Esters-buliding-blocks

Reference of 394-35-4, The chemical industry reduces the impact on the environment during synthesis 394-35-4, name is Methyl 2-fluorobenzoate, I believe this compound will play a more active role in future production and life.

3. 2-(2-((R)-sec-Butylamino)benzo[d]thiazol-6-yI)-3-(2-fluorophenyI)-3- oxopr op anenitrile[00170] To a solution of lithium bis(trimethylsilyl)amide (1.0 M in THF, 35.3 mL) in THF (60 mL) was added a solution of (R)-2-(2-(sec-butylamino)benzo[d]thiazol-6- yl)acetonitrile (3.74 g, 15.2 mmol) in THF (60 mL) at -780C over 40 min. The resulting solution was stirred at -780C for 10 min before a solution of methyl 2- fluorobenzoate (2.5 mL, 19.6 mmol) in THF (15 mL) was.added over 5 min. The mixture was stirred at -780C for 1 hr and then at rt for 3 hr before it was poured into ice-cold water (100 mL). After its pH value was adjusted to 9 with-6 N HCl, the mixture was extracted with AcOEt (3 x 60 mL). The combined extract was washed with brine and dried over anhydrous MgSO4. The solution was concentrated under EPO vacuum, and the residue was subjected to ISCO (2percent MeOH/CH2C12) to give a mixture (4.09 g) of the title compound and the starting material in a ratio of 1 : 1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-fluorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2007/16392; (2007); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 41248-23-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41248-23-1, name is Ethyl 1-hydroxycyclopentanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Example III-1′ 17.23 g (108.8 mmol) of ethyl 1-hydroxycyclopentanecarboxylate and 26.95 g (108.8 mmol) of 3-bromo-6-methylphenylacetyl chloride are combined, stirred at an oil bath temperature of 120 C. for 6 h and finally briefly heated to 140 C. and degassed on an oil pump.Yield: 39.73 g of an oil (99% of theory), log P (acidic) 4.52

The chemical industry reduces the impact on the environment during synthesis Ethyl 1-hydroxycyclopentanecarboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Bayer CropScience AG; US2011/306499; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2475-80-1, name is Methyl 2-amino-5-methoxybenzoate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 2-amino-5-methoxybenzoate

The product is obtained by reacting 4.00 g (22 mmol) methyl 2-amino-5-methoxy-benzoate with 5 equivalents of ethylmagnesium bromide in dichloromethane at -78 C.?RT. Brown oil. Yield: 4.47 g (97%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Boehringer Ingelheim International GmbH; US2006/189605; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 34837-84-8, name is Methyl 2-(4-fluorophenyl)acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34837-84-8, category: esters-buliding-blocks

To a stirred solution of diisopropylamine (13.0 g) in tetrahydrofurane (160 mL)was added a solution of n-butyllithium in hexane (51 .4 mL; c= 2.5 M) at -78 ¡ãC.The solution was stirred at 0 ¡ãC for 15 minutes. The solution was cooled to -78¡ãC and a solution of methyl (4-fluorophenyl)acetate (18.0 g), dissolved intetrahydrofurane (40 mL) was added. The solution was stirred at -78 ¡ãC for 30 minutes. Methyl iodide (10.0 mL) was added at -78 ¡ãC, and the solution was allowed to warm up to 0 ¡ãC within 1 h. Water was added and the reaction mixture was extracted with ethyl acetate. The organic phase was dried (sodium sulfate) and the solvent was removed in vacuum. Silicagelchromatography gave 18.9 g of the title compound.1H-NMR (400MHz, DMSO-d6): 6 [ppm] = 1.34 (d, 3H), 3.55 (5, 3H), 3.79 (q, 1H),7.08 – 7.15 (m, 2H), 7.25 – 7.32 (m, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-(4-fluorophenyl)acetate, and friends who are interested can also refer to it.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; LERCHEN, Hans-Georg; BIERER, Donald; WENGNER, Antje Margret; SIEMEISTER, Gerhard; LIENAU, Philip; KRENZ, Ursula; KOSEMUND, Dirk; STOeCKIGT, Detlef; BRUeNING, Michael; LUeCKING, Ulrich; TEREBESI, Ildiko; WO2014/198647; (2014); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 884497-46-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 884497-46-5, name is Methyl 3-amino-5-fluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Compound 14 (100 g, 591 mmol), compound 15 (107.68 g, 591 mmol) and dioxane (1000 ml) were added into a first reactor, then PPTS (60.82 g, 118.2 mmol) and MgSO4 (355.77 g, 2.96 mol) were added into the first reactor, then the first reactor was heated to reflux and stirred for 3 hours, cooled down to 50 C. NaBH4 (89.46 g, 2.36 mol) was added into the mixture and heated to 80 C., the first reactor was then stirred for 3 hours. After the reaction, the first reactor was cooled down to room temperature, methanol was added into the first reactor and white solid was filtered. The filtrate was concentrated and extracted by ethyl acetate, then washed with saturated NaHCO3 aqueous solution and sodium chloride aqueous solution. The organic phase was dehydrated with anhydrous sodium sulfate, filtered and concentrated to obtain crude product. The crude product was purified by column chromatography to give compound 16 (100 g, yield 53.3%). (0061)LC-MS (ESI) m/z: 318 (M+H)+.

The synthetic route of Methyl 3-amino-5-fluorobenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xu, Yong; Yohi, Peter W; Xu, Michael; Cruise, Douglas; (12 pag.)US9708319; (2017); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C9H11NO3

A solution of 1-({5-chloro-2-[(2-methylpropyl)oxy]phenyl}methyl)-5-methyl-1 H-pyrazole-3- carboxylic acid (807 mg), methyl 4-amino-2-methoxybenzoate (453 mg), N-(3- dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (516 mg) and 1- hydroxybenzotriazole hydrate (406 mg) in dichloromethane (10 ml) and dimethylformamide (10 ml) was stirred at ambient temperature for 24 hours. Ethyl acetate (60 ml) was added and the mixture washed with water (60 ml), saturated sodium bicarbonate solution (25 ml) and brine (2 x 20 ml), dried (MgSO4) and concentrated in vacuo. The residue was purified by SP4 Biotage chromatography using 5 to 40percent ethyl acetate in hexane to afford the title compound (738 mg, 61percent) as a white foamy solid. LC/MS [MH+] = 486/488, RT = 3.70 min.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 27492-84-8.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/114313; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2475-81-2, name is Methyl 2-amino-4-fluorobenzoate, A new synthetic method of this compound is introduced below., Safety of Methyl 2-amino-4-fluorobenzoate

Example 14A methyl 2-(benzylamino)-4-fluorobenzoate Methyl 2-amino-4-fluorobenzoate (0.90 g), benzaldehyde (0.54 mL), sodium triacetoxyborohydride (1.58 g) and acetic acid (0.3 mL) in CH2Cl2 (20 mL) were stirred for 3 hours. The reaction was quenched with methanol, concentrated, and chromatographed on silica gel with 5% ethyl acetate/hexanes.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ABBOTT LABORATORIES; US2010/184750; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 335599-07-0, name is Ethyl 3-oxa-bicyclo[3.1.0]hexane-6-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: Ethyl 3-oxa-bicyclo[3.1.0]hexane-6-carboxylate

Production Example 11-2(3-Oxa-bicyclo[3.1.0]hex-6-yl)methanol diastereomer 1 3-Oxa-bicyclo[3.1.0]hexane-6-carboxylic acid ethyl ester diastereomer 1 (10 g, 64.1 mmol) was dissolved in TIM (100 mL), and to the mixture, was added dropwise a 0.99M toluene (180 mL, 178 mmol) solution of DIBAL while cooling on ice, and stirred at room temperature for one hour. To the reaction mixture, were added a small amount of water and ethyl acetate, and the mixture was filtered with Celite, washed with ethyl acetate, and then the filtrate was distilled off under reduced pressure, and the residue was purified by column chromatography (heptane:ethyl acetate to 75% ethyl acetate) to obtain the title compound (2.6 g, 228 mmol) as a colorless oil.1H-NMR (CDCl3) delta: 1.10 (dt, J=3.6 Hz, 6.8 Hz, 1H), 1.53-1.56 (m, 2H), 3.53 (d, J=6.8 Hz, 2H), 3.70 (d, J=8.0 Hz, 2H), 3.88 (d, J=8.4 Hz, 2H)Production Example 11-3(3-Oxa-bicyclo[3.1.0]hex-6-yl)methanol diastereomer 2 From 3-oxa-bicyclo[3.1.0]hexane-6-carboxylic acid ethyl ester diastereomer 2 (5 g, 32.1 mmol), the title compound (2.1 g, 18.4 mmol) was obtained as a colorless oil according to the same procedure as in (3-oxa-bicyclo[3.1.0]hex-6-yl)methanol diastereomer 1.1H-NMR (CDCl3) delta: 1.23 (t, J=3.6 Hz, 1H), 1.80 (d, J=3.6 Hz, 2H), 3.79 (d, J=7.6 Hz, 2H), 3.91 (m, 4H)

The synthetic route of Ethyl 3-oxa-bicyclo[3.1.0]hexane-6-carboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eisai R&D Management Co., Ltd.; US2011/86882; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1195768-18-3, name is Methyl 3-amino-2-fluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., category: esters-buliding-blocks

General procedure: To a solution of PTMA (1d) (29.0 mg, 0.10 mmol) and aminobenzoates 2 (1.5 mmol or 0.20 mmol) in DMF (1.0 mL) at room temperature were added Et3N or pyridine (0.42 mmol) and HATU(76.1 mg, 0.20 mmol). The mixture was stirred at room temperature overnight and monitored by TLC. Then brine (10 mL) was added.The resulting mixture was extracted with EtOAc (3 5.0 mL), andthe combined organic portions were dried over anhydrous sodium sulfate and concentrated in vacuo. compounds 3 were finally prepared through flash column chromatography (eluent: EtOAc/lightpetroleum ether 1:20e5:1).

According to the analysis of related databases, 1195768-18-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Qiu, Lin; Tian, Kai; Pan, Jian; Jiang, Lin; Yang, Hu; Zhu, Xiangcheng; Shen, Ben; Duan, Yanwen; Huang, Yong; Tetrahedron; vol. 73; 6; (2017); p. 771 – 775;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 33689-29-1,Some common heterocyclic compound, 33689-29-1, name is Methyl 1-hydroxycyclopropanecarboxylate, molecular formula is C5H8O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Copper (I) iodide (650 mg, 3.41 mmol) and triethylamine (3.0 mL, 22 mmol) were added to a stirred solution of methyl 1-hydroxycyclopropanecarboxylate (2.0 g, 17.22 mmol) in acetonitrile (60 mL) at rt in a sealed tube. The reaction mixture was heated to 50 C and 2-fluorosulfonyl-2,2- difluoroacetic acid (15.0 g, 84.23 mmol) was added and stirred at 50 C at 18 h, then concentrated under reduced pressure at 30 C bath temperature. To the residue water (100 mL) was added and extracted with EtOAc (2 x 150 mL). The combined organic layers were washed with brine, dried (Na2S04), filtered and concentrated under reduced pressure at 30 C bath temperature which gave the title compound (1.1 g) as liquid. The compound was used in next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 1-hydroxycyclopropanecarboxylate, its application will become more common.

Reference:
Patent; MEDIVIR AKTIEBOLAG; ERSMARK, Karolina; KARLSTROeM, Sofia; KLASSON, Bjoern; LUNDGREN, Stina; ROSENQUIST, Asa; SALVADOR ODEN, Lourdes; (155 pag.)WO2018/226150; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics