Esters-buliding-blocks

Related Products of 62456-15-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 62456-15-9, name is trans-Methyl 4-aminocyclohexanecarboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 1: Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate:Methyl trans-4-aminocyclohexanecarboxylate (43 g, 222 mmol) was added to MeOH(500 ml) to give a colourless solution. The solution was cooled to 10C and triethylamine (46.4 ml, 333 mmol) was added dropwise, followed by a solution of di- tert-butyldicarbonate (53.3 g, 244 mmol) in MeOH (400 ml) over 20 minutes. The reaction was allowed to warm to RT and stirred overnight. The mixture was evaporated to dryness under reduced pressure. The resulting colourless solid was dissolved in EtOAc (1000 ml) and the solution obtained was washed successively with 10% citric acid solution (100 ml), saturated sodium bicarbonate solution (2 x 100ml) and saturated brine (100 ml), dried (MgS04) and evaporated under reduced pressure to give a colourless solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, trans-Methyl 4-aminocyclohexanecarboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ATKINSON Benjamin; BEATTIE David; CULSHAW Andrew James; DEVEREUX Nicholas James; MCKENNA Jeffrey; DALE James; WO2011/92293; A1; (2011);,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14062-25-0, name is Ethyl 2-(4-bromophenyl)acetate, A new synthetic method of this compound is introduced below., Product Details of 14062-25-0

Step A: Ethyl 2-(4-bromophenv0-2-methylpropanoateTo a stirred solution of ethyl 2-(4-bromophenyl)acetate (10 g, 41 mmol) in THF(80 mL) under nitrogen was added sodium hydride (4.9 g, 60 %, 123 mmol) in portions at 0 C. The resulting solution was stirred at 0 C for 30 minutes before the addition of iodomethane (17 g, 123 mmol) at 0 C. The resulting mixture was stirred at ambient temperature for additional 1 hour before the reaction was quenched with saturated NH4CI aqueous solution (20 mL) at 0 C. The solution was extracted with EtOAc(3xl00 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo. The crude residue was purified by MPLC on silica gel (eluting with 1-2 % EtOAc/hexane) to afford the title compound as a light yellow oil. ? NMR (400 MHz, CDC13) delta 7.46 (d, J= 6.8 Hz, 2H), 7.24 (d, J= 6.8 Hz, 2H), 4.14 (q, J= 7.2 Hz, 2H), 1.58 (s, 6H), 1.20 (t, J= 7.2 Hz, 3H). MS ESI: [M+H]+ m/z 271, 273.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BRUBAKER, Jason; DINSMORE, Christopher J.; HOFFMAN, Dawn Marie; JUNG, Joon; LIU, Duan; PETERSON, Scott; SIU, Tony; TORRES, Luis E.; ZHANG, Hongjun; WEI, Zhongyong; SHI, Feng; WO2013/40863; (2013); A1;,
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Some common heterocyclic compound, 18595-18-1, name is Methyl 3-amino-4-methylbenzoate, molecular formula is C9H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: Methyl 3-amino-4-methylbenzoate

Triethylamine (65 mg, 0.64 mmol) (Acros) was added to a mixture of 2-quinolone-3-carboxylic acid (100 mg, 0.53 mmol) (Maybridge)) and HATU (241 mg, 0.64 mmol) (Aldrich) in DMF (5.0 mL) at room temperature. Mixture was stirred until clear solution was obtained (light brown). 3-Amino-p-toluic acid methyl ester (0.12 g, 0.70 mmol) (TCI) was added. Mixture was stirred for another 20 hours. Precipitate was formed. Water (50 mL), aqueous saturated sodium bicarbonate solution (10 mL), and ethyl acetate (25 mL) were added. After thorough mixing, white precipitate was collected by filtration, washed with water and ethyl acetate and recrystallized from hot DMF-ethyl acetate-hexanes to give 4-methyl-3-[(2-oxo-1,2-dihydro-quinoline-3-carbonyl)-amino]-benzoic acid methyl ester fine yellow needles. (Yield 0.16 g, 90.0%). HR-MS (ES+) m/z Calculated for C19H17N2O4 ([M+H]+): 337.1183. Found: 337.1183.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 18595-18-1, its application will become more common.

Reference:
Patent; Dominique, Romyr; Luk, Kin-Chun; Qiao, Qi; Rossman, Pamela Loreen; US2012/184548; (2012); A1;,
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Electric Literature of 17994-94-4, A common heterocyclic compound, 17994-94-4, name is Methyl 7-aminoheptanoate hydrochloride, molecular formula is C8H18ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a mixture of aldehyde (1 mmol) and amine/amine hydrochloride (1 mmol) in anhydrous CH2Cl2 (10 mL) was added triethylamine (2.5 mmol) at rt, and the resulting solution was stirred vigorously for 1 h. To this was then added (Boc)2O (1.2 mmol) followed by sodium triacetoxyborohydride (2 mmol). The reaction was stirred for an additional 4 h at rt, quenched with saturated NaHCO3 solution, and extracted with CH2Cl2. The combined organic fractions were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The crude residue was purified by flash chromatography (95:05?50:50, hexanes/EtOAc) to afford the N-Boc secondary amine. Most of the title compounds were present as a mixture of rotational isomers in their 1H and 13C NMR spectra.

The synthetic route of 17994-94-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Neelarapu, Raghupathi; Petukhov, Pavel A.; Tetrahedron; vol. 68; 35; (2012); p. 7056 – 7062;,
Ester – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 73792-08-2, name is Methyl 4-amino-2-fluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 73792-08-2, Application In Synthesis of Methyl 4-amino-2-fluorobenzoate

General procedure: A solution of (7: R1=cyclopentyloxy) (100mg, 363mumol) in dichloromethane (5 mL), cooled to 0C, was treated with oxalyl chloride (63.6 muL, 727 mumol), followed by a drop of N,N-dimethylformamide. The resultant mixture was stirred for 1h at room temperature. The solvent was evaporated in vacuo and the residue dissolved in dichloromethane (5 mL) and then treated with a solution of methyl 4-aminobenzoate (8: R2=H, R=Me) (54.9mg, 363mumol) and di-isopropylethylamine (190muL, 1.09mmol) in dichloromethane (5mL). The reaction mixture was stirred for 12 h at room temperature and then partitioned between dichloromethane (20 mL) and aqueous 1M hydrochloric acid (20 mL). The phases were separated, and the organic phase was washed successively with water (2¡Á20 mL), and brine (20 mL), dried over magnesium sulfate, filtered and then the solvent was removed in vacuo. The residue was purified by silica gel chromatography (12 g, 0-100 % ethyl acetate/isohexane) to afford methyl 4-[3,5-dichloro-4-(cyclopentyloxy)benzamido]benzoate (10: R1 = cyclopentyloxy, R2 = H, R =Me) (30mg, 20% yield). 1H NMR (400MHz, CDCl3) delta 8.06 (2H, d, J=8.8Hz,), 7.85 (1H, br s), 7.82 (2H, s), 7.71 (2H, d, J=8.8Hz), 5.07-5.03 (1H, m), 3.92 (3H, s), 2.10-1.90 (4H, m), 1.85-1.70 (2H, m), 1.70-1.60 (2H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-2-fluorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Clarke, Earl; Jarvis, Christopher I.; Goncalves, Maria B.; Kalindjian, S. Barret; Adams, David R.; Brown, Jane T.; Shiers, Jason J.; Taddei, David M.A.; Ravier, Elodie; Barlow, Stephanie; Miller, Iain; Smith, Vanessa; Borthwick, Alan D.; Corcoran, Jonathan P.T.; Bioorganic and Medicinal Chemistry; vol. 26; 4; (2018); p. 798 – 814;,
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Reference of 927-68-4,Some common heterocyclic compound, 927-68-4, name is 2-Bromoethyl acetate, molecular formula is C4H7BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 7-1 (200 mg, 0.9 mmol) And sodium hydride (54mg, 1.35mmol) dissolved in 3ml DMF and stirred for 30 minutes, Add 2-bromoethyl acetate (165 mg, 0.99 mmol) in 2 ml of DMF, Stir overnight at room temperature. On the following day, after the reaction was detected by TLC, water was added for extraction. It was washed with saturated brine and dried over anhydrous sodium sulfate. Suction filtration, the filtrate was concentrated under reduced pressure, the crude product was separated by column chromatography, 172 mg of a colorless oil was obtained in a yield of 61%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromoethyl acetate, its application will become more common.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhang Ao; Meng Linghua; Ding Jian; Chen Shulun; Ding Chunyong; Guo Wei; (26 pag.)CN110143955; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 37466-90-3, name is Ethyl 3,4-diaminobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C9H12N2O2

Preparation of ethyl 2-phenyl-1 H-benzo[d]imidazole-5-carboxylate 4-fluoro-3-nitrobenzoic acid (0.05g, 0.27 mmol) was esterified in the presence of catalytic sulfuric acid in ethanol (10mL) by refluxing at 65 eC for 6 hours. Ammonium hydroxide 28% (0.26 mmol) was subsequently added to the solution, stirred for 0.5 hour, treated with tin (Pi) chloride (190mg, 1 mmol) and stirred for a further 0.5 hour. The resulting mixture was then treated with benzaldehyde (0.3 mmol) and sodium bisulfite (57 mg, 0.3 mmol) and left to stir for another 3 hour. The solution was cooled to room temperature and subsequently evaporated under reduced pressure. It was resuspended in ethyl acetate (10mL), washed with 10% sodium carbonate (20mL) and water (20mL x2), dried over sodium sulfate and concentrated under reduced pressure. The crude products were purified by column chromatography (silica gel, 70- 230 mesh; C HC I3-MeOH 9:1 ) to obtain the final products (70-90%).

The synthetic route of Ethyl 3,4-diaminobenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITI SAINS MALAYSIA; OON, Chern Ein; TAN, Soo Choon; YEONG, Keng Yoon; ALI, Mohamed Ashraf; (39 pag.)WO2017/52359; (2017); A1;,
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Related Products of 36692-49-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 36692-49-6 name is Methyl 3,4-diaminobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Typical procedure: Mix Et3N (2.53 mg, 0.025 mmol), 2-phenylacetaldehyde 1a (30 mg, 0.25 mmol), benzene-1,2-diamine 2a (32.4 mg, 0.3 mmol), in toluene (2.5 mL) under O2 (1 atm). The reaction mixture was stirred at 60 C for 12 h. After cooling down to room temperature and concentrating in vacuum, the residue was purified by flash chromatography on a short silica gel (eluent: petroleum ether/ethyl acetate=20:1) to afford 47 mg (91%) of 3aa.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3,4-diaminobenzoate, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Chun; Xu, Zejun; Zhang, Liangren; Jiao, Ning; Tetrahedron; vol. 68; 26; (2012); p. 5258 – 5262;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 35450-36-3, name is Methyl 2-bromo-5-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 35450-36-3

A mixture of methyl 2-bromo-5-methoxybenzoate (3.0 g, 12.2 mmol), vinylboronic acid (2.26 g, 14.7 mmol), K2CC>3 (5.08 g, 36.72 mmol) and Pd(dppf)Cl2-DCM (500 mg, 0.61 mmol) in 1,4-dioxane/H2Patent; CTXT PTY LIMITED; STUPPLE, Paul, Anthony; LAGIAKOS, Helen, Rachel; FOITZIK, Richard, Charles; CAMERINO, Michelle, Ang; NIKOLAKOPOULOS, George; BOZIKIS, Ylva, Elisabet, Bergman; KERSTEN, Wilhelmus, Johannes, Antonius; WALKER, Scott, Raymond; HUBERT, Jonathan, Grant; (0 pag.)WO2020/2587; (2020); A1;,
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Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7364-20-7, name is Methyl 4-ethylbenzoate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 7364-20-7

Under nitrogen protection, the1-formic acid methyl-4-ethylbenzene1 t (0.5 mmol), NBS (1.25 mmol) and acetonitrile (2 mL) were added to the reaction tube. Stir at 100 C for 12 hours. After stopping the reaction, cool to room temperature, evaporate the solvent and separate by column chromatography. The volume ratio (mL / mL) of the eluent used is ethyl acetate: petroleum ether = 0: 100 ~ 1: 200.1- (4-formic acid methyl) phenyl-1,2-dibromoethane3t, yield is 83%.

According to the analysis of related databases, 7364-20-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chinese Academy Of Sciences Lanzhou Chemical Physics Institute; Qian Bo; Li Weihe; (12 pag.)CN110862292; (2020); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics