Esters-buliding-blocks

Synthetic Route of 5335-05-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5335-05-7, name is Chloromethyl benzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of compound 1d (120.0 mg, 0.306 mmo.) in DMF (3 mL) was added LiH (4.8 mg, 0.61 mmoi) at 0 0C. Then chloromethyi benzoate v (57.4 mg, 0.337 mmo., dissolved in 0.5 mL DIVtF) was added. The solution was stirred at 0 0C for 3 hours, and then was gradually warmed up to 25 CC and stirred at 25 0C for overnight. AcOH (0.042 mL, 0.733 mmo.) was added and the product was purified by C18 chromatography (CH3CNZH2O: 5% to 90%, with 0.1% HCO2H) to give compound 66 (110.5 mg, 68.6%),

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Chloromethyl benzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SCHERING CORPORATION; SHANKAR, Bandarpalle, B.; KIM, Seong, Heon; YU, Wensheng; TONG, Ling; WONG, Michael, K. C.; LAVEY, Brian J.; KOZLOWSKI, Joseph, A.; CHEN, Lei; RIZVI, Razia, K.; KOSINSKI, Aneta, Maria; YANG, De-Yi; ZHOU, Guowei; ROSNER, Kristen, E.; FIRE, Luke; RICHARD, Judson, E.; LI, Dansu; WO2010/36638; (2010); A2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 105-76-0, name is Dibutyl maleate, A new synthetic method of this compound is introduced below., Safety of Dibutyl maleate

EXAMPLE 31 Synthesis of Dibutyl 5-EPDC from Hydroxylamine, Dibutyl Maleate, and 2-Ethylacrolein Hydroxylamine free base (50% aqueous solution, 8.0 g, 0.12 mol) was added dropwise to dibutyl maleate (25.0 g, 0.1 mol) in a 3-necked 250-ml flask blanketed with nitrogen. The reaction temperature was maintained below 55 C. with an ice bath. The mixture was stirred for 30 minutes and then analyzed by NMR, which indicated 96% conversion of dibutyl maleate to dibutyl N-hydroxyaspartate. Butanol (29.8 g), hexadecane (0.98 g), 2-ethylacrolein (10.0 g, 0.12 mol), and trifluoroacetic acid (2.0 g, 0.018 mol) were added in succession to the reaction mixture, which was then stirred at 90-95 C. for 4.5 hours under nitrogen.

The synthetic route of 105-76-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoechst Celanese Corporation; US5322948; (1994); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6942-37-6, name is Methyl 5-amino-2-bromobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: Methyl 5-amino-2-bromobenzoate

Step B. Preparation of methyl 2-bromo-5-(dimethylamino)benzoateTo a stirred solution of 5-amino-2-bromo-benzoic acid methyl ester (3.30 g, 14.35 mmol) in CH3OH (45 mL) containing CH2O (3.6 mL, 45.0 mmol) at room temperature was added a solution of NaBH3CN (945 mg, 14.35 mmol) and ZnCI2 (990 mg, 7.2 mmol) in CH3OH (45 mL). The reaction mixture was stirred at room temperature overnight, then concentrated. The residue was taken up in 0.1 N NaOH solution, extracted with EtOAc several times. The combined extracts were washed with H2O, brine, dried over dried Na2SO4, then filtered and concentrated. The residue was separated by silica gel column (hexane/EtOAc = 3 : 1) to give 2.991 g (92%) of methyl 2-bromo-5-(dimethylamino)benzoate as a yellow oil based on the partial recovery of (412 mg). methyl 2-bromo-5-(dimethylamino)benzoate, MS: m/z 259 (M + H)

The synthetic route of 6942-37-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WYETH; WO2009/120826; (2009); A1;,
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Related Products of 82702-31-6, These common heterocyclic compound, 82702-31-6, name is Methyl 3-bromo-4-fluorobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of Example 35a (1.86 g, 13.27 mmol) and methyl 3-bromo-4- fluorobenzoate (2.099 mL, 14.20 mmol) in dimethyl sulfoxide (14 mL) was added cesium carbonate (6.49 g, 19.91 mmol). The mixture was heated at 80 C for 2 hours, cooled, and diluted with water (100 mL), then extracted with methyl tert-butyl ether (200 mL). The aqueous phase was extracted with additional portions (2 x 100 mL) of methyl tert-butyl ether.The combined organics were dried over anhydrous sodium sulfate, filtered, and concentrated. The crude material was purified by chromatography (silica gel, eluting with 0-25 % ethyl acetate/heptanes) to provide 4.56g (97%) of the title compound.

The synthetic route of 82702-31-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; FIDANZE, Steven D.; HASVOLD, Lisa A.; LIU, Dachun; MCDANIEL, Keith F.; PRATT, John; SCHRIMPF, Michael; SHEPPARD, George S.; WANG, Le; LI, Bing; (191 pag.)WO2017/177955; (2017); A1;,
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Reference of 27492-84-8, These common heterocyclic compound, 27492-84-8, name is Methyl 4-amino-2-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) Methyl 2-methoxy-4-[(6a-methyl-5,6,6a,7,8,9-hexahydro-4H-2-phenalenyl)carboxamido]benzoate [Show Image] A suspension of 6a-methyl-5,6,6a,7,8,9-hexahydro-4H-2-phenalenecarboxylie acid (0.100 g) in anhydrous benzene (3 ml) was added with thionyl chloride (1 ml), and the mixture was refluxed by heating for 3 hours. The reaction mixture was concentrated under reduced pressure, the resulting residue was dissolved in anhydrous benzene (2 ml) and pyridine (5 ml), the solution was added with methyl 2-methoxy-4-aminobenzoate (0.087 g) and 4-dimethylaminopyridine (one pellet), and the mixture was stirred overnight at room temperature. The reaction mixture was added with 2 N aqueous hydrochloric acid and thereby made acidic, and the mixture was extracted with ethyl acetate. The organic layer was washed successively with water, 10percent aqueous sodium carbonate, and saturated brine, and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (developing solvent: ethyl acetate:n-hexane = 1:5) to obtain the title compound (0.145 g, yield: 85percent). 1H-NMR (400MHz, CDCl3): delta 1.17 (3H, s), 1.51 (2H, td, J=12.9, 5.1Hz), 1.71 (2H, dt, J=12.9, 3.9Hz), 1.78-1.89 (2H, m), 1.99-2.15 (2H, m), 2.82 (2H, dt, J=17.1, 8.6Hz), 2.96 (2H, ddd, J=17.1, 7.8, 3.0Hz), 3.87 (3H, s), 3.93 (3H, s), 6.97 (1H, dd, J=8.4, 1.8Hz), 7.38 (2H, s), 7.82 (1H, d, J=1.8Hz), 7.85 (1H, d, J=8.4Hz), 8.05 (1H, br-s)

Statistics shows that Methyl 4-amino-2-methoxybenzoate is playing an increasingly important role. we look forward to future research findings about 27492-84-8.

Reference:
Patent; Research Foundation Itsuu Laboratory; EP2189443; (2010); A1;,
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Ester – an overview | ScienceDirect Topics

106614-28-2, name is Methyl 2,4-difluorobenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H6F2O2

0.80mL fuming nitric acid was added dropwise 5mL concentrated sulfuric acid, stirred for 5min,Methyl 2,4-difluorobenzoate was added dropwise(1.50g, 8.71mmol, 1.0eq), and then reacted at room temperature for 30min, poured into ice water to precipitate a white solid, which was suction filtered to give a white solidProducts, dry, white solid product 1.8g.

The synthetic route of 106614-28-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sun Yat-sen University; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Kou Yuhui; Hu Bolin; Jiang Haigang; Ye Jiuyong; Liu Zhiqiang; Xie Hongming; Zhang Yingjun; Yan Ming; (39 pag.)CN106749233; (2017); A;,
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Electric Literature of 10203-58-4, The chemical industry reduces the impact on the environment during synthesis 10203-58-4, name is Diethyl isobutylmalonate, I believe this compound will play a more active role in future production and life.

To a solution of 8.34 g (38.6 mmol) of diethyl isobutylmalonate in 35 mL of 95% EtOH was added a solution of 9.0 g (161 mmol) of KOH in 110 mL of 95% EtOH. The mixture was stirred at 25 C. for 16 hours and then at reflux for 1 hour. The mixture was cooled, diluted with water and extracted with CH3 Cl. The aqueous layer was cooled to 0 C. and acidified to pH<1 with 30 mL of concentrated HCl, then it was extracted with CHCl3. The aqueous layer was further continuously extracted with CHCl3 overnight. The combined organic extracts were dried over anhydrous Na2 SO4 and evaporated to afford 5.44 g (33.9 mmol, 88%) of isobutylmalonic acid as a solid which was essentially pure according to 1 H NMR and which was used without further purification. Characteristic analytical data are as follows: mp 108-110 C.; 1 H NMR (300 MHz, CDCl3) delta3.52 (t, J=8 Hz, 1H), 1.84 (t, J=8 Hz, 2H), 1.66 (m, 1H), 0.94 (d, J-7 Hz, 6H); 13 C NMR (75 MHz, CDCl3) delta175.6 (C=O), 49.7 (CH), 37.1 (CH2), 25.7 (CH), 21.7 (CH3). In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diethyl isobutylmalonate, other downstream synthetic routes, hurry up and to see. Reference:
Patent; Florida State University; US5470834; (1995); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 57381-43-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57381-43-8 as follows.

Step 3: Preparation of 5-Bromo-2-r3-cyclopropyl-l-(3-methyl-pyridin-2-yl)-lH-pyrazol-5- ylaminol-benzoic acid methyl ester; To a mixture of 3-cyclopropyl-l-(3-methyl-pyridin-2-yl)-lH-pyrazol-5-amine (1.0 g, 4.667 mmol) and 2,5-dibromo-benzoic acid methyl ester (1.25 g, 4.243 mmol) in toluene (20 mL) was added BINAP (0.264 g, 0.424 mmol), followed by Pd2(dba)3 (0.233 g, 0.255 mmol). To the mixture was added cesium carbonate (1.94 g, 5.94 mmol) and the suspension was heated at 118 ¡ãC overnight and cooled to rt. The cooled reaction mixture was diluted with ethyl acetate and filtered through Celite and concentrated. The product (0.61 g, 31percent) was isolated by column chromatography (25percent ethyl acetate/ hexanes), then on the HPLC (20 to 90 percent acetonitrile). MS m/z 427.1 (M+); HPLC RT (min) 4.06 {method (A)}.

According to the analysis of related databases, 57381-43-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2007/27842; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

18927-05-4, name is Methyl 3-Methoxyphenylacetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C10H12O3

[0333] AIBN (10 mg) was added to a solution of (3-Methoxy-phenyl)-acetic acid methyl ester (2g, 11MMOL) in [CCl4] (30ml). The solution was then heated to reflux and NBS (2.3g, 13MMOL) was added in portions. After complete addition the reaction mixture was refluxed for 4h. After cooling, solid residue was filtered off and the filtrate concentrated to yield product BROMO-(3-METHOXY-PHENYL)-ACETIC acid methyl ester, that was washed repeatedly with pet ether.

The synthetic route of 18927-05-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHEMOCENTRYX, INC.; WO2003/105853; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 50413-30-4, name is Methyl 2-amino-4-methoxylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: Methyl 2-amino-4-methoxylbenzoate

ii. 5-chloro-4-methoxyanthranilic acid (IXc, R=CH3) Treatment of methyl-4-methoxyanthranilate with sulfuryl chloride as described above afforded methyl-4-methoxy-5-chloroanthranilate, M.P., 197-200 C. in 90% yield. Saponification of methyl-4-methoxy-5-chloro anthranilate yielded 5-chloro-4-methoxyanthranilic acid in 64% yield, M.P., 210-3 C. Analysis, Percent Calc’d for C8 H8 ClNO3; C, 47.66; H, 4.00; N, 6.95 Found: C, 48.00; H, 4.11; N, 6.94.

The synthetic route of 50413-30-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer Inc.; US4287341; (1981); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics