Esters-buliding-blocks

Application of 6627-89-0, A common heterocyclic compound, 6627-89-0, name is tert-Butyl phenyl carbonate, molecular formula is C11H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 2 7-t-Butyloxycarbonylaminoheptanoic Acid 7-Aminoheptanoic acid (20 g., 1.38 * 10-1 moles) was converted to the title compound using the method of Ulf Ragnarrson et al., Org. Syn., 53, 25 (1973), using tetramethylguanidine (17.3 g., 1.49 * 10-1 moles) and t-butylphenylcarbonate (30 g., 1.54 * 10-1 moles) in dimethylsulfoxide (100 ml.) for three days. The product (24 g.) had m.p. 56-58 after recrystallization from ethyl acetate-hexane-ether. Analysis for: C12 H23 NO4. Calculated: C, 58.75; H, 9.45; N, 5.71. Found: C, 59.14; H, 9.61; N, 5.86.

The synthetic route of 6627-89-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; American Home Products Corporation; US4133805; (1979); A;,
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Adding a certain compound to certain chemical reactions, such as: 4934-99-0, name is Methyl 3-hydroxycyclobutanecarboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4934-99-0, Quality Control of Methyl 3-hydroxycyclobutanecarboxylate

Methyl 3-(tert-butoxy)cyclobutane-1-carboxylate In a 30-mL round bottom flask purged and maintained with an inert atmosphere of nitrogen, methyl 3-hydroxycyclobutane-1-carboxylate (200 mg, 1.54 mmol, 1.00 equiv) and di-tert-butyl dicarbonate (771.4 mg, 3.53 mmol, 2.30 equiv) were mixed in dichloromethane (10 mL), to which was added magnesium perchlorate (34.3 mg, 0.15 mmol, 0.10 equiv) at room temperature. The resulting solution was then stirred for 16 h at 40 C. When the reaction was done, it was quenched with 10 mL water and the mixture was extracted with dichloromethane (3*10 mL). The organic layers were combined, dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by prep-TLC eluting with ethyl acetate in petroleum ether (50%) to afford methyl 3-(tert-butoxy)cyclobutane-1-carboxylate (200 mg, 70%) as yellow oil. MS: m/z=187.1 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-hydroxycyclobutanecarboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Merck Patent GmbH; GAILLARD, Pascale; SEENISAMY, Jeyaprakashnarayanan; LIU-BUJALSKI, Lesley; CALDWELL, Richard D.; POTNICK, Justin; QIU, Hui; NEAGU, Constantin; JONES, Reinaldo; WON, Annie Cho; GOUTOPOULOS, Andreas; SHERER, Brian A.; JOHNSON, Theresa L.; GARDBERG, Anna; (234 pag.)US2016/96834; (2016); A1;,
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Synthetic Route of 1127-01-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1127-01-1, name is Ethyl 1-hydroxycyclohexanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows.

2,09 g 1-HYDROXYCYCLOHEXANCARBONSaeURE-ETHYLESTER und 3 g der Verbindung gemaess Beispiel XXIV-1 werden im Oelbad auf 120C erhitzt und bis zum Ende der Gasentwicklung verruehrt und dann noch kurz auf 140C erhitzt. Ausbeute : 42 g (59 % der Theorie). 1H-NMR (400 MHz, CD3CN) : No. = 2,58 (q, 2H, CH2-AR), 3,77 (s, 3H, OCH3), 4,05 (m, 2H, O- CH2-CH3) ppm.

The chemical industry reduces the impact on the environment during synthesis Ethyl 1-hydroxycyclohexanecarboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; LUBOS-ERDELEN, Angelika; WO2004/80962; (2004); A1;,
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18469-52-8, name is Methyl 4-(aminomethyl)benzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Methyl 4-(aminomethyl)benzoate

Step 4. A solution of 5-fluoro-1H-indazole-3-carboxylic acid (0.25 g, 0.74 mmol) in dichloromethane (5.0 mL) was treated with triethylamine (0.083 g, 0.11 mL, 0.82 mmol), 4-dimethylamino pyridine (0.14 g, 1.1 mmol) and 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride (0.17 g, 0.89 mmol). 4-Aminomethyl-benzoic acid methyl ester (0.16 g, 0.82 mmol) was added. The mixture was stirred at room temperature for 16 hours, then partitioned between diethyl ether and 1N HCl. The organic phase was washed with water and brine, dried over magnesium sulphate and evaporated. The residue was purified by flash chromatography (heptane/ethyl acetate gradient), to yield 4-({[1-(4-difluoromethoxy-benzyl)-5-fluoro-1H-indazole-3-carbonyl]-amino}-methyl)-benzoic acid methyl ester as a yellow solid, 0.19 g (54%), m/z (ISP): 484.5 (M+H).

The synthetic route of 18469-52-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ackermann, Jean; Bleicher, Konrad; Ceccarelli, Simona M.; Chomienne, Odile; Mattei, Patrizio; US2008/103182; (2008); A1;,
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Ester – an overview | ScienceDirect Topics

2901-13-5, name is Ethyl 2-methyl-2-phenylpropanoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2901-13-5

Place aluminum chloride (586 g, 4.4 moles) and methylene chloride (300 mL) in a 2 L 3-neck round bottom flask equipped with an overhead stirrer, dry ice condenser, and nitrogen atmosphere. Cool to 10 C. and add, by dropwise addition, chlorobutyryl chloride (338 g, 2.4 moles), keeping the temperature below 15 C. After addition is complete, add, by dropwise addition, ethyl 2-methyl-2-phenylpropionate (384 g, 2 mol), keeping the temperature below 15 C. After addition was complete, warm the reaction mixture to 22 C. and stir for 1 hour. Raise the temperature to 90 C., stir for 90 minutes, cool to room temperature and slowly pounr into a 6 L stirred flask containing ice/water (4 kg). Filter through a celite precoat, separate the organic phase and wash the aqueous phase with methylene chloride (50 mL). Evaporate the solvent in vacuo to give a mixture of 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-proprionic acid, ethyl ester and 2-[3-(4-chloro-butyryl)-phenyl]-2-methyl-proprionic acid, ethyl ester.

The synthetic route of 2901-13-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merrell Pharmaceuticals, Inc.; US6348597; (2002); B2;,
Ester – Wikipedia,
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Synthetic Route of 1234616-21-7,Some common heterocyclic compound, 1234616-21-7, name is Methyl imidazo[1,2-b]pyridazine-6-carboxylate, molecular formula is C8H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Imidazo[1,2-b]pyridazin-6-ylmethanol (1-4) To a solution of methyl imidazo[1,2-b]pyridazine-6-carboxylate (1-3) (891 mg, 5.03 mmol) in ethanol (25 mL) was added NaBH4 (420 mg, 11.1 mmol) at room temperature. The suspension was stirred at room temperature for 2 h. The reaction mixture was concentrated in vacuum. The residue was purified by chromatography on silica gel to afford the title compound (630 mg). MS (m/z): 150 (M+1)+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl imidazo[1,2-b]pyridazine-6-carboxylate, its application will become more common.

Reference:
Patent; SU, Wei-Guo; JIA, Hong; DAI, Guangxiu; US2012/245178; (2012); A1;,
Ester – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1190-39-2, name is malonic acid dibutyl ester, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: malonic acid dibutyl ester

EXAMPLE 4 Example 3 was repeated except the organic solvent was omitted and the mol ratio of trans 1,4-dichlorobutene-2 to di-n-butyl malonate was 2:1. Di-n-butyl 2-vinylcyclopropane-1,1-dicarboxylate was obtained in 69% yield.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1190-39-2.

Reference:
Patent; Emery Industries, Inc.; US4252739; (1981); A;,
Ester – Wikipedia,
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Related Products of 23426-63-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 23426-63-3, name is Methyl 2-bromo-2-methylpropanoate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Toa solution of 1a (770 mg, 3.24 mmol) in DMF (20 mL) was added potassium carbonate (2.69g, 19.5 mmol).Thereaction mixture was stirred at ambient temperature for 30minutes. After addition of ethyl bromoacetate (1.08mL), the mixture was heated at 70oC for 2 hours. The mixture was cooled to ambient temperature andwater (60 mL) was added. The solution was extractedwith ethyl acetate (3 30 mL). The organic phase was washed withsaturated aqueous sodium chloride solution (2 ¡Á 15mL), dried over sodium sulfate, filtered and concentrated. The residue waspurified by column chromatography (silica gel, petroleum ether/ethyl acetate 5:1)to give the title compound (464 mg, 44% yield) as white solid.

The chemical industry reduces the impact on the environment during synthesis Methyl 2-bromo-2-methylpropanoate. I believe this compound will play a more active role in future production and life.

Reference:
Article; Huang, Yaping; Sun, Geng; Wang, Pengfei; Shi, Rui; Zhang, Yanchun; Wen, Xiaoan; Sun, Hongbin; Chen, Caiping; Bioorganic and Medicinal Chemistry Letters; vol. 28; 17; (2018); p. 2957 – 2960;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6279-86-3, name is Triethyl methanetricarboxylate, A new synthetic method of this compound is introduced below., name: Triethyl methanetricarboxylate

1,2,3,4-tetrahydroquinoline (1.78 g, 13.4 mmol) and triethyl methane tricarboxylate (3.1 g, 13.4 mmol) were heated at 230 C. for 30 minutes. The resulting compound is cooled to room temperature, filtered using ethyl acetate (50 mL) and MeOH (30 mL),The organics were concentrated and purified by column chromatography (ethylacetate: methanol = 49: 1) to ethyl 1-hydroxy-3-oxo-3,5,6,7-tetrahydropyrido [3,2,1-ij]quinoline-2-carboxylate (0.96 g, 3.5 mmol) was obtained.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Korea Research Institute of Chemical Technology; Park Cheol-min; Lee Seon-gyeong; Song Jong-hwan; (39 pag.)KR2019/67546; (2019); A;,
Ester – Wikipedia,
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Electric Literature of 69812-51-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69812-51-7, name is Methyl 4-chlorosulfonylbenzoate, This compound has unique chemical properties. The synthetic route is as follows.

Methyl 4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)-N-methyl-methylaminosulfonyl]phenyl-4-carboxylate (compound5(0086) Compound 4 (2.77 g, 10 mmol) and methyl-4-chlorosulfonylbenzenecarboxylate (2.46 g, 10.5 mmol) were dissolved in 30 mL DMF. TEA (3.03 g, 3 eq) was added and the solution was stirred for 12 hours at room temperature. The solvent was removed and silica gel plaque was made. Column separation offered a purified white powder compound 5 in 80% yields, Rf0.25 (CHCl3/CH3OH, 10/1); 1H NMR (DMSO-d6) delta 1.26 (s, 9H), 2.60 (2, 3H), 4.21 (s, 2H, 6.25 (s, 1H), 7.94 (d, 2H), 8.06 (d, 2H), 10.91 (br, 1H), 11.63 (br, 1H), 11.91 (br, 1H).

The chemical industry reduces the impact on the environment during synthesis Methyl 4-chlorosulfonylbenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Duquesne University of The Holy Ghost; GANGJEE, ALEEM; MATHERLY, LARRY H.; (12 pag.)US2016/229857; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics