with a saturated solution of NH4Cl (20 mL), a saturated solution of Na2CO3(20 mL) and brine (20 mL). The organic layer was dried over MgSO4, filtered and concentrated. The residue was purified using silica gel chromatography using heptane/ethyl acetate (5/5) as eluent. Methyl 4-(3-(2-chloro-6-nitrophenoxy)-1H-indazol-1-yl)-3-fluorobenzoate was isolated as a pale orange solid (1.00 g; 60.7%).1H NMR (DMSO-d6) delta: 3.90 (s, 3H), 7.43 – 7.36 (m, 1H), 7.50 (dd,J =8.7, 3.9 Hz, 1H), 7.68 – 7.57 (m, 3H), 7.99 – 7.90 (m, 3H), 8.11 (dd,J =8.2, 1.5 Hz, 1H), 8.20 (dd,J =8.3, 1.6 Hz, 1H)MS-ESIm/z442 [MH+].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 369-25-5.

Reference:
Article; Ouvry, Gilles; Bouix-Peter, Claire; Ciesielski, Fabrice; Chantalat, Laurent; Christin, Olivier; Comino, Catherine; Duvert, Denis; Feret, Christophe; Harris, Craig S.; Lamy, Laurent; Luzy, Anne-Pascale; Musicki, Branislav; Orfila, Danielle; Pascau, Jonathan; Parnet, Veronique; Perrin, Agnes; Pierre, Romain; Polge, Gaelle; Raffin, Catherine; Rival, Yves; Taquet, Nathalie; Thoreau, Etienne; Hennequin, Laurent F.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 23; (2016); p. 5802 – 5808;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 19063-55-9, These common heterocyclic compound, 19063-55-9, name is 6-Bromochromen-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

It mainly includes the following steps: taking the coumarin derivative (500 mg, 2.2 mmol) after bromination at the 6 position,N,N-dimethylbenzene derivative (618 mg, 2.5 mmol) and K2CO3 (133 mg), which are introduced para-borate borate.The solution was dissolved in a toluene-ethanol mixed solution (3:1, 80 ml).After passing nitrogen gas for 30 min, 15 mg of tetrakistriphenylphosphine palladium catalyst was added to the solvent, and the mixture was heated to 80 C, 1000 r / min, and reacted for 8 hours.After the reaction, it was cooled to room temperature, washed with a large amount of water and extracted with dichloromethane.After removing excess solvent by a rotary evaporator, 100 mL of a dichloromethane solution was added to dissolve the solid, washed with 40 mL of distilled water, and separated.The remaining water was removed with anhydrous sodium sulfate, separated, and dried.The crude product was separated and purified on a 200-300 mesh silica gel column using dichloromethane-n-hexane (volume ratio 2:5) as eluent to afford yellow compound A as shown in Fig. 2.The coumarin-type organic nonlinear optical material compound A obtained by the above production method had a yield of 60%.

Statistics shows that 6-Bromochromen-2-one is playing an increasingly important role. we look forward to future research findings about 19063-55-9.

Reference:
Patent; Shantou University; Xu Liang; Zheng Yusen; Long Xueting; Zhang Wenying; Lu Fushen; (10 pag.)CN109776471; (2019); A;,
Ester – Wikipedia,
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Application of 773873-95-3,Some common heterocyclic compound, 773873-95-3, name is Methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate, molecular formula is C9H6F2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[00193] (2,2-Difluorobenzo[d] [l,3]dioxol-5-yl)methanolMethod A: Methyl 2,2-difluorobenzo[Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2007/21982; (2007); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26218-04-2, Product Details of 26218-04-2

77.5 g of a 20 wt % aqueous solution of Na2CO3, 190.0 g of xylene and 68.5 g of 2-ethylhexyl 4-aminobenzoate are loaded into a 1 litre flask equipped with mechanical stirrer, thermometer, reflux condenser and dropping funnel. Keeping the mixture stirred at 65 C., a solution of 47.1 g of 4-nitrobenzoyl chloride is added to 47.0 g of xylene. The resulting mixture is then heated to reflux for 1 h. The organic phase is cooled, and the reaction product precipitates. The product is recovered by filtration, washing with xylene and drying at 110 C. under vacuum, to obtain 83 g of yellow powder corresponding to 2-ethylhexyl 4-(4-nitrobenzamido) benzoate.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Ethylhexyl 4-aminobenzoate, and friends who are interested can also refer to it.

Reference:
Patent; 3V Sigma S.P.A.; Maestri, Francesco; Berte’, Ferruccio; (8 pag.)US2018/30001; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some common heterocyclic compound, 15568-85-1, name is 5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione, molecular formula is C8H10O5, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-(Methoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

4-Chloro-l,7-naphthyridine was prepared as follows (the compound may also be prepared according to the procedure on page 962 in Science of Synthesis, 2005, ,15., 947-985):; – Diisopropylethylamine (58.2 ml) was added to a stirred suspension of 3-aminopyridine- iV-oxide hydrochloride salt (49 g) and 5-(methoxymethylidene)-2,2-dimethyl-l,3-dioxane- 4,6-dione (62.2 g) in isopropanol (150 ml) and the resultant mixture was heated to 9O0C for 20 minutes. The mixture was cooled in an ice bath and the precipitate was isolated and washed in turn with cool isopropanol and diethyl ether and dried under vacuum at 50C. There was thus obtained 2,2-dimethyl-5-[(l -oxidopyridin-3-ylamino)methylidene]-l ,3-dioxane-4,6-dione (81.9 g; 1H NMR Spectrum: (DMSOd6) 1.68 (s, 6H)5 7.44 (m, IH), 7.61 (d, IH), 8.1 (d, IH), 8.52 (2s, IH), 8.66 (s, IH), 11.15 (br s, IH); Mass Spectrum: M-H” 263.; The 4-chloro-l,5-naphthyridine was prepared as follows :; -Diisopropylethylamine (58.2 ml) was added to a stirred suspension of 3-aminopyridine- iV-oxide hydrochloride salt (49 g) and 5-(methoxymethylidene)-2,2-dimethyl-l,3-dioxane- 4,6-dione (62.2 g) in isopropanol (150 ml) and the resultant mixture was heated to 9O0C for 20 minutes. The mixture was cooled in an ice bath and the precipitate was isolated and washed in turn with cool isopropanol and diethyl ether and dried under vacuum at 500C. There was thus obtained 2,2-dimethyl-5-[(l-oxidopyridin-3-ylamino)methylidene]-l,3-dioxane-4,6-dione (81.9 g; 1H NMR SPeCtTUm: (DMSOd6) 1.68 (s, 6H), 7.44 (m, IH), 7.61 (d, IH), 8.1 (d, IH), 8.52 (2s, IH), 8.66 (s, IH), 11.15 (br s, IH); Mass Spectrum: M-H” 263.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 15568-85-1, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/113548; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 193290-19-6, name is Methyl 2-(4-bromo-2-fluorophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Methyl 2-(4-bromo-2-fluorophenyl)acetate

A suspension of methyl (4-bromo-2-fluorophenyl)acetate (5.5 g, 0.0223 mol; see step (v) above), Zn(CN)2 (1.79 g, 0.0156 mol) in dry DMF (30 mL) was purged with argon for 15 minutes before Pd(PPh3)4 (1.27 g, 0.0011 mol) was added. The resulting suspension was stirred at 800C overnight under a nitrogen atmosphere before the reaction was quenched with water and extracted with ethyl acetate. The organic layer was washed with water and brine and dried over sodium sulfate. Solvent evaporation under reduced pressure, followed by purification over silica gel (using 18% ethyl acetate in petroleum ether as eluent) gave the sub-title compound (3.6 g) as a pale yellow solid.

According to the analysis of related databases, 193290-19-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; WO2007/69986; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1678-68-8, name is trans-Ethyl 4-aminocyclohexanecarboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of trans-Ethyl 4-aminocyclohexanecarboxylate

Ethyl trans-4-aminocyclohexanecarboxylate (J. Med. Chem., 1971, 14, 600-614) (29.5 g, 143 mmol) was dissolved in 1,4-dioxane (290 ml) and water (290 ml), triethylamine (30.0 ml, 215 mmol) and 1-[2-(trimethylsilyl)ethoxycarbonyloxy]pyrrolidine-2,5-dione (40.8 g, 157 mmol) were added under ice cooling and the resulting mixture was stirred at room temperature for 2 days. The reaction mixture was concentrated and then the residue was diluted with ethyl acetate and washed with 10% aqueous citric acid solution, saturated sodium bicarbonate solution, and brine in that order. The organic layer was dried over anhydrous sodium sulfate and the solvent was concentrated under reduced pressure to give 44.3 g (98%) of the title compound as colorless needle-like crystals.1H-NMR (500 MHz, CDCl3) delta: 0.03 (9H, s), 0.92-1.01 (2H, m), 1.08-1.18 (2H, m), 1.25 (3H, t, J=7.2 Hz), 1.48-1.59 (2H, m), 1.97-2.11 (4H, m), 2.21 (1H, tt, J=12.3, 3.7 Hz), 3.38-3.54 (1H, m), 4.07-4.19 (4H, m), 4.38-4.49 (1H, m).

The synthetic route of 1678-68-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sugimoto, Yuuichi; Uoto, Kouichi; Wakabayashi, Takanori; Miyazaki, Masaki; Setoguchi, Masaki; Taniguchi, Toru; Yoshida, Keisuke; Yamaguchi, Akitake; Yoshida, Shoko; US2012/264738; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 756525-95-8, name is tert-Butyl 9-Amino-4,7-dioxanonanoate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: tert-Butyl 9-Amino-4,7-dioxanonanoate

To a solution of Z-Glu-OBz (0.5 g, 1.356 mmol) in CH2CI2 (3 mL) was added amino-DPEG2 t-buty ester (3 14 mg, 1.35 mmol), HATU (614 mg, 1.62 mmol), HO At (220 mg, 1 62 mmol) and TEA (0.563 ml, 4.04 mmol). The reaction mixture was stirred overnight at room temperature, diluted with EtOAc, and washed with brine (3x). The organic phase s dried over Na2S04, and concentrated. The crude product was purified on silica gel (ISCO, 40 g, 0-10 % MeOH / DCM eluent) to afford compound 74 (390 mg, 49.4 % yield). ESI MS: C31H42N2O9 (M+H) 587.3; found 587 3

According to the analysis of related databases, 756525-95-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERSANA THERAPEUTICS, INC.; THOMAS, Joshua D.; JONES, Brian D.; KELLEHER, Eugene W.; LOWINGER, Timothy B.; YANG, Liping; YIN, Mao; YURKOVETSKIY, Aleksandr V.; (397 pag.)WO2019/126691; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 18595-12-5, A common heterocyclic compound, 18595-12-5, name is Methyl 5-amino-2-methylbenzoate, molecular formula is C9H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

REFERENTIAL EXAMPLE 43 Production of 6-methyl-3-(1-pyrrolyl)benzyl alcohol 158 mg of methyl 3-amino-6-methylbenzoate was dissolved in 3 ml of acetic acid, and 139 mg of 2,5-dimethoxytetrahydrofuran was added. The mixture was heated under reflux for 1 hour. The reaction mixture was evaporated to dryness under reduced pressure. The residue was purified by silica gel column chromatography Wakogel C-200, 10 g; eluding solvent: hexane/ethyl acetate=10/1) to give 185 mg (yield 87%) of methyl 3-(1-pyrrolyl)-6-methylbenzoate, m.p. 56-57 C.

The synthetic route of 18595-12-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Banyu Pharmaceutical Co., Ltd.; US5234946; (1993); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics