Esters-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 541-16-2, name is Di-tert-Butyl malonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 541-16-2, Quality Control of Di-tert-Butyl malonate

To a 100 mL round bottom flask, was added p-acetamidobenzenesulfonyl azide (1.08 g, 4.5 mmol), acetonitrile (25 mL), triethylamine (0.62 mL, 4.5 mmol), and di-tert-butyl malonate (1 mL, 4.5 mmol). The reaction was stirred at rt for 48 hours, after which time the mixture was concentrated in vacuo to near dryness. Hexanes (25 mL) was added to the crude material and the precipitate was filtered. The filtrate was concentrated in vacuo and used directly in the following procedure. To a 100 mL round bottom flask containing the above crude material (1.87 g, 7.7 mmol), was added Rh2(OAc)4 (35 mg, 0.08 mmol) and toluene (50 mL), and 2-hydroxyEtOAc (1.24 g, 11.55 mmol). 1 The reaction was stirred at 70 C overnight, after which time the mixture was filtered over Celite and purified by silica gel column chromatography (20% EtOAc/hexanes) to afford the intermediate as a colorless oil (936 mg, 33% yield) which was used directly in the next step.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Di-tert-Butyl malonate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kelley, Amber M.; Minerali, Eni; Wilent, Jennifer E.; Chambers, Nicholas J.; Stingley, Kyla J.; Wilson, G. Tyler; Petersen, Kimberly S.; Tetrahedron Letters; (2019);,
Ester – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 90971-88-3, name is Methyl 2-bromo-5-methylbenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 90971-88-3, Quality Control of Methyl 2-bromo-5-methylbenzoate

To a mixture of 5-amino-3-ethyl-1-(2-methoxy-phenyl)-1 H-pyrazole-4-carbonitrile (Example 99, 1.0 g, 4.11 mmol), 2-bromo-5-methyl-benzoic acid methyl ester (0.78 g, 3.43 mmol) in toluene (25 mL) was added BINAP (0.21 g, 0.34 mmol) followed by tris (dibenzylideneacetone) (0) (0.19 g, 0.21 mmol). To the mixture was added cesium carbonate (1.56 g, 4.80 mmol) and the suspension was heated at 118C overnight and cooled to rt. Then reaction mixture was diluted with ethyl acetate and filtered through Celite and concentrated. The residue purified by silica gel column chromatography (25% ethyl acetate-hexanes) to give a pale yellow foamy solid (1.22 g, 91%). ES-MS m/z391.1 (MH+); HPLC RT (min) 3.73.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromo-5-methylbenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2005/112923; (2005); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 756525-95-8, These common heterocyclic compound, 756525-95-8, name is tert-Butyl 9-Amino-4,7-dioxanonanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of (6-((3-(3-(5-methyl-lH-imidazol-l-yl)-5- (trifluoromethyl)benzamido)benzyl)amino)-2H-indazole-3-carbonyl)-L-alanine (16) (170 mg, 0.28 mmol, 1.0 equiv) in DMF (6.8.0 mL, 40.0 vol. equiv) were added tert-butyl 3-(2-(2- aminoethoxy)ethoxy)propanoate (16) (78.60 mg, 0.34 mmol, 1.2 equiv), HATU (320 mg, 0.84 mmol, 3.0 equiv) and DIPEA (43.5 mg, 0.34 mmol, 1.20 equiv). The reaction mixture was stirred for 4 h at RT. The completion of reaction was monitored by TLC. The Reaction mixture was quenched with DMW (100 mL) and extracted with EtOAc (100 mL x 3). The combined organic extract was washed with brine (100 mL), dried over Na2S04 and concentrated under vacuum to get crude of desired compound. The crude was purified with column chromatography eluted with methanol in DCM (0 to 10%) to afford titled compound (17) (220 mg, 95.5%) as a light brown gum. 1H MR (300 MHz, OMSO-d6) delta 12.90 (s, 1H), 10.59 (s, 1H), 8.68 (s, 1H), 8.46 (s, 1H), 8.32-8.16 (m, 4H), 7.79-7.69 (m, 4H), 7.39-7.34 (t, 1H), 7.21-7.19 (d, 1H), 6.76-6.8 (s, 2H), 6.35 (s, 1H), 4.46-4.36 (m, 3H), 4.12-4.00 (t, 2H), 3.63-3.41 (m, 8H), 2.94 (s, 2H)2.21 (s, 3H), 1.45-1.38 (m, 12H). MS (ES+): 821.3 (M+l); MS (ES-): 819.5 (M-l).

Statistics shows that tert-Butyl 9-Amino-4,7-dioxanonanoate is playing an increasingly important role. we look forward to future research findings about 756525-95-8.

Reference:
Patent; QUARTZ THERAPEUTICS, INC.; ZAMBONI, Robert; HENNING, Ryan; JI, Alan; SMITH, Tyler; HELLER, Bradley; REDDY, Thumkunta Jagadeeswar; ROCHELEAU, Sylvain; BEAULIEU, Marc Andre; (266 pag.)WO2018/200981; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 2065-23-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2065-23-8 name is Methyl 2-phenoxyacetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Methyl phenoxyacetate (99.9 g, 0.6 mol) was added dropwise to [CHLOROSULFONIC] acid (279.6 g, 159.5 mL, 2.4 mol) at-5 C at such a rate to maintain internal temperature between 0 to-5 C (addition took about 60 min). Some solid formed during this addition. The cooling bath was removed and the reaction mixture was stirred at room temperature for an additional 1.5 hr. The reaction mixture was poured into a vigorously stirring mixture of dichloromethane (900 mL) and methanol (100 [ML)] at [0 C.] After 15 min the cooling bath was removed and the resulting mixture was stirred at room temperature for 1 hr. The resulting mixture was washed with ice cold water (2 X 250 mL). The combined aqueous layers were back extracted with dichloromethane [(1] X 250 mL). The combined organic layers were washed with brine [(1 X] 200 mL), dried over anhydrous magnesium sulfate (15 g) and concentrated under reduced pressure to give 132 g (83%) of the title compound as a white solid.’H NMR [(60MHZ)] [(CDC13)] 8 8.2-7. 2 (AB, 4H), 4.95 (s, 2H), 3.95 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-phenoxyacetate, and friends who are interested can also refer to it.

Reference:
Patent; GARST, Michael, E.; SACHS, George; SHIN, Jai, Moo; WO2004/9583; (2004); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 13195-64-7, name is Diisopropyl malonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13195-64-7, HPLC of Formula: C9H16O4

(1) using 830 mmol of sodium hydride as a catalyst,200 mmol of diisopropyl malonate with 440 mmolPropargyl bromide was added to 210 mL of anhydrous acetonitrile in an ice water bath.Stir the reaction for 8 hours.The product was washed with water, extracted with EtOAc EtOAc.Obtaining the product, compound 1;

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diisopropyl malonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Anhui Normal University; Zheng Xiaojie; Hu Yimin; (15 pag.)CN108947828; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 924-99-2, name is Ethyl 3-(dimethylamino)acrylate, A new synthetic method of this compound is introduced below., Quality Control of Ethyl 3-(dimethylamino)acrylate

Step c) 3-(4-Chloro-phenyl)-isoxazole-4-carboxylic acid ethyl ester To a solution of (E)- and/or (Z)-N-hydroxy-4-chloro-benzenecarboximidoyl chloride (58.0 g, 250.3 mmol) in diethylether (1.04 L) was added a solution of ethyl 3-(N,N-dimethylamino)acrylate (90.4 mL, 624 mmol) and triethylamine (50.1 mL, 362 mmol) in diethylether (1.04 L). The resulting mixture was then stirred for 14 h at room temperature and evaporated. Purification by chromatography (SiO2, heptane:ethyl acetate=100:0 to 4:1) afforded the title product (57 g, 91%) which was obtained as a white solid. MS: m/e=252.1 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Hoffmann-La Roche Inc.; Dott, Pascal; Hanlon, Steven Paul; Hildbrand, Stefan; Iding, Hans; Thomas, Andrew; Waldmeier, Pius; US2013/102778; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 59247-47-1,Some common heterocyclic compound, 59247-47-1, name is tert-Butyl 4-bromobenzoate, molecular formula is C11H13BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 100 mL round-bottom flask purged and maintained under an inert atmosphere of nitrogen was added (1S,4S,5R)-5-[[3-(2-chloro-6-methylphenyl)-5-cyclopropyl-1 ,2-oxazol-4-yl]methoxy]-2-azabicyclo[2.2.l]heptane ll3h (150 rng, 0.42 mmol, l.O equiv.), Tol (20 rnL),tert-butyl4-bromobenzoate (161.2 mg, 0.63 mmoL 1.50 equiv.), Cs2C03 (408 8 mg, 1.25mmol, 3.0 equiv.), BIANP (13 mg), and Pd2(dha)3 (19 mg, 0.02 mmol, 0.05 equiv.). The5 resulting mixture was stirred at 110 ¡ãC overnight Solids were filtered out. l11e illtrate wasconcentrated under vacuum to a residue which was pmified by silica gel columnchromatography eluting with ethyl acetate/petroleum ether (l: 10 to 1 :5). Removal of solventsgave tert-huty 1 4-l(l S,4S,5R)-5-U 3-(2-chloro-6-methy lpheny 1)-5-cyclopropy 1-1,2-oxazol-4-y l] rnethoxy ]-2-azabicyclo[2.2.1 ]heptan-2-yl]henzoate ll4a (l 00 mg, 45percent) as a light yellow10 oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl 4-bromobenzoate, its application will become more common.

Reference:
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (582 pag.)WO2018/39386; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 10047-10-6, name is Methyl 2-aminopentanoate hydrochloride, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10047-10-6, category: esters-buliding-blocks

General procedure: To a solution of N-chlorosulfonyl isocyanate (11.32 g; 80 mmol) in dry methylene chloride (120 mL) cooled in an ice bath was added dropwise a solution of t-butyl alcohol (5.93 g; 80 mmol) in dry methylene chloride (120 mL). The resulting mixture was added dropwise to a mixture of glycine methyl ester hydrochloride (10.05 g; 80 mmol) and triethylamine (16.16 g; 160 mmol) in dry methylene chloride (120 mL) kept at 0 C. The ice bath was removed and the reaction mixture was allowed to stir at room temperature overnight. The resulting solution was washed sequentially with 5% aqueous HCl (3 ¡Á 100 mL) and brine (100 mL). The organic layer was separated, dried over anhydrous sodium sulfate, filtered, and the solvent was removed on the rotary evaporator, leaving compound 1a as a white solid (14.56 g; 68% yield), mp 98-100 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Dou, Dengfeng; Tiew, Kok-Chuan; Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Alliston, Kevin R.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C.; Bioorganic and Medicinal Chemistry; vol. 20; 6; (2012); p. 2111 – 2118;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 18595-18-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18595-18-1, name is Methyl 3-amino-4-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Ammonium thiocyanate (50 mmol) is dissolved in 50 ml of acetone, 40 C lower dropwise acetyl chloride (50 mmol) in 10 ml acetone solution, stirring 1 hour, then cooling to room temperature, is slowly added 3-amino-4-methyl benzoic acid methyl ester in 75 ml of acetone solution, stirring the mixture at room temperature for 5 hours, adding 100 ml of water, is continuously stirred for 1 hour, filtering the precipitation separated out, water washing 3 times, hexane washing 3 times, vacuum drying to obtain title compound 11.3 g. 1 H-NMR (DMSO), delta 12.19 (1H, s), 11.56 (1H, s), 8.18 (1H, s), 7.77 (1H, d, J=8.0Hz), 7.45 (1H, d, J=8.0Hz), 3.84 (3H, s), 2.27 (3H, s), 2.17 (3H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-amino-4-methylbenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHIA TAI TIANQING PHARMACEUTICALGROUP CO LTD; Beijing Centaurus Biopharma Technology?Co.,?Ltd.; XIAO, DENGMING; LIANG, ZHI; HU, YUANDONG; HU, QUAN; ZHANG, QINGHUI; HAN, YONGXIN; WANG, HUAN; PENG, YONG; KONG, FANSHENG; LUO, HONG; (60 pag.)CN103130792; (2016); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 61644-18-6, A common heterocyclic compound, 61644-18-6, name is Chloromethyl isobutyrate, molecular formula is C5H9ClO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 6 Preparation of isobutyryloxymethyl trans-4-aminomethylcyclohexanecarboxylate (Method A) Sodium bromide (3.8 g; 0.037 mol and isobutyryloxymethyl chloride (5.1 g; 0.037 mol) was mixed with dimethylformamide (40 ml) and stirred for 3 h at room temperature. Trans-4-(tert.-butoxycarbonylaminomethyl)cyclohexane carboxylic acid (15.4 g; 0.06 mol) dissolved in dimethylformamide (100 ml) and triethylamine (12 g; 0.12 mol) was added and the stirring continued for 100 h at room temperature. The solvent was evaporated and water and diethylether were added. The ether layer was washed, dried and evaporated to give 6.1 g. This product was dissolved in ethyl acetate and ethyl acetate/hydrochloric acid was added. After 3 h at room temperature ether was added and the precipitate collected. Yield 3.5 g., m.p. 100 C. The product was dissolved in chloroform. Some undissolved material was filtered off and the solution was evaporated. M.p. 104 C. Calculated for: C13 H24 Cl NO4: C 53.2, H 8.23, N 4.77, O 21.8, Cl 12.1, found: 53.5, 7.78, 4.65, 21.2, 12.1.

The synthetic route of 61644-18-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KabiVitrum AB; US4483867; (1984); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics