Esters-buliding-blocks

Reference of 23426-63-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 23426-63-3, name is Methyl 2-bromo-2-methylpropanoate, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 3-PYRIDIN-3-YL-PHENOL (0.86 g, 5.0 mmol), methyl 2- bromoisobutyrate (3.60 g, 20.0 MMOL), and K2CO3 (2.76 g, 20.0 mmol) in anhydrous DMF (10 mL) was heated at 93 C under nitrogen for 3 h. After cooling, brine (40 mL) was added and the mixture was extracted with ethyl acetate (50 mL). The separated organic layer was washed with brine, filtered, and concentrated. The oil residue was taken up in 10 mL of 3 M HCI, stirred for 10 min, diluted with brine (10 mL), and extracted with ethyl acetate (2 x 30 mL). The separated aqueous layer was cooled in ice/water bath, adjusted to pH 10 with solid NA2CO3, and extracted with ethyl acetate (2 x 40 mL). The organic extract was dried over sodium sulfate and concentrated to afford 1.09 g (80%) of 2-METHYL-2- (3-PYRIDIN-3-YL-PHENOXY)-PROPIONIC acid methyl ester as a yellow oil :’H NMR (CD3) 6 1.62 (s, 6H), 3.79 (s, 3H), 6.82 (dd, 1 H), 7.08 (s, 1 H), 7.20 (d, 1 H), 7.38 (m, 2H), 7.81 (d, 1 H), 8.59 (d, 1 H), 8.80 (s, 1 H) ; MS M/Z (relative intensity) 271 (M+, 20), 212 (30), 171 (100).

The chemical industry reduces the impact on the environment during synthesis Methyl 2-bromo-2-methylpropanoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/48334; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 3697-68-5, name is Ethyl 1-(hydroxymethyl)cyclopropanecarboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3697-68-5, Formula: C7H12O3

To a solution of ethyl 1 -(hydroxymethyl)cyclopropanecarboxylate (2.0 g, 13.87 mmol) in DCM (25 mL) was added trichloroisocyanuric acid (3.26 g, 14.01 mmol) and followed by TEMPO (0.217 g, 1.387 mmol) at-S C. The reactionmixture was stirred for 1 h at -S C. The mixture was filtered through celite, and diluted with DCM (SO mL). The solution was washed with saturated Na2CO3 (SO mL), iN HC1 (SO mL), brine (SO mL), and saturated NH4C1 (3xSO mL). The organic layer was dried over Na2504, filtered, and concentrated under reduced pressure to obtain ethyl 1-formylcyclopropanecarboxylate (1.5 g, 10.55 mmol, 76 % yield) ascolorless liquid; product was used for next step without purification. ?H NMR (CDC13, oe = 7.26 ppm, 300 MHz): oe 10.40 (s, 1 H), 4.28 (q, J= 7.1 Hz, 2 H), 1.72 – 1.56 (m, 4 H), 1.32 (t, J= 7.1 Hz, 3 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HEWAWASAM, Piyasena; LOPEZ, Omar D.; TU, Yong; WANG, Alan Xiangdong; XU, Ningning; KADOW, John F.; MEANWELL, Nicholas A.; GUPTA, Samayamunthula Venkata Satya Arun Kumar; KUMAR, Indasi J. Gopi; PUNUGUPATI, Suresh Kumar; BELEMA, Makonen; WO2015/5901; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 426-65-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 426-65-3, name is Ethyl Pentafluoropropionate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of alkyne (1.0 eq) in THF (0.5 M) was added dropwise n-BuLi in solution in hexanes (1.1 eq) at -78 C. The mixture was stirred for 1 h at -78 C and ethyl trifluoroacetate (1.5 eq) was added. After the complete consumption of the alkyne (TLC), the mixture was diluted with MeOH (same volume than THF). The mixture was allowed to warm up to 0 C and NaBH4 (1.0 eq) was added. The mixture was stirred overnight while warming up to room temperature. The reaction was then quenched with a saturated solution of NH4Cl, extracted with Et2O (x3), washed with water and brine, dried over MgSO4 and concentrated under reduced pressure to give the alpha-trifluoromethyl secondary propargylic alcohol. The crude product was purified by flash column chromatography to afford the pure product.

The chemical industry reduces the impact on the environment during synthesis Ethyl Pentafluoropropionate. I believe this compound will play a more active role in future production and life.

Reference:
Article; Boreux, Arnaud; Lambion, Aubin; Campeau, Dominic; Sanita, Marina; Coronel, Ruben; Riant, Olivier; Gagosz, Fabien; Tetrahedron; vol. 74; 38; (2018); p. 5232 – 5239;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 758684-29-6, name is Methyl 3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 758684-29-6, Computed Properties of C10H11NO3

Benzenesulfonyl chloride (43.9 mg, 0.248 mmol) and N,N-diisopropylethylamine (0.108 mL, 0.621 mmol) were added to a solution of methyl 3,4-dihydro-2H- benzo[b][l,4]oxazine-6-carboxylate (40 mg, 0.207 mmol) in acetonitrile (2 mL), and the reaction stirred at ambient temperature overnight. The reaction was diluted with ethyl acetate and washed with brine. The organic phase was separated and concentrated to afford methyl 4- (phenylsulfonyl)-3,4-dihydro-2H-benzo[b][l,4]oxazine-6-carboxylate which was used directly in the next step without further purification. MS: (ES, m/z): 366 [M+S+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FORMA THERAPEUTICS, INC.; ZHENG, Xiaozhang; NG, Pui, Yee; THOMASON, Jennifer, R.; ZABLOCKI, Mary-Margaret; HAN, Bingsong; BARCZAK, Nicholas; LIU, Cuixian; RUDNITSKAYA, Aleksandra; LANCIA JR., David, R.; BAIR, Kenneth, W.; (315 pag.)WO2017/40963; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 49851-36-7,Some common heterocyclic compound, 49851-36-7, name is Methyl 2-(2-aminophenyl)acetate hydrochloride, molecular formula is C9H12ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

TEA (0.324 mL, 2.325 mmol) was added to a mixture of 3-acetamido-5-bromobenzoic acid (CAS 78238-1 1 -6) (200 mg, 0.775 mmol) and HATU (324 mg, 0.852 mmol) in DMF (3 mL) at 23 C. After 5 min, methyl 2-(2-aminophenyl)acetate hydrochloride (CAS 49851 -36-7) (165 mg, 0.775 mmol) was added and the resulting mixture was stirred at room temperature overnight. The mixture was partitioned between 4: 1 EtOAc/heptanes and water. The aqueous layer was extracted with 4: 1 EtOAc/heptanes. The combined organic layers were washed with 5% aqueous LiCI solution, the organics were dried (Na2S04), filtered and concentrated. The residue was purified by silica gel chromatography (EtOAc/heptanes 20-80%) to provide the title compound. MS (ESI+) m/z 405.2, 407.2 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-(2-aminophenyl)acetate hydrochloride, its application will become more common.

Reference:
Patent; NOVARTIS AG; BELANGER, David B.; FLOHR, Stefanie; GELIN, Christine Fang; JENDZA, Keith; JI, Nan; LIU, Donglei; LORTHIOIS, Edwige Liliane Jeanne; KARKI, Rajeshri Ganesh; MAINOLFI, Nello; POWERS, James J.; RANDL, Stefan Andreas; ROGEL, Olivier; VULPETTI, Anna; YOON, Taeyoung; WO2015/9977; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 85953-29-3, name is Methyl 2-chloro-4-fluorobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 85953-29-3

2-Chloro-4-fluoro-benzoic acid methyl ester (500 mg, 2.65 mmol) and 4-bromophenol (504 mg, 2.9131 mmol) were sequentially added to the dry reaction flask.Potassium carbonate (731 mg, 5.2971 mmol), DMAc (5 mL), protected by a nitrogen balloonThe reaction was heated to 120 C for 12 h, cooled to rt then water (20 mL) and ethyl acetate (20 mL). The aqueous phase was added with 1 M hydrochloric acid, and the pH was adjusted to 3-4, then ethyl acetate (15 mL) was added to precipitate a white solid and filtered.The filter cake was washed with ethyl acetate (5 mL).The title compound is a white solid(230 mg, 27%).

The synthetic route of Methyl 2-chloro-4-fluorobenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Liu Xinchang; Huang Jianzhou; Zhang Yingjun; S ¡¤geerdeman; (267 pag.)CN109111451; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 57381-43-8, name is Methyl 2,5-dibromobenzoate, A new synthetic method of this compound is introduced below., COA of Formula: C8H6Br2O2

To a dried 25 mL flask was introduced 3-tert-butyl-1-(2-methylphenyl)-1 H-pyrazol-5-amine (220 mg, 0.96 mmol), methyl 2,5-dibromobenzoate (235 mg, 0.80 mmol), Pd2(dba)3 (36.6 mg, 0.04 mmol), BINAP (49.8 mg, 0.08 mmol), and Cs2CO3 (365 mg, 1.12 mmol). The flask was degassed followed by addition of toluene (1 mL), and the mixture was then heated to 110¡ãC for 20 h. The mixture was cooled to rt, and diluted with ethyl acetate. The solid was filtered off, and the solvent was removed under reduced pressure. The residue was redissolved in methanol/THF (4: 1, v/v) and filtered though a C8-silica plug. HPLC purification using a gradient elution from 10percent to 90percent acetonitrile in water afforded 110 mg (31 percent) of the title compound. 1H NMR (300 MHz, CD2Cl2) No. 9.21 (s, 1 H), 7.41 (d, 1 H), 7.20-7.30 (m, 5 H), 7.10 (d, 1 H), 6.09 (s, 1 H), 3.72 (s, 3 H), 2.04 (s, 3 H), 1.30 (s, 9 H). ES-MS m/z 444.1 (MH+); HPLC RT (min) 4.30.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2005/112923; (2005); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63485-50-7, name is cis-Methyl 3-hydroxycyclobutanecarboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C6H10O3

cis-3-hydroxycyclobutylcarboxylic acid methyl ester (2730 g, 21.0 mol, 1.0 eq) prepared in Example 1 was dissolved in tetrahydrofuran (30 L) and cooled to -10 C.p-Nitrobenzoic acid (4178 g, 25.0 mol, 1.2 eq.), diethyl azodicarboxylate (4354 g, 25.0 mol, 1.2 eq.), triphenylphosphine (6557 g, 25.0 mol, 1.2 eq.).It was then stirred at room temperature for 16 h under nitrogen.The reaction was complete by TLC, the tetrahydrofuran was removed, and methyl t-butyl ether (20 L) was added and stirred for 0.5-1 h.Filter and filter cake was washed twice with methyl tert-butyl ether.All filtrates were collected and the filtrate was washed with saturated aqueous sodium bicarbonate.Dispense, dry and concentrate.The crude product was then beaten with a mixed solvent of ethyl acetate/petroleum ether, filtered and concentrated to give a pale yellow powder.Trans-III compound trans-p-nitrobenzoic acid (3-methoxycarbonylcyclobutyl) ester (4468 g, 16.0 mol), yield 76%, purity 95%.

The synthetic route of 63485-50-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Bide Pharmaceutical Technology Co., Ltd.; Xiong Shichuan; Mi Taoran; Fan Jianjian; Zhang Ruihao; (9 pag.)CN108129288; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some common heterocyclic compound, 15964-79-1, name is Methyl 2-(3,4-dimethoxyphenyl)acetate, molecular formula is C11H14O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 15964-79-1

To a solution of 315 mg (1.5 mmol) of 3,4-dimethoxyphenyl methyl acetate in 5 ml of anhydrous CHCl3, add at 0 C. and under an inert atmosphere 452 mul (3 mmol) of 1-naphthoyl chloride. Add dropwise 351 mul of SnCl4. Allow to return to room temperature. [0299] After 6 hours at room temperature, evaporate to dryness. Add 10 ml of MeOH. Stir at room temperature for 30 minutes. Evaporate to dryness. Add 7 ml of iced H2O. Allow to crystallize at 0 C. for 1 hour. Filter. Wash twice with 1 ml of H2O. Yield: 37%. The product is used as is for the subsequent reactions.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 15964-79-1, its application will become more common.

Reference:
Patent; Bourguignon, Jean-Jacques; Lagouge, Yan; Lugnier, Claire; Klotz, Eveline; Macher, Jean-Paul; Raboisson, Pierre; Schultz, Dominique; US2004/152888; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 1150566-27-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1150566-27-0, name is Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate (0.6 g, 2.66 mmol) was dissolved in tetrahydrofuran/water solution (12 ml/4 ml) and added to hydrated lithium hydroxide at 30C for 3 hours. Concentrate under reduced pressure, add 4ml of water to dissolve, then add 1mol/L dilute hydrochloric acid solution to adjust the pH value to 3, precipitate solids, suction filter, and dry to obtain 0.375g of white solid. Yield: 71.4%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; China Pharmaceutical University; Zhang Huibin; Chen Yun; Zhou Jinpei; Liu Xueting; Ma Hui; (29 pag.)CN107652293; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics