Esters-buliding-blocks

Minor groove DNA binders as antimicrobial agents. 1. Pyrrole tetraamides are potent antibacterials against vancomycin resistant enterococci and methicillin resistant Staphylococcus aureus was written by Dyatkina, Natalia B.;Roberts, Christopher D.;Keicher, Jesse D.;Dai, Yuqin;Nadherny, Joshua P.;Zhang, Wentao;Schmitz, Uli;Kongpachith, Ana;Fung, Kevin;Novikov, Alexander A.;Lou, Lillian;Velligan, Mark;Khorlin, Alexander A.;Chen, Ming S.. And the article was included in Journal of Medicinal Chemistry in 2002.COA of Formula: C7H8N2O4 This article mentions the following:

A new series of short pyrrole tetraamides are described whose submicromolar DNA binding affinity is an essential component for their strong antibacterial activity. This class of compounds is related to the linked bis-netropsins and bis-distamycins, but here, only one amino-pyrrole-carboxamide unit and an amidine tail is connected to either side of a central dicarboxylic acid linker. The highest degree of DNA binding, measured by compound-induced changes in UV melting temperatures of an AT-rich DNA oligomer, was observed for flat, aromatic linkers with no inherent bent, i.e., terephthalic acid or 1,4-pyridine-dicarboxylic acid. However, the antibacterial activity is critically linked to the size of the N-alkyl substituent of the pyrrole unit. None of the tetraamides with the commonly used methyl-pyrrole showed antibacterial activity. Isoamyl- or cyclopropylmethylene-substituted dipyrrole derivatives have the min. inhibitory concentrations in the submicromolar range. In vitro toxicity against human T-cells was studied for all compounds The degree to which compounds inhibited cell growth was neither directly correlated to DNA binding affinity nor directly correlated to antibacterial activity but seemed to depend strongly on the nature of the N-alkyl pyrrole substituents. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7COA of Formula: C7H8N2O4).

Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.COA of Formula: C7H8N2O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Stereocontrolled Alkylative Construction of Quaternary Carbon Centers was written by Kummer, David A.;Chain, William J.;Morales, Marvin R.;Quiroga, Olga;Myers, Andrew G.. And the article was included in Journal of the American Chemical Society in 2008.Related Products of 10203-58-4 This article mentions the following:

Protocols for the stereodefined formation of α,α-disubstituted enolates of pseudoephedrine amides are presented followed by the implementation of these in diastereoselective alkylation reactions. Direct alkylation of α,α-disubstituted pseudoephedrine amide substrates is demonstrated to be both efficient and diastereoselective across a range of substrates, as exemplified by alkylation of the diastereomeric pseudoephedrine α-methylbutyramides, where both substrates are found to undergo stereospecific replacement of the α-C-H bond with α-C-alkyl, with retention of stereochem. This is shown to arise by sequential stereospecific enolization and alkylation reactions, with the alkyl halide attacking a common π-face of the E- and Z-enolates, proposed to be opposite the pseudoephedrine alkoxide side chain. Pseudoephedrine α-phenylbutyramides are found to undergo highly stereoselective but not stereospecific α-alkylation reactions, which evidence suggests is due to facile enolate isomerization. Also α,α-disubstituted pseudoephedrine amide enolates can be generated in a highly stereocontrolled fashion by conjugate addition of an alkyllithium reagent to the s-cis-conformer of an α-alkyl-α,β-unsaturated pseudoephedrine amide, providing α,α-disubstituted enolate substrates that undergo alkylation in the same sense as those formed by direct deprotonation. Methods are presented to transform the α-quaternary pseudoephedrine amide products into optically active carboxylic acids, ketones, primary alcs., and aldehydes. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Related Products of 10203-58-4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 10203-58-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Straightforward Enantioselective Access to γ-Butyrolactones Bearing an All-Carbon β-Quaternary Stereocenter was written by Meninno, Sara;Fuoco, Tiziana;Tedesco, Consiglia;Lattanzi, Alessandra. And the article was included in Organic Letters in 2014.Application of 33166-79-9 This article mentions the following:

An enantioselective one-pot aldol/lactonization sequence has been developed to access highly challenging γ-butyrolactones bearing an all-carbon quaternary stereocenter at the β-position by reacting acylated succinic esters with aqueous formaldehyde in the presence of 3 mol % loading of a cinchona alkaloid-derived squaramide providing direct access to paraconic acid derivatives in high yield and fairly good level of enantioselectivity (up to 88% ee). Thus, e.g., keto diester I (R¹ = 2-phenyl-2-Pr, R³ = Me) + paraformaldehyde in presence of epi-hydroquinine-derived squaramide afforded lactone II in 79% yield and 78% ee. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Application of 33166-79-9).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 33166-79-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Diastereomeric (η⁴-diene)Fe(CO)₃ complexes containing chiral amide groups: a convenient method for the resolution of amino acids was written by Schumacher, Marc;Coste, Gerald;Miesch, Laurence. And the article was included in Synthesis in 2009.Electric Literature of C12H23NO4 This article mentions the following:

Diastereomeric (η⁴-N-substituted-hexa-2,4-dienamide)Fe(CO)₃ complexes bearing chiral amide groups were used for the resolution of (η⁴-dienecarboxylic acid)Fe(CO)₃ complexes. Using the latter, enantiomerically pure proteinogenic or nonproteinogenic α-amino acids were prepared In the experiment, the researchers used many compounds, for example, Boc-D-Leu-OMe (cas: 133467-01-3Electric Literature of C12H23NO4).

Boc-D-Leu-OMe (cas: 133467-01-3) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Electric Literature of C12H23NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nickel-selective coated disk electrode based on carbon nanotube composite modified with a new Schiff base was written by Tashkhourian, J.;Ghaderizadeh, S. M.;Montazerozohori, M.. And the article was included in Russian Journal of Electrochemistry in 2015.Application of 106-79-6 This article mentions the following:

A coated disk polyvinyl chloride (PVC) matrix membrane ion-selective electrode for detection of nickel ion was fabricated based on multiwalled carbon nanotube composite modified with bis(2-hydroxyacetophenone)-1,2-propandiimine (BHAPN) as ionophore. The electrode showed a Nernstian slope of 29.7 ± 0.45 mV decade^-1 over a wide concentration range of 9.1 × 10^-7 to 2.0 x 10^-2 mol L^-1 of Ni(NO₃)₂ with detection limit of 3.2 x 10^-7 mol L^-1. This electrode was applicable in the pH range of 3.0-7.9 and had a short response time of approx. 6.0 s. The electrode exhibited good selectivity for Ni(II) relative to other metal ions. The use of multiwalled carbon nanotube (MWCNTs) in a polymer matrix improves the linear range and sensitivity of the electrode. The practical anal. utility of the electrode was demonstrated by the using it as an indicator electrode for potentiometric titration of Ni(II) ions with EDTA solution In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Application of 106-79-6).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 106-79-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Analysis and comparison of volatile components in purple rice sweet wine with different sterilization treatments by electronic nose and headspace gas chromatography-ion mobility spectrometry was written by Peng, Xu-yi;Zheng, Jing-shao;Liu, Yu-hang;Xu, Lin-huan;Kuang, Wei-yang;Huang, Wei. And the article was included in Xiandai Shipin Keji in 2021.Product Details of 868-57-5 This article mentions the following:

In order to select a more suitable sterilization method and maintain the original flavor of purple rice sweet wine as much as possible, this article used electronic nose, headspace gas chromatog.-ion mobility spectroscopy (HS-GC-IMS) to analyze and compare the volatile components of four groups of samples of heat sterilization, irradiation sterilization, ultra-high pressure sterilization and unsterilized control. The results of electronic nose test showed that the discrimination between the samples was good, and the differences of volatile components were mainly caused by nitrogen oxides, alcs. and aldehydes and ketones, methyls, sulfides. HS-GC-IMS detection and identification found that the 4 groups of samples shared 42 substances in 7 categories of alcs., esters, aldehydes, ketones, acids, olefins and alkanes. The relative content of alcs. was the highest (62.03%∼65.73%), followed by esters (12.70%∼13.93%) and ketones (9.36%∼11.59%), the sterilization method had a great influence on the relative content of each component. The relative odor activity value (ROAV) showed that there were 11 key flavor compounds in the samples, mainly including Et 2-methylbutyrate (69.39∼100), acetaldehyde (38.61∼42.05), Et isovalerate (18.16∼27.23), isoamyl alc. (9.91∼18.08), butyraldehyde (14.13∼18.06), Et isobutyrate (8.22∼12.18). Both linear discriminant anal. and nearest neighbor algorithm anal. showed that the volatile components of ultra-high pressure and unsterilized samples were the most similar, followed by irradiation and heat sterilization samples, indicating that ultra-high pressure sterilization had the least effect on the aroma of samples, which was the best sterilization method for purple rice wine. The results of this study provide reference value for the selection of sterilization methods for sweet fermented rice. In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5Product Details of 868-57-5).

Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Product Details of 868-57-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Selective cyclization of alkynols and alkynylamines catalyzed by potassium tert-butoxide was written by Li, Deng Yuan;Shi, Ke Ji;Mao, Xiao Feng;Zhao, Zheng Le;Wu, Xin Yan;Liu, Pei Nian. And the article was included in Tetrahedron in 2014.Synthetic Route of C13H15NO2 This article mentions the following:

Potassium tert-butoxide (t-BuOK) was found to be an effective catalyst for the cyclization of aromatic alkynols and alkynylamines. In the presence of 10 mol % t-BuOK, a range of alkynols were converted to the corresponding exo-cyclic enol ethers as pure Z-stereoisomers with 100% selectivity and moderate to excellent yields. Moreover, the cyclization of alkynylamines was also achieved to afford indoles and isoindolin-1-ones in good yields. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3Synthetic Route of C13H15NO2).

tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C13H15NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis, structure, absorption and fluorescence of Pechmann dye heteroanalogues was written by Aysha, Tarek;Lunak, Stanislav Jr.;Lycka, Antonin;Vynuchal, Jan;Elias, Zdenek;Ruzicka, Ales;Padelkova, Zdenka;Hrdina, Radim. And the article was included in Dyes and Pigments in 2013.Synthetic Route of C9H10O3S This article mentions the following:

Three N-analogs of Pechmann dye with identical aryl groups in the 5, 5′-positions (aryl = Ph, 2-naphthyl, 2-thienyl) and carboxy ester groups in the 3,3′-positions were synthesized by oxidative dimerization of the corresponding 5-aryl-pyrrolinone esters. Derivatives with improved solubility in most organic solvents were prepared by subsequent N-methylation. The dyes were confirmed as E isomers, i.e. holding an all-trans 1,6-diaryl-1,3,5-hexatriene backbone, with slight torsion of central CC bond by X-ray diffraction and d. functional theory (DFT) calculations No E/Z photoisomerization was observed Full assignment of ¹H and ¹³C NMR signals was performed. The absorption spectra are quite similar with the maxima in the range 572 nm (aryl = phenyl)-643 nm (aryl = 2-thienyl) in accordance with time dependent DFT calculations of excitation energies. No fluorescence was observed in solution, while all compounds fluoresce in low temperature solvent glass (77 K) and a weak solid-state fluorescence of Ph and 2-naphthyl derivatives in red/IR region was detected. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Synthetic Route of C9H10O3S).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C9H10O3S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Propellanes. Part LXXXII. Preparation and labeling of [20.3.3]propellane-24,27-dione was written by Ashkenazi, Pnina;Kettenring, Juergen;Migdal, Shmuel;Gutman, Arie L.;Ginsburg, David. And the article was included in Helvetica Chimica Acta in 1985.SDS of cas: 3903-40-0 This article mentions the following:

The title compound I was prepared by Kolbe’s electrochem. reaction of MeO₂C(CH₂)₁₀CO₂H to give MeO₂C(CH₂)₂₀CO₂Me which was treated with Na and Me₃SiCl in PhMe, and then aqueous HCl-THF to give 89% the hydroxy ketone II (R = OH, R¹ = H). Treatment of II with Bi₂O₃ in AcOH gave 77% the diketone II (RR¹ = O) which was treated with MeO₂CCH₂COCH₂CO₂Me and KOH in MeOH-C₆H₆ for 10 days, followed by 6N HCl to give 83.3% I. Treatment of I with D₂O and HCl in a sealed tube at 120° achieved more than 90% incorporation of ²H at the positions α to the carbonyls. However, similar treatment of I with tritiated water achieved only 3% ³H-incorporation. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0SDS of cas: 3903-40-0).

12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 3903-40-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quantitative evaluation of the conjugation effect in the hydrolysis of para-substituted aromatic acid esters was written by Pritykin, L. M.;Selyutin, O. B.;Nikolaev, A. L.. And the article was included in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) in 1999.Product Details of 587-88-2 This article mentions the following:

The rate constants of alk. and acid hydrolysis of 10 series of para-substituted benzoic, cinnamic, phenylpropynoic, biphenylcarboxylic, phenylacetic, and 3-phenylpropionic acids linearly correlate with the population of the p_z-orbital of the phenylene C atom bearing the substituent. This parameter can be regarded as a quant. measure of the conjugation effect. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Product Details of 587-88-2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 587-88-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics