Esters-buliding-blocks

Electric Literature of 1732-09-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1732-09-8, name is Dimethyl octanedioate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Adipinsuredimethylester wurde kontinuierlich in Rieselfahrweise mit Rckfhrung (Verhltnis Zulauf/Rckfhrung = 10/1) bei einer Belastung von 0,5 kg/(l*h), einem Druck von 240 bar und Reaktionstemperaturen von 200 C bzw. 220 C in einem senkrechten Rohrreaktor, der mit 200 ml Katalysator 1 gefllt war, hydriert. Die Versuchsdauer betrug insgesamt 14 Tage. GC-analytisch wurden im Reaktoraustrag bei 200 C bzw. 220’C Esterumstze von 99 % bzw. 100 %, Hexandiol-Anteile von 57 % bzw. 62 % und Methanol-Gehalte von 30 % bzw. 31 % detektiert. Nach Ausbau war der Katalysator noch voll erhalten und wies eine hohe mechanische Stabilitt auf. Seitendruckfestigkeit und Abrieb sind in Tabelle 1 zusammengestellt. Die Versuchsergebnisse sind nochmals in Tabelle 2 zusammengefat.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl octanedioate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BASF AKTIENGESELLSCHAFT; EP1218326; (2004); B1;,
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Related Products of 764667-64-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 764667-64-3 as follows.

Under stirring at room temperature, to a 2L three-necked reaction flask equipped with 800mL of acetonitrile,The compound obtained in Example 1 (316.2 g, 1.0 mol, 1 eq)After it is completely dissolved,Add in an ice bath(R) -tert-butylsulfenamide(133.3 g, 1.1 mol, 1.1 eq),After adding the system slowly warmed to room temperature,65 C overnight,TLC detection of the reaction process, the reaction was completed, remove most of the solvent, add water,Dichloromethane extraction, the combined organic phase was dried over anhydrous sodium sulfate,Remove the solvent, methanol and methylene chloride solution to give a white solid,Yield 81%.

According to the analysis of related databases, 764667-64-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Suzhou Aimate Biological Technology Co., Ltd.; Wang Mingzhong; Zhu Mingxin; Su Dao; Liu Junpeng; (14 pag.)CN107501112; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15224-11-0 as follows. category: esters-buliding-blocks

Step 2: Ethyl 2-((methylsulfonyloxy)methyl)cyclopropanecarboxylate (C-6) To a solution of alcohol C-5 (0.50 g, 3.47 mmol) and triethylamine (1.45 mL, 10.41 mmol) in anhydrous methylene chloride (12.0 mL) at 0 C. was added methanesulfonic anhydride (0.908 g, 5.21 mmol) in one portion. The reaction mixture was then stirred at room temperature for 1 h, diluted with diethyl ether (50 mL) and quenched with an aqueous pH 7 phosphate buffer solution (30 mL). The aqueous layer was extracted with diethyl ether (2*50 mL). The combined organic extracts were then successively washed with an aqueous pH 7 phosphate buffer solution (70 mL) and brine (70 mL), dried over MgSO4, filtered, and concentrated to give ethyl 2-((methylsulfonyloxy)methyl)cyclopropanecarboxylate (C-6) as a colorless oil (0.698 g, 91% yield). This material was immediately placed under argon and dissolved with anhydrous DMF (1.57 mL) to give a 2.0 M stock solution, which was used as such for the next step.

According to the analysis of related databases, 15224-11-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ting, Pauline C.; Aslanian, Robert; Caplen, Mary Ann; Cao, Jianhua; Chan, Tin-Yau; Kim, David; Kim, Hyunjin; Kim, Jae-Hun; Kuang, Rongze; Lee, Joe F.; Schwerdt, John; Wu, Heping; Zorn, Nicolas; US2011/224137; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 120-51-4, name is Benzyl benzoate, A new synthetic method of this compound is introduced below., Safety of Benzyl benzoate

General procedure: Carboxylic ester (5.0 mmol), amine (6.5 mmol), and Cp2ZrCl2 (146.7 mg, 0.5 mmol) were suspended in 1.2 mL of anhydrous toluene. The reaction was stirred at 110C for 4-20 h. The solvent was then removed under reduced pressure. The crude product was purified on a Biotage Isolera One using a Biotage SNAP Ultra cartridge (12 g or 25 g, 10-60% EtOAc in n-heptane) to isolate the desired amide.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Lenstra, Danny C.; Nguyen, D. Thao; Mecinovi?, Jasmin; Tetrahedron; vol. 71; 34; (2015); p. 5547 – 5553;,
Ester – Wikipedia,
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Application of 1245643-11-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1245643-11-1, name is Methyl 3,4-diamino-5-bromobenzoate, This compound has unique chemical properties. The synthetic route is as follows.

Triethylamine (95.4 mL; 660 mmol) was added to a mixture of intermediates la and lb (75 g; 132.47 mmol) (ratio la/lb undetermined) in THF (3 L) at 0C. The reaction mixture was stirred at 0C for 10 min. Then, morpholine (55.8 mL; 634 mmol) and bromo-tris-pyrrolidino-phosphonium hexafluorophosphate (135.2 g; 290 mmol) were added. The reaction mixture was stirred at rt for 12h. The solvent was evaporated and the residue was washed with H20. The solid (yellow) was filtered, washed with ACN, then Et20 and dried under vacuum to give 80 g (85%) of a mixture intermediates 3a and 3b (ratio -4/1 by 1H NMR).

The chemical industry reduces the impact on the environment during synthesis Methyl 3,4-diamino-5-bromobenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; ANGIBAUD, Patrick, Rene; QUEROLLE, Olivier, Alexis, Georges; BERTHELOT, Didier, Jean-Claude; MEYER, Christophe; WILLOT, Matthieu, Philippe, Victor; MEERPOEL, Lieven; JOUSSEAUME, Thierry, Francois, Alain, Jean; (114 pag.)WO2018/178280; (2018); A1;,
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Ester – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 581065-95-4 as follows. Recommanded Product: 581065-95-4

N-Fmoc imino diacetic acid, PSMA11 , (107 mg, 0.30 mmol) was treated with PSMA12 (212 mg, 0.66 mmol), TBTU (193 mg, 0.60 mmol), HOBt (92 mg, 0.60 mmol), and DIEA (209 muIota_, 1.20 mmol) in DMF for 2 h. The reaction was concentrated in vacuo and purified through Si02 gel chromatography to afford PSMA13 (250 mg, 91 %). AP-ESI+ Mass calcd C49H75N3016: 961.51 , Found: 962.6 [M+H]+, 984.6 [M+Na]+

According to the analysis of related databases, 581065-95-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SOLSTICE BIOLOGICS, LTD.; BRADSHAW, Curt, W.; ELTEPU, Laxman; KABAKIBI, Ayman; LAM, Son; LIU, Bin; LIU, Dingguo; MEADE, Bryan, R.; SAKAMURI, Sukumar; WO2015/69932; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 206551-41-9, A common heterocyclic compound, 206551-41-9, name is Methyl 3-bromo-2-fluorobenzoate, molecular formula is C8H6BrFO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

REFERENCE EXAMPLE 83 To a mixture of methyl 3-bromo-2-fluorobenzoate (117 mg), 2-thiopheneboronic acid (83 mg) and 1,2-dimethoxyethane (2 ml) were added a 2M aqueous solution of sodium carbonate (0.83 ml) and tetrakis(triphenylphosphine)palladium(0) (29 mg) at ambient temperature. The mixture was heated for 3 hours at 90¡ã C. After cooling, the reaction mixture was diluted with ethyl acetate (30 ml), and washed with water (20 ml*3) and brine (20 ml). The organic layer was dried over magnesium sulfate and filtered. After evaporation, the residue was chromatographed on a silica gel eluding with a mixture of ethyl acetate and n-hexane to give methyl 2-fluoro-3-(2-thienyl)benzoate (99 mg). Mass: 237 (m/z, (M+H)+) NMR(DMSO-d6, delta): 3.89 (3H, s), 7.1-7.3 (1H, m), 7.39 (1H, t, J=7.8 Hz), 7.6-7.9 (3H, m), 8.0-8.2 (1H, m).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Yamada, Akira; Spears, Glen; Hayashida, Hisashi; Tomishima, Masaki; Ito, Kiyotaka; Imanishi, Masashi; US2003/176454; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4630-80-2, name is Methyl cyclopentanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H12O2

The 60% sodium hydride 24.4g (0.61 muM) added to the 335 ml in tetrahydrofuran, heated to 75 C. Cyclopentyl methyl formate 50g (0.39 muM) is dissolved in acetonitrile 25g (0.61 muM), slowly adding sodium hydride to the reaction solution. The completion of the dropping, 70 C reaction 15 hours, cooling, concentrated in order to remove a portion of the solvent, adding water 180 ml, extracted with ethyl acetate three times, the organic phase is discarded. The aqueous phase is 4M hydrochloric acid to pH=2, extracted with ethyl acetate three times, drying, so as to obtain bright yellow 3 – cyclopentyl -3 – oxo third nitrile (II) 49.75g, yield is 93%

According to the analysis of related databases, 4630-80-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Bei Ka Pharmaceutical Co., Ltd.; Wang Yong; Liu Ligang; Xiang Jie; Yang Shiqiong; Li Qian; Kang Litao; (11 pag.)CN104496904; (2017); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 70347-04-5, The chemical industry reduces the impact on the environment during synthesis 70347-04-5, name is Methyl 4-methoxy-3-methylbenzoate, I believe this compound will play a more active role in future production and life.

To a mixture of methyl 4-methoxy-3-methylbenzoate (1.0 eq) in CCl4 (0.37M), NBS (1.1 eq) and AIBN (0.2 eq) was stirred overnight at 95 C. under nitrogen atmosphere. The resulting mixture was concentrated and partitioned between DCM and water, the organic layer was dried over Na2SO4, concentrated and purified by flash chromatography on silica (eluent PE/EA=100:1 to 20:1) to give the title compound as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-methoxy-3-methylbenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Apros Therapeutics, Inc.; WU, Tom Yao-Hsiang; (209 pag.)US2018/155298; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 619-42-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 619-42-1 name is Methyl 4-bromobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a sealed vial was added aniline (1.2 eq), methyl 4-(phenylamino)benzoate (1 eq), Pd(OAc)2 (0.05mmol), rac-BINAP (0.05 eq), K2CO3 (3 eq) and toluene. Then the sealed vial was irradiated in the microwave at 130C for 2h. After the reaction completed, ethyl acetate was added to dilute the reaction mixture, and then filtered by diatomite. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography on silica gel to afford diphenylamine intermediate (8).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-bromobenzoate, and friends who are interested can also refer to it.

Reference:
Article; Huang, Yafei; Yu, Mingcheng; Sun, Nannan; Tang, Ting; Yu, Fazhi; Song, Xiaoxia; Xie, Qiong; Fu, Wei; Shao, Liming; Wang, Yonghui; European Journal of Medicinal Chemistry; vol. 148; (2018); p. 465 – 476;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics